Compile Data Set for Download or QSAR
Found 47 Enz. Inhib. hit(s) with all data for entry = 50026320
TargetIntegrin alpha-4(Homo sapiens (Human))
UCB

Curated by ChEMBL
LigandPNGBDBM50243822((S)-2-(2-Bromo-3-oxo-spiro[3.5]non-1-en-1-ylamino)...)copy SMILEScopy InChI
Affinity DataIC50: 2nMAssay Description:Inhibition of integrin alpha4beta1 receptor in human whole blood by flow cytometryMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2JW8DQZPubMed
TargetIntegrin alpha-4(Homo sapiens (Human))
UCB

Curated by ChEMBL
LigandPNGBDBM50243737((S)-2-(2-Isopropylsulfanyl-3-oxo-spiro[3.5]non-1-e...)copy SMILEScopy InChI
Affinity DataIC50: 2nMAssay Description:Inhibition of integrin alpha4beta1 receptor in human whole blood by flow cytometryMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2JW8DQZPubMed
TargetIntegrin alpha-4(Homo sapiens (Human))
UCB

Curated by ChEMBL
LigandPNGBDBM50243738((S)-2-(2-Methylsulfanyl-3-oxo-spiro[3.5]non-1-en-1...)copy SMILEScopy InChI
Affinity DataIC50: 2nMAssay Description:Inhibition of integrin alpha4beta1 receptor in human whole blood by flow cytometryMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2JW8DQZPubMed
TargetIntegrin alpha-4(Homo sapiens (Human))
UCB

Curated by ChEMBL
LigandPNGBDBM50243759((S)-2-(2-Bromo-3-oxo-spiro[3.5]non-1-en-1-ylamino)...)copy SMILEScopy InChI
Affinity DataIC50: 3nMAssay Description:Inhibition of integrin alpha4beta1 receptor in human whole blood by flow cytometryMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2JW8DQZPubMed
TargetIntegrin alpha-4(Homo sapiens (Human))
UCB

Curated by ChEMBL
LigandPNGBDBM50243823((S)-2-(2-Bromo-3-oxo-spiro[3.5]non-1-en-1-ylamino)...)copy SMILEScopy InChI
Affinity DataIC50: 3nMAssay Description:Inhibition of integrin alpha4beta1 receptor in human whole blood by flow cytometryMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2JW8DQZPubMed
TargetIntegrin alpha-4(Homo sapiens (Human))
UCB

Curated by ChEMBL
LigandPNGBDBM50243736((S)-2-(2-Bromo-3-oxo-spiro[3.5]non-1-en-1-ylamino)...)copy SMILEScopy InChI
Affinity DataIC50: 3nMAssay Description:Inhibition of integrin alpha4beta1 receptor in human whole blood by flow cytometryMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2JW8DQZPubMed
TargetIntegrin alpha-4(Homo sapiens (Human))
UCB

Curated by ChEMBL
LigandPNGBDBM50243758((S)-2-(2-Bromo-3-oxo-spiro[3.5]non-1-en-1-ylamino)...)copy SMILEScopy InChI
Affinity DataIC50: 3nMAssay Description:Inhibition of integrin alpha4beta1 receptor in human whole blood by flow cytometryMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2JW8DQZPubMed
TargetIntegrin alpha-4(Homo sapiens (Human))
UCB

Curated by ChEMBL
LigandPNGBDBM50243824((S)-2-(2-Bromo-3-oxo-spiro[3.5]non-1-en-1-ylamino)...)copy SMILEScopy InChI
Affinity DataIC50: 6nMAssay Description:Inhibition of integrin alpha4beta1 receptor in human whole blood by flow cytometryMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2JW8DQZPubMed
TargetIntegrin alpha-4(Homo sapiens (Human))
UCB

Curated by ChEMBL
LigandPNGBDBM50243735((S)-2-(2-Chloro-3-oxo-spiro[3.5]non-1-en-1-ylamino...)copy SMILEScopy InChI
Affinity DataIC50: 7nMAssay Description:Inhibition of integrin alpha4beta1 receptor in human whole blood by flow cytometryMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2JW8DQZPubMed
TargetIntegrin alpha-4(Homo sapiens (Human))
UCB

