Compile Data Set for Download or QSAR
Found 14 Enz. Inhib. hit(s) with all data for entry = 50045873
TargetHistone deacetylase 8(Homo sapiens (Human))
Shandong University

Curated by ChEMBL
LigandPNGBDBM19149(CHEMBL98 | N-hydroxy-N'-phenyloctanediamide | SAHA...)copy SMILEScopy InChI
Affinity DataIC50: 5.5nMAssay Description:Inhibition of full length human recombinant HDAC8 expressed in baculovirus infected insect S9 cells using Ac-Leu-GlyLys(Tfa)-AMC as substrate after 3...More data for this Ligand-Target Pair
TargetHistone deacetylase 6(Homo sapiens (Human))
Shandong University

Curated by ChEMBL
LigandPNGBDBM50087853(CHEMBL3426906)copy SMILEScopy InChI
Affinity DataIC50: 7.40nMAssay Description:Inhibition of full length human recombinant HDAC6 expressed in baculovirus infected insect S9 cells using Ac-Leu-GlyLys(Tfa)-AMC as substrate after 3...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2057HP5PubMed
TargetHistone deacetylase 6(Homo sapiens (Human))
Shandong University

Curated by ChEMBL
LigandPNGBDBM19149(CHEMBL98 | N-hydroxy-N'-phenyloctanediamide | SAHA...)copy SMILEScopy InChI
Affinity DataIC50: 22nMAssay Description:Inhibition of full length human recombinant HDAC6 expressed in baculovirus infected insect S9 cells using Ac-Leu-GlyLys(Tfa)-AMC as substrate after 3...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2057HP5PubMedDrugBank
TargetHistone deacetylase 4(Homo sapiens (Human))
Shandong University

Curated by ChEMBL
LigandPNGBDBM50087853(CHEMBL3426906)copy SMILEScopy InChI
Affinity DataIC50: 30nMAssay Description:Inhibition of human recombinant HDAC4 expressed in baculovirus infected insect S9 cells using Ac-Leu-GlyLys(Tfa)-AMC as substrate after 30 mins by fl...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2057HP5PubMed
TargetHistone deacetylase 11(Homo sapiens (Human))
Shandong University

Curated by ChEMBL
LigandPNGBDBM19149(CHEMBL98 | N-hydroxy-N'-phenyloctanediamide | SAHA...)copy SMILEScopy InChI
Affinity DataIC50: 35nMAssay Description:Inhibition of full length human recombinant HDAC11 expressed in baculovirus infected insect S9 cells after 30 mins by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2057HP5PubMed
TargetHistone deacetylase 1(Homo sapiens (Human))
Shandong University

Curated by ChEMBL
LigandPNGBDBM19149(CHEMBL98 | N-hydroxy-N'-phenyloctanediamide | SAHA...)copy SMILEScopy InChI
Affinity DataIC50: 38nMAssay Description:Inhibition of full length human recombinant HDAC1 expressed in baculovirus using Ac-Leu-GlyLys(Ac)-AMC as substrate after 30 mins by fluorescence ass...More data for this Ligand-Target Pair
TargetHistone deacetylase 3(Homo sapiens (Human))
Shandong University

Curated by ChEMBL
LigandPNGBDBM19149(CHEMBL98 | N-hydroxy-N'-phenyloctanediamide | SAHA...)copy SMILEScopy InChI
Affinity DataIC50: 59nMAssay Description:Inhibition of full length human recombinant HDAC3 expressed in baculovirus infected insect S9 cells using Ac-Leu-GlyLys(Ac)-AMC as substrate after 30...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2057HP5PubMedDrugBank
TargetHistone deacetylase 4(Homo sapiens (Human))
Shandong University

Curated by ChEMBL
LigandPNGBDBM19149(CHEMBL98 | N-hydroxy-N'-phenyloctanediamide | SAHA...)copy SMILEScopy InChI
Affinity DataIC50: 100nMAssay Description:Inhibition of human recombinant HDAC4 expressed in baculovirus infected insect S9 cells using Ac-Leu-GlyLys(Tfa)-AMC as substrate after 30 mins by fl...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2057HP5PubMed
TargetHistone deacetylase 2(Homo sapiens (Human))
Shandong University

Curated by ChEMBL
LigandPNGBDBM19149(CHEMBL98 | N-hydroxy-N'-phenyloctanediamide | SAHA...)copy SMILEScopy InChI
Affinity DataIC50: 121nMAssay Description:Inhibition of full length human recombinant HDAC2 expressed in baculovirus infected insect S9 cells using Ac-Leu-GlyLys(Ac)-AMC as substrate after 30...More data for this Ligand-Target Pair
TargetHistone deacetylase 1(Homo sapiens (Human))
Shandong University

Curated by ChEMBL
LigandPNGBDBM50087853(CHEMBL3426906)copy SMILEScopy InChI
Affinity DataIC50: 241nMAssay Description:Inhibition of full length human recombinant HDAC1 expressed in baculovirus using Ac-Leu-GlyLys(Ac)-AMC as substrate after 30 mins by fluorescence ass...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2057HP5PubMed
TargetHistone deacetylase 8(Homo sapiens (Human))
Shandong University

Curated by ChEMBL
LigandPNGBDBM50087853(CHEMBL3426906)copy SMILEScopy InChI
Affinity DataIC50: 343nMAssay Description:Inhibition of full length human recombinant HDAC8 expressed in baculovirus infected insect S9 cells using Ac-Leu-GlyLys(Tfa)-AMC as substrate after 3...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2057HP5PubMed
TargetHistone deacetylase 2(Homo sapiens (Human))
Shandong University

Curated by ChEMBL
LigandPNGBDBM50087853(CHEMBL3426906)copy SMILEScopy InChI
Affinity DataIC50: 381nMAssay Description:Inhibition of full length human recombinant HDAC2 expressed in baculovirus infected insect S9 cells using Ac-Leu-GlyLys(Ac)-AMC as substrate after 30...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2057HP5PubMed
TargetHistone deacetylase 3(Homo sapiens (Human))
Shandong University

Curated by ChEMBL
LigandPNGBDBM50087853(CHEMBL3426906)copy SMILEScopy InChI
Affinity DataIC50: 532nMAssay Description:Inhibition of full length human recombinant HDAC3 expressed in baculovirus infected insect S9 cells using Ac-Leu-GlyLys(Ac)-AMC as substrate after 30...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2057HP5PubMed
TargetHistone deacetylase 11(Homo sapiens (Human))
Shandong University

Curated by ChEMBL
LigandPNGBDBM50087853(CHEMBL3426906)copy SMILEScopy InChI
Affinity DataIC50: 608nMAssay Description:Inhibition of full length human recombinant HDAC11 expressed in baculovirus infected insect S9 cells after 30 mins by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2057HP5PubMed