Compile Data Set for Download or QSAR
Found 78 Enz. Inhib. hit(s) with all data for entry = 50032553
TargetSodium channel protein type 10 subunit alpha(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50330935(CHEMBL1277958 | N-(m-Tolyl)-6-(4-ethoxyphenyl)-pyr...)copy SMILEScopy InChI
Affinity DataIC50: 1nMAssay Description:Inhibition of human recombinant NaV1.8 expressed in HEK293 cells by conventional voltageclamp electrophysiology assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q24B31KGPubMed
TargetSodium channel protein type 10 subunit alpha(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50330948(CHEMBL1277959 | N-(2-Methylbenzyl)-6-(4-ethoxyphen...)copy SMILEScopy InChI
Affinity DataIC50: 2nMAssay Description:Inhibition of human recombinant NaV1.8 expressed in HEK293 cells by conventional voltageclamp electrophysiology assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q24B31KGPubMed
TargetSodium channel protein type 10 subunit alpha(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50330949(CHEMBL1277877 | N-(3,5-Dimethylphenyl)-6-(4-ethoxy...)copy SMILEScopy InChI
Affinity DataIC50: 2nMAssay Description:Inhibition of human recombinant NaV1.8 expressed in HEK293 cells by conventional voltageclamp electrophysiology assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q24B31KGPubMed
TargetSodium channel protein type 10 subunit alpha(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50330933(CHEMBL1277514 | N-(3,5-Dimethylphenyl)-6-(4-chloro...)copy SMILEScopy InChI
Affinity DataIC50: 3nMAssay Description:Inhibition of human recombinant NaV1.8 expressed in HEK293 cells by conventional voltageclamp electrophysiology assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q24B31KGPubMed
TargetSodium channel protein type 10 subunit alpha(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50330945(CHEMBL1278223 | N-(m-Tolyl)-6-(4-trifluoromethoxyp...)copy SMILEScopy InChI
Affinity DataIC50: 5nMAssay Description:Inhibition of human recombinant NaV1.8 expressed in HEK293 cells by conventional voltageclamp electrophysiology assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q24B31KGPubMed
TargetSodium channel protein type 10 subunit alpha(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50330941(CHEMBL1277512 | N-(3,5-Dimethoxyphenyl)-6-(4-chlor...)copy SMILEScopy InChI
Affinity DataIC50: 6nMAssay Description:Inhibition of human recombinant NaV1.8 expressed in HEK293 cells by conventional voltageclamp electrophysiology assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q24B31KGPubMed
TargetSodium channel protein type 10 subunit alpha(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50330937(CHEMBL1277513 | N-(m-Tolyl)-6-(4-chlorophenyl)-pyr...)copy SMILEScopy InChI
Affinity DataIC50: 6nMAssay Description:Inhibition of human recombinant NaV1.8 expressed in HEK293 cells by conventional voltageclamp electrophysiology assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q24B31KGPubMed
TargetSodium channel protein type 10 subunit alpha(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50212239(5-(4-chlorophenyl)-N-(3,5-dimethoxyphenyl)furan-2-...)copy SMILEScopy InChI
Affinity DataIC50: 8nMAssay Description:Inhibition of human recombinant NaV1.8 expressed in HEK293 cells by conventional voltageclamp electrophysiology assayMore data for this Ligand-Target Pair
TargetSodium channel protein type 10 subunit alpha(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50330944(CHEMBL1278044 | N-(3,5-Dimethylphenyl)-6-(4-cyanop...)copy SMILEScopy InChI
Affinity DataIC50: 8nMAssay Description:Inhibition of human recombinant NaV1.8 expressed in HEK293 cells by conventional voltageclamp electrophysiology assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q24B31KGPubMed
TargetSodium channel protein type 10 subunit alpha(Rattus norvegicus (Rat))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50330949(CHEMBL1277877 | N-(3,5-Dimethylphenyl)-6-(4-ethoxy...)copy SMILEScopy InChI
Affinity DataIC50: 12nMAssay Description:Inhibition of tetrodotoxin-resistant NaV1.8 in rat dorsal root ganglion neurons at holding potential -100 mV by whole-cell patch clamp electrophysiol...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q24B31KGPubMed
