Compile Data Set for Download or QSAR
Found 40 Enz. Inhib. hit(s) with all data for entry = 50032412
TargetCytochrome P450 3A4(Homo sapiens (Human))
Elan Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50328778(CHEMBL1270362 | N-((2S,3R)-4-(1-(3-(1,1-difluoro-2...)copy SMILEScopy InChI
Affinity DataIC50: 4nMAssay Description:Inhibition of CYP3A4 in presence of NADPHMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2NZ87V9PubMed
TargetCathepsin D(Homo sapiens (Human))
Elan Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50302838(CHEMBL572081 | N-((2S,3R)-4-(1-(3-(1H-pyrazol-1-yl...)copy SMILEScopy InChI
Affinity DataIC50: 22nMAssay Description:Inhibition of cathepsin-DMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2NZ87V9PubMed
TargetCathepsin D(Homo sapiens (Human))
Elan Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50302841(CHEMBL571860 | N-((2S,3R)-4-(1-(3-tert-butylphenyl...)copy SMILEScopy InChI
Affinity DataIC50: 25nMAssay Description:Inhibition of cathepsin-DMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2NZ87V9PubMed
TargetCytochrome P450 3A4(Homo sapiens (Human))
Elan Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50328778(CHEMBL1270362 | N-((2S,3R)-4-(1-(3-(1,1-difluoro-2...)copy SMILEScopy InChI
Affinity DataIC50: 46nMAssay Description:Inhibition of CYP3A4 in presence of NADPHMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2NZ87V9PubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Elan Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50302841(CHEMBL571860 | N-((2S,3R)-4-(1-(3-tert-butylphenyl...)copy SMILEScopy InChI
Affinity DataIC50: 47nMAssay Description:Inhibition of recombinant BACE1 purified from Escherichia coliMore data for this Ligand-Target Pair
TargetBeta-secretase 1(Homo sapiens (Human))
Elan Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50302838(CHEMBL572081 | N-((2S,3R)-4-(1-(3-(1H-pyrazol-1-yl...)copy SMILEScopy InChI
Affinity DataIC50: 59nMAssay Description:Inhibition of recombinant BACE1 purified from Escherichia coliMore data for this Ligand-Target Pair
TargetBeta-secretase 1(Homo sapiens (Human))
Elan Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50302839(CHEMBL570556 | N-((2S,3R)-4-(4-(3-tert-butylphenyl...)copy SMILEScopy InChI
Affinity DataIC50: 61nMAssay Description:Inhibition of recombinant BACE1 purified from Escherichia coliMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2NZ87V9PubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Elan Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50323493(CHEMBL1209106 | N-((2S,3R)-1-(3,5-difluorophenyl)-...)copy SMILEScopy InChI
Affinity DataIC50: 88nMAssay Description:Inhibition of recombinant BACE1 purified from Escherichia coliMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2NZ87V9PubMed
TargetCytochrome P450 3A4(Homo sapiens (Human))
Elan Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50328778(CHEMBL1270362 | N-((2S,3R)-4-(1-(3-(1,1-difluoro-2...)copy SMILEScopy InChI
Affinity DataIC50: 110nMAssay Description:Inhibition of CYP3A4 by competitive inhibition assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2NZ87V9PubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Elan Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50328786(CHEMBL1269840 | N-((2S,3R)-4-(4-(3-(1H-pyrazol-1-y...)copy SMILEScopy InChI
Affinity DataIC50: 110nMAssay Description:Inhibition of recombinant BACE1 purified from Escherichia coliMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2NZ87V9PubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Elan Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50328050(CHEMBL1257303 | N-((2S,3R)-4-(1-(3-tert-butylpheny...)copy SMILEScopy InChI
Affinity DataIC50: 140nMAssay Description:Inhibition of recombinant BACE1 purified from Escherichia coliMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2NZ87V9PubMed
TargetCathepsin D(Homo sapiens (Human))
Elan Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50323493(CHEMBL1209106 | N-((2S,3R)-1-(3,5-difluorophenyl)-...)copy SMILEScopy InChI
Affinity DataIC50: 140nMAssay Description:Inhibition of cathepsin-DMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2NZ87V9PubMed
TargetCathepsin D(Homo sapiens (Human))
Elan Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50328785(CHEMBL1269841 | N-((2S,3R)-1-(3,5-difluorophenyl)-...)copy SMILEScopy InChI
Affinity DataIC50: 150nMAssay Description:Inhibition of cathepsin-DMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2NZ87V9PubMed
TargetCathepsin D(Homo sapiens (Human))
