Found 45 Enz. Inhib. hit(s) with all data for entry = 50043505 TargetEukaryotic translation initiation factor 2-alpha kinase 3(Homo sapiens (Human))
GlaxoSmithKline Research and Development
Curated by ChEMBL
GlaxoSmithKline Research and Development
Curated by ChEMBL
Affinity DataIC50: 0.400nMAssay Description:Inhibition of GST-tagged PERK cytoplasmic domain (536 to 1116) (unknown origin) assessed as biotinylated His6-tagged EIF2alpha phosphorylation preinc...More data for this Ligand-Target Pair
3D Structure (crystal)TargetEukaryotic translation initiation factor 2-alpha kinase 3(Homo sapiens (Human))
GlaxoSmithKline Research and Development
Curated by ChEMBL
GlaxoSmithKline Research and Development
Curated by ChEMBL
Affinity DataIC50: 0.5nMAssay Description:Inhibition of GST-tagged PERK cytoplasmic domain (536 to 1116) (unknown origin) assessed as biotinylated His6-tagged EIF2alpha phosphorylation preinc...More data for this Ligand-Target Pair
TargetEukaryotic translation initiation factor 2-alpha kinase 3(Homo sapiens (Human))
GlaxoSmithKline Research and Development
Curated by ChEMBL
GlaxoSmithKline Research and Development
Curated by ChEMBL
Affinity DataIC50: 0.5nMAssay Description:Inhibition of GST-tagged PERK cytoplasmic domain (536 to 1116) (unknown origin) assessed as biotinylated His6-tagged EIF2alpha phosphorylation preinc...More data for this Ligand-Target Pair
TargetEukaryotic translation initiation factor 2-alpha kinase 3(Homo sapiens (Human))
GlaxoSmithKline Research and Development
Curated by ChEMBL
GlaxoSmithKline Research and Development
Curated by ChEMBL
Affinity DataIC50: 0.800nMAssay Description:Inhibition of GST-tagged PERK cytoplasmic domain (536 to 1116) (unknown origin) assessed as biotinylated His6-tagged EIF2alpha phosphorylation preinc...More data for this Ligand-Target Pair
TargetEukaryotic translation initiation factor 2-alpha kinase 3(Homo sapiens (Human))
GlaxoSmithKline Research and Development
Curated by ChEMBL
GlaxoSmithKline Research and Development
Curated by ChEMBL
Affinity DataIC50: 1.90nMAssay Description:Inhibition of GST-tagged PERK cytoplasmic domain (536 to 1116) (unknown origin) assessed as biotinylated His6-tagged EIF2alpha phosphorylation preinc...More data for this Ligand-Target Pair
TargetEukaryotic translation initiation factor 2-alpha kinase 3(Homo sapiens (Human))
GlaxoSmithKline Research and Development
Curated by ChEMBL
GlaxoSmithKline Research and Development
Curated by ChEMBL
Affinity DataIC50: 2.5nMAssay Description:Inhibition of GST-tagged PERK cytoplasmic domain (536 to 1116) (unknown origin) assessed as biotinylated His6-tagged EIF2alpha phosphorylation preinc...More data for this Ligand-Target Pair
TargetEukaryotic translation initiation factor 2-alpha kinase 3(Homo sapiens (Human))
GlaxoSmithKline Research and Development
Curated by ChEMBL
GlaxoSmithKline Research and Development
Curated by ChEMBL
Affinity DataIC50: 2.70nMAssay Description:Inhibition of GST-tagged PERK cytoplasmic domain (536 to 1116) (unknown origin) assessed as biotinylated His6-tagged EIF2alpha phosphorylation preinc...More data for this Ligand-Target Pair
TargetEukaryotic translation initiation factor 2-alpha kinase 3(Homo sapiens (Human))
GlaxoSmithKline Research and Development
Curated by ChEMBL
GlaxoSmithKline Research and Development
Curated by ChEMBL
Affinity DataIC50: 17nMAssay Description:Inhibition of GST-tagged PERK cytoplasmic domain (536 to 1116) (unknown origin) assessed as biotinylated His6-tagged EIF2alpha phosphorylation preinc...More data for this Ligand-Target Pair