TargetSodium channel protein type 10 subunit alpha(Rattus norvegicus (Rat))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50330945(CHEMBL1278223 | N-(m-Tolyl)-6-(4-trifluoromethoxyp...)copy SMILEScopy InChI
Affinity DataIC50: 16nMAssay Description:Inhibition of tetrodotoxin-resistant NaV1.8 in rat dorsal root ganglion neurons at holding potential -100 mV by whole-cell patch clamp electrophysiol...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q24B31KGPubMed
TargetSodium channel protein type 10 subunit alpha(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50330942(CHEMBL1278224 | N-(2-methylbenzyl)-6-(4-(trifluoro...)copy SMILEScopy InChI
Affinity DataIC50: 18nMAssay Description:Inhibition of human recombinant NaV1.8 expressed in HEK293 cells by conventional voltageclamp electrophysiology assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q24B31KGPubMed
TargetSodium channel protein type 10 subunit alpha(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50330932(CHEMBL1276882 | N-((2-Morpholin-4-yl-pyridin-3-yl)...)copy SMILEScopy InChI
Affinity DataIC50: 19nMAssay Description:Inhibition of human recombinant NaV1.8 expressed in HEK293 cells by conventional voltageclamp electrophysiology assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q24B31KGPubMed
TargetSodium channel protein type 10 subunit alpha(Rattus norvegicus (Rat))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50330948(CHEMBL1277959 | N-(2-Methylbenzyl)-6-(4-ethoxyphen...)copy SMILEScopy InChI
Affinity DataIC50: 19nMAssay Description:Inhibition of tetrodotoxin-resistant NaV1.8 in rat dorsal root ganglion neurons at holding potential -100 mV by whole-cell patch clamp electrophysiol...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q24B31KGPubMed
TargetSodium channel protein type 10 subunit alpha(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50330938(CHEMBL1277607 | N-(4-Chlorophenethyl)-6-(4-chlorop...)copy SMILEScopy InChI
Affinity DataIC50: 19nMAssay Description:Inhibition of human recombinant NaV1.8 expressed in HEK293 cells by conventional voltageclamp electrophysiology assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q24B31KGPubMed
TargetSodium channel protein type 10 subunit alpha(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50329217(CHEMBL1271106 | N-(2-Methylbenzyl)-6-(4-trifluorom...)copy SMILEScopy InChI
Affinity DataIC50: 21nMAssay Description:Inhibition of human recombinant NaV1.8 expressed in HEK293 cells by conventional voltageclamp electrophysiology assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q24B31KGPubMed
TargetSodium channel protein type 10 subunit alpha(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50330943(CHEMBL1277606 | N-(2-Methylbenzyl)-6-(4-chlorophen...)copy SMILEScopy InChI
Affinity DataIC50: 27nMAssay Description:Inhibition of human recombinant NaV1.8 expressed in HEK293 cells by conventional voltageclamp electrophysiology assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q24B31KGPubMed
TargetSodium channel protein type 10 subunit alpha(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50330934(CHEMBL1277876 | N-((2-Pyrrolidin-1-yl-pyridin-3-yl...)copy SMILEScopy InChI
Affinity DataIC50: 30nMAssay Description:Inhibition of human recombinant NaV1.8 expressed in HEK293 cells by conventional voltageclamp electrophysiology assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q24B31KGPubMed
TargetSodium channel protein type 10 subunit alpha(Rattus norvegicus (Rat))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50329217(CHEMBL1271106 | N-(2-Methylbenzyl)-6-(4-trifluorom...)copy SMILEScopy InChI
Affinity DataIC50: 34nMAssay Description:Inhibition of tetrodotoxin-resistant NaV1.8 in rat dorsal root ganglion neurons at holding potential -100 mV by whole-cell patch clamp electrophysiol...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q24B31KGPubMed
TargetSodium channel protein type 10 subunit alpha(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50330946(CHEMBL1277700 | N-((2-Morpholin-4-yl-pyridin-3-yl)...)copy SMILEScopy InChI
Affinity DataIC50: 37nMAssay Description:Inhibition of human recombinant NaV1.8 expressed in HEK293 cells by conventional voltageclamp electrophysiology assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q24B31KGPubMed
