Compile Data Set for Download or QSAR
Found 50 Enz. Inhib. hit(s) with all data for entry = 50044171
TargetE3 ubiquitin-protein ligase Mdm2(Homo sapiens (Human))
Amgen Inc.

Curated by ChEMBL
LigandPNGBDBM50448963(CHEMBL3125537 | US9296736, 351 | US9593129, Exampl...)copy SMILEScopy InChI
Affinity DataIC50: 0.100nMAssay Description:Binding affinity to GST-thrombin-tagged human MDM2 (1 to 188) expressed in Escherichia coli assessed as inhibition of interaction with p53 in serum f...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2C24XZZPubMed
TargetE3 ubiquitin-protein ligase Mdm2(Homo sapiens (Human))
Amgen Inc.

Curated by ChEMBL
LigandPNGBDBM50007645(CHEMBL3233126)copy SMILEScopy InChI
Affinity DataIC50: 0.300nMAssay Description:Binding affinity to GST-thrombin-tagged human MDM2 (1 to 188) expressed in Escherichia coli assessed as inhibition of interaction with p53 in serum f...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2C24XZZPubMed
TargetE3 ubiquitin-protein ligase Mdm2(Homo sapiens (Human))
Amgen Inc.

Curated by ChEMBL
LigandPNGBDBM50007642(CHEMBL3233123)copy SMILEScopy InChI
Affinity DataIC50: 0.300nMAssay Description:Binding affinity to GST-thrombin-tagged human MDM2 (1 to 188) expressed in Escherichia coli assessed as inhibition of interaction with p53 in serum f...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2C24XZZPubMed
TargetE3 ubiquitin-protein ligase Mdm2(Homo sapiens (Human))
Amgen Inc.

Curated by ChEMBL
LigandPNGBDBM50007638(CHEMBL3233140)copy SMILEScopy InChI
Affinity DataIC50: 0.400nMAssay Description:Binding affinity to GST-thrombin-tagged human MDM2 (1 to 188) expressed in Escherichia coli assessed as inhibition of interaction with p53 in serum f...More data for this Ligand-Target Pair
TargetE3 ubiquitin-protein ligase Mdm2(Homo sapiens (Human))
Amgen Inc.

Curated by ChEMBL
LigandPNGBDBM50007655(CHEMBL3233137)copy SMILEScopy InChI
Affinity DataIC50: 0.400nMAssay Description:Binding affinity to GST-thrombin-tagged human MDM2 (1 to 188) expressed in Escherichia coli assessed as inhibition of interaction with p53 in serum f...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2C24XZZPubMed
TargetE3 ubiquitin-protein ligase Mdm2(Homo sapiens (Human))
Amgen Inc.

Curated by ChEMBL
LigandPNGBDBM50007646(CHEMBL3233127)copy SMILEScopy InChI
Affinity DataIC50: 0.400nMAssay Description:Binding affinity to GST-thrombin-tagged human MDM2 (1 to 188) expressed in Escherichia coli assessed as inhibition of interaction with p53 in serum f...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2C24XZZPubMed
TargetE3 ubiquitin-protein ligase Mdm2(Homo sapiens (Human))
Amgen Inc.

Curated by ChEMBL
LigandPNGBDBM50007657(CHEMBL3233139)copy SMILEScopy InChI
Affinity DataIC50: 0.5nMAssay Description:Binding affinity to GST-thrombin-tagged human MDM2 (1 to 188) expressed in Escherichia coli assessed as inhibition of interaction with p53 in serum f...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2C24XZZPubMed
TargetE3 ubiquitin-protein ligase Mdm2(Homo sapiens (Human))
Amgen Inc.

Curated by ChEMBL
LigandPNGBDBM50007658(CHEMBL3233141)copy SMILEScopy InChI
Affinity DataIC50: 0.5nMAssay Description:Binding affinity to GST-thrombin-tagged human MDM2 (1 to 188) expressed in Escherichia coli assessed as inhibition of interaction with p53 in buffer ...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2C24XZZPubMed
TargetE3 ubiquitin-protein ligase Mdm2(Homo sapiens (Human))
Amgen Inc.

