Compile Data Set for Download or QSAR
Found 20 Enz. Inhib. hit(s) with all data for entry = 50030376
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
Bristol-Myers SquibbPharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50295294((+/-)-trans-3-(2-((dimethylamino)methyl)cyclopenty...)copy SMILEScopy InChI
Affinity DataIC50: 0.320nMAssay Description:Displacement of [125I]RTI-55 from human SERT expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2Q81D3KPubMed
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
Bristol-Myers SquibbPharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50295294((+/-)-trans-3-(2-((dimethylamino)methyl)cyclopenty...)copy SMILEScopy InChI
Affinity DataIC50: 0.320nMAssay Description:Displacement of [125I]RTI-55 from human SERT expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2Q81D3KPubMed
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
Bristol-Myers SquibbPharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50173715((+)3-((1S,2S)-2-Dimethylaminomethyl-cyclopropyl)-1...)copy SMILEScopy InChI
Affinity DataIC50: 0.360nMAssay Description:Displacement of [125I]RTI-55 from human SERT expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2Q81D3KPubMed
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
Bristol-Myers SquibbPharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50209168((R)-3-(4-(dimethylamino)cyclohex-1-enyl)-1H-indole...)copy SMILEScopy InChI
Affinity DataIC50: 0.720nMAssay Description:Displacement of [125I]RTI-55 from human SERT expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2Q81D3KPubMed
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
Bristol-Myers SquibbPharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50295295((+/-)-cis-3-(2-((dimethylamino)methyl)cyclopentyl)...)copy SMILEScopy InChI
Affinity DataIC50: 1.20nMAssay Description:Displacement of [125I]RTI-55 from human SERT expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2Q81D3KPubMed
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
Bristol-Myers SquibbPharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50295295((+/-)-cis-3-(2-((dimethylamino)methyl)cyclopentyl)...)copy SMILEScopy InChI
Affinity DataIC50: 1.20nMAssay Description:Displacement of [125I]RTI-55 from human SERT expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2Q81D3KPubMed
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
Bristol-Myers SquibbPharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50295288((+/-)-trans-3-(2-((methylamino)methyl)cyclopentyl)...)copy SMILEScopy InChI
Affinity DataIC50: 7nMAssay Description:Displacement of [125I]RTI-55 from human SERT expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2Q81D3KPubMed
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
Bristol-Myers SquibbPharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50295293((+/-)-trans-3-(2-((ethyl(methyl)amino)methyl)cyclo...)copy SMILEScopy InChI
Affinity DataIC50: 10nMAssay Description:Displacement of [125I]RTI-55 from human SERT expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2Q81D3KPubMed
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
Bristol-Myers SquibbPharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50295289((+/-)-trans-3-(2-(pyrrolidin-1-ylmethyl)cyclopenty...)copy SMILEScopy InChI
Affinity DataIC50: 22nMAssay Description:Displacement of [125I]RTI-55 from human SERT expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2Q81D3KPubMed
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
Bristol-Myers SquibbPharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50295297(CHEMBL559092 | trans-3-((1R,2R)-2-((dimethylamino)...)copy SMILEScopy InChI
Affinity DataIC50: 58nMAssay Description:Displacement of [125I]RTI-55 from human SERT expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2Q81D3KPubMed
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
Bristol-Myers SquibbPharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50295292((+/-)-trans-3-(2-((benzyl(methyl)amino)methyl)cycl...)copy SMILEScopy InChI
Affinity DataIC50: 85nMAssay Description:Displacement of [125I]RTI-55 from human SERT expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2Q81D3KPubMed
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
Bristol-Myers SquibbPharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50295296(CHEMBL539470 | cis-3-((1R,2S)-2-((dimethylamino)me...)copy SMILEScopy InChI
Affinity DataIC50: 130nMAssay Description:Displacement of [125I]RTI-55 from human SERT expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2Q81D3KPubMed
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
Bristol-Myers SquibbPharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50295291((+/-)-trans-3-(2-((ethylamino)methyl)cyclopentyl)-...)copy SMILEScopy InChI
Affinity DataIC50: 170nMAssay Description:Displacement of [125I]RTI-55 from human SERT expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2Q81D3KPubMed
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
Bristol-Myers SquibbPharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50295290((+/-)-trans-3-(2-((diethylamino)methyl)cyclopentyl...)copy SMILEScopy InChI
Affinity DataIC50: 240nMAssay Description:Displacement of [125I]RTI-55 from human SERT expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2Q81D3KPubMed
TargetSodium-dependent dopamine transporter(Homo sapiens (Human))
Bristol-Myers SquibbPharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50209168((R)-3-(4-(dimethylamino)cyclohex-1-enyl)-1H-indole...)copy SMILEScopy InChI
Affinity DataIC50: 290nMAssay Description:Displacement of [125I]RTI-55 from human DAT expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2Q81D3KPubMed
TargetSodium-dependent noradrenaline transporter(Homo sapiens (Human))
Bristol-Myers SquibbPharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50209168((R)-3-(4-(dimethylamino)cyclohex-1-enyl)-1H-indole...)copy SMILEScopy InChI
Affinity DataIC50: 390nMAssay Description:Displacement of [125I]nisoxetine from human NET expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2Q81D3KPubMed
TargetSodium-dependent dopamine transporter(Homo sapiens (Human))
Bristol-Myers SquibbPharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50295294((+/-)-trans-3-(2-((dimethylamino)methyl)cyclopenty...)copy SMILEScopy InChI
Affinity DataIC50: 690nMAssay Description:Displacement of [125I]RTI-55 from human DAT expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2Q81D3KPubMed
TargetSodium-dependent dopamine transporter(Homo sapiens (Human))
Bristol-Myers SquibbPharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50173715((+)3-((1S,2S)-2-Dimethylaminomethyl-cyclopropyl)-1...)copy SMILEScopy InChI
Affinity DataIC50: 4.20E+3nMAssay Description:Displacement of [125I]RTI-55 from human DAT expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2Q81D3KPubMed
TargetSodium-dependent noradrenaline transporter(Homo sapiens (Human))
Bristol-Myers SquibbPharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50295294((+/-)-trans-3-(2-((dimethylamino)methyl)cyclopenty...)copy SMILEScopy InChI
Affinity DataIC50: 7.90E+3nMAssay Description:Displacement of [125I]nisoxetine from human NET expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2Q81D3KPubMed
TargetSodium-dependent noradrenaline transporter(Homo sapiens (Human))
Bristol-Myers SquibbPharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50173715((+)3-((1S,2S)-2-Dimethylaminomethyl-cyclopropyl)-1...)copy SMILEScopy InChI
Affinity DataIC50: 9.20E+3nMAssay Description:Displacement of [125I]nisoxetine from human NET expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2Q81D3KPubMed