TargetSodium channel protein type 10 subunit alpha(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50330936(6-(4-cyanophenyl)-N-(3-isopropoxyphenyl)pyrazine-2...)copy SMILEScopy InChI
Affinity DataIC50: 49nMAssay Description:Inhibition of human recombinant NaV1.8 expressed in HEK293 cells by conventional voltageclamp electrophysiology assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q24B31KGPubMed
TargetSodium channel protein type 10 subunit alpha(Rattus norvegicus (Rat))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50330933(CHEMBL1277514 | N-(3,5-Dimethylphenyl)-6-(4-chloro...)copy SMILEScopy InChI
Affinity DataIC50: 52nMAssay Description:Inhibition of tetrodotoxin-resistant NaV1.8 in rat dorsal root ganglion neurons at holding potential -100 mV by whole-cell patch clamp electrophysiol...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q24B31KGPubMed
TargetSodium channel protein type 10 subunit alpha(Mus musculus)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50330949(CHEMBL1277877 | N-(3,5-Dimethylphenyl)-6-(4-ethoxy...)copy SMILEScopy InChI
Affinity DataIC50: 56nMAssay Description:Inhibition of mouse NaV1.8 expressed in HEK293 cells by isotopic efflux assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q24B31KGPubMed
TargetSodium channel protein type 10 subunit alpha(Mus musculus)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50329217(CHEMBL1271106 | N-(2-Methylbenzyl)-6-(4-trifluorom...)copy SMILEScopy InChI
Affinity DataIC50: 58nMAssay Description:Inhibition of mouse NaV1.8 expressed in HEK293 cells by isotopic efflux assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q24B31KGPubMed
TargetSodium channel protein type 10 subunit alpha(Mus musculus)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50330945(CHEMBL1278223 | N-(m-Tolyl)-6-(4-trifluoromethoxyp...)copy SMILEScopy InChI
Affinity DataIC50: 66nMAssay Description:Inhibition of mouse NaV1.8 expressed in HEK293 cells by isotopic efflux assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q24B31KGPubMed
TargetSodium channel protein type 10 subunit alpha(Rattus norvegicus (Rat))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50330935(CHEMBL1277958 | N-(m-Tolyl)-6-(4-ethoxyphenyl)-pyr...)copy SMILEScopy InChI
Affinity DataIC50: 68nMAssay Description:Inhibition of tetrodotoxin-resistant NaV1.8 in rat dorsal root ganglion neurons at holding potential -100 mV by whole-cell patch clamp electrophysiol...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q24B31KGPubMed
TargetSodium channel protein type 10 subunit alpha(Rattus norvegicus (Rat))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50330944(CHEMBL1278044 | N-(3,5-Dimethylphenyl)-6-(4-cyanop...)copy SMILEScopy InChI
Affinity DataIC50: 84nMAssay Description:Inhibition of tetrodotoxin-resistant NaV1.8 in rat dorsal root ganglion neurons at holding potential -100 mV by whole-cell patch clamp electrophysiol...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q24B31KGPubMed
TargetSodium channel protein type 10 subunit alpha(Rattus norvegicus (Rat))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50330932(CHEMBL1276882 | N-((2-Morpholin-4-yl-pyridin-3-yl)...)copy SMILEScopy InChI
Affinity DataIC50: 85nMAssay Description:Inhibition of tetrodotoxin-resistant NaV1.8 in rat dorsal root ganglion neurons at holding potential -100 mV by whole-cell patch clamp electrophysiol...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q24B31KGPubMed
TargetSodium channel protein type 10 subunit alpha(Rattus norvegicus (Rat))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50330940(CHEMBL1276881 | N-((2-Chloropyridin-3-yl)methyl)-6...)copy SMILEScopy InChI
Affinity DataIC50: 90nMAssay Description:Inhibition of tetrodotoxin-resistant NaV1.8 in rat dorsal root ganglion neurons at holding potential -100 mV by whole-cell patch clamp electrophysiol...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q24B31KGPubMed
TargetSodium channel protein type 10 subunit alpha(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50330940(CHEMBL1276881 | N-((2-Chloropyridin-3-yl)methyl)-6...)copy SMILEScopy InChI
Affinity DataIC50: 99nMAssay Description:Inhibition of human recombinant NaV1.8 expressed in HEK293 cells by conventional voltageclamp electrophysiology assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q24B31KGPubMed