Curated by ChEMBL
LigandPNGBDBM50243821((S)-2-(2-Bromo-3-oxo-spiro[3.5]non-1-en-1-ylamino)...)copy SMILEScopy InChI
Affinity DataIC50: 8nMAssay Description:Inhibition of integrin alpha4beta1 receptor in human whole blood by flow cytometryMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2JW8DQZPubMed
TargetIntegrin alpha-4(Homo sapiens (Human))
UCB

Curated by ChEMBL
LigandPNGBDBM50243820((S)-2-(2-Bromo-3-oxo-spiro[3.5]non-1-en-1-ylamino)...)copy SMILEScopy InChI
Affinity DataIC50: 8nMAssay Description:Inhibition of integrin alpha4beta1 receptor in human whole blood by flow cytometryMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2JW8DQZPubMed
TargetIntegrin alpha-4(Homo sapiens (Human))
UCB

Curated by ChEMBL
LigandPNGBDBM50243818((S)-2-(2-Bromo-3-oxo-spiro[3.5]non-1-en-1-ylamino)...)copy SMILEScopy InChI
Affinity DataIC50: 9nMAssay Description:Inhibition of integrin alpha4beta1 receptor in human whole blood by flow cytometryMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2JW8DQZPubMed
TargetIntegrin alpha-4(Homo sapiens (Human))
UCB

Curated by ChEMBL
LigandPNGBDBM50243819((S)-2-(2-Bromo-3-oxo-spiro[3.5]non-1-en-1-ylamino)...)copy SMILEScopy InChI
Affinity DataIC50: 9nMAssay Description:Inhibition of integrin alpha4beta1 receptor in human whole blood by flow cytometryMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2JW8DQZPubMed
TargetIntegrin alpha-4(Homo sapiens (Human))
UCB

Curated by ChEMBL
LigandPNGBDBM50243757((S)-2-(2-Bromo-3-oxo-spiro[3.5]non-1-en-1-ylamino)...)copy SMILEScopy InChI
Affinity DataIC50: 10nMAssay Description:Inhibition of integrin alpha4beta1 receptor in human whole blood by flow cytometryMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2JW8DQZPubMed
TargetIntegrin alpha-4(Homo sapiens (Human))
UCB

Curated by ChEMBL
LigandPNGBDBM50243756((S)-2-(2-Bromo-3-oxo-spiro[3.5]non-1-en-1-ylamino)...)copy SMILEScopy InChI
Affinity DataIC50: 10nMAssay Description:Inhibition of integrin alpha4beta1 receptor in human whole blood by flow cytometryMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2JW8DQZPubMed
TargetIntegrin alpha-4(Homo sapiens (Human))
UCB

Curated by ChEMBL
LigandPNGBDBM50244342((2S)-2-(2-bromo-4,4-dimethyl-3-oxocyclobut-1-enyla...)copy SMILEScopy InChI
Affinity DataIC50: 10nMAssay Description:Inhibition of integrin alpha4beta1 receptor in human whole blood by flow cytometryMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2JW8DQZPubMed
TargetIntegrin alpha-4(Homo sapiens (Human))
UCB

Curated by ChEMBL
LigandPNGBDBM50243815((S)-2-(2-Bromo-3-oxo-spiro[3.5]non-1-en-1-ylamino)...)copy SMILEScopy InChI
Affinity DataIC50: 11nMAssay Description:Inhibition of integrin alpha4beta1 receptor in human whole blood by flow cytometryMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2JW8DQZPubMed
TargetIntegrin alpha-4(Homo sapiens (Human))
UCB

Curated by ChEMBL
LigandPNGBDBM50243755((S)-2-(2-Bromo-3-oxo-spiro[3.5]non-1-en-1-ylamino)...)copy SMILEScopy InChI
Affinity DataIC50: 11nMAssay Description:Inhibition of integrin alpha4beta1 receptor in human whole blood by flow cytometryMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2JW8DQZPubMed
TargetIntegrin alpha-4(Homo sapiens (Human))
UCB

