Compile Data Set for Download or QSAR
Found 42 Enz. Inhib. hit(s) with all data for entry = 50028580
TargetProstaglandin E2 receptor EP1 subtype(Homo sapiens (Human))
GlaxoSmithKline

Curated by ChEMBL
LigandPNGBDBM50259611(CHEMBL467114 | sodium 6-(5-chloro-2-(4-chloro-2-fl...)copy SMILEScopy InChI
Affinity DataKi:  7.94nMAssay Description:Antagonist activity at human recombinant EP1 receptor expressed in CHO cells assessed as inhibition of PGE2-mediated intracellular calcium mobilizati...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2HT2P68PubMed
TargetThromboxane A2 receptor(Homo sapiens (Human))
GlaxoSmithKline

Curated by ChEMBL
LigandPNGBDBM50259611(CHEMBL467114 | sodium 6-(5-chloro-2-(4-chloro-2-fl...)copy SMILEScopy InChI
Affinity DataKi:  10nMAssay Description:Inhibition of TP receptorMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2HT2P68PubMed
TargetProstaglandin E2 receptor EP1 subtype(Homo sapiens (Human))
GlaxoSmithKline

Curated by ChEMBL
LigandPNGBDBM50259613(CHEMBL467720 | sodium 6-(5-chloro-2-(2,4-dichlorob...)copy SMILEScopy InChI
Affinity DataKi:  25.1nMAssay Description:Antagonist activity at human recombinant EP1 receptor expressed in CHO cells assessed as inhibition of PGE2-mediated intracellular calcium mobilizati...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2HT2P68PubMed
TargetProstaglandin E2 receptor EP1 subtype(Homo sapiens (Human))
GlaxoSmithKline

Curated by ChEMBL
LigandPNGBDBM50259612(CHEMBL513491 | sodium 6-(5-chloro-2-(2-chloro-4-fl...)copy SMILEScopy InChI
Affinity DataKi:  100nMAssay Description:Antagonist activity at human recombinant EP1 receptor expressed in CHO cells assessed as inhibition of PGE2-mediated intracellular calcium mobilizati...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2HT2P68PubMed
TargetProstaglandin E2 receptor EP1 subtype(Homo sapiens (Human))
GlaxoSmithKline

Curated by ChEMBL
LigandPNGBDBM50414022(CHEMBL2110364 | GSK-180100B)copy SMILEScopy InChI
Affinity DataIC50: 0.129nMAssay Description:Displacement of [3H]PGE2 from human EP1 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2HT2P68PubMed
TargetProstaglandin E2 receptor EP1 subtype(Homo sapiens (Human))
GlaxoSmithKline

Curated by ChEMBL
LigandPNGBDBM50197898(6-(2-(2-(2,4-difluorobenzyloxy)-5-chlorophenyl)cyc...)copy SMILEScopy InChI
Affinity DataIC50: 2.51nMAssay Description:Displacement of [3H]PGE2 from human EP1 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2HT2P68PubMed
TargetProstaglandin E2 receptor EP1 subtype(Homo sapiens (Human))
GlaxoSmithKline

Curated by ChEMBL
LigandPNGBDBM50197899(5-(2-(2-(benzyloxy)-5-(trifluoromethyl)phenyl)cycl...)copy SMILEScopy InChI
Affinity DataIC50: 10nMAssay Description:Displacement of [3H]PGE2 from human EP1 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2HT2P68PubMed
TargetProstaglandin E2 receptor EP1 subtype(Homo sapiens (Human))
GlaxoSmithKline

Curated by ChEMBL
LigandPNGBDBM50259613(CHEMBL467720 | sodium 6-(5-chloro-2-(2,4-dichlorob...)copy SMILEScopy InChI
Affinity DataIC50: 10nMAssay Description:Displacement of [3H]PGE2 from human EP1 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2HT2P68PubMed
TargetProstaglandin E2 receptor EP1 subtype(Homo sapiens (Human))
GlaxoSmithKline

Curated by ChEMBL
LigandPNGBDBM50259612(CHEMBL513491 | sodium 6-(5-chloro-2-(2-chloro-4-fl...)copy SMILEScopy InChI
Affinity DataIC50: 12.6nMAssay Description:Displacement of [3H]PGE2 from human EP1 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2HT2P68PubMed
TargetProstaglandin E2 receptor EP1 subtype(Homo sapiens (Human))
GlaxoSmithKline

