Found 15 Enz. Inhib. hit(s) with all data for entry = 50036714 TargetBifunctional dihydrofolate reductase-thymidylate synthase(Plasmodium falciparum (isolate K1 / Thailand))
University of Manchester
Curated by ChEMBL
University of Manchester
Curated by ChEMBL
Affinity DataKi: 0.300nMAssay Description:Binding affinity was evaluated as inhibition of recombinant wild type (WT) Plasmodium falciparum DHFR-TS.More data for this Ligand-Target Pair
TargetBifunctional dihydrofolate reductase-thymidylate synthase(Plasmodium falciparum (isolate K1 / Thailand))
University of Manchester
Curated by ChEMBL
University of Manchester
Curated by ChEMBL
Affinity DataKi: 1.10nMAssay Description:Binding affinity was evaluated as inhibition of recombinant wild type (WT) Plasmodium falciparum DHFR-TS.More data for this Ligand-Target Pair
TargetBifunctional dihydrofolate reductase-thymidylate synthase(Plasmodium falciparum (isolate K1 / Thailand))
University of Manchester
Curated by ChEMBL
University of Manchester
Curated by ChEMBL
Affinity DataKi: 1.5nMAssay Description:Binding affinity was evaluated as inhibition of recombinant wild type (WT) Plasmodium falciparum DHFR-TS.More data for this Ligand-Target Pair
3D Structure (crystal)TargetBifunctional dihydrofolate reductase-thymidylate synthase(Plasmodium falciparum (isolate K1 / Thailand))
University of Manchester
Curated by ChEMBL
University of Manchester
Curated by ChEMBL
Affinity DataKi: 2.40nMAssay Description:Binding affinity was evaluated as inhibition of mutant (C59R + S108N) Plasmodium falciparum DHFR-TS.More data for this Ligand-Target Pair
TargetBifunctional dihydrofolate reductase-thymidylate synthase(Plasmodium falciparum (isolate K1 / Thailand))
University of Manchester
Curated by ChEMBL
University of Manchester
Curated by ChEMBL
Affinity DataKi: 2.60nMAssay Description:Binding affinity was evaluated as inhibition of recombinant wild type (WT) Plasmodium falciparum DHFR-TS.More data for this Ligand-Target Pair
TargetBifunctional dihydrofolate reductase-thymidylate synthase(Plasmodium falciparum (isolate K1 / Thailand))
University of Manchester
Curated by ChEMBL
University of Manchester
Curated by ChEMBL
Affinity DataKi: 4.70nMAssay Description:Binding affinity was evaluated as inhibition of recombinant wild type (WT) Plasmodium falciparum DHFR-TS.More data for this Ligand-Target Pair
TargetBifunctional dihydrofolate reductase-thymidylate synthase(Plasmodium falciparum (isolate K1 / Thailand))
University of Manchester
Curated by ChEMBL
University of Manchester
Curated by ChEMBL
Affinity DataKi: 14nMAssay Description:Inhibitory activity against mutant Plasmodium falciparum DHFR-TSMore data for this Ligand-Target Pair
TargetBifunctional dihydrofolate reductase-thymidylate synthase(Plasmodium falciparum (isolate K1 / Thailand))
University of Manchester
Curated by ChEMBL
University of Manchester
Curated by ChEMBL
Affinity DataKi: 14nMAssay Description:Binding affinity was evaluated as inhibition of mutant (C59R + S108N) Plasmodium falciparum DHFR-TS.More data for this Ligand-Target Pair
TargetBifunctional dihydrofolate reductase-thymidylate synthase(Plasmodium falciparum (isolate K1 / Thailand))
University of Manchester
Curated by ChEMBL
University of Manchester
Curated by ChEMBL
Affinity DataKi: 15nMAssay Description:Binding affinity was evaluated as inhibition of mutant (C59R + S108N) Plasmodium falciparum DHFR-TS.More data for this Ligand-Target Pair
TargetBifunctional dihydrofolate reductase-thymidylate synthase(Plasmodium falciparum (isolate K1 / Thailand))
University of Manchester
Curated by ChEMBL
University of Manchester
Curated by ChEMBL
Affinity DataKi: 72nMAssay Description:Binding affinity was evaluated as inhibition of mutant (C59R + S108N) Plasmodium falciparum DHFR-TS.More data for this Ligand-Target Pair
TargetBifunctional dihydrofolate reductase-thymidylate synthase(Plasmodium falciparum (isolate K1 / Thailand))
University of Manchester
Curated by ChEMBL
University of Manchester
Curated by ChEMBL
Affinity DataKi: 82nMAssay Description:Binding affinity was evaluated as inhibition of mutant (C59R + S108N) Plasmodium falciparum DHFR-TS.More data for this Ligand-Target Pair
TargetBifunctional dihydrofolate reductase-thymidylate synthase(Plasmodium falciparum (isolate K1 / Thailand))
University of Manchester
Curated by ChEMBL
University of Manchester
Curated by ChEMBL
Affinity DataIC50: 2.70nMAssay Description:Inhibitory activity against recombinant wild type (WT) Plasmodium falciparum DHFR-TSMore data for this Ligand-Target Pair
TargetBifunctional dihydrofolate reductase-thymidylate synthase(Plasmodium falciparum (isolate K1 / Thailand))
University of Manchester
Curated by ChEMBL
University of Manchester
Curated by ChEMBL
Affinity DataIC50: 9.30nMAssay Description:Inhibitory activity against recombinant wild type (WT) Plasmodium falciparum DHFR-TSMore data for this Ligand-Target Pair
TargetBifunctional dihydrofolate reductase-thymidylate synthase(Plasmodium falciparum (isolate K1 / Thailand))
University of Manchester
Curated by ChEMBL
University of Manchester
Curated by ChEMBL
Affinity DataIC50: 13nMAssay Description:Inhibitory activity against mutant Plasmodium falciparum DHFR-TSMore data for this Ligand-Target Pair
TargetBifunctional dihydrofolate reductase-thymidylate synthase(Plasmodium falciparum (isolate K1 / Thailand))
University of Manchester
Curated by ChEMBL
University of Manchester
Curated by ChEMBL
Affinity DataIC50: 73nMAssay Description:Inhibitory activity against mutant Plasmodium falciparum DHFR-TSMore data for this Ligand-Target Pair
