Compile Data Set for Download or QSAR
Found 36 Enz. Inhib. hit(s) with all data for entry = 50046726
TargetMitogen-activated protein kinase kinase kinase 12(Homo sapiens (Human))
WuXi AppTec Co., Ltd.

Curated by ChEMBL
LigandPNGBDBM50128338(CHEMBL3629019)copy SMILEScopy InChI
Affinity DataKi:  25nMAssay Description:Inhibition of N-terminally GST- tagged human DLK catalytic domain (1 to 520 amino acids) using N-terminally HIS-tagged MKK4 K131M as substrate incuba...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q27D2WZ0PubMed
TargetMitogen-activated protein kinase kinase kinase 12(Homo sapiens (Human))
WuXi AppTec Co., Ltd.

Curated by ChEMBL
LigandPNGBDBM50128294(CHEMBL3629013)copy SMILEScopy InChI
Affinity DataKi:  42nMAssay Description:Inhibition of N-terminally GST- tagged human DLK catalytic domain (1 to 520 amino acids) using N-terminally HIS-tagged MKK4 K131M as substrate incuba...More data for this Ligand-Target Pair
TargetMitogen-activated protein kinase kinase kinase 12(Homo sapiens (Human))
WuXi AppTec Co., Ltd.

Curated by ChEMBL
LigandPNGBDBM50128333(CHEMBL3629014)copy SMILEScopy InChI
Affinity DataKi:  48nMAssay Description:Inhibition of N-terminally GST- tagged human DLK catalytic domain (1 to 520 amino acids) using N-terminally HIS-tagged MKK4 K131M as substrate incuba...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q27D2WZ0PubMed
TargetMitogen-activated protein kinase kinase kinase 12(Homo sapiens (Human))
WuXi AppTec Co., Ltd.

Curated by ChEMBL
LigandPNGBDBM50128337(CHEMBL3629018)copy SMILEScopy InChI
Affinity DataKi:  48nMAssay Description:Inhibition of N-terminally GST- tagged human DLK catalytic domain (1 to 520 amino acids) using N-terminally HIS-tagged MKK4 K131M as substrate incuba...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q27D2WZ0PubMed
TargetMitogen-activated protein kinase kinase kinase 12(Homo sapiens (Human))
WuXi AppTec Co., Ltd.

Curated by ChEMBL
LigandPNGBDBM50128339(CHEMBL3629172)copy SMILEScopy InChI
Affinity DataKi:  54nMAssay Description:Inhibition of N-terminally GST- tagged human DLK catalytic domain (1 to 520 amino acids) using N-terminally HIS-tagged MKK4 K131M as substrate incuba...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q27D2WZ0PubMed
TargetMitogen-activated protein kinase kinase kinase 12(Homo sapiens (Human))
WuXi AppTec Co., Ltd.

Curated by ChEMBL
LigandPNGBDBM50128336(CHEMBL3629017)copy SMILEScopy InChI
Affinity DataKi:  133nMAssay Description:Inhibition of N-terminally GST- tagged human DLK catalytic domain (1 to 520 amino acids) using N-terminally HIS-tagged MKK4 K131M as substrate incuba...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q27D2WZ0PubMed
TargetMitogen-activated protein kinase kinase kinase 12(Homo sapiens (Human))
WuXi AppTec Co., Ltd.

Curated by ChEMBL
LigandPNGBDBM50128329(CHEMBL3629009)copy SMILEScopy InChI
Affinity DataKi:  145nMAssay Description:Inhibition of N-terminally GST- tagged human DLK catalytic domain (1 to 520 amino acids) using N-terminally HIS-tagged MKK4 K131M as substrate incuba...More data for this Ligand-Target Pair
TargetMitogen-activated protein kinase kinase kinase 12(Homo sapiens (Human))
WuXi AppTec Co., Ltd.

Curated by ChEMBL
LigandPNGBDBM50128330(CHEMBL3629010)copy SMILEScopy InChI
Affinity DataKi:  160nMAssay Description:Inhibition of N-terminally GST- tagged human DLK catalytic domain (1 to 520 amino acids) using N-terminally HIS-tagged MKK4 K131M as substrate incuba...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q27D2WZ0PubMed
TargetMitogen-activated protein kinase kinase kinase 12(Homo sapiens (Human))
WuXi AppTec Co., Ltd.