Curated by ChEMBL
LigandPNGBDBM50259611(CHEMBL467114 | sodium 6-(5-chloro-2-(4-chloro-2-fl...)copy SMILEScopy InChI
Affinity DataIC50: 12.6nMAssay Description:Displacement of [3H]PGE2 from human EP1 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2HT2P68PubMed
TargetProstaglandin E2 receptor EP1 subtype(Homo sapiens (Human))
GlaxoSmithKline

Curated by ChEMBL
LigandPNGBDBM50259548(6-(5'-chloro-2'-isobutoxy-biphenyl-2-yl)-pyridine-...)copy SMILEScopy InChI
Affinity DataIC50: 15.8nMAssay Description:Displacement of [3H]PGE2 from human EP1 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2HT2P68PubMed
TargetProstaglandin E2 receptor EP1 subtype(Homo sapiens (Human))
GlaxoSmithKline

Curated by ChEMBL
LigandPNGBDBM50414026(CHEMBL466101)copy SMILEScopy InChI
Affinity DataIC50: 25.1nMAssay Description:Displacement of [3H]PGE2 from human EP1 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2HT2P68PubMed
TargetProstaglandin E2 receptor EP1 subtype(Homo sapiens (Human))
GlaxoSmithKline

Curated by ChEMBL
LigandPNGBDBM50414032(CHEMBL511252)copy SMILEScopy InChI
Affinity DataIC50: 31.6nMAssay Description:Displacement of [3H]PGE2 from human EP1 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2HT2P68PubMed
TargetProstaglandin E2 receptor EP1 subtype(Homo sapiens (Human))
GlaxoSmithKline

Curated by ChEMBL
LigandPNGBDBM50414028(CHEMBL466103)copy SMILEScopy InChI
Affinity DataIC50: 39.8nMAssay Description:Displacement of [3H]PGE2 from human EP1 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2HT2P68PubMed
TargetProstaglandin E2 receptor EP1 subtype(Homo sapiens (Human))
GlaxoSmithKline

Curated by ChEMBL
LigandPNGBDBM50414029(CHEMBL467113)copy SMILEScopy InChI
Affinity DataIC50: 39.8nMAssay Description:Displacement of [3H]PGE2 from human EP1 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2HT2P68PubMed
TargetProstaglandin E2 receptor EP1 subtype(Homo sapiens (Human))
GlaxoSmithKline

Curated by ChEMBL
LigandPNGBDBM50414030(CHEMBL257998)copy SMILEScopy InChI
Affinity DataIC50: 39.8nMAssay Description:Displacement of [3H]PGE2 from human EP1 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2HT2P68PubMed
TargetProstaglandin E2 receptor EP1 subtype(Homo sapiens (Human))
GlaxoSmithKline

Curated by ChEMBL
LigandPNGBDBM50414027(CHEMBL466102)copy SMILEScopy InChI
Affinity DataIC50: 79.4nMAssay Description:Displacement of [3H]PGE2 from human EP1 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2HT2P68PubMed
TargetProstaglandin E2 receptor EP1 subtype(Homo sapiens (Human))
GlaxoSmithKline

Curated by ChEMBL
LigandPNGBDBM50414024(CHEMBL508276)copy SMILEScopy InChI
Affinity DataIC50: 79.4nMAssay Description:Displacement of [3H]PGE2 from human EP1 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2HT2P68PubMed
TargetProstaglandin E2 receptor EP1 subtype(Homo sapiens (Human))
GlaxoSmithKline

Curated by ChEMBL
LigandPNGBDBM50414031(CHEMBL468723)copy SMILEScopy InChI
Affinity DataIC50: 100nMAssay Description:Displacement of [3H]PGE2 from human EP1 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2HT2P68PubMed
TargetProstaglandin E2 receptor EP1 subtype(Homo sapiens (Human))
GlaxoSmithKline

Curated by ChEMBL
LigandPNGBDBM50414025(CHEMBL511733)copy SMILEScopy InChI
Affinity DataIC50: 100nMAssay Description:Displacement of [3H]PGE2 from human EP1 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2HT2P68PubMed
TargetProstaglandin E2 receptor EP1 subtype(Homo sapiens (Human))
GlaxoSmithKline

