Compile Data Set for Download or QSAR
Found 19 Enz. Inhib. hit(s) with all data for entry = 50042514
TargetRenin(Homo sapiens (Human))
Novartis Pharma AG

Curated by ChEMBL
LigandPNGBDBM50427040(CHEMBL2322207)copy SMILEScopy InChI
Affinity DataIC50: 4nMAssay Description:Inhibition of human recombinant renin using fluorescence-quenched (RE(EDANS)IHPFHLVIHTK(Dabcyl)R as substrate incubated for 1 hr prior to substrate a...More data for this Ligand-Target Pair
TargetRenin(Homo sapiens (Human))
Novartis Pharma AG

Curated by ChEMBL
LigandPNGBDBM50427040(CHEMBL2322207)copy SMILEScopy InChI
Affinity DataIC50: 4nMAssay Description:Inhibition of human plasma reninMore data for this Ligand-Target Pair
TargetRenin(Homo sapiens (Human))
Novartis Pharma AG

Curated by ChEMBL
LigandPNGBDBM18012(trans,trans-4-arylpiperidine-based compound, 1)copy SMILEScopy InChI
Affinity DataIC50: 8.90nMAssay Description:Inhibition of plasma renin (unknown origin)More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q25X2B8ZPubMed
TargetRenin(Homo sapiens (Human))
Novartis Pharma AG

Curated by ChEMBL
LigandPNGBDBM50427040(CHEMBL2322207)copy SMILEScopy InChI
Affinity DataIC50: 25nMAssay Description:Inhibition of human plasma reninMore data for this Ligand-Target Pair
TargetRenin(Homo sapiens (Human))
Novartis Pharma AG

Curated by ChEMBL
LigandPNGBDBM50427039(CHEMBL2322208)copy SMILEScopy InChI
Affinity DataIC50: 90nMAssay Description:Inhibition of human plasma reninMore data for this Ligand-Target Pair
TargetRenin(Homo sapiens (Human))
Novartis Pharma AG

Curated by ChEMBL
LigandPNGBDBM50427041(CHEMBL2322210)copy SMILEScopy InChI
Affinity DataIC50: 100nMAssay Description:Inhibition of human plasma reninMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q25X2B8ZPubMed
TargetRenin(Homo sapiens (Human))
Novartis Pharma AG

Curated by ChEMBL
LigandPNGBDBM50427042(CHEMBL2322211)copy SMILEScopy InChI
Affinity DataIC50: 100nMAssay Description:Inhibition of human recombinant renin using fluorescence-quenched (RE(EDANS)IHPFHLVIHTK(Dabcyl)R as substrate incubated for 1 hr prior to substrate a...More data for this Ligand-Target Pair
TargetRenin(Homo sapiens (Human))
Novartis Pharma AG

Curated by ChEMBL
LigandPNGBDBM50427038(CHEMBL2322206)copy SMILEScopy InChI
Affinity DataIC50: 500nMAssay Description:Inhibition of human plasma reninMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q25X2B8ZPubMed
TargetRenin(Homo sapiens (Human))
Novartis Pharma AG

Curated by ChEMBL
LigandPNGBDBM50427037(CHEMBL2322204)copy SMILEScopy InChI
Affinity DataIC50: 1.20E+3nMAssay Description:Inhibition of human plasma reninMore data for this Ligand-Target Pair
TargetRenin(Homo sapiens (Human))
Novartis Pharma AG

Curated by ChEMBL
LigandPNGBDBM50427037(CHEMBL2322204)copy SMILEScopy InChI
Affinity DataIC50: 1.20E+3nMAssay Description:Inhibition of human recombinant renin using fluorescence-quenched (RE(EDANS)IHPFHLVIHTK(Dabcyl)R as substrate incubated for 1 hr prior to substrate a...More data for this Ligand-Target Pair
TargetRenin(Homo sapiens (Human))
Novartis Pharma AG

Curated by ChEMBL
LigandPNGBDBM50427036(CHEMBL2322205)copy SMILEScopy InChI
Affinity DataIC50: 4.00E+3nMAssay Description:Inhibition of human plasma reninMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q25X2B8ZPubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Novartis Pharma AG

Curated by ChEMBL
LigandPNGBDBM50427040(CHEMBL2322207)copy SMILEScopy InChI
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of human recombinant BACE1 expressed in baculovirus-infected SF9 cells using fluorescence-quenched RE(EDANS)-EVNLDAEF-K(DABSYL)-R as subst...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q25X2B8ZPubMed
TargetBeta-secretase 2(Homo sapiens (Human))
Novartis Pharma AG

Curated by ChEMBL
LigandPNGBDBM50427040(CHEMBL2322207)copy SMILEScopy InChI
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of human recombinant BACE2 expressed in baculovirus-infected SF9 cells using fluorescence-quenched RE(EDANS)-EVNLDAEF-K(DABSYL)-R as subst...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q25X2B8ZPubMed
TargetGastricsin(Homo sapiens (Human))
Novartis Pharma AG

Curated by ChEMBL
LigandPNGBDBM50427040(CHEMBL2322207)copy SMILEScopy InChI
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of human recombinant pepsin C expressed in Escherichia coli using fluorescence-quenched Dabcyl-E-R-Nle-F-L-S-F-P-EDANS as substrate incuba...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q25X2B8ZPubMed
TargetRenin(Homo sapiens (Human))
Novartis Pharma AG

Curated by ChEMBL
LigandPNGBDBM50427043(CHEMBL2322203)copy SMILEScopy InChI
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of human plasma reninMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q25X2B8ZPubMed
TargetCathepsin E(Homo sapiens (Human))
Novartis Pharma AG

Curated by ChEMBL
LigandPNGBDBM50427040(CHEMBL2322207)copy SMILEScopy InChI
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of human recombinant cathepsin E expressed in Escherichia coli using fluorescence-quenched Ac-E-D(EDANS)-KPILFFRLG-K(Dabcyl)-E-Amid as sub...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q25X2B8ZPubMed
TargetCathepsin D(Homo sapiens (Human))
Novartis Pharma AG

Curated by ChEMBL
LigandPNGBDBM50427040(CHEMBL2322207)copy SMILEScopy InChI
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of human recombinant cathepsin D expressed in baculovirus-infected SF9 cells using fluorescence-quenched Ac-E-D(EDANS)-KPILFFRLG-K(Dabcyl)...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q25X2B8ZPubMed
TargetRenin(Homo sapiens (Human))
Novartis Pharma AG

Curated by ChEMBL
LigandPNGBDBM50427041(CHEMBL2322210)copy SMILEScopy InChI
Affinity DataKd: >5.00E+5nMAssay Description:Binding affinity to human recombinant renin by NMR titration analysisMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q25X2B8ZPubMed
TargetRenin(Homo sapiens (Human))
Novartis Pharma AG

Curated by ChEMBL
LigandPNGBDBM50427042(CHEMBL2322211)copy SMILEScopy InChI
Affinity DataKd: >5.00E+5nMAssay Description:Binding affinity to human recombinant renin by NMR titration analysisMore data for this Ligand-Target Pair