Compile Data Set for Download or QSAR
Found 30 Enz. Inhib. hit(s) with all data for entry = 50021458
TargetMetabotropic glutamate receptor 5(Rattus norvegicus (Rat))
Pfizer Global Research & Development

Curated by ChEMBL
LigandPNGBDBM50224920(3-methoxy-5-(2-methyl-1,6-naphthyridin-7-yl)benzon...)copy SMILEScopy InChI
Affinity DataIC50: 6.19nMAssay Description:Antagonist activity at rat mGlu5 receptor expressed in CHO cells assessed as inhibition of quisqualate-stimulated calcium mobilizationMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2V40TXSPubMed
TargetMetabotropic glutamate receptor 5(Rattus norvegicus (Rat))
Pfizer Global Research & Development

Curated by ChEMBL
LigandPNGBDBM50224924(2-(3,4-dimethylphenyl)-1,8-naphthyridine | CHEMBL2...)copy SMILEScopy InChI
Affinity DataIC50: 45nMAssay Description:Antagonist activity at rat mGlu5 receptor expressed in CHO cells assessed as inhibition of quisqualate-stimulated calcium mobilizationMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2V40TXSPubMed
TargetMetabotropic glutamate receptor 5(Rattus norvegicus (Rat))
Pfizer Global Research & Development

Curated by ChEMBL
LigandPNGBDBM50224929(2-(3-bromophenyl)-7-methyl-1,8-naphthyridine | CHE...)copy SMILEScopy InChI
Affinity DataIC50: 47.9nMAssay Description:Antagonist activity at rat mGlu5 receptor expressed in CHO cells assessed as inhibition of quisqualate-stimulated calcium mobilizationMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2V40TXSPubMed
TargetMetabotropic glutamate receptor 5(Rattus norvegicus (Rat))
Pfizer Global Research & Development

Curated by ChEMBL
LigandPNGBDBM50224922(2-(3,5-dimethoxyphenyl)-7-methyl-1,8-naphthyridine...)copy SMILEScopy InChI
Affinity DataIC50: 51.7nMAssay Description:Antagonist activity at rat mGlu5 receptor expressed in CHO cells assessed as inhibition of quisqualate-stimulated calcium mobilizationMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2V40TXSPubMed
TargetMetabotropic glutamate receptor 5(Rattus norvegicus (Rat))
Pfizer Global Research & Development

Curated by ChEMBL
LigandPNGBDBM50224932(3-methoxy-5-(1,5-naphthyridin-3-yl)benzonitrile | ...)copy SMILEScopy InChI
Affinity DataIC50: 55nMAssay Description:Antagonist activity at rat mGlu5 receptor expressed in CHO cells assessed as inhibition of quisqualate-stimulated calcium mobilizationMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2V40TXSPubMed
TargetMetabotropic glutamate receptor 5(Rattus norvegicus (Rat))
Pfizer Global Research & Development

Curated by ChEMBL
LigandPNGBDBM50224941(2-(3,5-dimethoxyphenyl)-1,8-naphthyridine | CHEMBL...)copy SMILEScopy InChI
Affinity DataIC50: 67nMAssay Description:Antagonist activity at rat mGlu5 receptor expressed in CHO cells assessed as inhibition of quisqualate-stimulated calcium mobilizationMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2V40TXSPubMed
TargetMetabotropic glutamate receptor 5(Rattus norvegicus (Rat))
Pfizer Global Research & Development

Curated by ChEMBL
LigandPNGBDBM50224940(3-methoxy-5-(1,6-naphthyridin-7-yl)benzonitrile | ...)copy SMILEScopy InChI
Affinity DataIC50: 68nMAssay Description:Antagonist activity at rat mGlu5 receptor expressed in CHO cells assessed as inhibition of quisqualate-stimulated calcium mobilizationMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2V40TXSPubMed
TargetMetabotropic glutamate receptor 5(Rattus norvegicus (Rat))
Pfizer Global Research & Development