TargetEukaryotic translation initiation factor 2-alpha kinase 3(Homo sapiens (Human))
GlaxoSmithKline Research and Development
Curated by ChEMBL
GlaxoSmithKline Research and Development
Curated by ChEMBL
Affinity DataIC50: 19nMAssay Description:Inhibition of GST-tagged PERK cytoplasmic domain (536 to 1116) (unknown origin) assessed as biotinylated His6-tagged EIF2alpha phosphorylation preinc...More data for this Ligand-Target Pair
TargetEukaryotic translation initiation factor 2-alpha kinase 3(Homo sapiens (Human))
GlaxoSmithKline Research and Development
Curated by ChEMBL
GlaxoSmithKline Research and Development
Curated by ChEMBL
Affinity DataIC50: 23nMAssay Description:Inhibition of GST-tagged PERK cytoplasmic domain (536 to 1116) (unknown origin) assessed as biotinylated His6-tagged EIF2alpha phosphorylation preinc...More data for this Ligand-Target Pair
TargetEukaryotic translation initiation factor 2-alpha kinase 3(Homo sapiens (Human))
GlaxoSmithKline Research and Development
Curated by ChEMBL
GlaxoSmithKline Research and Development
Curated by ChEMBL
Affinity DataIC50: 30nMAssay Description:Inhibition of thapsigargin-induced autophosphorylation of PERK in human A549 cells preincubated for 1 hr followed by thapsigargin-induction measured ...More data for this Ligand-Target Pair
TargetEukaryotic translation initiation factor 2-alpha kinase 3(Homo sapiens (Human))
GlaxoSmithKline Research and Development
Curated by ChEMBL
GlaxoSmithKline Research and Development
Curated by ChEMBL
Affinity DataIC50: 30nMAssay Description:Inhibition of thapsigargin-induced autophosphorylation of PERK in human A549 cells preincubated for 1 hr followed by thapsigargin-induction measured ...More data for this Ligand-Target Pair
TargetEukaryotic translation initiation factor 2-alpha kinase 3(Homo sapiens (Human))
GlaxoSmithKline Research and Development
Curated by ChEMBL
GlaxoSmithKline Research and Development
Curated by ChEMBL
Affinity DataIC50: 30nMAssay Description:Inhibition of thapsigargin-induced autophosphorylation of PERK in human A549 cells preincubated for 1 hr followed by thapsigargin-induction measured ...More data for this Ligand-Target Pair
TargetEukaryotic translation initiation factor 2-alpha kinase 1(Homo sapiens (Human))
GlaxoSmithKline Research and Development
Curated by ChEMBL
GlaxoSmithKline Research and Development
Curated by ChEMBL
Affinity DataIC50: 37nMAssay Description:Inhibition of HRI (unknown origin) assessed as EIF2AK1 phosphorylationMore data for this Ligand-Target Pair
TargetEukaryotic translation initiation factor 2-alpha kinase 3(Homo sapiens (Human))
GlaxoSmithKline Research and Development
Curated by ChEMBL
GlaxoSmithKline Research and Development
Curated by ChEMBL
Affinity DataIC50: 58nMAssay Description:Inhibition of GST-tagged PERK cytoplasmic domain (536 to 1116) (unknown origin) assessed as biotinylated His6-tagged EIF2alpha phosphorylation preinc...More data for this Ligand-Target Pair
TargetEukaryotic translation initiation factor 2-alpha kinase 1(Homo sapiens (Human))
GlaxoSmithKline Research and Development
Curated by ChEMBL
GlaxoSmithKline Research and Development
Curated by ChEMBL
Affinity DataIC50: 61nMAssay Description:Inhibition of HRI (unknown origin) assessed as EIF2AK1 phosphorylationMore data for this Ligand-Target Pair
TargetEukaryotic translation initiation factor 2-alpha kinase 3(Homo sapiens (Human))
GlaxoSmithKline Research and Development
Curated by ChEMBL