Curated by ChEMBL
LigandPNGBDBM50007639(CHEMBL3233130)copy SMILEScopy InChI
Affinity DataIC50: 0.5nMAssay Description:Binding affinity to GST-thrombin-tagged human MDM2 (1 to 188) expressed in Escherichia coli assessed as inhibition of interaction with p53 in serum f...More data for this Ligand-Target Pair
TargetE3 ubiquitin-protein ligase Mdm2(Homo sapiens (Human))
Amgen Inc.

Curated by ChEMBL
LigandPNGBDBM50007644(CHEMBL3233125)copy SMILEScopy InChI
Affinity DataIC50: 0.5nMAssay Description:Binding affinity to GST-thrombin-tagged human MDM2 (1 to 188) expressed in Escherichia coli assessed as inhibition of interaction with p53 in serum f...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2C24XZZPubMed
TargetE3 ubiquitin-protein ligase Mdm2(Homo sapiens (Human))
Amgen Inc.

Curated by ChEMBL
LigandPNGBDBM50007643(CHEMBL3233124)copy SMILEScopy InChI
Affinity DataIC50: 0.600nMAssay Description:Binding affinity to GST-thrombin-tagged human MDM2 (1 to 188) expressed in Escherichia coli assessed as inhibition of interaction with p53 in serum f...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2C24XZZPubMed
TargetE3 ubiquitin-protein ligase Mdm2(Homo sapiens (Human))
Amgen Inc.

Curated by ChEMBL
LigandPNGBDBM50007641(CHEMBL3233122)copy SMILEScopy InChI
Affinity DataIC50: 0.800nMAssay Description:Binding affinity to GST-thrombin-tagged human MDM2 (1 to 188) expressed in Escherichia coli assessed as inhibition of interaction with p53 in serum f...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2C24XZZPubMed
TargetE3 ubiquitin-protein ligase Mdm2(Homo sapiens (Human))
Amgen Inc.

Curated by ChEMBL
LigandPNGBDBM50007652(CHEMBL3233134)copy SMILEScopy InChI
Affinity DataIC50: 0.900nMAssay Description:Binding affinity to GST-thrombin-tagged human MDM2 (1 to 188) expressed in Escherichia coli assessed as inhibition of interaction with p53 in serum f...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2C24XZZPubMed
TargetE3 ubiquitin-protein ligase Mdm2(Homo sapiens (Human))
Amgen Inc.

Curated by ChEMBL
LigandPNGBDBM50007651(CHEMBL3233133)copy SMILEScopy InChI
Affinity DataIC50: 0.900nMAssay Description:Binding affinity to GST-thrombin-tagged human MDM2 (1 to 188) expressed in Escherichia coli assessed as inhibition of interaction with p53 in serum f...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2C24XZZPubMed
TargetE3 ubiquitin-protein ligase Mdm2(Homo sapiens (Human))
Amgen Inc.

Curated by ChEMBL
LigandPNGBDBM50007649(CHEMBL3233131)copy SMILEScopy InChI
Affinity DataIC50: 1nMAssay Description:Binding affinity to GST-thrombin-tagged human MDM2 (1 to 188) expressed in Escherichia coli assessed as inhibition of interaction with p53 in serum f...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2C24XZZPubMed
TargetE3 ubiquitin-protein ligase Mdm2(Homo sapiens (Human))
Amgen Inc.

Curated by ChEMBL
LigandPNGBDBM50448963(CHEMBL3125537 | US9296736, 351 | US9593129, Exampl...)copy SMILEScopy InChI
Affinity DataIC50: 1.10nMAssay Description:Binding affinity to GST-thrombin-tagged human MDM2 (1 to 188) expressed in Escherichia coli assessed as inhibition of interaction with p53 in buffer ...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2C24XZZPubMed
TargetE3 ubiquitin-protein ligase Mdm2(Homo sapiens (Human))
Amgen Inc.