Curated by ChEMBL
LigandPNGBDBM50414023(CHEMBL258041)copy SMILEScopy InChI
Affinity DataIC50: 158nMAssay Description:Displacement of [3H]PGE2 from human EP1 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2HT2P68PubMed
TargetProstaglandin E2 receptor EP1 subtype(Homo sapiens (Human))
GlaxoSmithKline

Curated by ChEMBL
LigandPNGBDBM50414033(CHEMBL511919)copy SMILEScopy InChI
Affinity DataIC50: 200nMAssay Description:Displacement of [3H]PGE2 from human EP1 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2HT2P68PubMed
TargetProstacyclin receptor(Homo sapiens (Human))
GlaxoSmithKline

Curated by ChEMBL
LigandPNGBDBM50259611(CHEMBL467114 | sodium 6-(5-chloro-2-(4-chloro-2-fl...)copy SMILEScopy InChI
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of IP receptorMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2HT2P68PubMed
TargetProstaglandin E2 receptor EP3 subtype(Homo sapiens (Human))
GlaxoSmithKline

Curated by ChEMBL
LigandPNGBDBM50259611(CHEMBL467114 | sodium 6-(5-chloro-2-(4-chloro-2-fl...)copy SMILEScopy InChI
Affinity DataIC50: 1.26E+3nMAssay Description:Inhibition of EP3 receptor by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2HT2P68PubMed
TargetProstaglandin E2 receptor EP2 subtype(Homo sapiens (Human))
GlaxoSmithKline

Curated by ChEMBL
LigandPNGBDBM50259611(CHEMBL467114 | sodium 6-(5-chloro-2-(4-chloro-2-fl...)copy SMILEScopy InChI
Affinity DataIC50: 1.58E+3nMAssay Description:Inhibition of EP2 receptorMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2HT2P68PubMed
TargetCytochrome P450 2C9(Homo sapiens (Human))
GlaxoSmithKline

Curated by ChEMBL
LigandPNGBDBM50259613(CHEMBL467720 | sodium 6-(5-chloro-2-(2,4-dichlorob...)copy SMILEScopy InChI
Affinity DataIC50: 4.80E+3nMAssay Description:Inhibition of human CYP2C9More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2HT2P68PubMed
TargetCytochrome P450 2C9(Homo sapiens (Human))
GlaxoSmithKline

Curated by ChEMBL
LigandPNGBDBM50259611(CHEMBL467114 | sodium 6-(5-chloro-2-(4-chloro-2-fl...)copy SMILEScopy InChI
Affinity DataIC50: 8.00E+3nMAssay Description:Inhibition of human CYP2C9More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2HT2P68PubMed
TargetProstaglandin F2-alpha receptor(Homo sapiens (Human))
GlaxoSmithKline

Curated by ChEMBL
LigandPNGBDBM50259611(CHEMBL467114 | sodium 6-(5-chloro-2-(4-chloro-2-fl...)copy SMILEScopy InChI
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of FP receptorMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2HT2P68PubMed
TargetCytochrome P450 2C9(Homo sapiens (Human))
GlaxoSmithKline

Curated by ChEMBL
LigandPNGBDBM50259612(CHEMBL513491 | sodium 6-(5-chloro-2-(2-chloro-4-fl...)copy SMILEScopy InChI
Affinity DataIC50: 1.50E+4nMAssay Description:Inhibition of human CYP2C9More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2HT2P68PubMed
TargetCytochrome P450 1A2(Homo sapiens (Human))
GlaxoSmithKline

Curated by ChEMBL
LigandPNGBDBM50259611(CHEMBL467114 | sodium 6-(5-chloro-2-(4-chloro-2-fl...)copy SMILEScopy InChI
Affinity DataIC50: 2.00E+4nMAssay Description:Inhibition of human CYP1A2More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2HT2P68PubMed
TargetCytochrome P450 2C19(Homo sapiens (Human))
GlaxoSmithKline

Curated by ChEMBL
LigandPNGBDBM50259612(CHEMBL513491 | sodium 6-(5-chloro-2-(2-chloro-4-fl...)copy SMILEScopy InChI
Affinity DataIC50: 2.80E+4nMAssay Description:Inhibition of human CYP2C19More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2HT2P68PubMed
TargetProstaglandin E2 receptor EP4 subtype(Homo sapiens (Human))
GlaxoSmithKline

