Compile Data Set for Download or QSAR
Found 24 Enz. Inhib. hit(s) with all data for entry = 50030788
TargetHistamine H1 receptor(Homo sapiens (Human))
The Schering Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50301397(CHEMBL571390 | [1-(4-Methyl-benzyl)-piperidin-4-yl...)copy SMILEScopy InChI
Affinity DataKi:  16nMAssay Description:Displacement of [3H]pyrilamine from human recombinant histamine H1 receptor expressed in CHO cell by betaplate scintillation countingMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2NP24HJPubMed
TargetHistamine H1 receptor(Homo sapiens (Human))
The Schering Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50301394(CHEMBL568892 | methyl 4-(4-(4-(hydroxydiphenylmeth...)copy SMILEScopy InChI
Affinity DataKi:  20nMAssay Description:Displacement of [3H]pyrilamine from human recombinant histamine H1 receptor expressed in CHO cell by betaplate scintillation countingMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2NP24HJPubMed
TargetHistamine H1 receptor(Homo sapiens (Human))
The Schering Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM22874(2-(4-{1-hydroxy-4-[4-(hydroxydiphenylmethyl)piperi...)copy SMILEScopy InChI
Affinity DataKi:  27nMAssay Description:Displacement of [3H]pyrilamine from human recombinant histamine H1 receptor expressed in CHO cell by betaplate scintillation countingMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2NP24HJPubMedDrugBank
TargetHistamine H1 receptor(Homo sapiens (Human))
The Schering Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50301391(1-[4-(4-methylphenyl)butyl]-alpha,alpha-diphenyl-4...)copy SMILEScopy InChI
Affinity DataKi:  39nMAssay Description:Displacement of [3H]pyrilamine from human recombinant histamine H1 receptor expressed in CHO cell by betaplate scintillation countingMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2NP24HJPubMed
TargetHistamine H1 receptor(Homo sapiens (Human))
The Schering Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50017376((+/-)1-(4-tert-butylphenyl)-4-(4-(hydroxydiphenylm...)copy SMILEScopy InChI
Affinity DataKi:  40nMAssay Description:Displacement of [3H]pyrilamine from human recombinant histamine H1 receptor expressed in CHO cell by betaplate scintillation countingMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2NP24HJPubMed
TargetHistamine H1 receptor(Homo sapiens (Human))
The Schering Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50301393(1-[4-(4-methylcyclohexyl)butyl]alpha,alpha-dipheny...)copy SMILEScopy InChI
Affinity DataKi:  61nMAssay Description:Displacement of [3H]pyrilamine from human recombinant histamine H1 receptor expressed in CHO cell by betaplate scintillation countingMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2NP24HJPubMed
TargetHistamine H1 receptor(Homo sapiens (Human))
The Schering Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50301398(CHEMBL571391 | Diphenyl-[1-(2-p-tolyl-ethyl)-piper...)copy SMILEScopy InChI
Affinity DataKi:  64nMAssay Description:Displacement of [3H]pyrilamine from human recombinant histamine H1 receptor expressed in CHO cell by betaplate scintillation countingMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2NP24HJPubMed
TargetHistamine H1 receptor(Homo sapiens (Human))
The Schering Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50301396(CHEMBL572034 | Phenyl-[1-(4-p-tolyl-butyl)-piperid...)copy SMILEScopy InChI
Affinity DataKi:  121nMAssay Description:Displacement of [3H]pyrilamine from human recombinant histamine H1 receptor expressed in CHO cell by betaplate scintillation countingMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2NP24HJPubMed
TargetHistamine H1 receptor(Homo sapiens (Human))
The Schering Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50301399(CHEMBL570695 | Diphenyl-[1-(3-p-tolyl-propyl)-pipe...)copy SMILEScopy InChI
Affinity DataKi:  155nMAssay Description:Displacement of [3H]pyrilamine from human recombinant histamine H1 receptor expressed in CHO cell by betaplate scintillation countingMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2NP24HJPubMed
TargetHistamine H1 receptor(Homo sapiens (Human))
The Schering Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50301392(4-[4-[4-[hydroxy(diphenyl)methyl]-1-piperidinyl]bu...)copy SMILEScopy InChI
Affinity DataKi:  203nMAssay Description:Displacement of [3H]pyrilamine from human recombinant histamine H1 receptor expressed in CHO cell by betaplate scintillation countingMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2NP24HJPubMed
TargetHistamine H1 receptor(Homo sapiens (Human))
The Schering Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50017724(CHEMBL127508 | Diphenyl-piperidin-4-yl-methanol | ...)copy SMILEScopy InChI
Affinity DataKi:  659nMAssay Description:Displacement of [3H]pyrilamine from human recombinant histamine H1 receptor expressed in CHO cell by betaplate scintillation countingMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2NP24HJPubMed