GlaxoSmithKline Research and Development
Curated by ChEMBL
Affinity DataIC50: 64nMAssay Description:Inhibition of GST-tagged PERK cytoplasmic domain (536 to 1116) (unknown origin) assessed as biotinylated His6-tagged EIF2alpha phosphorylation preinc...More data for this Ligand-Target Pair
TargetInterferon-induced, double-stranded RNA-activated protein kinase(Homo sapiens (Human))
GlaxoSmithKline Research and Development
Curated by ChEMBL
GlaxoSmithKline Research and Development
Curated by ChEMBL
Affinity DataIC50: 99nMAssay Description:Inhibition of PKR (unknown origin) assessed as EIF2AK2 phosphorylationMore data for this Ligand-Target Pair
TargetEukaryotic translation initiation factor 2-alpha kinase 3(Homo sapiens (Human))
GlaxoSmithKline Research and Development
Curated by ChEMBL
GlaxoSmithKline Research and Development
Curated by ChEMBL
Affinity DataIC50: 100nMAssay Description:Inhibition of thapsigargin-induced autophosphorylation of PERK in human A549 cells preincubated for 1 hr followed by thapsigargin-induction measured ...More data for this Ligand-Target Pair
TargetEukaryotic translation initiation factor 2-alpha kinase 3(Homo sapiens (Human))
GlaxoSmithKline Research and Development
Curated by ChEMBL
GlaxoSmithKline Research and Development
Curated by ChEMBL
Affinity DataIC50: 100nMAssay Description:Inhibition of thapsigargin-induced autophosphorylation of PERK in human A549 cells preincubated for 1 hr followed by thapsigargin-induction measured ...More data for this Ligand-Target Pair
TargetInterferon-induced, double-stranded RNA-activated protein kinase(Homo sapiens (Human))
GlaxoSmithKline Research and Development
Curated by ChEMBL
GlaxoSmithKline Research and Development
Curated by ChEMBL
Affinity DataIC50: 359nMAssay Description:Inhibition of PKR (unknown origin) assessed as EIF2AK2 phosphorylationMore data for this Ligand-Target Pair
TargetEukaryotic translation initiation factor 2-alpha kinase 1(Homo sapiens (Human))
GlaxoSmithKline Research and Development
Curated by ChEMBL
GlaxoSmithKline Research and Development
Curated by ChEMBL
Affinity DataIC50: 460nMAssay Description:Inhibition of HRI (unknown origin) assessed as EIF2AK1 phosphorylationMore data for this Ligand-Target Pair
TargeteIF-2-alpha kinase GCN2(Homo sapiens (Human))
GlaxoSmithKline Research and Development
Curated by ChEMBL
GlaxoSmithKline Research and Development
Curated by ChEMBL
Affinity DataIC50: 776nMAssay Description:Inhibition of GCN2 (unknown origin) assessed as EIF2AK4 phosphorylationMore data for this Ligand-Target Pair
TargetCytochrome P450 2C8(Homo sapiens (Human))
GlaxoSmithKline Research and Development
Curated by ChEMBL
GlaxoSmithKline Research and Development
Curated by ChEMBL
Affinity DataIC50: 890nMAssay Description:Inhibition of CYP2C8 in human liver microsomes using paclitaxel as substrate after 5 to 60 mins by LC-MS/MS analysisMore data for this Ligand-Target Pair
TargetInterferon-induced, double-stranded RNA-activated protein kinase(Homo sapiens (Human))
GlaxoSmithKline Research and Development
Curated by ChEMBL
GlaxoSmithKline Research and Development
Curated by ChEMBL
Affinity DataIC50: 905nMAssay Description:Inhibition of PKR (unknown origin) assessed as EIF2AK2 phosphorylationMore data for this Ligand-Target Pair
TargeteIF-2-alpha kinase GCN2(Homo sapiens (Human))
GlaxoSmithKline Research and Development
Curated by ChEMBL
GlaxoSmithKline Research and Development
Curated by ChEMBL
Affinity DataIC50: 3.39E+3nMAssay Description:Inhibition of GCN2 (unknown origin) assessed as EIF2AK4 phosphorylationMore data for this Ligand-Target Pair
