Compile Data Set for Download or QSAR
Found 25 Enz. Inhib. hit(s) with all data for entry = 50031701
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM15241(1-(2,6-dichlorophenyl)-5-(2,4-difluorophenyl)-7-(p...)copy SMILEScopy InChI
Affinity DataKi:  870nMAssay Description:Displacement of labeled MK-499 from human ERG in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q23T9HCCPubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50194461(7-amino-5-(2,4-difluorophenyl)-1-(2,6-difluorophen...)copy SMILEScopy InChI
Affinity DataKi:  5.10E+3nMAssay Description:Displacement of labeled MK-499 from human ERG in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q23T9HCCPubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50317588(6-(2,4-difluorophenyl)-1-(2-fluoro-5-(5-methyl-1,3...)copy SMILEScopy InChI
Affinity DataKi: >2.00E+4nMAssay Description:Displacement of labeled MK-499 from human ERG in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q23T9HCCPubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50317587(6-(2,4-difluorophenyl)-1-(2-fluoro-5-(1,3,4-oxadia...)copy SMILEScopy InChI
Affinity DataKi: >2.00E+4nMAssay Description:Displacement of labeled MK-499 from human ERG in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q23T9HCCPubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50317579(6-(2,4-difluorophenyl)-1-(2,6-difluorophenyl)-2H-q...)copy SMILEScopy InChI
Affinity DataKi: >2.00E+4nMAssay Description:Displacement of labeled MK-499 from human ERG in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q23T9HCCPubMed
TargetMitogen-activated protein kinase 14(Mus musculus (mouse))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50194461(7-amino-5-(2,4-difluorophenyl)-1-(2,6-difluorophen...)copy SMILEScopy InChI
Affinity DataIC50: 0.600nMAssay Description:Inhibition of mouse p38alpha after 3 hrs by SPA methodMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q23T9HCCPubMed
TargetMitogen-activated protein kinase 14(Mus musculus (mouse))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50317582(CHEMBL1096830 | methyl 4-(6-(2,4-difluorophenyl)-2...)copy SMILEScopy InChI
Affinity DataIC50: 1.5nMAssay Description:Inhibition of mouse p38alpha after 3 hrs by SPA methodMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q23T9HCCPubMed
TargetMitogen-activated protein kinase 14(Mus musculus (mouse))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50317580(4-(6-(2,4-difluorophenyl)-2-oxo-2H-quinolizin-1-yl...)copy SMILEScopy InChI
Affinity DataIC50: 1.5nMAssay Description:Inhibition of mouse p38alpha after 3 hrs by SPA methodMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q23T9HCCPubMed
TargetMitogen-activated protein kinase 14(Mus musculus (mouse))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM15241(1-(2,6-dichlorophenyl)-5-(2,4-difluorophenyl)-7-(p...)copy SMILEScopy InChI
Affinity DataIC50: 2.60nMAssay Description:Inhibition of mouse p38alpha after 3 hrs by SPA methodMore data for this Ligand-Target Pair
TargetMitogen-activated protein kinase 14(Mus musculus (mouse))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50317584(1-(2,6-difluoro-4-(1,3,4-oxadiazol-2-yl)phenyl)-6-...)copy SMILEScopy InChI
Affinity DataIC50: 5.30nMAssay Description:Inhibition of mouse p38alpha after 3 hrs by SPA methodMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q23T9HCCPubMed
TargetMitogen-activated protein kinase 14(Mus musculus (mouse))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50317585(1-(4-(5-amino-1,3,4-oxadiazol-2-yl)-2,6-difluoroph...)copy SMILEScopy InChI
Affinity DataIC50: 6.80nMAssay Description:Inhibition of mouse p38alpha after 3 hrs by SPA methodMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q23T9HCCPubMed
TargetMitogen-activated protein kinase 14(Mus musculus (mouse))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50317579(6-(2,4-difluorophenyl)-1-(2,6-difluorophenyl)-2H-q...)copy SMILEScopy InChI
Affinity DataIC50: 7.10nMAssay Description:Inhibition of mouse p38alpha after 3 hrs by SPA methodMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q23T9HCCPubMed
TargetMitogen-activated protein kinase 14(Mus musculus (mouse))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50317586(1-(2,6-difluoro-4-(3-methyl-1,2,4-oxadiazol-5-yl)p...)copy SMILEScopy InChI
