Compile Data Set for Download or QSAR
Found 31 Enz. Inhib. hit(s) with all data for entry = 50048497
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D(Homo sapiens (Human))
Zambon Group

Curated by ChEMBL
LigandPNGBDBM14775(3-(cyclopentyloxy)-N-(3,5-dichloropyridin-4-yl)-4-...)copy SMILEScopy InChI
Affinity DataKi:  1.5nMAssay Description:Inhibition of human VCAM and Ramos cell VLA-4 interactionMore data for this Ligand-Target Pair
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D(Homo sapiens (Human))
Zambon Group

Curated by ChEMBL
LigandPNGBDBM14361((R,S)-Rolipram | 4-(3-cyclopentyloxy-4-methoxy-phe...)copy SMILEScopy InChI
Affinity DataKi:  1.60nMAssay Description:Inhibition of human VCAM and Ramos cell VLA-4 interactionMore data for this Ligand-Target Pair
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D(Homo sapiens (Human))
Zambon Group

Curated by ChEMBL
LigandPNGBDBM50218578(CHEMBL79902)copy SMILEScopy InChI
Affinity DataKi:  17nMAssay Description:Affinity for alpha4-beta1 integrin from HL60 cell lysateMore data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2MS3VZ5PubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D(Homo sapiens (Human))
Zambon Group

Curated by ChEMBL
LigandPNGBDBM50218586(CHEMBL79471)copy SMILEScopy InChI
Affinity DataKi:  34nMAssay Description:Inhibition of rolipram binding to PDE4More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2MS3VZ5PubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D(Homo sapiens (Human))
Zambon Group

Curated by ChEMBL
LigandPNGBDBM50346088((1r,4r)-4-cyano-4-(3-(cyclopentyloxy)-4-methoxyphe...)copy SMILEScopy InChI
Affinity DataKi:  38nMAssay Description:Inhibition of rolipram binding to PDE4More data for this Ligand-Target Pair
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D(Homo sapiens (Human))
Zambon Group

Curated by ChEMBL
LigandPNGBDBM50218589(CHEMBL79535)copy SMILEScopy InChI
Affinity DataKi:  89nMAssay Description:Inhibition of alpha4-beta1 VCAM binding in Jurkat cell adhesion assayMore data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2MS3VZ5PubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D(Homo sapiens (Human))
Zambon Group

Curated by ChEMBL
LigandPNGBDBM50218260(CHEMBL70391)copy SMILEScopy InChI
Affinity DataKi:  149nMAssay Description:Inhibition of rolipram binding to PDE4More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2MS3VZ5PubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D(Homo sapiens (Human))
Zambon Group

Curated by ChEMBL
LigandPNGBDBM50218588(CHEMBL312375)copy SMILEScopy InChI
Affinity DataKi:  204nMAssay Description:Inhibition of rolipram binding to PDE4More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2MS3VZ5PubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D(Homo sapiens (Human))
Zambon Group

Curated by ChEMBL
LigandPNGBDBM50218580(CHEMBL310387)copy SMILEScopy InChI
Affinity DataKi:  271nMAssay Description:Inhibition of rolipram binding to PDE4More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2MS3VZ5PubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D(Homo sapiens (Human))
Zambon Group

Curated by ChEMBL
LigandPNGBDBM50218583(CHEMBL81364)copy SMILEScopy InChI
Affinity DataKi:  383nMAssay Description:Inhibition of rolipram binding to PDE4More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2MS3VZ5PubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D(Homo sapiens (Human))
Zambon Group

Curated by ChEMBL
LigandPNGBDBM50218587(CHEMBL312322)copy SMILEScopy InChI
Affinity DataKi:  436nMAssay Description:Inhibition of rolipram binding to PDE4More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2MS3VZ5PubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D(Homo sapiens (Human))
Zambon Group

Curated by ChEMBL
LigandPNGBDBM50218585(CHEMBL3085289)copy SMILEScopy InChI
Affinity DataKi:  452nMAssay Description:Inhibition of rolipram binding to PDE4More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2MS3VZ5PubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D(Homo sapiens (Human))
Zambon Group

Curated by ChEMBL
LigandPNGBDBM50218578(CHEMBL79902)copy SMILEScopy InChI
Affinity DataIC50: 4nMAssay Description:Inhibition of human Phosphodiesterase 4More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2MS3VZ5PubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D(Homo sapiens (Human))
Zambon Group

Curated by ChEMBL
LigandPNGBDBM50218582(CHEMBL123993)copy SMILEScopy InChI
Affinity DataIC50: 4nMAssay Description:Inhibition of human VCAM binding to VLA-4 of Ramos cells in ELISAMore data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2MS3VZ5PubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D(Homo sapiens (Human))
Zambon Group

Curated by ChEMBL
LigandPNGBDBM50218590(CHEMBL333428)copy SMILEScopy InChI
Affinity DataIC50: 6nMAssay Description:Percent inhibition of human neutrophil phosphodiesterase 4 at 10e-7 MMore data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2MS3VZ5PubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D(Homo sapiens (Human))
Zambon Group