Curated by ChEMBL
LigandPNGBDBM50128334(CHEMBL3629015)copy SMILEScopy InChI
Affinity DataKi:  378nMAssay Description:Inhibition of N-terminally GST- tagged human DLK catalytic domain (1 to 520 amino acids) using N-terminally HIS-tagged MKK4 K131M as substrate incuba...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q27D2WZ0PubMed
TargetMitogen-activated protein kinase kinase kinase 12(Homo sapiens (Human))
WuXi AppTec Co., Ltd.

Curated by ChEMBL
LigandPNGBDBM50128340(CHEMBL3629173)copy SMILEScopy InChI
Affinity DataKi:  569nMAssay Description:Inhibition of N-terminally GST- tagged human DLK catalytic domain (1 to 520 amino acids) using N-terminally HIS-tagged MKK4 K131M as substrate incuba...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q27D2WZ0PubMed
TargetMitogen-activated protein kinase kinase kinase 12(Homo sapiens (Human))
WuXi AppTec Co., Ltd.

Curated by ChEMBL
LigandPNGBDBM50128335(CHEMBL3629016)copy SMILEScopy InChI
Affinity DataKi:  593nMAssay Description:Inhibition of N-terminally GST- tagged human DLK catalytic domain (1 to 520 amino acids) using N-terminally HIS-tagged MKK4 K131M as substrate incuba...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q27D2WZ0PubMed
TargetMitogen-activated protein kinase kinase kinase 12(Homo sapiens (Human))
WuXi AppTec Co., Ltd.

Curated by ChEMBL
LigandPNGBDBM50128341(CHEMBL3629174)copy SMILEScopy InChI
Affinity DataKi: >1.60E+3nMAssay Description:Inhibition of N-terminally GST- tagged human DLK catalytic domain (1 to 520 amino acids) using N-terminally HIS-tagged MKK4 K131M as substrate incuba...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q27D2WZ0PubMed
TargetMitogen-activated protein kinase kinase kinase 12(Homo sapiens (Human))
WuXi AppTec Co., Ltd.

Curated by ChEMBL
LigandPNGBDBM50128332(CHEMBL3629012)copy SMILEScopy InChI
Affinity DataKi: >1.60E+3nMAssay Description:Inhibition of N-terminally GST- tagged human DLK catalytic domain (1 to 520 amino acids) using N-terminally HIS-tagged MKK4 K131M as substrate incuba...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q27D2WZ0PubMed
TargetMitogen-activated protein kinase kinase kinase 12(Homo sapiens (Human))
WuXi AppTec Co., Ltd.

Curated by ChEMBL
LigandPNGBDBM50128331(CHEMBL3629011)copy SMILEScopy InChI
Affinity DataKi: >1.60E+3nMAssay Description:Inhibition of N-terminally GST- tagged human DLK catalytic domain (1 to 520 amino acids) using N-terminally HIS-tagged MKK4 K131M as substrate incuba...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q27D2WZ0PubMed
TargetMitogen-activated protein kinase kinase kinase 12(Homo sapiens (Human))
WuXi AppTec Co., Ltd.

Curated by ChEMBL
LigandPNGBDBM50128337(CHEMBL3629018)copy SMILEScopy InChI
Affinity DataIC50: 459nMAssay Description:Inhibition of Dox inducible human DLK transfected in HEK293 cells assessed as reduction in JNK phosphorylation incubated for 5.5 hrs measured by Hoec...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q27D2WZ0PubMed
TargetMitogen-activated protein kinase kinase kinase 12(Homo sapiens (Human))
WuXi AppTec Co., Ltd.

Curated by ChEMBL
LigandPNGBDBM50128294(CHEMBL3629013)copy SMILEScopy InChI
Affinity DataIC50: 536nMAssay Description:Inhibition of Dox inducible human DLK transfected in HEK293 cells assessed as reduction in JNK phosphorylation incubated for 5.5 hrs measured by Hoec...More data for this Ligand-Target Pair
TargetMitogen-activated protein kinase kinase kinase 12(Homo sapiens (Human))
WuXi AppTec Co., Ltd.