Elan Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50328786(CHEMBL1269840 | N-((2S,3R)-4-(4-(3-(1H-pyrazol-1-y...)copy SMILEScopy InChI
Affinity DataIC50: 160nMAssay Description:Inhibition of cathepsin-DMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2NZ87V9PubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Elan Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50328783(CHEMBL1269949 | N-((2S,3R)-4-(2-(3-tert-butylpheny...)copy SMILEScopy InChI
Affinity DataIC50: 200nMAssay Description:Inhibition of recombinant BACE1 purified from Escherichia coliMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2NZ87V9PubMed
TargetCathepsin D(Homo sapiens (Human))
Elan Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50328050(CHEMBL1257303 | N-((2S,3R)-4-(1-(3-tert-butylpheny...)copy SMILEScopy InChI
Affinity DataIC50: 220nMAssay Description:Inhibition of cathepsin-DMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2NZ87V9PubMed
TargetCathepsin D(Homo sapiens (Human))
Elan Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50302839(CHEMBL570556 | N-((2S,3R)-4-(4-(3-tert-butylphenyl...)copy SMILEScopy InChI
Affinity DataIC50: 230nMAssay Description:Inhibition of cathepsin-DMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2NZ87V9PubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Elan Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50328778(CHEMBL1270362 | N-((2S,3R)-4-(1-(3-(1,1-difluoro-2...)copy SMILEScopy InChI
Affinity DataIC50: 230nMAssay Description:Inhibition of recombinant BACE1 purified from Escherichia coliMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2NZ87V9PubMed
TargetCathepsin D(Homo sapiens (Human))
Elan Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50328049(CHEMBL1257302 | N-((2S,3R)-4-(1-(6-tert-butylpyrim...)copy SMILEScopy InChI
Affinity DataIC50: 250nMAssay Description:Inhibition of cathepsin-DMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2NZ87V9PubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Elan Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50328785(CHEMBL1269841 | N-((2S,3R)-1-(3,5-difluorophenyl)-...)copy SMILEScopy InChI
Affinity DataIC50: 290nMAssay Description:Inhibition of recombinant BACE1 purified from Escherichia coliMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2NZ87V9PubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Elan Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50328779(CHEMBL1270263 | N-((2S,3R)-1-(3,5-difluorophenyl)-...)copy SMILEScopy InChI
Affinity DataIC50: 290nMAssay Description:Inhibition of recombinant BACE1 purified from Escherichia coliMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2NZ87V9PubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Elan Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50328061(CHEMBL1258002 | N-((2S,3R)-1-(3,5-difluorophenyl)-...)copy SMILEScopy InChI
Affinity DataIC50: 350nMAssay Description:Inhibition of recombinant BACE1 purified from Escherichia coliMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2NZ87V9PubMed
TargetCathepsin D(Homo sapiens (Human))
Elan Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50328776(CHEMBL1270458 | N-((2S,3R)-4-(1-(3-tert-butylpheny...)copy SMILEScopy InChI
Affinity DataIC50: 380nMAssay Description:Inhibition of cathepsin-DMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2NZ87V9PubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Elan Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50328777(CHEMBL1270363 | N-((2S,3R)-4-(1-(3-(1,3-difluoro-2...)copy SMILEScopy InChI
Affinity DataIC50: 390nMAssay Description:Inhibition of recombinant BACE1 purified from Escherichia coliMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2NZ87V9PubMed
TargetCathepsin D(Homo sapiens (Human))
Elan Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50328779(CHEMBL1270263 | N-((2S,3R)-1-(3,5-difluorophenyl)-...)copy SMILEScopy InChI
Affinity DataIC50: 480nMAssay Description:Inhibition of cathepsin-DMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2NZ87V9PubMed
TargetCathepsin D(Homo sapiens (Human))
Elan Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50328781(CHEMBL1270164 | N-((2S,3R)-1-(3,5-difluorophenyl)-...)copy SMILEScopy InChI
Affinity DataIC50: 480nMAssay Description:Inhibition of cathepsin-DMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2NZ87V9PubMed
TargetCathepsin D(Homo sapiens (Human))
Elan Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50328778(CHEMBL1270362 | N-((2S,3R)-4-(1-(3-(1,1-difluoro-2...)copy SMILEScopy InChI
