Compile Data Set for Download or QSAR
Found 48 Enz. Inhib. hit(s) with all data for entry = 50031965
TargetRAC-alpha serine/threonine-protein kinase(Homo sapiens (Human))
Pfizer Global Research and Development

Curated by ChEMBL
LigandPNGBDBM50322393((S)-N-((3-amino-1-(5-ethyl-7H-pyrrolo[2,3-d]pyrimi...)copy SMILEScopy InChI
Affinity DataIC50: 0.5nMAssay Description:Inhibition of AKT1 after 90 mins by IMAP assayMore data for this Ligand-Target Pair
TargetRAC-alpha serine/threonine-protein kinase(Homo sapiens (Human))
Pfizer Global Research and Development

Curated by ChEMBL
LigandPNGBDBM50322395((S)-N-((3-amino-1-(5-methyl-7H-pyrrolo[2,3-d]pyrim...)copy SMILEScopy InChI
Affinity DataIC50: 1nMAssay Description:Inhibition of AKT1 after 90 mins by IMAP assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q24X580CPubMed
TargetRAC-alpha serine/threonine-protein kinase(Homo sapiens (Human))
Pfizer Global Research and Development

Curated by ChEMBL
LigandPNGBDBM50322394((S)-N-((3-amino-1-(5-chloro-7H-pyrrolo[2,3-d]pyrim...)copy SMILEScopy InChI
Affinity DataIC50: 1.10nMAssay Description:Inhibition of AKT1 after 90 mins by IMAP assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q24X580CPubMed
TargetRAC-alpha serine/threonine-protein kinase(Homo sapiens (Human))
Pfizer Global Research and Development

Curated by ChEMBL
LigandPNGBDBM50322401((S)-N-((3-amino-1-(5-ethyl-7H-pyrrolo[2,3-d]pyrimi...)copy SMILEScopy InChI
Affinity DataIC50: 1.40nMAssay Description:Inhibition of AKT1 after 90 mins by IMAP assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q24X580CPubMed
TargetRAC-alpha serine/threonine-protein kinase(Homo sapiens (Human))
Pfizer Global Research and Development

Curated by ChEMBL
LigandPNGBDBM50322397((S)-N-((3-amino-1-(5-ethyl-7H-pyrrolo[2,3-d]pyrimi...)copy SMILEScopy InChI
Affinity DataIC50: 1.80nMAssay Description:Inhibition of AKT1 after 90 mins by IMAP assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q24X580CPubMed
TargetRAC-alpha serine/threonine-protein kinase(Homo sapiens (Human))
Pfizer Global Research and Development

Curated by ChEMBL
LigandPNGBDBM24855(4-{1,2-dihydrospiro[indole-3,4'-piperidine]}-7H-py...)copy SMILEScopy InChI
Affinity DataIC50: 2nMAssay Description:Inhibition of AKT1 after 90 mins by IMAP assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q24X580CPubMed
TargetRAC-alpha serine/threonine-protein kinase(Homo sapiens (Human))
Pfizer Global Research and Development

Curated by ChEMBL
LigandPNGBDBM50322402((S)-N-((3-amino-1-(5-chloro-7H-pyrrolo[2,3-d]pyrim...)copy SMILEScopy InChI
Affinity DataIC50: 2.60nMAssay Description:Inhibition of AKT1 after 90 mins by IMAP assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q24X580CPubMed
TargetRAC-alpha serine/threonine-protein kinase(Homo sapiens (Human))
Pfizer Global Research and Development

Curated by ChEMBL
LigandPNGBDBM50322403((S)-N-((3-amino-1-(5-methyl-7H-pyrrolo[2,3-d]pyrim...)copy SMILEScopy InChI
Affinity DataIC50: 3nMAssay Description:Inhibition of AKT1 after 90 mins by IMAP assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q24X580CPubMed
TargetRAC-alpha serine/threonine-protein kinase(Homo sapiens (Human))
Pfizer Global Research and Development

Curated by ChEMBL
LigandPNGBDBM50322398((S)-N-((3-amino-1-(5-chloro-7H-pyrrolo[2,3-d]pyrim...)copy SMILEScopy InChI
Affinity DataIC50: 3.30nMAssay Description:Inhibition of AKT1 after 90 mins by IMAP assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q24X580CPubMed
TargetRAC-alpha serine/threonine-protein kinase(Homo sapiens (Human))
Pfizer Global Research and Development