TargetHistamine H1 receptor(Homo sapiens (Human))
The Schering Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50301395(1-(4-p-Tolyl-butyl)-piperidine | CHEMBL571073)copy SMILEScopy InChI
Affinity DataKi:  3.20E+3nMAssay Description:Displacement of [3H]pyrilamine from human recombinant histamine H1 receptor expressed in CHO cell by betaplate scintillation countingMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2NP24HJPubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
The Schering Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM22874(2-(4-{1-hydroxy-4-[4-(hydroxydiphenylmethyl)piperi...)copy SMILEScopy InChI
Affinity DataIC50: 100nMAssay Description:Inhibition of human ERG in L929 cells by whole cell patch-clamp assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2NP24HJPubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
The Schering Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50017376((+/-)1-(4-tert-butylphenyl)-4-(4-(hydroxydiphenylm...)copy SMILEScopy InChI
Affinity DataIC50: 312nMAssay Description:Inhibition of human ERG in L929 cells by whole cell patch-clamp assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2NP24HJPubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
The Schering Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50017376((+/-)1-(4-tert-butylphenyl)-4-(4-(hydroxydiphenylm...)copy SMILEScopy InChI
Affinity DataIC50: 312nMAssay Description:Inhibition of human ERG in L929 cells at 10 uM by whole cell patch-clamp assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2NP24HJPubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
The Schering Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50301391(1-[4-(4-methylphenyl)butyl]-alpha,alpha-diphenyl-4...)copy SMILEScopy InChI
Affinity DataIC50: 396nMAssay Description:Inhibition of human ERG in L929 cells at 10 uM by whole cell patch-clamp assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2NP24HJPubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
The Schering Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50301391(1-[4-(4-methylphenyl)butyl]-alpha,alpha-diphenyl-4...)copy SMILEScopy InChI
Affinity DataIC50: 396nMAssay Description:Inhibition of human ERG in L929 cells by whole cell patch-clamp assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2NP24HJPubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
The Schering Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50301392(4-[4-[4-[hydroxy(diphenyl)methyl]-1-piperidinyl]bu...)copy SMILEScopy InChI
Affinity DataIC50: 1.10E+4nMAssay Description:Inhibition of human ERG in L929 cells at 10 uM by whole cell patch-clamp assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2NP24HJPubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
The Schering Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50301392(4-[4-[4-[hydroxy(diphenyl)methyl]-1-piperidinyl]bu...)copy SMILEScopy InChI
Affinity DataIC50: 1.10E+4nMAssay Description:Inhibition of human ERG in L929 cells by whole cell patch-clamp assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2NP24HJPubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
The Schering Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50017724(CHEMBL127508 | Diphenyl-piperidin-4-yl-methanol | ...)copy SMILEScopy InChI
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of human ERG in L929 cells at 10 uM by whole cell patch-clamp assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2NP24HJPubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
The Schering Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50017724(CHEMBL127508 | Diphenyl-piperidin-4-yl-methanol | ...)copy SMILEScopy InChI
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of human ERG in L929 cells by whole cell patch-clamp assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2NP24HJPubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
The Schering Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50301393(1-[4-(4-methylcyclohexyl)butyl]alpha,alpha-dipheny...)copy SMILEScopy InChI
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of human ERG in L929 cells by whole cell patch-clamp assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2NP24HJPubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
The Schering Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM22874(2-(4-{1-hydroxy-4-[4-(hydroxydiphenylmethyl)piperi...)copy SMILEScopy InChI
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of human ERG in L929 cells at 10 uM by whole cell patch-clamp assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2NP24HJPubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
The Schering Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50301393(1-[4-(4-methylcyclohexyl)butyl]alpha,alpha-dipheny...)copy SMILEScopy InChI
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of human ERG in L929 cells at 10 uM by whole cell patch-clamp assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2NP24HJPubMed