Affinity DataIC50: 490nMAssay Description:Inhibition of cathepsin-DMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2NZ87V9PubMed
TargetCathepsin D(Homo sapiens (Human))
Elan Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50328777(CHEMBL1270363 | N-((2S,3R)-4-(1-(3-(1,3-difluoro-2...)copy SMILEScopy InChI
Affinity DataIC50: 500nMAssay Description:Inhibition of cathepsin-DMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2NZ87V9PubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Elan Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50328776(CHEMBL1270458 | N-((2S,3R)-4-(1-(3-tert-butylpheny...)copy SMILEScopy InChI
Affinity DataIC50: 610nMAssay Description:Inhibition of recombinant BACE1 purified from Escherichia coliMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2NZ87V9PubMed
TargetCathepsin D(Homo sapiens (Human))
Elan Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50328783(CHEMBL1269949 | N-((2S,3R)-4-(2-(3-tert-butylpheny...)copy SMILEScopy InChI
Affinity DataIC50: 610nMAssay Description:Inhibition of cathepsin-DMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2NZ87V9PubMed
TargetCathepsin D(Homo sapiens (Human))
Elan Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50328061(CHEMBL1258002 | N-((2S,3R)-1-(3,5-difluorophenyl)-...)copy SMILEScopy InChI
Affinity DataIC50: 720nMAssay Description:Inhibition of cathepsin-DMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2NZ87V9PubMed
TargetCathepsin D(Homo sapiens (Human))
Elan Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50328782(CHEMBL1270163 | N-((2S,3R)-4-(1-(3-(1H-pyrazol-1-y...)copy SMILEScopy InChI
Affinity DataIC50: 750nMAssay Description:Inhibition of cathepsin-DMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2NZ87V9PubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Elan Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50328781(CHEMBL1270164 | N-((2S,3R)-1-(3,5-difluorophenyl)-...)copy SMILEScopy InChI
Affinity DataIC50: 760nMAssay Description:Inhibition of recombinant BACE1 purified from Escherichia coliMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2NZ87V9PubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Elan Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50328782(CHEMBL1270163 | N-((2S,3R)-4-(1-(3-(1H-pyrazol-1-y...)copy SMILEScopy InChI
Affinity DataIC50: 980nMAssay Description:Inhibition of recombinant BACE1 purified from Escherichia coliMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2NZ87V9PubMed
TargetCathepsin D(Homo sapiens (Human))
Elan Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50328780(CHEMBL1270262 | N-((2S,3R)-1-(3,5-difluorophenyl)-...)copy SMILEScopy InChI
Affinity DataIC50: 1.20E+3nMAssay Description:Inhibition of cathepsin-DMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2NZ87V9PubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Elan Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50328784(CHEMBL1269948 | N-((2S,3R)-4-(3-tert-butylbenzylam...)copy SMILEScopy InChI
Affinity DataIC50: 1.30E+3nMAssay Description:Inhibition of recombinant BACE1 purified from Escherichia coliMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2NZ87V9PubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Elan Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50328780(CHEMBL1270262 | N-((2S,3R)-1-(3,5-difluorophenyl)-...)copy SMILEScopy InChI
Affinity DataIC50: 1.30E+3nMAssay Description:Inhibition of recombinant BACE1 purified from Escherichia coliMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2NZ87V9PubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Elan Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50328775(CHEMBL1270459 | N-((2S,3R)-4-((1R,2R)-1-(3-(1,1-di...)copy SMILEScopy InChI
Affinity DataIC50: 1.70E+3nMAssay Description:Inhibition of recombinant BACE1 purified from Escherichia coliMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2NZ87V9PubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Elan Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50328049(CHEMBL1257302 | N-((2S,3R)-4-(1-(6-tert-butylpyrim...)copy SMILEScopy InChI
Affinity DataIC50: 2.40E+3nMAssay Description:Inhibition of recombinant BACE1 purified from Escherichia coliMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2NZ87V9PubMed
TargetCathepsin D(Homo sapiens (Human))
Elan Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50328784(CHEMBL1269948 | N-((2S,3R)-4-(3-tert-butylbenzylam...)copy SMILEScopy InChI
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of cathepsin-DMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2NZ87V9PubMed