Curated by ChEMBL
LigandPNGBDBM50243817((S)-2-(2-Bromo-3-oxo-spiro[3.5]non-1-en-1-ylamino)...)copy SMILEScopy InChI
Affinity DataIC50: 13nMAssay Description:Inhibition of integrin alpha4beta1 receptor in human whole blood by flow cytometryMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2JW8DQZPubMed
TargetIntegrin alpha-4(Homo sapiens (Human))
UCB

Curated by ChEMBL
LigandPNGBDBM50243816((S)-2-(2-Bromo-3-oxo-spiro[3.5]non-1-en-1-ylamino)...)copy SMILEScopy InChI
Affinity DataIC50: 14nMAssay Description:Inhibition of integrin alpha4beta1 receptor in human whole blood by flow cytometryMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2JW8DQZPubMed
TargetIntegrin alpha-4(Homo sapiens (Human))
UCB

Curated by ChEMBL
LigandPNGBDBM50243814((S)-2-(2-Bromo-3-oxo-spiro[3.5]non-1-en-1-ylamino)...)copy SMILEScopy InChI
Affinity DataIC50: 18nMAssay Description:Inhibition of integrin alpha4beta1 receptor in human whole blood by flow cytometryMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2JW8DQZPubMed
TargetIntegrin alpha-4(Homo sapiens (Human))
UCB

Curated by ChEMBL
LigandPNGBDBM50244341((2S)-2-(2-chloro-4,4-dimethyl-3-oxocyclobut-1-enyl...)copy SMILEScopy InChI
Affinity DataIC50: 19nMAssay Description:Inhibition of integrin alpha4beta1 receptor in human whole blood by flow cytometryMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2JW8DQZPubMed
TargetIntegrin alpha-4(Homo sapiens (Human))
UCB

Curated by ChEMBL
LigandPNGBDBM50243753((S)-2-(2-Bromo-3-oxo-spiro[3.5]non-1-en-1-ylamino)...)copy SMILEScopy InChI
Affinity DataIC50: 22nMAssay Description:Inhibition of integrin alpha4beta1 receptor in human whole blood by flow cytometryMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2JW8DQZPubMed
TargetIntegrin alpha-4(Homo sapiens (Human))
UCB

Curated by ChEMBL
LigandPNGBDBM50243752((S)-2-(2-Bromo-3-oxo-spiro[3.5]non-1-en-1-ylamino)...)copy SMILEScopy InChI
Affinity DataIC50: 22nMAssay Description:Inhibition of integrin alpha4beta1 receptor in human whole blood by flow cytometryMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2JW8DQZPubMed
TargetIntegrin alpha-4(Homo sapiens (Human))
UCB

Curated by ChEMBL
LigandPNGBDBM50244384((S)-2-(3-Oxo-spiro[3.5]non-1-en-1-ylamino)-3-[4-(2...)copy SMILEScopy InChI
Affinity DataIC50: 24nMAssay Description:Inhibition of integrin alpha4beta1 receptor in human whole blood by flow cytometryMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2JW8DQZPubMed
TargetIntegrin alpha-4(Homo sapiens (Human))
UCB

Curated by ChEMBL
LigandPNGBDBM50243750((S)-2-(2-Bromo-3-oxo-spiro[3.5]non-1-en-1-ylamino)...)copy SMILEScopy InChI
Affinity DataIC50: 46nMAssay Description:Inhibition of integrin alpha4beta1 receptor in human whole blood by flow cytometryMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2JW8DQZPubMed
TargetIntegrin alpha-4(Homo sapiens (Human))
UCB

Curated by ChEMBL
LigandPNGBDBM50243751((S)-2-(2-Bromo-3-oxo-spiro[3.5]non-1-en-1-ylamino)...)copy SMILEScopy InChI
Affinity DataIC50: 71nMAssay Description:Inhibition of integrin alpha4beta1 receptor in human whole blood by flow cytometryMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2JW8DQZPubMed
TargetIntegrin alpha-4(Homo sapiens (Human))
UCB

