Compile Data Set for Download or QSAR
Found 34 Enz. Inhib. hit(s) with all data for entry = 50035964
TargetSigma non-opioid intracellular receptor 1(Homo sapiens (Human))
Virginia Commonwealth University

Curated by ChEMBL
LigandPNGBDBM50006981(CHEMBL19841 | [1-Methyl-2-(3-trifluoromethyl-pheny...)copy SMILEScopy InChI
Affinity DataKi:  3.90nMAssay Description:Inhibition of [3H]DTG binding to Sigma opioid receptorMore data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2WW7J9ZPubMed
TargetSigma non-opioid intracellular receptor 1(Homo sapiens (Human))
Virginia Commonwealth University

Curated by ChEMBL
LigandPNGBDBM21398(4-[4-(4-Chloro-phenyl)-4-hydroxy-piperidin-1-yl]-1...)copy SMILEScopy InChI
Affinity DataKi:  5nMAssay Description:Inhibition of [3H]DTG binding to Sigma opioid receptorMore data for this Ligand-Target Pair
TargetSigma non-opioid intracellular receptor 1(Homo sapiens (Human))
Virginia Commonwealth University

Curated by ChEMBL
LigandPNGBDBM50006982(CHEMBL281619 | [2-(3-Bromo-phenyl)-1-methyl-ethyl]...)copy SMILEScopy InChI
Affinity DataKi:  6nMAssay Description:Inhibition of [3H]DTG binding to Sigma opioid receptorMore data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2WW7J9ZPubMed
TargetSigma non-opioid intracellular receptor 1(Homo sapiens (Human))
Virginia Commonwealth University

Curated by ChEMBL
LigandPNGBDBM50006974(CHEMBL53253 | [1-Methyl-2-(4-propyl-phenyl)-ethyl]...)copy SMILEScopy InChI
Affinity DataKi:  6.20nMAssay Description:Inhibition of [3H]DTG binding to Sigma opioid receptorMore data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2WW7J9ZPubMed
TargetSigma non-opioid intracellular receptor 1(Homo sapiens (Human))
Virginia Commonwealth University

Curated by ChEMBL
LigandPNGBDBM50006972((1-Methyl-2-naphthalen-2-yl-ethyl)-(3-phenyl-propy...)copy SMILEScopy InChI
Affinity DataKi:  6.30nMAssay Description:Inhibition of [3H]DTG binding to Sigma opioid receptorMore data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2WW7J9ZPubMed
TargetSigma non-opioid intracellular receptor 1(Homo sapiens (Human))
Virginia Commonwealth University

Curated by ChEMBL
LigandPNGBDBM50006969(CHEMBL20768 | [2-(4-Ethoxy-phenyl)-1-methyl-ethyl]...)copy SMILEScopy InChI
Affinity DataKi:  6.80nMAssay Description:Opioid activity in terms of inhibition of [3H]dihydromorphine binding to opioid receptor mu in rat brain membrane.More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2WW7J9ZPubMed
TargetSigma non-opioid intracellular receptor 1(Homo sapiens (Human))
Virginia Commonwealth University

Curated by ChEMBL
LigandPNGBDBM50006968((3-Phenyl-propyl)-(6,7,8,9-tetrahydro-5H-benzocycl...)copy SMILEScopy InChI
Affinity DataKi:  7.90nMAssay Description:Inhibition of [3H]DTG binding to Sigma opioid receptorMore data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2WW7J9ZPubMed
TargetSigma non-opioid intracellular receptor 1(Homo sapiens (Human))
Virginia Commonwealth University

Curated by ChEMBL
LigandPNGBDBM50006970(CHEMBL293952 | [2-(4-Iodo-phenyl)-1-methyl-ethyl]-...)copy SMILEScopy InChI
Affinity DataKi:  8.30nMAssay Description:Opioid activity in terms of inhibition of [3H]dihydromorphine binding to opioid receptor mu in rat brain membrane.More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2WW7J9ZPubMed
TargetSigma non-opioid intracellular receptor 1(Homo sapiens (Human))
Virginia Commonwealth University