Curated by ChEMBL
LigandPNGBDBM50218586(CHEMBL79471)copy SMILEScopy InChI
Affinity DataIC50: 14nMAssay Description:Inhibition of human VCAM binding to VLA-4 of Ramos cells in ELISAMore data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2MS3VZ5PubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D(Homo sapiens (Human))
Zambon Group

Curated by ChEMBL
LigandPNGBDBM50218584(CHEMBL332844)copy SMILEScopy InChI
Affinity DataIC50: 16nMAssay Description:Percent inhibition of human Phosphodiesterase 4 at 10e-7 MMore data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2MS3VZ5PubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D(Homo sapiens (Human))
Zambon Group

Curated by ChEMBL
LigandPNGBDBM50218591(CHEMBL123550)copy SMILEScopy InChI
Affinity DataIC50: 19nMAssay Description:Percent inhibition of human Phosphodiesterase 4 at 10e-7 MMore data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2MS3VZ5PubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D(Homo sapiens (Human))
Zambon Group

Curated by ChEMBL
LigandPNGBDBM50218579(CHEMBL123330)copy SMILEScopy InChI
Affinity DataIC50: 19nMAssay Description:Percent inhibition of human Phosphodiesterase 4 at 10e-7 MMore data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2MS3VZ5PubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D(Homo sapiens (Human))
Zambon Group

Curated by ChEMBL
LigandPNGBDBM50218576(CHEMBL123403)copy SMILEScopy InChI
Affinity DataIC50: 23nMAssay Description:Percent inhibition of human Phosphodiesterase 4 at 10e-7 MMore data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2MS3VZ5PubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D(Homo sapiens (Human))
Zambon Group

Curated by ChEMBL
LigandPNGBDBM50218580(CHEMBL310387)copy SMILEScopy InChI
Affinity DataIC50: 37nMAssay Description:Inhibition of human Phosphodiesterase 4More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2MS3VZ5PubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D(Homo sapiens (Human))
Zambon Group

Curated by ChEMBL
LigandPNGBDBM50218589(CHEMBL79535)copy SMILEScopy InChI
Affinity DataIC50: 38nMAssay Description:Inhibition of human Phosphodiesterase 4More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2MS3VZ5PubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D(Homo sapiens (Human))
Zambon Group

Curated by ChEMBL
LigandPNGBDBM50218581(CHEMBL332514)copy SMILEScopy InChI
Affinity DataIC50: 39nMAssay Description:Percent inhibition of human Phosphodiesterase 4 at 10e-7 MMore data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2MS3VZ5PubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D(Homo sapiens (Human))
Zambon Group

Curated by ChEMBL
LigandPNGBDBM50218577(CHEMBL80107)copy SMILEScopy InChI
Affinity DataIC50: 48nMAssay Description:Inhibition of human Phosphodiesterase 4More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2MS3VZ5PubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D(Homo sapiens (Human))
Zambon Group

Curated by ChEMBL
LigandPNGBDBM50218260(CHEMBL70391)copy SMILEScopy InChI
Affinity DataIC50: 53nMAssay Description:Inhibition of human Phosphodiesterase 4More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2MS3VZ5PubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D(Homo sapiens (Human))
Zambon Group

Curated by ChEMBL
LigandPNGBDBM50346088((1r,4r)-4-cyano-4-(3-(cyclopentyloxy)-4-methoxyphe...)copy SMILEScopy InChI
Affinity DataIC50: 73nMAssay Description:Affinity for alpha4-beta1 integrin from HL60 cell lysateMore data for this Ligand-Target Pair
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D(Homo sapiens (Human))
Zambon Group

Curated by ChEMBL
LigandPNGBDBM50218588(CHEMBL312375)copy SMILEScopy InChI
Affinity DataIC50: 93nMAssay Description:Inhibition of human Phosphodiesterase 4More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2MS3VZ5PubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D(Homo sapiens (Human))
Zambon Group

Curated by ChEMBL
LigandPNGBDBM50218587(CHEMBL312322)copy SMILEScopy InChI
Affinity DataIC50: 132nMAssay Description:Inhibition of alphaM-beta2 mediated cell adhesionMore data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2MS3VZ5PubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D(Homo sapiens (Human))
Zambon Group

Curated by ChEMBL
LigandPNGBDBM50218583(CHEMBL81364)copy SMILEScopy InChI
Affinity DataIC50: 241nMAssay Description:Inhibition of human VCAM binding to VLA-4 of Ramos cells in ELISAMore data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2MS3VZ5PubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D(Homo sapiens (Human))
Zambon Group

Curated by ChEMBL
LigandPNGBDBM14361((R,S)-Rolipram | 4-(3-cyclopentyloxy-4-methoxy-phe...)copy SMILEScopy InChI
Affinity DataIC50: 1.68E+3nMAssay Description:Inhibition of human Phosphodiesterase 4More data for this Ligand-Target Pair
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D(Homo sapiens (Human))
Zambon Group

Curated by ChEMBL
LigandPNGBDBM50218585(CHEMBL3085289)copy SMILEScopy InChI
Affinity DataIC50: 1.52E+4nMAssay Description:Inhibition of human VCAM binding to VLA-4 of Ramos cells in ELISAMore data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2MS3VZ5PubMed