Curated by ChEMBL
LigandPNGBDBM50243749((S)-2-(2-Bromo-3-oxo-spiro[3.5]non-1-en-1-ylamino)...)copy SMILEScopy InChI
Affinity DataIC50: 83nMAssay Description:Inhibition of integrin alpha4beta1 receptor in human whole blood by flow cytometryMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2JW8DQZPubMed
TargetIntegrin alpha-4(Homo sapiens (Human))
UCB

Curated by ChEMBL
LigandPNGBDBM50243748((S)-2-(2-Bromo-3-oxo-spiro[3.5]non-1-en-1-ylamino)...)copy SMILEScopy InChI
Affinity DataIC50: 95nMAssay Description:Inhibition of integrin alpha4beta1 receptor in human whole blood by flow cytometryMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2JW8DQZPubMed
TargetIntegrin alpha-4(Homo sapiens (Human))
UCB

Curated by ChEMBL
LigandPNGBDBM50244308((2S)-2-(4,4-dimethyl-3-oxocyclobut-1-enylamino)-3-...)copy SMILEScopy InChI
Affinity DataIC50: 126nMAssay Description:Inhibition of integrin alpha4beta1 receptor in human whole blood by flow cytometryMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2JW8DQZPubMed
TargetIntegrin alpha-4(Homo sapiens (Human))
UCB

Curated by ChEMBL
LigandPNGBDBM50244382((S)-2-(2-Bromo-3-oxo-spiro[3.5]non-1-en-1-ylamino)...)copy SMILEScopy InChI
Affinity DataIC50: 236nMAssay Description:Inhibition of integrin alpha4beta1 receptor in human whole blood by flow cytometryMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2JW8DQZPubMed
TargetIntegrin alpha-4(Homo sapiens (Human))
UCB

Curated by ChEMBL
LigandPNGBDBM50244344((S)-2-(2-Chloro-3-oxo-spiro[3.5]non-1-en-1-ylamino...)copy SMILEScopy InChI
Affinity DataIC50: 504nMAssay Description:Inhibition of integrin alpha4beta1 receptor in human whole blood by flow cytometryMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2JW8DQZPubMed
TargetIntegrin alpha-4(Homo sapiens (Human))
UCB

Curated by ChEMBL
LigandPNGBDBM50243806((S)-2-(2-Bromo-3-oxo-spiro[3.5]non-1-en-1-ylamino)...)copy SMILEScopy InChI
Affinity DataIC50: 570nMAssay Description:Inhibition of integrin alpha4beta1 receptor in human whole blood by flow cytometryMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2JW8DQZPubMed
TargetIntegrin alpha-4(Homo sapiens (Human))
UCB

Curated by ChEMBL
LigandPNGBDBM50244343((S)-2-(3-Oxo-spiro[3.5]non-1-en-1-ylamino)-3-[4-(2...)copy SMILEScopy InChI
Affinity DataIC50: 1.62E+3nMAssay Description:Inhibition of integrin alpha4beta1 receptor in human whole blood by flow cytometryMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2JW8DQZPubMed
TargetIntegrin alpha-4(Homo sapiens (Human))
UCB

Curated by ChEMBL
LigandPNGBDBM50244383((S)-2-(2-Bromo-3-oxo-spiro[3.5]non-1-en-1-ylamino)...)copy SMILEScopy InChI
Affinity DataIC50: 2.68E+3nMAssay Description:Inhibition of integrin alpha4beta1 receptor in human whole blood by flow cytometryMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2JW8DQZPubMed
TargetCytochrome P450 2C9(Homo sapiens (Human))
UCB

Curated by ChEMBL
LigandPNGBDBM50243822((S)-2-(2-Bromo-3-oxo-spiro[3.5]non-1-en-1-ylamino)...)copy SMILEScopy InChI
Affinity DataIC50: 8.00E+3nMAssay Description:Inhibition of CYP2C9More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2JW8DQZPubMed
TargetCytochrome P450 3A4(Homo sapiens (Human))
UCB