Curated by ChEMBL
LigandPNGBDBM50006975(CHEMBL19802 | [2-(4-Bromo-phenyl)-1-methyl-ethyl]-...)copy SMILEScopy InChI
Affinity DataKi:  8.80nMAssay Description:Inhibition of [3H]DTG binding to Sigma opioid receptorMore data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2WW7J9ZPubMed
TargetSigma non-opioid intracellular receptor 1(Homo sapiens (Human))
Virginia Commonwealth University

Curated by ChEMBL
LigandPNGBDBM50006967(CHEMBL53170 | [2-(4-Methoxy-phenyl)-1-methyl-ethyl...)copy SMILEScopy InChI
Affinity DataKi:  9.5nMAssay Description:Opioid activity in terms of inhibition of [3H]dihydromorphine binding to opioid receptor mu in rat brain membrane.More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2WW7J9ZPubMed
TargetSigma non-opioid intracellular receptor 1(Homo sapiens (Human))
Virginia Commonwealth University

Curated by ChEMBL
LigandPNGBDBM50006978(4-[2-(3-Phenyl-propylamino)-propyl]-phenol | CHEMB...)copy SMILEScopy InChI
Affinity DataKi:  10nMAssay Description:Opioid activity in terms of inhibition of [3H]dihydromorphine binding to opioid receptor mu in rat brain membrane.More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2WW7J9ZPubMed
TargetSigma non-opioid intracellular receptor 1(Homo sapiens (Human))
Virginia Commonwealth University

Curated by ChEMBL
LigandPNGBDBM50006973(CHEMBL298758 | [2-(3,4-Dichloro-phenyl)-1-methyl-e...)copy SMILEScopy InChI
Affinity DataKi:  12nMAssay Description:Inhibition of [3H]DTG binding to Sigma opioid receptorMore data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2WW7J9ZPubMed
TargetSigma non-opioid intracellular receptor 1(Homo sapiens (Human))
Virginia Commonwealth University

Curated by ChEMBL
LigandPNGBDBM50006971((1-Methyl-2-naphthalen-1-yl-ethyl)-(3-phenyl-propy...)copy SMILEScopy InChI
Affinity DataKi:  18nMAssay Description:Inhibition of [3H]DTG binding to Sigma opioid receptorMore data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2WW7J9ZPubMed
TargetSigma non-opioid intracellular receptor 1(Homo sapiens (Human))
Virginia Commonwealth University

Curated by ChEMBL
LigandPNGBDBM50006980((3-Phenyl-propyl)-(1,2,3,4-tetrahydro-naphthalen-2...)copy SMILEScopy InChI
Affinity DataKi:  20nMAssay Description:Inhibition of [3H]DTG binding to Sigma opioid receptorMore data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2WW7J9ZPubMed
TargetSigma non-opioid intracellular receptor 1(Homo sapiens (Human))
Virginia Commonwealth University

Curated by ChEMBL
LigandPNGBDBM50041279(((R)-1-Methyl-2-phenyl-ethyl)-(3-phenyl-propyl)-am...)copy SMILEScopy InChI
Affinity DataKi:  22nMAssay Description:Inhibition of [3H]DTG binding to Sigma opioid receptorMore data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2WW7J9ZPubMed
TargetSigma non-opioid intracellular receptor 1(Homo sapiens (Human))
Virginia Commonwealth University

Curated by ChEMBL
LigandPNGBDBM50041261(((S)-1-Methyl-2-phenyl-ethyl)-(3-phenyl-propyl)-am...)copy SMILEScopy InChI
Affinity DataKi:  22nMAssay Description:Inhibition of [3H]DTG binding to Sigma opioid receptorMore data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2WW7J9ZPubMed
TargetSigma non-opioid intracellular receptor 1(Homo sapiens (Human))
Virginia Commonwealth University

Curated by ChEMBL
LigandPNGBDBM50006976(CHEMBL54808 | [2-(4-Benzyloxy-phenyl)-1-methyl-eth...)copy SMILEScopy InChI
Affinity DataKi:  27nMAssay Description:Opioid activity in terms of inhibition of [3H]dihydromorphine binding to opioid receptor mu in rat brain membrane.More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2WW7J9ZPubMed
TargetSigma non-opioid intracellular receptor 1(Homo sapiens (Human))
Virginia Commonwealth University