Curated by ChEMBL
LigandPNGBDBM50224923(3-(1,8-naphthyridin-2-yl)benzonitrile | CHEMBL2353...)copy SMILEScopy InChI
Affinity DataIC50: 115nMAssay Description:Antagonist activity at rat mGlu5 receptor expressed in CHO cells assessed as inhibition of quisqualate-stimulated calcium mobilizationMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2V40TXSPubMed
TargetMetabotropic glutamate receptor 5(Rattus norvegicus (Rat))
Pfizer Global Research & Development

Curated by ChEMBL
LigandPNGBDBM50224936(2-(3-chlorophenyl)-7-methyl-1,8-naphthyridine | CH...)copy SMILEScopy InChI
Affinity DataIC50: 177nMAssay Description:Antagonist activity at rat mGlu5 receptor expressed in CHO cells assessed as inhibition of quisqualate-stimulated calcium mobilizationMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2V40TXSPubMed
TargetMetabotropic glutamate receptor 5(Rattus norvegicus (Rat))
Pfizer Global Research & Development

Curated by ChEMBL
LigandPNGBDBM50224925(2-(3,5-difluorophenyl)-7-methyl-1,8-naphthyridine ...)copy SMILEScopy InChI
Affinity DataIC50: 181nMAssay Description:Antagonist activity at rat mGlu5 receptor expressed in CHO cells assessed as inhibition of quisqualate-stimulated calcium mobilizationMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2V40TXSPubMed
TargetMetabotropic glutamate receptor 5(Rattus norvegicus (Rat))
Pfizer Global Research & Development

Curated by ChEMBL
LigandPNGBDBM50224917(2-m-tolyl-1,8-naphthyridine | CHEMBL395902)copy SMILEScopy InChI
Affinity DataIC50: 225nMAssay Description:Antagonist activity at rat mGlu5 receptor expressed in CHO cells assessed as inhibition of quisqualate-stimulated calcium mobilizationMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2V40TXSPubMed
TargetMetabotropic glutamate receptor 5(Rattus norvegicus (Rat))
Pfizer Global Research & Development

Curated by ChEMBL
LigandPNGBDBM50224939(2-methyl-7-m-tolyl-1,8-naphthyridine | CHEMBL23562...)copy SMILEScopy InChI
Affinity DataIC50: 277nMAssay Description:Antagonist activity at rat mGlu5 receptor expressed in CHO cells assessed as inhibition of quisqualate-stimulated calcium mobilizationMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2V40TXSPubMed
TargetMetabotropic glutamate receptor 5(Rattus norvegicus (Rat))
Pfizer Global Research & Development

Curated by ChEMBL
LigandPNGBDBM50224926(7-(3,5-dimethoxyphenyl)-2-methyl-1,6-naphthyridine...)copy SMILEScopy InChI
Affinity DataIC50: 345nMAssay Description:Antagonist activity at rat mGlu5 receptor expressed in CHO cells assessed as inhibition of quisqualate-stimulated calcium mobilizationMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2V40TXSPubMed
TargetMetabotropic glutamate receptor 5(Rattus norvegicus (Rat))
Pfizer Global Research & Development

Curated by ChEMBL
LigandPNGBDBM50224921(3-(methoxymethoxy)-5-(1,6-naphthyridin-7-yl)benzon...)copy SMILEScopy InChI
Affinity DataIC50: 468nMAssay Description:Antagonist activity at rat mGlu5 receptor expressed in CHO cells assessed as inhibition of quisqualate-stimulated calcium mobilizationMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2V40TXSPubMed
TargetMetabotropic glutamate receptor 5(Rattus norvegicus (Rat))
Pfizer Global Research & Development

Curated by ChEMBL
LigandPNGBDBM50224931(3-(7-methyl-1,8-naphthyridin-2-yl)benzonitrile | C...)copy SMILEScopy InChI
Affinity DataIC50: 480nMAssay Description:Antagonist activity at rat mGlu5 receptor expressed in CHO cells assessed as inhibition of quisqualate-stimulated calcium mobilizationMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2V40TXSPubMed
TargetMetabotropic glutamate receptor 5(Rattus norvegicus (Rat))
Pfizer Global Research & Development

