Compile Data Set for Download or QSAR
Found 36 Enz. Inhib. hit(s) with all data for entry = 50027900
TargetSphingosine 1-phosphate receptor 1(Homo sapiens (Human))
Praecis Pharmaceuticals Inc

Curated by ChEMBL
LigandPNGBDBM50277149((S)-2-amino-3-(3-fluoro-4-(octyloxy)phenylamino)-2...)copy SMILEScopy InChI
Affinity DataIC50: 0.140nMAssay Description:Displacement of [33P]sphingosine-1-phosphate from human S1P1 receptorMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2H70FNKPubMed
TargetSphingosine 1-phosphate receptor 1(Homo sapiens (Human))
Praecis Pharmaceuticals Inc

Curated by ChEMBL
LigandPNGBDBM50277186((R)-2-amino-2-(4-(4-(octyloxy)phenyl)-1H-imidazol-...)copy SMILEScopy InChI
Affinity DataIC50: 0.260nMAssay Description:Displacement of [33P]sphingosine-1-phosphate from human S1P1 receptorMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2H70FNKPubMed
TargetSphingosine 1-phosphate receptor 1(Homo sapiens (Human))
Praecis Pharmaceuticals Inc

Curated by ChEMBL
LigandPNGBDBM50277185((S)-2-amino-3-(2-fluoro-4-(octyloxy)phenylamino)-2...)copy SMILEScopy InChI
Affinity DataIC50: 0.350nMAssay Description:Displacement of [33P]sphingosine-1-phosphate from human S1P1 receptorMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2H70FNKPubMed
TargetSphingosine 1-phosphate receptor 1(Homo sapiens (Human))
Praecis Pharmaceuticals Inc

Curated by ChEMBL
LigandPNGBDBM50277187((R)-2-amino-2-(4-(3-fluoro-4-(octyloxy)phenyl)-1H-...)copy SMILEScopy InChI
Affinity DataIC50: 0.350nMAssay Description:Displacement of [33P]sphingosine-1-phosphate from human S1P1 receptorMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2H70FNKPubMed
TargetSphingosine 1-phosphate receptor 1(Homo sapiens (Human))
Praecis Pharmaceuticals Inc

Curated by ChEMBL
LigandPNGBDBM50158348((2S,3R,4E)-2-amino-3-hydroxyoctadec-4-en-1-yl dihy...)copy SMILEScopy InChI
Affinity DataIC50: 0.470nMAssay Description:Displacement of [33P]sphingosine-1-phosphate from human S1P1 receptorMore data for this Ligand-Target Pair
TargetSphingosine 1-phosphate receptor 3(Homo sapiens (Human))
Praecis Pharmaceuticals Inc

Curated by ChEMBL
LigandPNGBDBM50158348((2S,3R,4E)-2-amino-3-hydroxyoctadec-4-en-1-yl dihy...)copy SMILEScopy InChI
Affinity DataIC50: 0.660nMAssay Description:Displacement of [33P]sphingosine-1-phosphate from human S1P3 receptorMore data for this Ligand-Target Pair
TargetSphingosine 1-phosphate receptor 1(Homo sapiens (Human))
Praecis Pharmaceuticals Inc

Curated by ChEMBL
LigandPNGBDBM50277148((S)-2-amino-2-methyl-3-(4-(octyloxy)phenylamino)-3...)copy SMILEScopy InChI
Affinity DataIC50: 0.730nMAssay Description:Displacement of [33P]sphingosine-1-phosphate from human S1P1 receptorMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2H70FNKPubMed
TargetSphingosine 1-phosphate receptor 5(Homo sapiens (Human))
Praecis Pharmaceuticals Inc

Curated by ChEMBL
LigandPNGBDBM50277187((R)-2-amino-2-(4-(3-fluoro-4-(octyloxy)phenyl)-1H-...)copy SMILEScopy InChI
Affinity DataIC50: 1.10nMAssay Description:Displacement of [33P]sphingosine-1-phosphate from human S1P5 receptorMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2H70FNKPubMed
TargetSphingosine 1-phosphate receptor 5(Homo sapiens (Human))
Praecis Pharmaceuticals Inc

Curated by ChEMBL
LigandPNGBDBM50158348((2S,3R,4E)-2-amino-3-hydroxyoctadec-4-en-1-yl dihy...)copy SMILEScopy InChI
Affinity DataIC50: 1.10nMAssay Description:Displacement of [33P]sphingosine-1-phosphate from human S1P5 receptorMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2H70FNKPubMed
TargetSphingosine 1-phosphate receptor 4(Homo sapiens (Human))
Praecis Pharmaceuticals Inc

