Compile Data Set for Download or QSAR
Found 74 Enz. Inhib. hit(s) with all data for entry = 50040918
TargetTGF-beta receptor type-1(Homo sapiens (Human))
Taisho Pharmaceutical Co., Ltd

Curated by ChEMBL
LigandPNGBDBM50402166(CHEMBL2207988)copy SMILEScopy InChI
Affinity DataIC50: 2.70nMAssay Description:Inhibition of human ALK5 using GST-tagged Smad3 as substrate assessed as substrate phosphorylation after 30 mins by ELISAMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2542PQ0PubMed
TargetTGF-beta receptor type-1(Homo sapiens (Human))
Taisho Pharmaceutical Co., Ltd

Curated by ChEMBL
LigandPNGBDBM50402175(CHEMBL2208016)copy SMILEScopy InChI
Affinity DataIC50: 4.5nMAssay Description:Inhibition of human ALK5 using GST-tagged Smad3 as substrate assessed as substrate phosphorylation after 30 mins by ELISAMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2542PQ0PubMed
TargetTGF-beta receptor type-1(Homo sapiens (Human))
Taisho Pharmaceutical Co., Ltd

Curated by ChEMBL
LigandPNGBDBM50402168(CHEMBL2208237)copy SMILEScopy InChI
Affinity DataIC50: 5.5nMAssay Description:Inhibition of human ALK5 using GST-tagged Smad3 as substrate assessed as substrate phosphorylation after 30 mins by ELISAMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2542PQ0PubMed
TargetTGF-beta receptor type-1(Homo sapiens (Human))
Taisho Pharmaceutical Co., Ltd

Curated by ChEMBL
LigandPNGBDBM50402158(CHEMBL2207996)copy SMILEScopy InChI
Affinity DataIC50: 5.80nMAssay Description:Inhibition of human ALK5 using GST-tagged Smad3 as substrate assessed as substrate phosphorylation after 30 mins by ELISAMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2542PQ0PubMed
TargetTGF-beta receptor type-1(Homo sapiens (Human))
Taisho Pharmaceutical Co., Ltd

Curated by ChEMBL
LigandPNGBDBM50402165(CHEMBL2207989)copy SMILEScopy InChI
Affinity DataIC50: 5.80nMAssay Description:Inhibition of human ALK5 using GST-tagged Smad3 as substrate assessed as substrate phosphorylation after 30 mins by ELISAMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2542PQ0PubMed
TargetTGF-beta receptor type-1(Homo sapiens (Human))
Taisho Pharmaceutical Co., Ltd

Curated by ChEMBL
LigandPNGBDBM50402159(CHEMBL2207995)copy SMILEScopy InChI
Affinity DataIC50: 7nMAssay Description:Inhibition of human ALK5 using GST-tagged Smad3 as substrate assessed as substrate phosphorylation after 30 mins by ELISAMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2542PQ0PubMed
TargetTGF-beta receptor type-1(Homo sapiens (Human))
Taisho Pharmaceutical Co., Ltd

Curated by ChEMBL
LigandPNGBDBM50402144(CHEMBL2208011)copy SMILEScopy InChI
Affinity DataIC50: 7.20nMAssay Description:Inhibition of human ALK5 using GST-tagged Smad3 as substrate assessed as substrate phosphorylation after 30 mins by ELISAMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2542PQ0PubMed
TargetTGF-beta receptor type-1(Homo sapiens (Human))
Taisho Pharmaceutical Co., Ltd

Curated by ChEMBL
LigandPNGBDBM50402172(CHEMBL2208019)copy SMILEScopy InChI
Affinity DataIC50: 7.30nMAssay Description:Inhibition of human ALK5 using GST-tagged Smad3 as substrate assessed as substrate phosphorylation after 30 mins by ELISAMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2542PQ0PubMed
TargetTGF-beta receptor type-1(Homo sapiens (Human))
Taisho Pharmaceutical Co., Ltd