Curated by ChEMBL
LigandPNGBDBM50128338(CHEMBL3629019)copy SMILEScopy InChI
Affinity DataIC50: 632nMAssay Description:Inhibition of Dox inducible human DLK transfected in HEK293 cells assessed as reduction in JNK phosphorylation incubated for 5.5 hrs measured by Hoec...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q27D2WZ0PubMed
TargetMitogen-activated protein kinase kinase kinase 12(Homo sapiens (Human))
WuXi AppTec Co., Ltd.

Curated by ChEMBL
LigandPNGBDBM50128339(CHEMBL3629172)copy SMILEScopy InChI
Affinity DataIC50: 698nMAssay Description:Inhibition of Dox inducible human DLK transfected in HEK293 cells assessed as reduction in JNK phosphorylation incubated for 5.5 hrs measured by Hoec...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q27D2WZ0PubMed
TargetMitogen-activated protein kinase kinase kinase 12(Homo sapiens (Human))
WuXi AppTec Co., Ltd.

Curated by ChEMBL
LigandPNGBDBM50128333(CHEMBL3629014)copy SMILEScopy InChI
Affinity DataIC50: 721nMAssay Description:Inhibition of Dox inducible human DLK transfected in HEK293 cells assessed as reduction in JNK phosphorylation incubated for 5.5 hrs measured by Hoec...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q27D2WZ0PubMed
TargetMitogen-activated protein kinase 8(Homo sapiens (Human))
WuXi AppTec Co., Ltd.

Curated by ChEMBL
LigandPNGBDBM50128294(CHEMBL3629013)copy SMILEScopy InChI
Affinity DataIC50: 1.04E+3nMAssay Description:Inhibition of JNK1 (unknown origin) by FRET methodMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q27D2WZ0PubMed
TargetMitogen-activated protein kinase kinase kinase 12(Homo sapiens (Human))
WuXi AppTec Co., Ltd.

Curated by ChEMBL
LigandPNGBDBM50128336(CHEMBL3629017)copy SMILEScopy InChI
Affinity DataIC50: 1.40E+3nMAssay Description:Inhibition of Dox inducible human DLK transfected in HEK293 cells assessed as reduction in JNK phosphorylation incubated for 5.5 hrs measured by Hoec...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q27D2WZ0PubMed
TargetMitogen-activated protein kinase 10(Homo sapiens (Human))
WuXi AppTec Co., Ltd.

Curated by ChEMBL
LigandPNGBDBM50128294(CHEMBL3629013)copy SMILEScopy InChI
Affinity DataIC50: 2.10E+3nMAssay Description:Inhibition of JNK3 (unknown origin) by FRET methodMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q27D2WZ0PubMed
TargetDual specificity mitogen-activated protein kinase kinase 7(Homo sapiens (Human))
WuXi AppTec Co., Ltd.

Curated by ChEMBL
LigandPNGBDBM50128294(CHEMBL3629013)copy SMILEScopy InChI
Affinity DataIC50: 5.00E+3nMAssay Description:Inhibition of MKK7 (unknown origin) using KFMMTPpYVVTR substrate incubated for 1 hr measured by MpTPpYV probe-based fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q27D2WZ0PubMed
TargetDual specificity mitogen-activated protein kinase kinase 4(Homo sapiens (Human))
WuXi AppTec Co., Ltd.

Curated by ChEMBL
LigandPNGBDBM50128294(CHEMBL3629013)copy SMILEScopy InChI
Affinity DataIC50: 5.00E+3nMAssay Description:Inhibition of MKK4 (unknown origin) using KFMMTPpYVVTR substrate incubated for 1 hr measured by MpTPpYV probe-based fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q27D2WZ0PubMed
TargetMitogen-activated protein kinase 9(Homo sapiens (Human))
WuXi AppTec Co., Ltd.

Curated by ChEMBL
LigandPNGBDBM50128294(CHEMBL3629013)copy SMILEScopy InChI
Affinity DataIC50: 5.00E+3nMAssay Description:Inhibition of JNK2 (unknown origin) by FRET methodMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q27D2WZ0PubMed
TargetMitogen-activated protein kinase kinase kinase 12(Homo sapiens (Human))
WuXi AppTec Co., Ltd.