Curated by ChEMBL
LigandPNGBDBM50277186((R)-2-amino-2-(4-(4-(octyloxy)phenyl)-1H-imidazol-...)copy SMILEScopy InChI
Affinity DataIC50: 1.10nMAssay Description:Displacement of [33P]sphingosine-1-phosphate from human S1P4 receptorMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2H70FNKPubMed
TargetSphingosine 1-phosphate receptor 5(Homo sapiens (Human))
Praecis Pharmaceuticals Inc

Curated by ChEMBL
LigandPNGBDBM50277186((R)-2-amino-2-(4-(4-(octyloxy)phenyl)-1H-imidazol-...)copy SMILEScopy InChI
Affinity DataIC50: 1.40nMAssay Description:Displacement of [33P]sphingosine-1-phosphate from human S1P5 receptorMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2H70FNKPubMed
TargetSphingosine 1-phosphate receptor 4(Homo sapiens (Human))
Praecis Pharmaceuticals Inc

Curated by ChEMBL
LigandPNGBDBM50277185((S)-2-amino-3-(2-fluoro-4-(octyloxy)phenylamino)-2...)copy SMILEScopy InChI
Affinity DataIC50: 1.80nMAssay Description:Displacement of [33P]sphingosine-1-phosphate from human S1P4 receptorMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2H70FNKPubMed
TargetSphingosine 1-phosphate receptor 4(Homo sapiens (Human))
Praecis Pharmaceuticals Inc

Curated by ChEMBL
LigandPNGBDBM50277187((R)-2-amino-2-(4-(3-fluoro-4-(octyloxy)phenyl)-1H-...)copy SMILEScopy InChI
Affinity DataIC50: 1.90nMAssay Description:Displacement of [33P]sphingosine-1-phosphate from human S1P4 receptorMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2H70FNKPubMed
TargetSphingosine 1-phosphate receptor 4(Homo sapiens (Human))
Praecis Pharmaceuticals Inc

Curated by ChEMBL
LigandPNGBDBM50158348((2S,3R,4E)-2-amino-3-hydroxyoctadec-4-en-1-yl dihy...)copy SMILEScopy InChI
Affinity DataIC50: 2.40nMAssay Description:Displacement of [33P]sphingosine-1-phosphate from human S1P4 receptorMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2H70FNKPubMed
TargetSphingosine 1-phosphate receptor 5(Homo sapiens (Human))
Praecis Pharmaceuticals Inc

Curated by ChEMBL
LigandPNGBDBM50277185((S)-2-amino-3-(2-fluoro-4-(octyloxy)phenylamino)-2...)copy SMILEScopy InChI
Affinity DataIC50: 3.20nMAssay Description:Displacement of [33P]sphingosine-1-phosphate from human S1P5 receptorMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2H70FNKPubMed
TargetSphingosine 1-phosphate receptor 4(Homo sapiens (Human))
Praecis Pharmaceuticals Inc

Curated by ChEMBL
LigandPNGBDBM50277149((S)-2-amino-3-(3-fluoro-4-(octyloxy)phenylamino)-2...)copy SMILEScopy InChI
Affinity DataIC50: 3.5nMAssay Description:Displacement of [33P]sphingosine-1-phosphate from human S1P4 receptorMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2H70FNKPubMed
TargetSphingosine 1-phosphate receptor 3(Homo sapiens (Human))
Praecis Pharmaceuticals Inc

Curated by ChEMBL
LigandPNGBDBM50277185((S)-2-amino-3-(2-fluoro-4-(octyloxy)phenylamino)-2...)copy SMILEScopy InChI
Affinity DataIC50: 3.60nMAssay Description:Displacement of [33P]sphingosine-1-phosphate from human S1P3 receptorMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2H70FNKPubMed
TargetSphingosine 1-phosphate receptor 4(Homo sapiens (Human))
Praecis Pharmaceuticals Inc

Curated by ChEMBL
LigandPNGBDBM50277148((S)-2-amino-2-methyl-3-(4-(octyloxy)phenylamino)-3...)copy SMILEScopy InChI
Affinity DataIC50: 4nMAssay Description:Displacement of [33P]sphingosine-1-phosphate from human S1P4 receptorMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2H70FNKPubMed
TargetSphingosine 1-phosphate receptor 3(Homo sapiens (Human))
Praecis Pharmaceuticals Inc