TargetSodium channel protein type 10 subunit alpha(Mus musculus)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50330948(CHEMBL1277959 | N-(2-Methylbenzyl)-6-(4-ethoxyphen...)copy SMILEScopy InChI
Affinity DataIC50: 110nMAssay Description:Inhibition of mouse NaV1.8 expressed in HEK293 cells by isotopic efflux assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q24B31KGPubMed
TargetSodium channel protein type 10 subunit alpha(Rattus norvegicus (Rat))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50330943(CHEMBL1277606 | N-(2-Methylbenzyl)-6-(4-chlorophen...)copy SMILEScopy InChI
Affinity DataIC50: 110nMAssay Description:Inhibition of tetrodotoxin-resistant NaV1.8 in rat dorsal root ganglion neurons at holding potential -100 mV by whole-cell patch clamp electrophysiol...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q24B31KGPubMed
TargetSodium channel protein type 10 subunit alpha(Rattus norvegicus (Rat))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50330936(6-(4-cyanophenyl)-N-(3-isopropoxyphenyl)pyrazine-2...)copy SMILEScopy InChI
Affinity DataIC50: 130nMAssay Description:Inhibition of tetrodotoxin-resistant NaV1.8 in rat dorsal root ganglion neurons at holding potential -100 mV by whole-cell patch clamp electrophysiol...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q24B31KGPubMed
TargetSodium channel protein type 10 subunit alpha(Rattus norvegicus (Rat))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50212239(5-(4-chlorophenyl)-N-(3,5-dimethoxyphenyl)furan-2-...)copy SMILEScopy InChI
Affinity DataIC50: 140nMAssay Description:Inhibition of tetrodotoxin-resistant NaV1.8 in rat dorsal root ganglion neurons at holding potential -100 mV by whole-cell patch clamp electrophysiol...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q24B31KGPubMed
TargetSodium channel protein type 10 subunit alpha(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50330939(CHEMBL1278138 | N-(2-Methylbenzyl)-6-(4-cyanopheny...)copy SMILEScopy InChI
Affinity DataIC50: 150nMAssay Description:Inhibition of human recombinant NaV1.8 expressed in HEK293 cells by conventional voltageclamp electrophysiology assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q24B31KGPubMed
TargetSodium channel protein type 10 subunit alpha(Rattus norvegicus (Rat))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50330942(CHEMBL1278224 | N-(2-methylbenzyl)-6-(4-(trifluoro...)copy SMILEScopy InChI
Affinity DataIC50: 170nMAssay Description:Inhibition of tetrodotoxin-resistant NaV1.8 in rat dorsal root ganglion neurons at holding potential -100 mV by whole-cell patch clamp electrophysiol...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q24B31KGPubMed
TargetSodium channel protein type 10 subunit alpha(Rattus norvegicus (Rat))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50330941(CHEMBL1277512 | N-(3,5-Dimethoxyphenyl)-6-(4-chlor...)copy SMILEScopy InChI
Affinity DataIC50: 190nMAssay Description:Inhibition of tetrodotoxin-resistant NaV1.8 in rat dorsal root ganglion neurons at holding potential -100 mV by whole-cell patch clamp electrophysiol...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q24B31KGPubMed
TargetSodium channel protein type 10 subunit alpha(Mus musculus)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50330934(CHEMBL1277876 | N-((2-Pyrrolidin-1-yl-pyridin-3-yl...)copy SMILEScopy InChI
Affinity DataIC50: 210nMAssay Description:Inhibition of mouse NaV1.8 expressed in HEK293 cells by isotopic efflux assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q24B31KGPubMed
TargetSodium channel protein type 10 subunit alpha(Mus musculus)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50330942(CHEMBL1278224 | N-(2-methylbenzyl)-6-(4-(trifluoro...)copy SMILEScopy InChI
Affinity DataIC50: 240nMAssay Description:Inhibition of mouse NaV1.8 expressed in HEK293 cells by isotopic efflux assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q24B31KGPubMed
TargetSodium channel protein type 10 subunit alpha(Rattus norvegicus (Rat))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50330937(CHEMBL1277513 | N-(m-Tolyl)-6-(4-chlorophenyl)-pyr...)copy SMILEScopy InChI
Affinity DataIC50: 280nMAssay Description:Inhibition of tetrodotoxin-resistant NaV1.8 in rat dorsal root ganglion neurons at holding potential -100 mV by whole-cell patch clamp electrophysiol...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q24B31KGPubMed