TargetCytochrome P450 2C9(Homo sapiens (Human))
GlaxoSmithKline Research and Development
Curated by ChEMBL
GlaxoSmithKline Research and Development
Curated by ChEMBL
Affinity DataIC50: 4.50E+3nMAssay Description:Inhibition of CYP2C9 in human liver microsomes using diclofenac as substrate after 5 to 60 mins by LC-MS/MS analysisMore data for this Ligand-Target Pair
TargetCytochrome P450 2C8(Homo sapiens (Human))
GlaxoSmithKline Research and Development
Curated by ChEMBL
GlaxoSmithKline Research and Development
Curated by ChEMBL
Affinity DataIC50: 5.83E+3nMAssay Description:Inhibition of CYP2C8 in human liver microsomes using paclitaxel as substrate after 5 to 60 mins by LC-MS/MS analysisMore data for this Ligand-Target Pair
TargetCytochrome P450 2C19(Homo sapiens (Human))
GlaxoSmithKline Research and Development
Curated by ChEMBL
GlaxoSmithKline Research and Development
Curated by ChEMBL
Affinity DataIC50: 7.00E+3nMAssay Description:Inhibition of CYP2C19 in human liver microsomes using mephenytoin as substrate after 5 to 60 mins by LC-MS/MS analysisMore data for this Ligand-Target Pair
TargetCytochrome P450 2C9(Homo sapiens (Human))
GlaxoSmithKline Research and Development
Curated by ChEMBL
GlaxoSmithKline Research and Development
Curated by ChEMBL
Affinity DataIC50: 1.92E+4nMAssay Description:Inhibition of CYP2C9 in human liver microsomes using diclofenac as substrate after 5 to 60 mins by LC-MS/MS analysisMore data for this Ligand-Target Pair
TargetCytochrome P450 1A2(Homo sapiens (Human))
GlaxoSmithKline Research and Development
Curated by ChEMBL
GlaxoSmithKline Research and Development
Curated by ChEMBL
Affinity DataIC50: 2.10E+4nMAssay Description:Inhibition of CYP1A2 in human liver microsomes using phenacetin as substrate after 5 to 60 mins by LC-MS/MS analysisMore data for this Ligand-Target Pair
TargetCytochrome P450 2D6(Homo sapiens (Human))
GlaxoSmithKline Research and Development
Curated by ChEMBL
GlaxoSmithKline Research and Development
Curated by ChEMBL
Affinity DataIC50: 2.30E+4nMAssay Description:Inhibition of CYP2D6 in human liver microsomes using dextromethorphan as substrate after 5 to 60 mins by LC-MS/MS analysisMore data for this Ligand-Target Pair
TargetCytochrome P450 2D6(Homo sapiens (Human))
GlaxoSmithKline Research and Development
Curated by ChEMBL
GlaxoSmithKline Research and Development
Curated by ChEMBL
Affinity DataIC50: 2.37E+4nMAssay Description:Inhibition of CYP2D6 in human liver microsomes using bufuralol as substrate after 5 to 60 mins by LC-MS/MS analysisMore data for this Ligand-Target Pair
TargetCytochrome P450 2C9(Homo sapiens (Human))
GlaxoSmithKline Research and Development
Curated by ChEMBL
GlaxoSmithKline Research and Development
Curated by ChEMBL
Affinity DataIC50: 2.47E+4nMAssay Description:Inhibition of CYP2C9 in human liver microsomes using diclofenac as substrate after 5 to 60 mins by LC-MS/MS analysisMore data for this Ligand-Target Pair
TargetCytochrome P450 1A2(Homo sapiens (Human))
GlaxoSmithKline Research and Development
Curated by ChEMBL
GlaxoSmithKline Research and Development
Curated by ChEMBL
Affinity DataIC50: 2.50E+4nMAssay Description:Inhibition of CYP1A2 in human liver microsomes using phenacetin as substrate after 5 to 60 mins by LC-MS/MS analysisMore data for this Ligand-Target Pair
TargetCytochrome P450 1A2(Homo sapiens (Human))
GlaxoSmithKline Research and Development
Curated by ChEMBL
GlaxoSmithKline Research and Development