Affinity DataIC50: 8.80nMAssay Description:Inhibition of mouse p38alpha after 3 hrs by SPA methodMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q23T9HCCPubMed
TargetMitogen-activated protein kinase 14(Mus musculus (mouse))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50317588(6-(2,4-difluorophenyl)-1-(2-fluoro-5-(5-methyl-1,3...)copy SMILEScopy InChI
Affinity DataIC50: 13nMAssay Description:Inhibition of mouse p38alpha after 3 hrs by SPA methodMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q23T9HCCPubMed
TargetMitogen-activated protein kinase 14(Mus musculus (mouse))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50317583(1-(2,6-difluoro-4-(5-methyl-1,3,4-oxadiazol-2-yl)p...)copy SMILEScopy InChI
Affinity DataIC50: 14nMAssay Description:Inhibition of mouse p38alpha after 3 hrs by SPA methodMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q23T9HCCPubMed
TargetMitogen-activated protein kinase 14(Mus musculus (mouse))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50317587(6-(2,4-difluorophenyl)-1-(2-fluoro-5-(1,3,4-oxadia...)copy SMILEScopy InChI
Affinity DataIC50: 14.7nMAssay Description:Inhibition of mouse p38alpha after 3 hrs by SPA methodMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q23T9HCCPubMed
TargetMitogen-activated protein kinase 14(Mus musculus (mouse))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50317581(4-(6-(2,4-difluorophenyl)-2-oxo-2H-quinolizin-1-yl...)copy SMILEScopy InChI
Affinity DataIC50: 20nMAssay Description:Inhibition of mouse p38alpha after 3 hrs by SPA methodMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q23T9HCCPubMed
TargetNuclear receptor subfamily 1 group I member 2(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50317586(1-(2,6-difluoro-4-(3-methyl-1,2,4-oxadiazol-5-yl)p...)copy SMILEScopy InChI
Affinity DataEC50: >3.00E+4nMAssay Description:Activation of PXRMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q23T9HCCPubMed
TargetNuclear receptor subfamily 1 group I member 2(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50317585(1-(4-(5-amino-1,3,4-oxadiazol-2-yl)-2,6-difluoroph...)copy SMILEScopy InChI
Affinity DataEC50: >3.00E+4nMAssay Description:Activation of PXRMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q23T9HCCPubMed
TargetNuclear receptor subfamily 1 group I member 2(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50317584(1-(2,6-difluoro-4-(1,3,4-oxadiazol-2-yl)phenyl)-6-...)copy SMILEScopy InChI
Affinity DataEC50: >3.00E+4nMAssay Description:Activation of PXRMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q23T9HCCPubMed
TargetNuclear receptor subfamily 1 group I member 2(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50317583(1-(2,6-difluoro-4-(5-methyl-1,3,4-oxadiazol-2-yl)p...)copy SMILEScopy InChI
Affinity DataEC50: >3.00E+4nMAssay Description:Activation of PXRMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q23T9HCCPubMed
TargetNuclear receptor subfamily 1 group I member 2(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50317582(CHEMBL1096830 | methyl 4-(6-(2,4-difluorophenyl)-2...)copy SMILEScopy InChI
Affinity DataEC50: >3.00E+4nMAssay Description:Activation of PXRMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q23T9HCCPubMed
TargetNuclear receptor subfamily 1 group I member 2(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50317581(4-(6-(2,4-difluorophenyl)-2-oxo-2H-quinolizin-1-yl...)copy SMILEScopy InChI
Affinity DataEC50: >3.00E+4nMAssay Description:Activation of PXRMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q23T9HCCPubMed
TargetNuclear receptor subfamily 1 group I member 2(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50317580(4-(6-(2,4-difluorophenyl)-2-oxo-2H-quinolizin-1-yl...)copy SMILEScopy InChI
Affinity DataEC50: >3.00E+4nMAssay Description:Activation of PXRMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q23T9HCCPubMed
TargetNuclear receptor subfamily 1 group I member 2(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50317579(6-(2,4-difluorophenyl)-1-(2,6-difluorophenyl)-2H-q...)copy SMILEScopy InChI
Affinity DataEC50:  3.30E+3nMAssay Description:Activation of PXRMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q23T9HCCPubMed