Curated by ChEMBL
LigandPNGBDBM50402173(CHEMBL2208018)copy SMILEScopy InChI
Affinity DataIC50: 7.70nMAssay Description:Inhibition of human ALK5 using GST-tagged Smad3 as substrate assessed as substrate phosphorylation after 30 mins by ELISAMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2542PQ0PubMed
TargetTGF-beta receptor type-1(Homo sapiens (Human))
Taisho Pharmaceutical Co., Ltd

Curated by ChEMBL
LigandPNGBDBM50402163(CHEMBL2207991)copy SMILEScopy InChI
Affinity DataIC50: 8.10nMAssay Description:Inhibition of human ALK5 using GST-tagged Smad3 as substrate assessed as substrate phosphorylation after 30 mins by ELISAMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2542PQ0PubMed
TargetTGF-beta receptor type-1(Homo sapiens (Human))
Taisho Pharmaceutical Co., Ltd

Curated by ChEMBL
LigandPNGBDBM50402174(CHEMBL2208017)copy SMILEScopy InChI
Affinity DataIC50: 8.10nMAssay Description:Inhibition of human ALK5 using GST-tagged Smad3 as substrate assessed as substrate phosphorylation after 30 mins by ELISAMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2542PQ0PubMed
TargetTGF-beta receptor type-1(Homo sapiens (Human))
Taisho Pharmaceutical Co., Ltd

Curated by ChEMBL
LigandPNGBDBM50402162(CHEMBL2207992)copy SMILEScopy InChI
Affinity DataIC50: 8.20nMAssay Description:Inhibition of human ALK5 using GST-tagged Smad3 as substrate assessed as substrate phosphorylation after 30 mins by ELISAMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2542PQ0PubMed
TargetTGF-beta receptor type-1(Homo sapiens (Human))
Taisho Pharmaceutical Co., Ltd

Curated by ChEMBL
LigandPNGBDBM50402145(CHEMBL2208010)copy SMILEScopy InChI
Affinity DataIC50: 8.30nMAssay Description:Inhibition of human ALK5 using GST-tagged Smad3 as substrate assessed as substrate phosphorylation after 30 mins by ELISAMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2542PQ0PubMed
TargetTGF-beta receptor type-1(Homo sapiens (Human))
Taisho Pharmaceutical Co., Ltd

Curated by ChEMBL
LigandPNGBDBM50402169(CHEMBL2208022)copy SMILEScopy InChI
Affinity DataIC50: 8.60nMAssay Description:Inhibition of human ALK5 using GST-tagged Smad3 as substrate assessed as substrate phosphorylation after 30 mins by ELISAMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2542PQ0PubMed
TargetTGF-beta receptor type-1(Homo sapiens (Human))
Taisho Pharmaceutical Co., Ltd

Curated by ChEMBL
LigandPNGBDBM50402156(CHEMBL2207998)copy SMILEScopy InChI
Affinity DataIC50: 8.70nMAssay Description:Inhibition of human ALK5 using GST-tagged Smad3 as substrate assessed as substrate phosphorylation after 30 mins by ELISAMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2542PQ0PubMed
TargetTGF-beta receptor type-1(Homo sapiens (Human))
Taisho Pharmaceutical Co., Ltd

Curated by ChEMBL
LigandPNGBDBM50402166(CHEMBL2207988)copy SMILEScopy InChI
Affinity DataIC50: 8.70nMAssay Description:Inhibition of ALK5-mediated TNFalpha-induced Smad2/3 phosphorylation in human A549 cells preincubated for 2 hrs before addition of TNFalpha after 1 h...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2542PQ0PubMed
TargetTGF-beta receptor type-1(Homo sapiens (Human))
Taisho Pharmaceutical Co., Ltd