Curated by ChEMBL
LigandPNGBDBM50007654(CHEMBL3233136)copy SMILEScopy InChI
Affinity DataIC50: 1.10nMAssay Description:Binding affinity to GST-thrombin-tagged human MDM2 (1 to 188) expressed in Escherichia coli assessed as inhibition of interaction with p53 in serum f...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2C24XZZPubMed
TargetE3 ubiquitin-protein ligase Mdm2(Homo sapiens (Human))
Amgen Inc.

Curated by ChEMBL
LigandPNGBDBM50007640(CHEMBL3233121)copy SMILEScopy InChI
Affinity DataIC50: 1.10nMAssay Description:Binding affinity to GST-thrombin-tagged human MDM2 (1 to 188) expressed in Escherichia coli assessed as inhibition of interaction with p53 in serum f...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2C24XZZPubMed
TargetE3 ubiquitin-protein ligase Mdm2(Homo sapiens (Human))
Amgen Inc.

Curated by ChEMBL
LigandPNGBDBM50007648(CHEMBL3233129)copy SMILEScopy InChI
Affinity DataIC50: 1.30nMAssay Description:Binding affinity to GST-thrombin-tagged human MDM2 (1 to 188) expressed in Escherichia coli assessed as inhibition of interaction with p53 in serum f...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2C24XZZPubMed
TargetE3 ubiquitin-protein ligase Mdm2(Homo sapiens (Human))
Amgen Inc.

Curated by ChEMBL
LigandPNGBDBM50007638(CHEMBL3233140)copy SMILEScopy InChI
Affinity DataIC50: 1.80nMAssay Description:Binding affinity to GST-thrombin-tagged human MDM2 (1 to 188) expressed in Escherichia coli assessed as inhibition of interaction with p53 in buffer ...More data for this Ligand-Target Pair
TargetE3 ubiquitin-protein ligase Mdm2(Homo sapiens (Human))
Amgen Inc.

Curated by ChEMBL
LigandPNGBDBM50007639(CHEMBL3233130)copy SMILEScopy InChI
Affinity DataIC50: 2nMAssay Description:Binding affinity to GST-thrombin-tagged human MDM2 (1 to 188) expressed in Escherichia coli assessed as inhibition of interaction with p53 in buffer ...More data for this Ligand-Target Pair
TargetE3 ubiquitin-protein ligase Mdm2(Homo sapiens (Human))
Amgen Inc.

Curated by ChEMBL
LigandPNGBDBM50007656(CHEMBL3233138)copy SMILEScopy InChI
Affinity DataIC50: 2nMAssay Description:Binding affinity to GST-thrombin-tagged human MDM2 (1 to 188) expressed in Escherichia coli assessed as inhibition of interaction with p53 in serum f...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2C24XZZPubMed
TargetE3 ubiquitin-protein ligase Mdm2(Homo sapiens (Human))
Amgen Inc.

Curated by ChEMBL
LigandPNGBDBM50007644(CHEMBL3233125)copy SMILEScopy InChI
Affinity DataIC50: 2nMAssay Description:Binding affinity to GST-thrombin-tagged human MDM2 (1 to 188) expressed in Escherichia coli assessed as inhibition of interaction with p53 in buffer ...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2C24XZZPubMed
TargetE3 ubiquitin-protein ligase Mdm2(Homo sapiens (Human))
Amgen Inc.

Curated by ChEMBL
LigandPNGBDBM50007658(CHEMBL3233141)copy SMILEScopy InChI
Affinity DataIC50: 2nMAssay Description:Binding affinity to GST-thrombin-tagged human MDM2 (1 to 188) expressed in Escherichia coli assessed as inhibition of interaction with p53 in serum f...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2C24XZZPubMed
TargetE3 ubiquitin-protein ligase Mdm2(Homo sapiens (Human))
Amgen Inc.

Curated by ChEMBL
LigandPNGBDBM50007655(CHEMBL3233137)copy SMILEScopy InChI
Affinity DataIC50: 2.10nMAssay Description:Binding affinity to GST-thrombin-tagged human MDM2 (1 to 188) expressed in Escherichia coli assessed as inhibition of interaction with p53 in buffer ...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2C24XZZPubMed
TargetE3 ubiquitin-protein ligase Mdm2(Homo sapiens (Human))
Amgen Inc.