Curated by ChEMBL
LigandPNGBDBM50322388(5-chloro-4-(2,8-diazaspiro[4.5]decan-2-yl)-7H-pyrr...)copy SMILEScopy InChI
Affinity DataIC50: 4nMAssay Description:Inhibition of AKT1 after 90 mins by IMAP assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q24X580CPubMed
TargetRAC-alpha serine/threonine-protein kinase(Homo sapiens (Human))
Pfizer Global Research and Development

Curated by ChEMBL
LigandPNGBDBM50322403((S)-N-((3-amino-1-(5-methyl-7H-pyrrolo[2,3-d]pyrim...)copy SMILEScopy InChI
Affinity DataIC50: 7.40nMAssay Description:Inhibition of AKT1 after 90 mins by IMAP assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q24X580CPubMed
TargetRAC-alpha serine/threonine-protein kinase(Homo sapiens (Human))
Pfizer Global Research and Development

Curated by ChEMBL
LigandPNGBDBM50322396((S)-N-((3-amino-1-(5-cyano-7H-pyrrolo[2,3-d]pyrimi...)copy SMILEScopy InChI
Affinity DataIC50: 7.70nMAssay Description:Inhibition of AKT1 after 90 mins by IMAP assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q24X580CPubMed
TargetRAC-alpha serine/threonine-protein kinase(Homo sapiens (Human))
Pfizer Global Research and Development

Curated by ChEMBL
LigandPNGBDBM50322404((S)-N-((3-amino-1-(5-cyano-7H-pyrrolo[2,3-d]pyrimi...)copy SMILEScopy InChI
Affinity DataIC50: 7.80nMAssay Description:Inhibition of AKT1 after 90 mins by IMAP assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q24X580CPubMed
TargetRAC-beta serine/threonine-protein kinase(Homo sapiens (Human))
Pfizer Global Research and Development

Curated by ChEMBL
LigandPNGBDBM50322393((S)-N-((3-amino-1-(5-ethyl-7H-pyrrolo[2,3-d]pyrimi...)copy SMILEScopy InChI
Affinity DataIC50: 9nMAssay Description:Inhibition of AKT2 after 90 mins by IMAP assayMore data for this Ligand-Target Pair
TargetRAC-alpha serine/threonine-protein kinase(Homo sapiens (Human))
Pfizer Global Research and Development

Curated by ChEMBL
LigandPNGBDBM50322399((S)-N-((3-amino-1-(5-methyl-7H-pyrrolo[2,3-d]pyrim...)copy SMILEScopy InChI
Affinity DataIC50: 11.4nMAssay Description:Inhibition of AKT1 after 90 mins by IMAP assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q24X580CPubMed
TargetRAC-gamma serine/threonine-protein kinase(Homo sapiens (Human))
Pfizer Global Research and Development

Curated by ChEMBL
LigandPNGBDBM50322393((S)-N-((3-amino-1-(5-ethyl-7H-pyrrolo[2,3-d]pyrimi...)copy SMILEScopy InChI
Affinity DataIC50: 12nMAssay Description:Inhibition of AKT3 after 90 mins by IMAP assayMore data for this Ligand-Target Pair
TargetRAC-alpha serine/threonine-protein kinase(Homo sapiens (Human))
Pfizer Global Research and Development

Curated by ChEMBL
LigandPNGBDBM50322412(CHEMBL1171840 | phenyl(3-amino-1-(5-methyl-7H-pyrr...)copy SMILEScopy InChI
Affinity DataIC50: 16nMAssay Description:Inhibition of AKT1 after 90 mins by IMAP assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q24X580CPubMed
TargetRAC-alpha serine/threonine-protein kinase(Homo sapiens (Human))
Pfizer Global Research and Development

Curated by ChEMBL
LigandPNGBDBM50322400((S)-N-((3-amino-1-(5-cyano-7H-pyrrolo[2,3-d]pyrimi...)copy SMILEScopy InChI
Affinity DataIC50: 17.5nMAssay Description:Inhibition of AKT1 after 90 mins by IMAP assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q24X580CPubMed
TargetRAC-alpha serine/threonine-protein kinase(Homo sapiens (Human))
Pfizer Global Research and Development

Curated by ChEMBL
LigandPNGBDBM50322405(CHEMBL1171672 | N-((3-amino-1-(5-methyl-7H-pyrrolo...)copy SMILEScopy InChI
Affinity DataIC50: 38nMAssay Description:Inhibition of AKT1 after 90 mins by IMAP assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q24X580CPubMed
TargetRAC-alpha serine/threonine-protein kinase(Homo sapiens (Human))
Pfizer Global Research and Development