Curated by ChEMBL
LigandPNGBDBM50277186((R)-2-amino-2-(4-(4-(octyloxy)phenyl)-1H-imidazol-...)copy SMILEScopy InChI
Affinity DataIC50: 5.30nMAssay Description:Displacement of [33P]sphingosine-1-phosphate from human S1P3 receptorMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2H70FNKPubMed
TargetSphingosine 1-phosphate receptor 3(Homo sapiens (Human))
Praecis Pharmaceuticals Inc

Curated by ChEMBL
LigandPNGBDBM50277187((R)-2-amino-2-(4-(3-fluoro-4-(octyloxy)phenyl)-1H-...)copy SMILEScopy InChI
Affinity DataIC50: 5.80nMAssay Description:Displacement of [33P]sphingosine-1-phosphate from human S1P3 receptorMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2H70FNKPubMed
TargetSphingosine 1-phosphate receptor 3(Homo sapiens (Human))
Praecis Pharmaceuticals Inc

Curated by ChEMBL
LigandPNGBDBM50277149((S)-2-amino-3-(3-fluoro-4-(octyloxy)phenylamino)-2...)copy SMILEScopy InChI
Affinity DataIC50: 5.90nMAssay Description:Displacement of [33P]sphingosine-1-phosphate from human S1P3 receptorMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2H70FNKPubMed
TargetSphingosine 1-phosphate receptor 3(Homo sapiens (Human))
Praecis Pharmaceuticals Inc

Curated by ChEMBL
LigandPNGBDBM50277148((S)-2-amino-2-methyl-3-(4-(octyloxy)phenylamino)-3...)copy SMILEScopy InChI
Affinity DataIC50: 5.90nMAssay Description:Displacement of [33P]sphingosine-1-phosphate from human S1P3 receptorMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2H70FNKPubMed
TargetSphingosine 1-phosphate receptor 5(Homo sapiens (Human))
Praecis Pharmaceuticals Inc

Curated by ChEMBL
LigandPNGBDBM50277149((S)-2-amino-3-(3-fluoro-4-(octyloxy)phenylamino)-2...)copy SMILEScopy InChI
Affinity DataIC50: 6.90nMAssay Description:Displacement of [33P]sphingosine-1-phosphate from human S1P5 receptorMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2H70FNKPubMed
TargetSphingosine 1-phosphate receptor 5(Homo sapiens (Human))
Praecis Pharmaceuticals Inc

Curated by ChEMBL
LigandPNGBDBM50277148((S)-2-amino-2-methyl-3-(4-(octyloxy)phenylamino)-3...)copy SMILEScopy InChI
Affinity DataIC50: 8.80nMAssay Description:Displacement of [33P]sphingosine-1-phosphate from human S1P5 receptorMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2H70FNKPubMed
TargetSphingosine 1-phosphate receptor 1(Homo sapiens (Human))
Praecis Pharmaceuticals Inc

Curated by ChEMBL
LigandPNGBDBM50277187((R)-2-amino-2-(4-(3-fluoro-4-(octyloxy)phenyl)-1H-...)copy SMILEScopy InChI
Affinity DataEC50:  0.450nMAssay Description:Agonist activity at human S1P1 receptor assessed as stimulation of [35S]GTPgammaS bindingMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2H70FNKPubMed
TargetSphingosine 1-phosphate receptor 3(Homo sapiens (Human))
Praecis Pharmaceuticals Inc

Curated by ChEMBL
LigandPNGBDBM50277186((R)-2-amino-2-(4-(4-(octyloxy)phenyl)-1H-imidazol-...)copy SMILEScopy InChI
Affinity DataEC50:  14.8nMAssay Description:Agonist activity at human S1P3 receptor assessed as stimulation of [35S]GTPgammaS bindingMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2H70FNKPubMed
TargetSphingosine 1-phosphate receptor 1(Homo sapiens (Human))
Praecis Pharmaceuticals Inc

Curated by ChEMBL
LigandPNGBDBM50277186((R)-2-amino-2-(4-(4-(octyloxy)phenyl)-1H-imidazol-...)copy SMILEScopy InChI
Affinity DataEC50:  0.550nMAssay Description:Agonist activity at human S1P1 receptor assessed as stimulation of [35S]GTPgammaS bindingMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2H70FNKPubMed
TargetSphingosine 1-phosphate receptor 3(Homo sapiens (Human))
Praecis Pharmaceuticals Inc