TargetSodium channel protein type 10 subunit alpha(Rattus norvegicus (Rat))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50330946(CHEMBL1277700 | N-((2-Morpholin-4-yl-pyridin-3-yl)...)copy SMILEScopy InChI
Affinity DataIC50: 280nMAssay Description:Inhibition of tetrodotoxin-resistant NaV1.8 in rat dorsal root ganglion neurons at holding potential -100 mV by whole-cell patch clamp electrophysiol...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q24B31KGPubMed
TargetSodium channel protein type 10 subunit alpha(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50330947(CHEMBL1277792 | N-((3-Morpholinopyridin-4-yl)methy...)copy SMILEScopy InChI
Affinity DataIC50: 320nMAssay Description:Inhibition of human recombinant NaV1.8 expressed in HEK293 cells by conventional voltageclamp electrophysiology assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q24B31KGPubMed
TargetSodium channel protein type 2 subunit alpha(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50330949(CHEMBL1277877 | N-(3,5-Dimethylphenyl)-6-(4-ethoxy...)copy SMILEScopy InChI
Affinity DataIC50: 360nMAssay Description:Inhibition of human recombinant NaV1.2 by electrophysiologyMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q24B31KGPubMed
TargetSodium channel protein type 10 subunit alpha(Rattus norvegicus (Rat))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50330938(CHEMBL1277607 | N-(4-Chlorophenethyl)-6-(4-chlorop...)copy SMILEScopy InChI
Affinity DataIC50: 360nMAssay Description:Inhibition of tetrodotoxin-resistant NaV1.8 in rat dorsal root ganglion neurons at holding potential -100 mV by whole-cell patch clamp electrophysiol...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q24B31KGPubMed
TargetSodium channel protein type 10 subunit alpha(Rattus norvegicus (Rat))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50330939(CHEMBL1278138 | N-(2-Methylbenzyl)-6-(4-cyanopheny...)copy SMILEScopy InChI
Affinity DataIC50: 450nMAssay Description:Inhibition of tetrodotoxin-resistant NaV1.8 in rat dorsal root ganglion neurons at holding potential -100 mV by whole-cell patch clamp electrophysiol...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q24B31KGPubMed
TargetSodium channel protein type 10 subunit alpha(Mus musculus)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50330944(CHEMBL1278044 | N-(3,5-Dimethylphenyl)-6-(4-cyanop...)copy SMILEScopy InChI
Affinity DataIC50: 470nMAssay Description:Inhibition of mouse NaV1.8 expressed in HEK293 cells by isotopic efflux assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q24B31KGPubMed
TargetSodium channel protein type 2 subunit alpha(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50330948(CHEMBL1277959 | N-(2-Methylbenzyl)-6-(4-ethoxyphen...)copy SMILEScopy InChI
Affinity DataIC50: 470nMAssay Description:Inhibition of human recombinant NaV1.2 by electrophysiologyMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q24B31KGPubMed
TargetSodium channel protein type 10 subunit alpha(Mus musculus)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50330932(CHEMBL1276882 | N-((2-Morpholin-4-yl-pyridin-3-yl)...)copy SMILEScopy InChI
Affinity DataIC50: 480nMAssay Description:Inhibition of mouse NaV1.8 expressed in HEK293 cells by isotopic efflux assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q24B31KGPubMed
TargetSodium channel protein type 10 subunit alpha(Mus musculus)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50330933(CHEMBL1277514 | N-(3,5-Dimethylphenyl)-6-(4-chloro...)copy SMILEScopy InChI
Affinity DataIC50: 490nMAssay Description:Inhibition of mouse NaV1.8 expressed in HEK293 cells by isotopic efflux assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q24B31KGPubMed
TargetSodium channel protein type 10 subunit alpha(Rattus norvegicus (Rat))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50330934(CHEMBL1277876 | N-((2-Pyrrolidin-1-yl-pyridin-3-yl...)copy SMILEScopy InChI
Affinity DataIC50: 550nMAssay Description:Inhibition of tetrodotoxin-resistant NaV1.8 in rat dorsal root ganglion neurons at holding potential -100 mV by whole-cell patch clamp electrophysiol...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q24B31KGPubMed
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