Curated by ChEMBL
LigandPNGBDBM50402157(CHEMBL2207997)copy SMILEScopy InChI
Affinity DataIC50: 8.80nMAssay Description:Inhibition of human ALK5 using GST-tagged Smad3 as substrate assessed as substrate phosphorylation after 30 mins by ELISAMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2542PQ0PubMed
TargetTGF-beta receptor type-1(Homo sapiens (Human))
Taisho Pharmaceutical Co., Ltd

Curated by ChEMBL
LigandPNGBDBM50402161(CHEMBL2207993)copy SMILEScopy InChI
Affinity DataIC50: 9nMAssay Description:Inhibition of human ALK5 using GST-tagged Smad3 as substrate assessed as substrate phosphorylation after 30 mins by ELISAMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2542PQ0PubMed
TargetTGF-beta receptor type-1(Homo sapiens (Human))
Taisho Pharmaceutical Co., Ltd

Curated by ChEMBL
LigandPNGBDBM50402149(CHEMBL2208006)copy SMILEScopy InChI
Affinity DataIC50: 9nMAssay Description:Inhibition of human ALK5 using GST-tagged Smad3 as substrate assessed as substrate phosphorylation after 30 mins by ELISAMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2542PQ0PubMed
TargetTGF-beta receptor type-1(Homo sapiens (Human))
Taisho Pharmaceutical Co., Ltd

Curated by ChEMBL
LigandPNGBDBM50402164(CHEMBL2207990)copy SMILEScopy InChI
Affinity DataIC50: 9nMAssay Description:Inhibition of human ALK5 using GST-tagged Smad3 as substrate assessed as substrate phosphorylation after 30 mins by ELISAMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2542PQ0PubMed
TargetTGF-beta receptor type-1(Homo sapiens (Human))
Taisho Pharmaceutical Co., Ltd

Curated by ChEMBL
LigandPNGBDBM50402171(CHEMBL2208020)copy SMILEScopy InChI
Affinity DataIC50: 9.10nMAssay Description:Inhibition of human ALK5 using GST-tagged Smad3 as substrate assessed as substrate phosphorylation after 30 mins by ELISAMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2542PQ0PubMed
TargetTGF-beta receptor type-1(Homo sapiens (Human))
Taisho Pharmaceutical Co., Ltd

Curated by ChEMBL
LigandPNGBDBM50402167(CHEMBL2208238)copy SMILEScopy InChI
Affinity DataIC50: 9.30nMAssay Description:Inhibition of human ALK5 using GST-tagged Smad3 as substrate assessed as substrate phosphorylation after 30 mins by ELISAMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2542PQ0PubMed
TargetTGF-beta receptor type-1(Homo sapiens (Human))
Taisho Pharmaceutical Co., Ltd

Curated by ChEMBL
LigandPNGBDBM50402170(CHEMBL2208021)copy SMILEScopy InChI
Affinity DataIC50: 11nMAssay Description:Inhibition of human ALK5 using GST-tagged Smad3 as substrate assessed as substrate phosphorylation after 30 mins by ELISAMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2542PQ0PubMed
TargetTGF-beta receptor type-1(Homo sapiens (Human))
Taisho Pharmaceutical Co., Ltd

Curated by ChEMBL
LigandPNGBDBM50402177(CHEMBL2208014)copy SMILEScopy InChI
Affinity DataIC50: 11nMAssay Description:Inhibition of human ALK5 using GST-tagged Smad3 as substrate assessed as substrate phosphorylation after 30 mins by ELISAMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2542PQ0PubMed
TargetTGF-beta receptor type-1(Homo sapiens (Human))
Taisho Pharmaceutical Co., Ltd

Curated by ChEMBL
LigandPNGBDBM50402147(CHEMBL2208008)copy SMILEScopy InChI
Affinity DataIC50: 12nMAssay Description:Inhibition of human ALK5 using GST-tagged Smad3 as substrate assessed as substrate phosphorylation after 30 mins by ELISAMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2542PQ0PubMed
TargetTGF-beta receptor type-1(Homo sapiens (Human))
Taisho Pharmaceutical Co., Ltd