Curated by ChEMBL
LigandPNGBDBM50322408(CHEMBL1171501 | N-((3-amino-1-(5-methyl-7H-pyrrolo...)copy SMILEScopy InChI
Affinity DataIC50: 44nMAssay Description:Inhibition of AKT1 after 90 mins by IMAP assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q24X580CPubMed
TargetRAC-alpha serine/threonine-protein kinase(Homo sapiens (Human))
Pfizer Global Research and Development

Curated by ChEMBL
LigandPNGBDBM50322410((3-amino-1-(5-methyl-7H-pyrrolo[2,3-d]pyrimidin-4-...)copy SMILEScopy InChI
Affinity DataIC50: 58nMAssay Description:Inhibition of AKT1 after 90 mins by IMAP assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q24X580CPubMed
TargetRAC-alpha serine/threonine-protein kinase(Homo sapiens (Human))
Pfizer Global Research and Development

Curated by ChEMBL
LigandPNGBDBM50322411(CHEMBL1171485 | N-((3-amino-1-(5-methyl-7H-pyrrolo...)copy SMILEScopy InChI
Affinity DataIC50: 61nMAssay Description:Inhibition of AKT1 after 90 mins by IMAP assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q24X580CPubMed
TargetRAC-alpha serine/threonine-protein kinase(Homo sapiens (Human))
Pfizer Global Research and Development

Curated by ChEMBL
LigandPNGBDBM50322407(CHEMBL1171842 | N-((3-amino-1-(5-methyl-7H-pyrrolo...)copy SMILEScopy InChI
Affinity DataIC50: 62nMAssay Description:Inhibition of AKT1 after 90 mins by IMAP assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q24X580CPubMed
TargetRAC-alpha serine/threonine-protein kinase(Homo sapiens (Human))
Pfizer Global Research and Development

Curated by ChEMBL
LigandPNGBDBM50322391((R)-1-(5-chloro-7H-pyrrolo[2,3-d]pyrimidin-4-yl)py...)copy SMILEScopy InChI
Affinity DataIC50: 68nMAssay Description:Inhibition of AKT1 after 90 mins by IMAP assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q24X580CPubMed
TargetRAC-alpha serine/threonine-protein kinase(Homo sapiens (Human))
Pfizer Global Research and Development

Curated by ChEMBL
LigandPNGBDBM50322409(N-((3-amino-1-(5-methyl-7H-pyrrolo[2,3-d]pyrimidin...)copy SMILEScopy InChI
Affinity DataIC50: 160nMAssay Description:Inhibition of AKT1 after 90 mins by IMAP assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q24X580CPubMed
TargetRAC-alpha serine/threonine-protein kinase(Homo sapiens (Human))
Pfizer Global Research and Development

Curated by ChEMBL
LigandPNGBDBM50322390((3R)-1-(5-methyl-7H-pyrrolo[2,3-d]pyrimidin-4-yl)p...)copy SMILEScopy InChI
Affinity DataIC50: 180nMAssay Description:Inhibition of AKT1 after 90 mins by IMAP assayMore data for this Ligand-Target Pair
TargetRAC-alpha serine/threonine-protein kinase(Homo sapiens (Human))
Pfizer Global Research and Development

Curated by ChEMBL
LigandPNGBDBM50322389(1-(5-chloro-7H-pyrrolo[2,3-d]pyrimidin-4-yl)piperi...)copy SMILEScopy InChI
Affinity DataIC50: 200nMAssay Description:Inhibition of AKT1 after 90 mins by IMAP assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q24X580CPubMed
TargetRAC-alpha serine/threonine-protein kinase(Homo sapiens (Human))
Pfizer Global Research and Development

Curated by ChEMBL
LigandPNGBDBM50322394((S)-N-((3-amino-1-(5-chloro-7H-pyrrolo[2,3-d]pyrim...)copy SMILEScopy InChI
Affinity DataIC50: 280nMAssay Description:Inhibition of AKT1-mediated GSK3alpha phosphorylation in human U87 cells after 1 hr by ELISAMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q24X580CPubMed
TargetRAC-alpha serine/threonine-protein kinase(Homo sapiens (Human))
Pfizer Global Research and Development

Curated by ChEMBL
LigandPNGBDBM24837(N-[2-(4H-1,2,4-triazol-3-yl)phenyl]-7H-pyrrolo[2,3...)copy SMILEScopy InChI
Affinity DataIC50: 288nMAssay Description:Inhibition of AKT1 after 90 mins by IMAP assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q24X580CPubMed
TargetRAC-alpha serine/threonine-protein kinase(Homo sapiens (Human))
Pfizer Global Research and Development