Curated by ChEMBL
LigandPNGBDBM50006977(CHEMBL55317 | Indan-2-yl-(3-phenyl-propyl)-amine)copy SMILEScopy InChI
Affinity DataKi:  27nMAssay Description:Inhibition of [3H]DTG binding to Sigma opioid receptorMore data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2WW7J9ZPubMed
TargetSigma non-opioid intracellular receptor 1(Homo sapiens (Human))
Virginia Commonwealth University

Curated by ChEMBL
LigandPNGBDBM81982(CAS_97-39-2 | DITOLYLGUANIDINE | DTG | Di-o-tolylg...)copy SMILEScopy InChI
Affinity DataKi:  29nMAssay Description:Opioid activity in terms of inhibition of [3H]dihydromorphine binding to opioid receptor mu in rat brain membrane.More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2WW7J9ZPubMed
TargetSigma non-opioid intracellular receptor 1(Homo sapiens (Human))
Virginia Commonwealth University

Curated by ChEMBL
LigandPNGBDBM81924((R)-3-(1-Propyl-piperidin-3-yl)-phenol | 3PPP(+/-)...)copy SMILEScopy InChI
Affinity DataKi:  79nMAssay Description:Opioid activity in terms of inhibition of [3H]dihydromorphine binding to opioid receptor mu in rat brain membrane.More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2WW7J9ZPubMed
TargetSigma non-opioid intracellular receptor 1(Homo sapiens (Human))
Virginia Commonwealth University

Curated by ChEMBL
LigandPNGBDBM50006979((3-Phenyl-propyl)-(6,7,8,9-tetrahydro-5H-benzocycl...)copy SMILEScopy InChI
Affinity DataKi:  83nMAssay Description:Inhibition of [3H]DTG binding to Sigma opioid receptorMore data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2WW7J9ZPubMed
TargetSigma non-opioid intracellular receptor 1(RAT)
Virginia Commonwealth University

Curated by ChEMBL
LigandPNGBDBM21398(4-[4-(4-Chloro-phenyl)-4-hydroxy-piperidin-1-yl]-1...)copy SMILEScopy InChI
Affinity DataIC50: 3nMAssay Description:Inhibitory activity against Sigma opioid receptorMore data for this Ligand-Target Pair
TargetD(2) dopamine receptor(Rattus norvegicus (rat))
Virginia Commonwealth University

Curated by ChEMBL
LigandPNGBDBM50006973(CHEMBL298758 | [2-(3,4-Dichloro-phenyl)-1-methyl-e...)copy SMILEScopy InChI
Affinity DataIC50: 1.79E+3nMAssay Description:In vitro binding affinity at Dopamine receptor D2 in rat striata using [3H]domperidone as radioligandMore data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2WW7J9ZPubMed
TargetD(2) dopamine receptor(Rattus norvegicus (rat))
Virginia Commonwealth University

Curated by ChEMBL
LigandPNGBDBM50006970(CHEMBL293952 | [2-(4-Iodo-phenyl)-1-methyl-ethyl]-...)copy SMILEScopy InChI
Affinity DataIC50: 3.80E+3nMAssay Description:In vitro binding affinity at Dopamine receptor D2 in rat striata using [3H]domperidone as radioligandMore data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2WW7J9ZPubMed
TargetD(2) dopamine receptor(Rattus norvegicus (rat))
Virginia Commonwealth University

Curated by ChEMBL
LigandPNGBDBM50006968((3-Phenyl-propyl)-(6,7,8,9-tetrahydro-5H-benzocycl...)copy SMILEScopy InChI
Affinity DataIC50: 5.80E+3nMAssay Description:In vitro binding affinity at Dopamine receptor D2 in rat striata using [3H]domperidone as radioligandMore data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2WW7J9ZPubMed
TargetD(2) dopamine receptor(Rattus norvegicus (rat))
Virginia Commonwealth University