Curated by ChEMBL
LigandPNGBDBM50090686(2-Methyl-7-phenyl-[1,8]naphthyridine | 2-methyl-7-...)copy SMILEScopy InChI
Affinity DataIC50: 664nMAssay Description:Antagonist activity at rat mGlu5 receptor expressed in CHO cells assessed as inhibition of quisqualate-stimulated calcium mobilizationMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2V40TXSPubMed
TargetMetabotropic glutamate receptor 5(Rattus norvegicus (Rat))
Pfizer Global Research & Development

Curated by ChEMBL
LigandPNGBDBM50224938(2-methyl-7-m-tolyl-1,6-naphthyridine | CHEMBL23643...)copy SMILEScopy InChI
Affinity DataIC50: 676nMAssay Description:Antagonist activity at rat mGlu5 receptor expressed in CHO cells assessed as inhibition of quisqualate-stimulated calcium mobilizationMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2V40TXSPubMed
TargetMetabotropic glutamate receptor 5(Rattus norvegicus (Rat))
Pfizer Global Research & Development

Curated by ChEMBL
LigandPNGBDBM50224930(7-m-tolyl-1,6-naphthyridine | CHEMBL238388)copy SMILEScopy InChI
Affinity DataIC50: 1.27E+3nMAssay Description:Antagonist activity at rat mGlu5 receptor expressed in CHO cells assessed as inhibition of quisqualate-stimulated calcium mobilizationMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2V40TXSPubMed
TargetMetabotropic glutamate receptor 5(Rattus norvegicus (Rat))
Pfizer Global Research & Development

Curated by ChEMBL
LigandPNGBDBM50224933(3-fluoro-5-(1,6-naphthyridin-7-yl)benzonitrile | C...)copy SMILEScopy InChI
Affinity DataIC50: 1.59E+3nMAssay Description:Antagonist activity at rat mGlu5 receptor expressed in CHO cells assessed as inhibition of quisqualate-stimulated calcium mobilizationMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2V40TXSPubMed
TargetMetabotropic glutamate receptor 5(Rattus norvegicus (Rat))
Pfizer Global Research & Development

Curated by ChEMBL
LigandPNGBDBM50224918(2-phenyl-1,8-naphthyridine | CHEMBL235396)copy SMILEScopy InChI
Affinity DataIC50: 1.84E+3nMAssay Description:Antagonist activity at rat mGlu5 receptor expressed in CHO cells assessed as inhibition of quisqualate-stimulated calcium mobilizationMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2V40TXSPubMed
TargetMetabotropic glutamate receptor 5(Rattus norvegicus (Rat))
Pfizer Global Research & Development

Curated by ChEMBL
LigandPNGBDBM50224943(7-(3-fluoro-5-methylphenyl)-2-methyl-1,6-naphthyri...)copy SMILEScopy InChI
Affinity DataIC50: 2.93E+3nMAssay Description:Antagonist activity at rat mGlu5 receptor expressed in CHO cells assessed as inhibition of quisqualate-stimulated calcium mobilizationMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2V40TXSPubMed
TargetMetabotropic glutamate receptor 5(Rattus norvegicus (Rat))
Pfizer Global Research & Development

Curated by ChEMBL
LigandPNGBDBM50224927(7-(3,5-dimethoxyphenyl)-1,6-naphthyridine | CHEMBL...)copy SMILEScopy InChI
Affinity DataIC50: 6.07E+3nMAssay Description:Antagonist activity at rat mGlu5 receptor expressed in CHO cells assessed as inhibition of quisqualate-stimulated calcium mobilizationMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2V40TXSPubMed
TargetMetabotropic glutamate receptor 5(Rattus norvegicus (Rat))
Pfizer Global Research & Development