Curated by ChEMBL
LigandPNGBDBM50128340(CHEMBL3629173)copy SMILEScopy InChI
Affinity DataIC50: 8.60E+3nMAssay Description:Inhibition of Dox inducible human DLK transfected in HEK293 cells assessed as reduction in JNK phosphorylation incubated for 5.5 hrs measured by Hoec...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q27D2WZ0PubMed
TargetMitogen-activated protein kinase kinase kinase 11(Homo sapiens (Human))
WuXi AppTec Co., Ltd.

Curated by ChEMBL
LigandPNGBDBM50128294(CHEMBL3629013)copy SMILEScopy InChI
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of MLK3 (unknown origin) by FRET methodMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q27D2WZ0PubMed
TargetMitogen-activated protein kinase kinase kinase 10(Homo sapiens (Human))
WuXi AppTec Co., Ltd.

Curated by ChEMBL
LigandPNGBDBM50128294(CHEMBL3629013)copy SMILEScopy InChI
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of MLK2 (unknown origin) by FRET methodMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q27D2WZ0PubMed
TargetMitogen-activated protein kinase kinase kinase 9(Homo sapiens (Human))
WuXi AppTec Co., Ltd.

Curated by ChEMBL
LigandPNGBDBM50128294(CHEMBL3629013)copy SMILEScopy InChI
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of MLK1 (unknown origin) by FRET methodMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q27D2WZ0PubMed
TargetMacrophage colony-stimulating factor 1 receptor(Homo sapiens (Human))
WuXi AppTec Co., Ltd.

Curated by ChEMBL
LigandPNGBDBM50128294(CHEMBL3629013)copy SMILEScopy InChI
Affinity DataIC50: 5.70E+4nMAssay Description:Inhibition of CSF1R (unknown origin) by FRET methodMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q27D2WZ0PubMed
TargetReceptor-type tyrosine-protein kinase FLT3(Homo sapiens (Human))
WuXi AppTec Co., Ltd.

Curated by ChEMBL
LigandPNGBDBM50128294(CHEMBL3629013)copy SMILEScopy InChI
Affinity DataIC50: 3.22E+5nMAssay Description:Inhibition of Flt3 (unknown origin) by FRET methodMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q27D2WZ0PubMed
TargetHigh affinity nerve growth factor receptor(Homo sapiens (Human))
WuXi AppTec Co., Ltd.

Curated by ChEMBL
LigandPNGBDBM50128294(CHEMBL3629013)copy SMILEScopy InChI
Affinity DataIC50: 4.64E+5nMAssay Description:Inhibition of TrkA (unknown origin) by FRET methodMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q27D2WZ0PubMed
TargetMast/stem cell growth factor receptor Kit(Homo sapiens (Human))
WuXi AppTec Co., Ltd.

Curated by ChEMBL
LigandPNGBDBM50128294(CHEMBL3629013)copy SMILEScopy InChI
Affinity DataIC50: 5.34E+5nMAssay Description:Inhibition of Kit (unknown origin) by FRET methodMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q27D2WZ0PubMed
TargetGlycogen synthase kinase-3 beta(Homo sapiens (Human))
WuXi AppTec Co., Ltd.

Curated by ChEMBL
LigandPNGBDBM50128294(CHEMBL3629013)copy SMILEScopy InChI
Affinity DataIC50: 6.82E+5nMAssay Description:Inhibition of GSK3beta (unknown origin) by FRET methodMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q27D2WZ0PubMed
TargetProto-oncogene tyrosine-protein kinase Src(Homo sapiens (Human))
WuXi AppTec Co., Ltd.

Curated by ChEMBL
LigandPNGBDBM50128294(CHEMBL3629013)copy SMILEScopy InChI
Affinity DataIC50: 1.01E+6nMAssay Description:Inhibition of Src (unknown origin) by FRET methodMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q27D2WZ0PubMed
TargetBDNF/NT-3 growth factors receptor(Homo sapiens (Human))
WuXi AppTec Co., Ltd.

Curated by ChEMBL
LigandPNGBDBM50128294(CHEMBL3629013)copy SMILEScopy InChI
Affinity DataIC50: 1.19E+6nMAssay Description:Inhibition of TrkB (unknown origin) by FRET methodMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q27D2WZ0PubMed