Curated by ChEMBL
LigandPNGBDBM50277185((S)-2-amino-3-(2-fluoro-4-(octyloxy)phenylamino)-2...)copy SMILEScopy InChI
Affinity DataEC50:  9.80nMAssay Description:Agonist activity at human S1P3 receptor assessed as stimulation of [35S]GTPgammaS bindingMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2H70FNKPubMed
TargetSphingosine 1-phosphate receptor 1(Homo sapiens (Human))
Praecis Pharmaceuticals Inc

Curated by ChEMBL
LigandPNGBDBM50277185((S)-2-amino-3-(2-fluoro-4-(octyloxy)phenylamino)-2...)copy SMILEScopy InChI
Affinity DataEC50:  2.10nMAssay Description:Agonist activity at human S1P1 receptor assessed as stimulation of [35S]GTPgammaS bindingMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2H70FNKPubMed
TargetSphingosine 1-phosphate receptor 3(Homo sapiens (Human))
Praecis Pharmaceuticals Inc

Curated by ChEMBL
LigandPNGBDBM50277187((R)-2-amino-2-(4-(3-fluoro-4-(octyloxy)phenyl)-1H-...)copy SMILEScopy InChI
Affinity DataEC50:  10.8nMAssay Description:Agonist activity at human S1P3 receptor assessed as stimulation of [35S]GTPgammaS bindingMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2H70FNKPubMed
TargetSphingosine 1-phosphate receptor 1(Homo sapiens (Human))
Praecis Pharmaceuticals Inc

Curated by ChEMBL
LigandPNGBDBM50277149((S)-2-amino-3-(3-fluoro-4-(octyloxy)phenylamino)-2...)copy SMILEScopy InChI
Affinity DataEC50:  1.10nMAssay Description:Agonist activity at human S1P1 receptor assessed as stimulation of [35S]GTPgammaS bindingMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2H70FNKPubMed
TargetSphingosine 1-phosphate receptor 3(Homo sapiens (Human))
Praecis Pharmaceuticals Inc

Curated by ChEMBL
LigandPNGBDBM50277148((S)-2-amino-2-methyl-3-(4-(octyloxy)phenylamino)-3...)copy SMILEScopy InChI
Affinity DataEC50:  16.3nMAssay Description:Agonist activity at human S1P3 receptor assessed as stimulation of [35S]GTPgammaS bindingMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2H70FNKPubMed
TargetSphingosine 1-phosphate receptor 1(Homo sapiens (Human))
Praecis Pharmaceuticals Inc

Curated by ChEMBL
LigandPNGBDBM50277148((S)-2-amino-2-methyl-3-(4-(octyloxy)phenylamino)-3...)copy SMILEScopy InChI
Affinity DataEC50:  2.40nMAssay Description:Agonist activity at human S1P1 receptor assessed as stimulation of [35S]GTPgammaS bindingMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2H70FNKPubMed
TargetSphingosine 1-phosphate receptor 3(Homo sapiens (Human))
Praecis Pharmaceuticals Inc

Curated by ChEMBL
LigandPNGBDBM50158348((2S,3R,4E)-2-amino-3-hydroxyoctadec-4-en-1-yl dihy...)copy SMILEScopy InChI
Affinity DataEC50:  3nMAssay Description:Agonist activity at human S1P3 receptor assessed as stimulation of [35S]GTPgammaS bindingMore data for this Ligand-Target Pair
TargetSphingosine 1-phosphate receptor 1(Homo sapiens (Human))
Praecis Pharmaceuticals Inc

Curated by ChEMBL
LigandPNGBDBM50158348((2S,3R,4E)-2-amino-3-hydroxyoctadec-4-en-1-yl dihy...)copy SMILEScopy InChI
Affinity DataEC50:  7.90nMAssay Description:Agonist activity at human S1P1 receptor assessed as stimulation of [35S]GTPgammaS bindingMore data for this Ligand-Target Pair
TargetSphingosine 1-phosphate receptor 3(Homo sapiens (Human))
Praecis Pharmaceuticals Inc

Curated by ChEMBL
LigandPNGBDBM50277149((S)-2-amino-3-(3-fluoro-4-(octyloxy)phenylamino)-2...)copy SMILEScopy InChI
Affinity DataEC50:  10.1nMAssay Description:Agonist activity at human S1P3 receptor assessed as stimulation of [35S]GTPgammaS bindingMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2H70FNKPubMed