Curated by ChEMBL
LigandPNGBDBM50007642(CHEMBL3233123)copy SMILEScopy InChI
Affinity DataIC50: 2.30nMAssay Description:Binding affinity to GST-thrombin-tagged human MDM2 (1 to 188) expressed in Escherichia coli assessed as inhibition of interaction with p53 in buffer ...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2C24XZZPubMed
TargetE3 ubiquitin-protein ligase Mdm2(Homo sapiens (Human))
Amgen Inc.

Curated by ChEMBL
LigandPNGBDBM50007645(CHEMBL3233126)copy SMILEScopy InChI
Affinity DataIC50: 2.40nMAssay Description:Binding affinity to GST-thrombin-tagged human MDM2 (1 to 188) expressed in Escherichia coli assessed as inhibition of interaction with p53 in buffer ...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2C24XZZPubMed
TargetE3 ubiquitin-protein ligase Mdm2(Homo sapiens (Human))
Amgen Inc.

Curated by ChEMBL
LigandPNGBDBM50007656(CHEMBL3233138)copy SMILEScopy InChI
Affinity DataIC50: 2.5nMAssay Description:Binding affinity to GST-thrombin-tagged human MDM2 (1 to 188) expressed in Escherichia coli assessed as inhibition of interaction with p53 in buffer ...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2C24XZZPubMed
TargetE3 ubiquitin-protein ligase Mdm2(Homo sapiens (Human))
Amgen Inc.

Curated by ChEMBL
LigandPNGBDBM50007647(CHEMBL3233128)copy SMILEScopy InChI
Affinity DataIC50: 3nMAssay Description:Binding affinity to GST-thrombin-tagged human MDM2 (1 to 188) expressed in Escherichia coli assessed as inhibition of interaction with p53 in serum f...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2C24XZZPubMed
TargetE3 ubiquitin-protein ligase Mdm2(Homo sapiens (Human))
Amgen Inc.

Curated by ChEMBL
LigandPNGBDBM50007641(CHEMBL3233122)copy SMILEScopy InChI
Affinity DataIC50: 3.70nMAssay Description:Binding affinity to GST-thrombin-tagged human MDM2 (1 to 188) expressed in Escherichia coli assessed as inhibition of interaction with p53 in buffer ...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2C24XZZPubMed
TargetE3 ubiquitin-protein ligase Mdm2(Homo sapiens (Human))
Amgen Inc.

Curated by ChEMBL
LigandPNGBDBM50007646(CHEMBL3233127)copy SMILEScopy InChI
Affinity DataIC50: 4nMAssay Description:Binding affinity to GST-thrombin-tagged human MDM2 (1 to 188) expressed in Escherichia coli assessed as inhibition of interaction with p53 in buffer ...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2C24XZZPubMed
TargetE3 ubiquitin-protein ligase Mdm2(Homo sapiens (Human))
Amgen Inc.

Curated by ChEMBL
LigandPNGBDBM50007650(CHEMBL3233132)copy SMILEScopy InChI
Affinity DataIC50: 5nMAssay Description:Binding affinity to GST-thrombin-tagged human MDM2 (1 to 188) expressed in Escherichia coli assessed as inhibition of interaction with p53 in serum f...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2C24XZZPubMed
TargetE3 ubiquitin-protein ligase Mdm2(Homo sapiens (Human))
Amgen Inc.

Curated by ChEMBL
LigandPNGBDBM50007653(CHEMBL3233135)copy SMILEScopy InChI
Affinity DataIC50: 5nMAssay Description:Binding affinity to GST-thrombin-tagged human MDM2 (1 to 188) expressed in Escherichia coli assessed as inhibition of interaction with p53 in serum f...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2C24XZZPubMed
TargetE3 ubiquitin-protein ligase Mdm2(Homo sapiens (Human))
Amgen Inc.

