Compile Data Set for Download or QSAR
Found 6 Enz. Inhib. hit(s) with all data for entry = 50038587
TargetDNA topoisomerase 2-alpha(Homo sapiens (Human))
Osaka University of Pharmaceutical Sciences

Curated by ChEMBL
LigandPNGBDBM50377927(Clerodol | Fagarasterol | Farganasterol | LUPEOL |...)copy SMILEScopy InChI
Affinity DataIC50: 1.04E+4nMAssay Description:Inhibition of human 1 unit topoisomerase 2alpha catalytic activity assessed as relaxation of 198 ng supercoiled pBR322 DNA by agarose gel electrophor...More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2X92C63PubMed
TargetDNA topoisomerase 2-alpha(Homo sapiens (Human))
Osaka University of Pharmaceutical Sciences

Curated by ChEMBL
LigandPNGBDBM50260250(CHEMBL491188 | Olean-12-en-3beta,15alpha-diol)copy SMILEScopy InChI
Affinity DataIC50: 1.75E+4nMAssay Description:Inhibition of human 1 unit topoisomerase 2alpha catalytic activity assessed as relaxation of 198 ng supercoiled pBR322 DNA by agarose gel electrophor...More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2X92C63PubMed
TargetDNA topoisomerase 2-alpha(Homo sapiens (Human))
Osaka University of Pharmaceutical Sciences

Curated by ChEMBL
LigandPNGBDBM23207((1R,2R,5S,8R,9R,10R,13R,14R,17S,19R)-5-(hydroxymet...)copy SMILEScopy InChI
Affinity DataIC50: 3.86E+4nMAssay Description:Inhibition of human 1 unit topoisomerase 2alpha catalytic activity assessed as relaxation of 198 ng supercoiled pBR322 DNA by agarose gel electrophor...More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2X92C63PubMed
TargetDNA topoisomerase 2-alpha(Homo sapiens (Human))
Osaka University of Pharmaceutical Sciences

Curated by ChEMBL
LigandPNGBDBM50260252(CHEMBL489552 | olean-12-en-3bea,15alpha,24-triol)copy SMILEScopy InChI
Affinity DataIC50: 3.87E+4nMAssay Description:Inhibition of human 1 unit topoisomerase 2alpha catalytic activity assessed as relaxation of 198 ng supercoiled pBR322 DNA by agarose gel electrophor...More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2X92C63PubMed
TargetDNA topoisomerase 2-alpha(Homo sapiens (Human))
Osaka University of Pharmaceutical Sciences

Curated by ChEMBL
LigandPNGBDBM50127140((-)-etoposide | (5S,5aR,8aR,9R)-9-(4-hydroxy-3,5-d...)copy SMILEScopy InChI
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of human 1 unit topoisomerase 2alpha catalytic activity assessed as relaxation of 198 ng supercoiled pBR322 DNA by agarose gel electrophor...More data for this Ligand-Target Pair
TargetDNA topoisomerase 2-alpha(Homo sapiens (Human))
Osaka University of Pharmaceutical Sciences

Curated by ChEMBL
LigandPNGBDBM50260251(CHEMBL489551 | olean-12-en-3beta,24-diol)copy SMILEScopy InChI
Affinity DataIC50: 2.00E+5nMAssay Description:Inhibition of human 1 unit topoisomerase 2alpha catalytic activity assessed as relaxation of 198 ng supercoiled pBR322 DNA by agarose gel electrophor...More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2X92C63PubMed