Curated by ChEMBL
LigandPNGBDBM50243822((S)-2-(2-Bromo-3-oxo-spiro[3.5]non-1-en-1-ylamino)...)copy SMILEScopy InChI
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of CYP3A4More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2JW8DQZPubMed
TargetCytochrome P450 2C9(Homo sapiens (Human))
UCB

Curated by ChEMBL
LigandPNGBDBM50243736((S)-2-(2-Bromo-3-oxo-spiro[3.5]non-1-en-1-ylamino)...)copy SMILEScopy InChI
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of CYP2C9More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2JW8DQZPubMed
TargetCytochrome P450 2C9(Homo sapiens (Human))
UCB

Curated by ChEMBL
LigandPNGBDBM50243818((S)-2-(2-Bromo-3-oxo-spiro[3.5]non-1-en-1-ylamino)...)copy SMILEScopy InChI
Affinity DataIC50: 1.80E+4nMAssay Description:Inhibition of CYP2C9More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2JW8DQZPubMed
TargetCytochrome P450 3A4(Homo sapiens (Human))
UCB

Curated by ChEMBL
LigandPNGBDBM50243736((S)-2-(2-Bromo-3-oxo-spiro[3.5]non-1-en-1-ylamino)...)copy SMILEScopy InChI
Affinity DataIC50: 6.20E+4nMAssay Description:Inhibition of CYP3A4More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2JW8DQZPubMed
TargetCytochrome P450 3A4(Homo sapiens (Human))
UCB

Curated by ChEMBL
LigandPNGBDBM50243818((S)-2-(2-Bromo-3-oxo-spiro[3.5]non-1-en-1-ylamino)...)copy SMILEScopy InChI
Affinity DataIC50: 7.90E+4nMAssay Description:Inhibition of CYP3A4More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2JW8DQZPubMed
TargetCytochrome P450 1A2(Homo sapiens (Human))
UCB

Curated by ChEMBL
LigandPNGBDBM50243818((S)-2-(2-Bromo-3-oxo-spiro[3.5]non-1-en-1-ylamino)...)copy SMILEScopy InChI
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of CYP1A2More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2JW8DQZPubMed
TargetCytochrome P450 1A2(Homo sapiens (Human))
UCB

Curated by ChEMBL
LigandPNGBDBM50243822((S)-2-(2-Bromo-3-oxo-spiro[3.5]non-1-en-1-ylamino)...)copy SMILEScopy InChI
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of CYP1A2More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2JW8DQZPubMed
TargetCytochrome P450 2D6(Homo sapiens (Human))
UCB

Curated by ChEMBL
LigandPNGBDBM50243822((S)-2-(2-Bromo-3-oxo-spiro[3.5]non-1-en-1-ylamino)...)copy SMILEScopy InChI
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of CYP2D6More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2JW8DQZPubMed
TargetCytochrome P450 1A2(Homo sapiens (Human))
UCB

Curated by ChEMBL
LigandPNGBDBM50243736((S)-2-(2-Bromo-3-oxo-spiro[3.5]non-1-en-1-ylamino)...)copy SMILEScopy InChI
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of CYP1A2More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2JW8DQZPubMed
TargetCytochrome P450 2D6(Homo sapiens (Human))
UCB

Curated by ChEMBL
LigandPNGBDBM50243736((S)-2-(2-Bromo-3-oxo-spiro[3.5]non-1-en-1-ylamino)...)copy SMILEScopy InChI
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of CYP2D6More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2JW8DQZPubMed
TargetCytochrome P450 2D6(Homo sapiens (Human))
UCB

Curated by ChEMBL
LigandPNGBDBM50243818((S)-2-(2-Bromo-3-oxo-spiro[3.5]non-1-en-1-ylamino)...)copy SMILEScopy InChI
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of CYP2D6More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2JW8DQZPubMed