Curated by ChEMBL
LigandPNGBDBM50007657(CHEMBL3233139)copy SMILEScopy InChI
Affinity DataIC50: 5.10nMAssay Description:Binding affinity to GST-thrombin-tagged human MDM2 (1 to 188) expressed in Escherichia coli assessed as inhibition of interaction with p53 in buffer ...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2C24XZZPubMed
TargetE3 ubiquitin-protein ligase Mdm2(Homo sapiens (Human))
Amgen Inc.

Curated by ChEMBL
LigandPNGBDBM50007643(CHEMBL3233124)copy SMILEScopy InChI
Affinity DataIC50: 6nMAssay Description:Binding affinity to GST-thrombin-tagged human MDM2 (1 to 188) expressed in Escherichia coli assessed as inhibition of interaction with p53 in buffer ...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2C24XZZPubMed
TargetE3 ubiquitin-protein ligase Mdm2(Homo sapiens (Human))
Amgen Inc.

Curated by ChEMBL
LigandPNGBDBM50007654(CHEMBL3233136)copy SMILEScopy InChI
Affinity DataIC50: 6.90nMAssay Description:Binding affinity to GST-thrombin-tagged human MDM2 (1 to 188) expressed in Escherichia coli assessed as inhibition of interaction with p53 in buffer ...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2C24XZZPubMed
TargetE3 ubiquitin-protein ligase Mdm2(Homo sapiens (Human))
Amgen Inc.

Curated by ChEMBL
LigandPNGBDBM50007648(CHEMBL3233129)copy SMILEScopy InChI
Affinity DataIC50: 10nMAssay Description:Binding affinity to GST-thrombin-tagged human MDM2 (1 to 188) expressed in Escherichia coli assessed as inhibition of interaction with p53 in buffer ...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2C24XZZPubMed
TargetE3 ubiquitin-protein ligase Mdm2(Homo sapiens (Human))
Amgen Inc.

Curated by ChEMBL
LigandPNGBDBM50007652(CHEMBL3233134)copy SMILEScopy InChI
Affinity DataIC50: 10nMAssay Description:Binding affinity to GST-thrombin-tagged human MDM2 (1 to 188) expressed in Escherichia coli assessed as inhibition of interaction with p53 in buffer ...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2C24XZZPubMed
TargetE3 ubiquitin-protein ligase Mdm2(Homo sapiens (Human))
Amgen Inc.

Curated by ChEMBL
LigandPNGBDBM50007640(CHEMBL3233121)copy SMILEScopy InChI
Affinity DataIC50: 11nMAssay Description:Binding affinity to GST-thrombin-tagged human MDM2 (1 to 188) expressed in Escherichia coli assessed as inhibition of interaction with p53 in buffer ...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2C24XZZPubMed
TargetE3 ubiquitin-protein ligase Mdm2(Homo sapiens (Human))
Amgen Inc.

Curated by ChEMBL
LigandPNGBDBM50007651(CHEMBL3233133)copy SMILEScopy InChI
Affinity DataIC50: 17nMAssay Description:Binding affinity to GST-thrombin-tagged human MDM2 (1 to 188) expressed in Escherichia coli assessed as inhibition of interaction with p53 in buffer ...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2C24XZZPubMed
TargetE3 ubiquitin-protein ligase Mdm2(Homo sapiens (Human))
Amgen Inc.

Curated by ChEMBL
LigandPNGBDBM50007649(CHEMBL3233131)copy SMILEScopy InChI
Affinity DataIC50: 18nMAssay Description:Binding affinity to GST-thrombin-tagged human MDM2 (1 to 188) expressed in Escherichia coli assessed as inhibition of interaction with p53 in buffer ...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2C24XZZPubMed
TargetE3 ubiquitin-protein ligase Mdm2(Homo sapiens (Human))
Amgen Inc.

Curated by ChEMBL
LigandPNGBDBM50448936(CHEMBL3125527 | US9296736, 342 | US9593129, Exampl...)copy SMILEScopy InChI
Affinity DataIC50: 18nMAssay Description:Binding affinity to MDM2 in human SJSA1 cells assessed as upregulation of p21 mRNA expression after 7 hrs by qRT-PCR analysis in absence of human ser...More data for this Ligand-Target Pair
TargetE3 ubiquitin-protein ligase Mdm2(Homo sapiens (Human))
Amgen Inc.