Curated by ChEMBL
Affinity DataIC50: 2.50E+4nMAssay Description:Inhibition of CYP1A2 in human liver microsomes using phenacetin as substrate after 5 to 60 mins by LC-MS/MS analysisMore data for this Ligand-Target Pair
TargetCytochrome P450 1A2(Homo sapiens (Human))
GlaxoSmithKline Research and Development
Curated by ChEMBL
GlaxoSmithKline Research and Development
Curated by ChEMBL
Affinity DataIC50: 2.50E+4nMAssay Description:Inhibition of CYP1A2 in human liver microsomes using phenacetin as substrate after 5 to 60 mins by LC-MS/MS analysisMore data for this Ligand-Target Pair
TargetCytochrome P450 2C9(Homo sapiens (Human))
GlaxoSmithKline Research and Development
Curated by ChEMBL
GlaxoSmithKline Research and Development
Curated by ChEMBL
Affinity DataIC50: 2.50E+4nMAssay Description:Inhibition of CYP2C9 in human liver microsomes using diclofenac as substrate after 5 to 60 mins by LC-MS/MS analysisMore data for this Ligand-Target Pair
TargetCytochrome P450 2C19(Homo sapiens (Human))
GlaxoSmithKline Research and Development
Curated by ChEMBL
GlaxoSmithKline Research and Development
Curated by ChEMBL
Affinity DataIC50: 2.50E+4nMAssay Description:Inhibition of CYP2C19 in human liver microsomes using mephenytoin as substrate after 5 to 60 mins by LC-MS/MS analysisMore data for this Ligand-Target Pair
TargetCytochrome P450 2C19(Homo sapiens (Human))
GlaxoSmithKline Research and Development
Curated by ChEMBL
GlaxoSmithKline Research and Development
Curated by ChEMBL
Affinity DataIC50: 2.50E+4nMAssay Description:Inhibition of CYP2C19 in human liver microsomes using mephenytoin as substrate after 5 to 60 mins by LC-MS/MS analysisMore data for this Ligand-Target Pair
TargetCytochrome P450 2C19(Homo sapiens (Human))
GlaxoSmithKline Research and Development
Curated by ChEMBL
GlaxoSmithKline Research and Development
Curated by ChEMBL
Affinity DataIC50: 2.50E+4nMAssay Description:Inhibition of CYP2C19 in human liver microsomes using mephenytoin as substrate after 5 to 60 mins by LC-MS/MS analysisMore data for this Ligand-Target Pair
TargetCytochrome P450 2D6(Homo sapiens (Human))
GlaxoSmithKline Research and Development
Curated by ChEMBL
GlaxoSmithKline Research and Development
Curated by ChEMBL
Affinity DataIC50: 2.50E+4nMAssay Description:Inhibition of CYP2D6 in human liver microsomes using bufuralol as substrate after 5 to 60 mins by LC-MS/MS analysisMore data for this Ligand-Target Pair
TargetCytochrome P450 2C8(Homo sapiens (Human))
GlaxoSmithKline Research and Development
Curated by ChEMBL
GlaxoSmithKline Research and Development
Curated by ChEMBL
Affinity DataIC50: 2.50E+4nMAssay Description:Inhibition of CYP2C8 in human liver microsomes using paclitaxel as substrate after 5 to 60 mins by LC-MS/MS analysisMore data for this Ligand-Target Pair
TargetCytochrome P450 2C8(Homo sapiens (Human))
GlaxoSmithKline Research and Development
Curated by ChEMBL
GlaxoSmithKline Research and Development
Curated by ChEMBL
Affinity DataIC50: 2.50E+4nMAssay Description:Inhibition of CYP2C8 in human liver microsomes using paclitaxel as substrate after 5 to 60 mins by LC-MS/MS analysisMore data for this Ligand-Target Pair
TargetCytochrome P450 2D6(Homo sapiens (Human))
GlaxoSmithKline Research and Development
Curated by ChEMBL
GlaxoSmithKline Research and Development
Curated by ChEMBL
Affinity DataIC50: 2.50E+4nMAssay Description:Inhibition of CYP2D6 in human liver microsomes using bufuralol as substrate after 5 to 60 mins by LC-MS/MS analysisMore data for this Ligand-Target Pair