Curated by ChEMBL
LigandPNGBDBM50402155(CHEMBL2207999)copy SMILEScopy InChI
Affinity DataIC50: 12nMAssay Description:Inhibition of human ALK5 using GST-tagged Smad3 as substrate assessed as substrate phosphorylation after 30 mins by ELISAMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2542PQ0PubMed
TargetTGF-beta receptor type-1(Homo sapiens (Human))
Taisho Pharmaceutical Co., Ltd

Curated by ChEMBL
LigandPNGBDBM50402150(CHEMBL2208005)copy SMILEScopy InChI
Affinity DataIC50: 13nMAssay Description:Inhibition of human ALK5 using GST-tagged Smad3 as substrate assessed as substrate phosphorylation after 30 mins by ELISAMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2542PQ0PubMed
TargetTGF-beta receptor type-1(Homo sapiens (Human))
Taisho Pharmaceutical Co., Ltd

Curated by ChEMBL
LigandPNGBDBM50402160(CHEMBL2207994)copy SMILEScopy InChI
Affinity DataIC50: 14nMAssay Description:Inhibition of human ALK5 using GST-tagged Smad3 as substrate assessed as substrate phosphorylation after 30 mins by ELISAMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2542PQ0PubMed
TargetTGF-beta receptor type-1(Homo sapiens (Human))
Taisho Pharmaceutical Co., Ltd

Curated by ChEMBL
LigandPNGBDBM50402165(CHEMBL2207989)copy SMILEScopy InChI
Affinity DataIC50: 17nMAssay Description:Inhibition of ALK5-mediated TNFalpha-induced Smad2/3 phosphorylation in human A549 cells preincubated for 2 hrs before addition of TNFalpha after 1 h...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2542PQ0PubMed
TargetTGF-beta receptor type-1(Homo sapiens (Human))
Taisho Pharmaceutical Co., Ltd

Curated by ChEMBL
LigandPNGBDBM50402176(CHEMBL2208015)copy SMILEScopy InChI
Affinity DataIC50: 17nMAssay Description:Inhibition of human ALK5 using GST-tagged Smad3 as substrate assessed as substrate phosphorylation after 30 mins by ELISAMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2542PQ0PubMed
TargetTGF-beta receptor type-1(Homo sapiens (Human))
Taisho Pharmaceutical Co., Ltd

Curated by ChEMBL
LigandPNGBDBM50402153(CHEMBL2208001)copy SMILEScopy InChI
Affinity DataIC50: 21nMAssay Description:Inhibition of human ALK5 using GST-tagged Smad3 as substrate assessed as substrate phosphorylation after 30 mins by ELISAMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2542PQ0PubMed
TargetTGF-beta receptor type-1(Homo sapiens (Human))
Taisho Pharmaceutical Co., Ltd

Curated by ChEMBL
LigandPNGBDBM50402154(CHEMBL2208000)copy SMILEScopy InChI
Affinity DataIC50: 23nMAssay Description:Inhibition of human ALK5 using GST-tagged Smad3 as substrate assessed as substrate phosphorylation after 30 mins by ELISAMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2542PQ0PubMed
TargetTGF-beta receptor type-1(Homo sapiens (Human))
Taisho Pharmaceutical Co., Ltd

Curated by ChEMBL
LigandPNGBDBM50402179(CHEMBL2208012)copy SMILEScopy InChI
Affinity DataIC50: 25nMAssay Description:Inhibition of human ALK5 using GST-tagged Smad3 as substrate assessed as substrate phosphorylation after 30 mins by ELISAMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2542PQ0PubMed
TargetTGF-beta receptor type-1(Homo sapiens (Human))
Taisho Pharmaceutical Co., Ltd

Curated by ChEMBL
LigandPNGBDBM50402152(CHEMBL2208003)copy SMILEScopy InChI
Affinity DataIC50: 26nMAssay Description:Inhibition of human ALK5 using GST-tagged Smad3 as substrate assessed as substrate phosphorylation after 30 mins by ELISAMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2542PQ0PubMed
TargetTGF-beta receptor type-1(Homo sapiens (Human))
Taisho Pharmaceutical Co., Ltd