Curated by ChEMBL
LigandPNGBDBM50007650(CHEMBL3233132)copy SMILEScopy InChI
Affinity DataIC50: 20nMAssay Description:Binding affinity to GST-thrombin-tagged human MDM2 (1 to 188) expressed in Escherichia coli assessed as inhibition of interaction with p53 in buffer ...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2C24XZZPubMed
TargetE3 ubiquitin-protein ligase Mdm2(Homo sapiens (Human))
Amgen Inc.

Curated by ChEMBL
LigandPNGBDBM50007653(CHEMBL3233135)copy SMILEScopy InChI
Affinity DataIC50: 23nMAssay Description:Binding affinity to GST-thrombin-tagged human MDM2 (1 to 188) expressed in Escherichia coli assessed as inhibition of interaction with p53 in buffer ...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2C24XZZPubMed
TargetE3 ubiquitin-protein ligase Mdm2(Homo sapiens (Human))
Amgen Inc.

Curated by ChEMBL
LigandPNGBDBM50007647(CHEMBL3233128)copy SMILEScopy InChI
Affinity DataIC50: 26nMAssay Description:Binding affinity to GST-thrombin-tagged human MDM2 (1 to 188) expressed in Escherichia coli assessed as inhibition of interaction with p53 in buffer ...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2C24XZZPubMed
TargetE3 ubiquitin-protein ligase Mdm2(Homo sapiens (Human))
Amgen Inc.

Curated by ChEMBL
LigandPNGBDBM50007638(CHEMBL3233140)copy SMILEScopy InChI
Affinity DataIC50: 160nMAssay Description:Binding affinity to MDM2 in human HCT116 cells expressing p53 assessed as upregulation of p21 mRNA expression after 7 hrs by qRT-PCR analysis in pres...More data for this Ligand-Target Pair
TargetE3 ubiquitin-protein ligase Mdm2(Homo sapiens (Human))
Amgen Inc.

Curated by ChEMBL
LigandPNGBDBM50007639(CHEMBL3233130)copy SMILEScopy InChI
Affinity DataIC50: 240nMAssay Description:Binding affinity to MDM2 in human SJSA1 cells assessed as upregulation of p21 mRNA expression after 7 hrs by qRT-PCR analysis in absence of human ser...More data for this Ligand-Target Pair
TargetProtein Mdm4(Homo sapiens (Human))
Amgen Inc.

Curated by ChEMBL
LigandPNGBDBM50007638(CHEMBL3233140)copy SMILEScopy InChI
Affinity DataIC50: 1.00E+5nMAssay Description:Binding affinity to MDMX (unknown origin) assessed as inhibition of interaction with p53 in serum free buffer incubated for 20 mins prior to p53 addi...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2C24XZZPubMed
TargetE3 ubiquitin-protein ligase Mdm2(Homo sapiens (Human))
Amgen Inc.

Curated by ChEMBL
LigandPNGBDBM50007639(CHEMBL3233130)copy SMILEScopy InChI
Affinity DataKd:  0.392nMAssay Description:Binding affinity to GST-thrombin-tagged human MDM2 (1 to 188) expressed in Escherichia coli after 1 to 2 mins by surface plasmon resonance spectrosco...More data for this Ligand-Target Pair
TargetE3 ubiquitin-protein ligase Mdm2(Homo sapiens (Human))
Amgen Inc.

Curated by ChEMBL
LigandPNGBDBM50448936(CHEMBL3125527 | US9296736, 342 | US9593129, Exampl...)copy SMILEScopy InChI
Affinity DataKd:  0.0360nMAssay Description:Binding affinity to GST-thrombin-tagged human MDM2 (1 to 188) expressed in Escherichia coli after 1 to 2 mins by surface plasmon resonance spectrosco...More data for this Ligand-Target Pair