Curated by ChEMBL
LigandPNGBDBM50322395((S)-N-((3-amino-1-(5-methyl-7H-pyrrolo[2,3-d]pyrim...)copy SMILEScopy InChI
Affinity DataIC50: 310nMAssay Description:Inhibition of AKT1-mediated GSK3alpha phosphorylation in human U87 cells after 1 hr by ELISAMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q24X580CPubMed
TargetRAC-alpha serine/threonine-protein kinase(Homo sapiens (Human))
Pfizer Global Research and Development

Curated by ChEMBL
LigandPNGBDBM50322393((S)-N-((3-amino-1-(5-ethyl-7H-pyrrolo[2,3-d]pyrimi...)copy SMILEScopy InChI
Affinity DataIC50: 310nMAssay Description:Inhibition of AKT1-mediated GSK3alpha phosphorylation in human U87 cells after 1 hr by ELISAMore data for this Ligand-Target Pair
TargetRAC-alpha serine/threonine-protein kinase(Homo sapiens (Human))
Pfizer Global Research and Development

Curated by ChEMBL
LigandPNGBDBM50322398((S)-N-((3-amino-1-(5-chloro-7H-pyrrolo[2,3-d]pyrim...)copy SMILEScopy InChI
Affinity DataIC50: 350nMAssay Description:Inhibition of AKT1-mediated GSK3alpha phosphorylation in human U87 cells after 1 hr by ELISAMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q24X580CPubMed
TargetRAC-alpha serine/threonine-protein kinase(Homo sapiens (Human))
Pfizer Global Research and Development

Curated by ChEMBL
LigandPNGBDBM50322402((S)-N-((3-amino-1-(5-chloro-7H-pyrrolo[2,3-d]pyrim...)copy SMILEScopy InChI
Affinity DataIC50: 360nMAssay Description:Inhibition of AKT1-mediated GSK3alpha phosphorylation in human U87 cells after 1 hr by ELISAMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q24X580CPubMed
TargetRAC-alpha serine/threonine-protein kinase(Homo sapiens (Human))
Pfizer Global Research and Development

Curated by ChEMBL
LigandPNGBDBM50322384((R)-N-(1-(5-methyl-7H-pyrrolo[2,3-d]pyrimidin-4-yl...)copy SMILEScopy InChI
Affinity DataIC50: 600nMAssay Description:Inhibition of AKT1 after 90 mins by IMAP assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q24X580CPubMed
TargetRAC-alpha serine/threonine-protein kinase(Homo sapiens (Human))
Pfizer Global Research and Development

Curated by ChEMBL
LigandPNGBDBM50322401((S)-N-((3-amino-1-(5-ethyl-7H-pyrrolo[2,3-d]pyrimi...)copy SMILEScopy InChI
Affinity DataIC50: 650nMAssay Description:Inhibition of AKT1-mediated GSK3alpha phosphorylation in human U87 cells after 1 hr by ELISAMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q24X580CPubMed
TargetRAC-alpha serine/threonine-protein kinase(Homo sapiens (Human))
Pfizer Global Research and Development

Curated by ChEMBL
LigandPNGBDBM50322383((R)-1-(1-(5-methyl-7H-pyrrolo[2,3-d]pyrimidin-4-yl...)copy SMILEScopy InChI
Affinity DataIC50: 700nMAssay Description:Inhibition of AKT1 after 90 mins by IMAP assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q24X580CPubMed
TargetRAC-alpha serine/threonine-protein kinase(Homo sapiens (Human))
Pfizer Global Research and Development

Curated by ChEMBL
LigandPNGBDBM50322386((R)-N-(1-(5-methyl-7H-pyrrolo[2,3-d]pyrimidin-4-yl...)copy SMILEScopy InChI
Affinity DataIC50: 700nMAssay Description:Inhibition of AKT1 after 90 mins by IMAP assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q24X580CPubMed
TargetRAC-alpha serine/threonine-protein kinase(Homo sapiens (Human))
Pfizer Global Research and Development

Curated by ChEMBL
LigandPNGBDBM50322406(CHEMBL1171841 | N-((3-amino-1-(5-methyl-7H-pyrrolo...)copy SMILEScopy InChI
Affinity DataIC50: 765nMAssay Description:Inhibition of AKT1 after 90 mins by IMAP assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q24X580CPubMed
TargetRAC-alpha serine/threonine-protein kinase(Homo sapiens (Human))
Pfizer Global Research and Development

Curated by ChEMBL
LigandPNGBDBM50322397((S)-N-((3-amino-1-(5-ethyl-7H-pyrrolo[2,3-d]pyrimi...)copy SMILEScopy InChI
Affinity DataIC50: 920nMAssay Description:Inhibition of AKT1-mediated GSK3alpha phosphorylation in human U87 cells after 1 hr by ELISAMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q24X580CPubMed
TargetRAC-alpha serine/threonine-protein kinase(Homo sapiens (Human))
Pfizer Global Research and Development