Curated by ChEMBL
LigandPNGBDBM50224937(7-(3-fluoro-5-methylphenyl)-1,6-naphthyridine | CH...)copy SMILEScopy InChI
Affinity DataIC50: 6.57E+3nMAssay Description:Antagonist activity at rat mGlu5 receptor expressed in CHO cells assessed as inhibition of quisqualate-stimulated calcium mobilizationMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2V40TXSPubMed
TargetMetabotropic glutamate receptor 5(Rattus norvegicus (Rat))
Pfizer Global Research & Development

Curated by ChEMBL
LigandPNGBDBM50224944(7-(3-methoxyphenyl)-2-methyl-1,6-naphthyridine | C...)copy SMILEScopy InChI
Affinity DataIC50: 7.90E+3nMAssay Description:Antagonist activity at rat mGlu5 receptor expressed in CHO cells assessed as inhibition of quisqualate-stimulated calcium mobilizationMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2V40TXSPubMed
TargetMetabotropic glutamate receptor 5(Rattus norvegicus (Rat))
Pfizer Global Research & Development

Curated by ChEMBL
LigandPNGBDBM50224945(3-(3,4-dimethylphenyl)-1,5-naphthyridine | CHEMBL2...)copy SMILEScopy InChI
Affinity DataIC50: 1.20E+4nMAssay Description:Antagonist activity at rat mGlu5 receptor expressed in CHO cells assessed as inhibition of quisqualate-stimulated calcium mobilizationMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2V40TXSPubMed
TargetMetabotropic glutamate receptor 5(Rattus norvegicus (Rat))
Pfizer Global Research & Development

Curated by ChEMBL
LigandPNGBDBM50224919(3-m-tolyl-1,5-naphthyridine | CHEMBL236263)copy SMILEScopy InChI
Affinity DataIC50: 1.57E+4nMAssay Description:Antagonist activity at rat mGlu5 receptor expressed in CHO cells assessed as inhibition of quisqualate-stimulated calcium mobilizationMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2V40TXSPubMed
TargetMetabotropic glutamate receptor 5(Rattus norvegicus (Rat))
Pfizer Global Research & Development

Curated by ChEMBL
LigandPNGBDBM50224942(3-(1,5-naphthyridin-3-yl)benzonitrile | CHEMBL3947...)copy SMILEScopy InChI
Affinity DataIC50: 1.86E+4nMAssay Description:Antagonist activity at rat mGlu5 receptor expressed in CHO cells assessed as inhibition of quisqualate-stimulated calcium mobilizationMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2V40TXSPubMed
TargetMetabotropic glutamate receptor 5(Rattus norvegicus (Rat))
Pfizer Global Research & Development

Curated by ChEMBL
LigandPNGBDBM50224934(2-methyl-7-phenyl-1,6-naphthyridine | CHEMBL236429)copy SMILEScopy InChI
Affinity DataIC50: 3.00E+4nMAssay Description:Antagonist activity at rat mGlu5 receptor expressed in CHO cells assessed as inhibition of quisqualate-stimulated calcium mobilizationMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2V40TXSPubMed
TargetMetabotropic glutamate receptor 5(Rattus norvegicus (Rat))
Pfizer Global Research & Development

Curated by ChEMBL
LigandPNGBDBM50224935(7-phenyl-1,6-naphthyridine | CHEMBL235399)copy SMILEScopy InChI
Affinity DataIC50: 3.00E+4nMAssay Description:Antagonist activity at rat mGlu5 receptor expressed in CHO cells assessed as inhibition of quisqualate-stimulated calcium mobilizationMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2V40TXSPubMed
TargetMetabotropic glutamate receptor 5(Rattus norvegicus (Rat))
Pfizer Global Research & Development

Curated by ChEMBL
LigandPNGBDBM50224928(3-(3,5-dimethylphenyl)-1,5-naphthyridine | CHEMBL2...)copy SMILEScopy InChI
Affinity DataIC50: 3.00E+4nMAssay Description:Antagonist activity at rat mGlu5 receptor expressed in CHO cells assessed as inhibition of quisqualate-stimulated calcium mobilizationMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2V40TXSPubMed