Curated by ChEMBL
LigandPNGBDBM50402178(CHEMBL2208013)copy SMILEScopy InChI
Affinity DataIC50: 26nMAssay Description:Inhibition of human ALK5 using GST-tagged Smad3 as substrate assessed as substrate phosphorylation after 30 mins by ELISAMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2542PQ0PubMed
TargetTGF-beta receptor type-1(Homo sapiens (Human))
Taisho Pharmaceutical Co., Ltd

Curated by ChEMBL
LigandPNGBDBM50402151(CHEMBL2208004)copy SMILEScopy InChI
Affinity DataIC50: 28nMAssay Description:Inhibition of human ALK5 using GST-tagged Smad3 as substrate assessed as substrate phosphorylation after 30 mins by ELISAMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2542PQ0PubMed
TargetTGF-beta receptor type-1(Homo sapiens (Human))
Taisho Pharmaceutical Co., Ltd

Curated by ChEMBL
LigandPNGBDBM50402163(CHEMBL2207991)copy SMILEScopy InChI
Affinity DataIC50: 33nMAssay Description:Inhibition of ALK5-mediated TNFalpha-induced Smad2/3 phosphorylation in human A549 cells preincubated for 2 hrs before addition of TNFalpha after 1 h...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2542PQ0PubMed
TargetTGF-beta receptor type-1(Homo sapiens (Human))
Taisho Pharmaceutical Co., Ltd

Curated by ChEMBL
LigandPNGBDBM50402164(CHEMBL2207990)copy SMILEScopy InChI
Affinity DataIC50: 35nMAssay Description:Inhibition of ALK5-mediated TNFalpha-induced Smad2/3 phosphorylation in human A549 cells preincubated for 2 hrs before addition of TNFalpha after 1 h...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2542PQ0PubMed
TargetTGF-beta receptor type-1(Homo sapiens (Human))
Taisho Pharmaceutical Co., Ltd

Curated by ChEMBL
LigandPNGBDBM50402175(CHEMBL2208016)copy SMILEScopy InChI
Affinity DataIC50: 35nMAssay Description:Inhibition of ALK5-mediated TNFalpha-induced Smad2/3 phosphorylation in human A549 cells preincubated for 2 hrs before addition of TNFalpha after 1 h...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2542PQ0PubMed
TargetTGF-beta receptor type-1(Homo sapiens (Human))
Taisho Pharmaceutical Co., Ltd

Curated by ChEMBL
LigandPNGBDBM50402168(CHEMBL2208237)copy SMILEScopy InChI
Affinity DataIC50: 36nMAssay Description:Inhibition of ALK5-mediated TNFalpha-induced Smad2/3 phosphorylation in human A549 cells preincubated for 2 hrs before addition of TNFalpha after 1 h...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2542PQ0PubMed
TargetTGF-beta receptor type-1(Homo sapiens (Human))
Taisho Pharmaceutical Co., Ltd

Curated by ChEMBL
LigandPNGBDBM50402172(CHEMBL2208019)copy SMILEScopy InChI
Affinity DataIC50: 36nMAssay Description:Inhibition of ALK5-mediated TNFalpha-induced Smad2/3 phosphorylation in human A549 cells preincubated for 2 hrs before addition of TNFalpha after 1 h...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2542PQ0PubMed
TargetTGF-beta receptor type-1(Homo sapiens (Human))
Taisho Pharmaceutical Co., Ltd

Curated by ChEMBL
LigandPNGBDBM50402146(CHEMBL2208009)copy SMILEScopy InChI
Affinity DataIC50: 37nMAssay Description:Inhibition of human ALK5 using GST-tagged Smad3 as substrate assessed as substrate phosphorylation after 30 mins by ELISAMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2542PQ0PubMed
TargetTGF-beta receptor type-1(Homo sapiens (Human))
Taisho Pharmaceutical Co., Ltd