Curated by ChEMBL
LigandPNGBDBM50322403((S)-N-((3-amino-1-(5-methyl-7H-pyrrolo[2,3-d]pyrim...)copy SMILEScopy InChI
Affinity DataIC50: 1.46E+3nMAssay Description:Inhibition of AKT1-mediated GSK3alpha phosphorylation in human U87 cells after 1 hr by ELISAMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q24X580CPubMed
TargetRAC-alpha serine/threonine-protein kinase(Homo sapiens (Human))
Pfizer Global Research and Development

Curated by ChEMBL
LigandPNGBDBM50322396((S)-N-((3-amino-1-(5-cyano-7H-pyrrolo[2,3-d]pyrimi...)copy SMILEScopy InChI
Affinity DataIC50: 1.86E+3nMAssay Description:Inhibition of AKT1-mediated GSK3alpha phosphorylation in human U87 cells after 1 hr by ELISAMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q24X580CPubMed
TargetRAC-alpha serine/threonine-protein kinase(Homo sapiens (Human))
Pfizer Global Research and Development

Curated by ChEMBL
LigandPNGBDBM50322382((R)-N-ethyl-1-(5-methyl-7H-pyrrolo[2,3-d]pyrimidin...)copy SMILEScopy InChI
Affinity DataIC50: 1.90E+3nMAssay Description:Inhibition of AKT1 after 90 mins by IMAP assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q24X580CPubMed
TargetRAC-alpha serine/threonine-protein kinase(Homo sapiens (Human))
Pfizer Global Research and Development

Curated by ChEMBL
LigandPNGBDBM50322399((S)-N-((3-amino-1-(5-methyl-7H-pyrrolo[2,3-d]pyrim...)copy SMILEScopy InChI
Affinity DataIC50: 1.95E+3nMAssay Description:Inhibition of AKT1-mediated GSK3alpha phosphorylation in human U87 cells after 1 hr by ELISAMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q24X580CPubMed
TargetRAC-alpha serine/threonine-protein kinase(Homo sapiens (Human))
Pfizer Global Research and Development

Curated by ChEMBL
LigandPNGBDBM50322413((R)-N-benzyl-1-(5-methyl-7H-pyrrolo[2,3-d]pyrimidi...)copy SMILEScopy InChI
Affinity DataIC50: 2.40E+3nMAssay Description:Inhibition of AKT1 after 90 mins by IMAP assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q24X580CPubMed
TargetRAC-alpha serine/threonine-protein kinase(Homo sapiens (Human))
Pfizer Global Research and Development

Curated by ChEMBL
LigandPNGBDBM50322385((R)-N-(1-(5-methyl-7H-pyrrolo[2,3-d]pyrimidin-4-yl...)copy SMILEScopy InChI
Affinity DataIC50: 4.00E+3nMAssay Description:Inhibition of AKT1 after 90 mins by IMAP assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q24X580CPubMed
TargetRAC-alpha serine/threonine-protein kinase(Homo sapiens (Human))
Pfizer Global Research and Development

Curated by ChEMBL
LigandPNGBDBM50322404((S)-N-((3-amino-1-(5-cyano-7H-pyrrolo[2,3-d]pyrimi...)copy SMILEScopy InChI
Affinity DataIC50: 5.74E+3nMAssay Description:Inhibition of AKT1-mediated GSK3alpha phosphorylation in human U87 cells after 1 hr by ELISAMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q24X580CPubMed
TargetRAC-alpha serine/threonine-protein kinase(Homo sapiens (Human))
Pfizer Global Research and Development

Curated by ChEMBL
LigandPNGBDBM50322400((S)-N-((3-amino-1-(5-cyano-7H-pyrrolo[2,3-d]pyrimi...)copy SMILEScopy InChI
Affinity DataIC50: 6.34E+3nMAssay Description:Inhibition of AKT1-mediated GSK3alpha phosphorylation in human U87 cells after 1 hr by ELISAMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q24X580CPubMed
TargetRAC-alpha serine/threonine-protein kinase(Homo sapiens (Human))
Pfizer Global Research and Development

Curated by ChEMBL
LigandPNGBDBM50322387((R)-N-(1-(5-methyl-7H-pyrrolo[2,3-d]pyrimidin-4-yl...)copy SMILEScopy InChI
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of AKT1 after 90 mins by IMAP assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q24X580CPubMed