Curated by ChEMBL
LigandPNGBDBM50006967(CHEMBL53170 | [2-(4-Methoxy-phenyl)-1-methyl-ethyl...)copy SMILEScopy InChI
Affinity DataIC50: 9.32E+3nMAssay Description:In vitro binding affinity at Dopamine receptor D2 in rat striata using [3H]domperidone as radioligandMore data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2WW7J9ZPubMed
TargetD(1A) dopamine receptor(RAT)
Virginia Commonwealth University

Curated by ChEMBL
LigandPNGBDBM50006967(CHEMBL53170 | [2-(4-Methoxy-phenyl)-1-methyl-ethyl...)copy SMILEScopy InChI
Affinity DataIC50: 1.00E+4nMAssay Description:In vitro binding affinity at Dopamine receptor D1 using [3H]SCH-23390 as radioligandMore data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2WW7J9ZPubMed
TargetD(1A) dopamine receptor(RAT)
Virginia Commonwealth University

Curated by ChEMBL
LigandPNGBDBM50006970(CHEMBL293952 | [2-(4-Iodo-phenyl)-1-methyl-ethyl]-...)copy SMILEScopy InChI
Affinity DataIC50: 1.00E+4nMAssay Description:In vitro binding affinity at Dopamine receptor D1 using [3H]SCH-23390 as radioligandMore data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2WW7J9ZPubMed
TargetD(1A) dopamine receptor(RAT)
Virginia Commonwealth University

Curated by ChEMBL
LigandPNGBDBM50006968((3-Phenyl-propyl)-(6,7,8,9-tetrahydro-5H-benzocycl...)copy SMILEScopy InChI
Affinity DataIC50: 1.00E+4nMAssay Description:In vitro binding affinity at Dopamine receptor D1 using [3H]SCH-23390 as radioligandMore data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2WW7J9ZPubMed
TargetSigma non-opioid intracellular receptor 1(RAT)
Virginia Commonwealth University

Curated by ChEMBL
LigandPNGBDBM50006967(CHEMBL53170 | [2-(4-Methoxy-phenyl)-1-methyl-ethyl...)copy SMILEScopy InChI
Affinity DataIC50: 1.00E+4nMAssay Description:In vitro binding affinity at PCP binding site of sigma-opioid receptors using (+)-[3H]-MK-801 as radioligandMore data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2WW7J9ZPubMed
TargetSigma non-opioid intracellular receptor 1(RAT)
Virginia Commonwealth University

Curated by ChEMBL
LigandPNGBDBM50006970(CHEMBL293952 | [2-(4-Iodo-phenyl)-1-methyl-ethyl]-...)copy SMILEScopy InChI
Affinity DataIC50: 1.00E+4nMAssay Description:In vitro binding affinity at PCP binding site of sigma-opioid receptors using (+)-[3H]-MK-801 as radioligandMore data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2WW7J9ZPubMed
TargetSigma non-opioid intracellular receptor 1(RAT)
Virginia Commonwealth University

Curated by ChEMBL
LigandPNGBDBM50006973(CHEMBL298758 | [2-(3,4-Dichloro-phenyl)-1-methyl-e...)copy SMILEScopy InChI
Affinity DataIC50: 1.00E+4nMAssay Description:In vitro binding affinity at PCP binding site of Sigma opioid receptor using (+)-[3H]-NANM as radioligandMore data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2WW7J9ZPubMed
TargetD(1A) dopamine receptor(RAT)
Virginia Commonwealth University

Curated by ChEMBL
LigandPNGBDBM50006973(CHEMBL298758 | [2-(3,4-Dichloro-phenyl)-1-methyl-e...)copy SMILEScopy InChI
Affinity DataIC50: 1.00E+4nMAssay Description:In vitro binding affinity at Dopamine receptor D1 using [3H]SCH-23390 as radioligandMore data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2WW7J9ZPubMed
TargetSigma non-opioid intracellular receptor 1(RAT)
Virginia Commonwealth University

Curated by ChEMBL
LigandPNGBDBM50006968((3-Phenyl-propyl)-(6,7,8,9-tetrahydro-5H-benzocycl...)copy SMILEScopy InChI
Affinity DataIC50: 1.00E+4nMAssay Description:In vitro binding affinity at PCP binding site of Sigma opioid receptor using (+)-[3H]-NANM as radioligandMore data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2WW7J9ZPubMed