Curated by ChEMBL
LigandPNGBDBM50402173(CHEMBL2208018)copy SMILEScopy InChI
Affinity DataIC50: 38nMAssay Description:Inhibition of ALK5-mediated TNFalpha-induced Smad2/3 phosphorylation in human A549 cells preincubated for 2 hrs before addition of TNFalpha after 1 h...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2542PQ0PubMed
TargetTGF-beta receptor type-1(Homo sapiens (Human))
Taisho Pharmaceutical Co., Ltd

Curated by ChEMBL
LigandPNGBDBM50402156(CHEMBL2207998)copy SMILEScopy InChI
Affinity DataIC50: 40nMAssay Description:Inhibition of ALK5-mediated TNFalpha-induced Smad2/3 phosphorylation in human A549 cells preincubated for 2 hrs before addition of TNFalpha after 1 h...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2542PQ0PubMed
TargetTGF-beta receptor type-1(Homo sapiens (Human))
Taisho Pharmaceutical Co., Ltd

Curated by ChEMBL
LigandPNGBDBM50402169(CHEMBL2208022)copy SMILEScopy InChI
Affinity DataIC50: 41nMAssay Description:Inhibition of ALK5-mediated TNFalpha-induced Smad2/3 phosphorylation in human A549 cells preincubated for 2 hrs before addition of TNFalpha after 1 h...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2542PQ0PubMed
TargetTGF-beta receptor type-1(Homo sapiens (Human))
Taisho Pharmaceutical Co., Ltd

Curated by ChEMBL
LigandPNGBDBM50402149(CHEMBL2208006)copy SMILEScopy InChI
Affinity DataIC50: 42nMAssay Description:Inhibition of ALK5-mediated TNFalpha-induced Smad2/3 phosphorylation in human A549 cells preincubated for 2 hrs before addition of TNFalpha after 1 h...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2542PQ0PubMed
TargetTGF-beta receptor type-1(Homo sapiens (Human))
Taisho Pharmaceutical Co., Ltd

Curated by ChEMBL
LigandPNGBDBM50402161(CHEMBL2207993)copy SMILEScopy InChI
Affinity DataIC50: 43nMAssay Description:Inhibition of ALK5-mediated TNFalpha-induced Smad2/3 phosphorylation in human A549 cells preincubated for 2 hrs before addition of TNFalpha after 1 h...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2542PQ0PubMed
TargetTGF-beta receptor type-1(Homo sapiens (Human))
Taisho Pharmaceutical Co., Ltd

Curated by ChEMBL
LigandPNGBDBM50402157(CHEMBL2207997)copy SMILEScopy InChI
Affinity DataIC50: 45nMAssay Description:Inhibition of ALK5-mediated TNFalpha-induced Smad2/3 phosphorylation in human A549 cells preincubated for 2 hrs before addition of TNFalpha after 1 h...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2542PQ0PubMed
TargetTGF-beta receptor type-1(Homo sapiens (Human))
Taisho Pharmaceutical Co., Ltd

Curated by ChEMBL
LigandPNGBDBM50402148(CHEMBL2208007)copy SMILEScopy InChI
Affinity DataIC50: 45nMAssay Description:Inhibition of human ALK5 using GST-tagged Smad3 as substrate assessed as substrate phosphorylation after 30 mins by ELISAMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2542PQ0PubMed
TargetTGF-beta receptor type-1(Homo sapiens (Human))
Taisho Pharmaceutical Co., Ltd

Curated by ChEMBL
LigandPNGBDBM50402162(CHEMBL2207992)copy SMILEScopy InChI
Affinity DataIC50: 48nMAssay Description:Inhibition of ALK5-mediated TNFalpha-induced Smad2/3 phosphorylation in human A549 cells preincubated for 2 hrs before addition of TNFalpha after 1 h...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2542PQ0PubMed
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