Curated by ChEMBL
LigandPNGBDBM50259611(CHEMBL467114 | sodium 6-(5-chloro-2-(4-chloro-2-fl...)copy SMILEScopy InChI
Affinity DataIC50: 3.16E+4nMAssay Description:Inhibition of EP4 receptorMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2HT2P68PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
GlaxoSmithKline

Curated by ChEMBL
LigandPNGBDBM50259611(CHEMBL467114 | sodium 6-(5-chloro-2-(4-chloro-2-fl...)copy SMILEScopy InChI
Affinity DataIC50: 3.16E+4nMAssay Description:Inhibition of human ERG channelMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2HT2P68PubMed
TargetCytochrome P450 1A2(Homo sapiens (Human))
GlaxoSmithKline

Curated by ChEMBL
LigandPNGBDBM50259613(CHEMBL467720 | sodium 6-(5-chloro-2-(2,4-dichlorob...)copy SMILEScopy InChI
Affinity DataIC50: 3.20E+4nMAssay Description:Inhibition of human CYP1A2More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2HT2P68PubMed
TargetCytochrome P450 3A4(Homo sapiens (Human))
GlaxoSmithKline

Curated by ChEMBL
LigandPNGBDBM50259612(CHEMBL513491 | sodium 6-(5-chloro-2-(2-chloro-4-fl...)copy SMILEScopy InChI
Affinity DataIC50: 3.50E+4nMAssay Description:Inhibition of human CYP3A4 using DEF substrateMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2HT2P68PubMed
TargetCytochrome P450 2D6(Homo sapiens (Human))
GlaxoSmithKline

Curated by ChEMBL
LigandPNGBDBM50259613(CHEMBL467720 | sodium 6-(5-chloro-2-(2,4-dichlorob...)copy SMILEScopy InChI
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of human CYP2D6More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2HT2P68PubMed
TargetCytochrome P450 2C19(Homo sapiens (Human))
GlaxoSmithKline

Curated by ChEMBL
LigandPNGBDBM50259613(CHEMBL467720 | sodium 6-(5-chloro-2-(2,4-dichlorob...)copy SMILEScopy InChI
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of human CYP2C19More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2HT2P68PubMed
TargetCytochrome P450 1A2(Homo sapiens (Human))
GlaxoSmithKline

Curated by ChEMBL
LigandPNGBDBM50259612(CHEMBL513491 | sodium 6-(5-chloro-2-(2-chloro-4-fl...)copy SMILEScopy InChI
Affinity DataIC50: 6.10E+4nMAssay Description:Inhibition of human CYP1A2More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2HT2P68PubMed
TargetCytochrome P450 2C19(Homo sapiens (Human))
GlaxoSmithKline

Curated by ChEMBL
LigandPNGBDBM50259611(CHEMBL467114 | sodium 6-(5-chloro-2-(4-chloro-2-fl...)copy SMILEScopy InChI
Affinity DataIC50: 8.50E+4nMAssay Description:Inhibition of human CYP2C19More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2HT2P68PubMed
TargetCytochrome P450 3A4(Homo sapiens (Human))
GlaxoSmithKline

Curated by ChEMBL
LigandPNGBDBM50259612(CHEMBL513491 | sodium 6-(5-chloro-2-(2-chloro-4-fl...)copy SMILEScopy InChI
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of human CYP3A4 using PPR substrateMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2HT2P68PubMed
TargetCytochrome P450 2D6(Homo sapiens (Human))
GlaxoSmithKline

Curated by ChEMBL
LigandPNGBDBM50259611(CHEMBL467114 | sodium 6-(5-chloro-2-(4-chloro-2-fl...)copy SMILEScopy InChI
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of human CYP2D6More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2HT2P68PubMed
TargetCytochrome P450 2D6(Homo sapiens (Human))
GlaxoSmithKline

Curated by ChEMBL
LigandPNGBDBM50259612(CHEMBL513491 | sodium 6-(5-chloro-2-(2-chloro-4-fl...)copy SMILEScopy InChI
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of human CYP2D6More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2HT2P68PubMed