Compile Data Set for Download or QSAR
Found 37 Enz. Inhib. hit(s) with all data for entry = 50048974
TargetTranslocator protein(Rattus norvegicus (rat))
University of KwaZulu-Natal

Curated by ChEMBL
LigandPNGBDBM50232182(CHEMBL4097327)copy SMILEScopy InChI
Affinity DataKi:  0.800nMAssay Description:Displacement of [3H]PK11195 from PBZR in rat kidney mitochondrial membranes measured after 90 mins by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2S184RNPubMed
TargetCorticotropin-releasing factor receptor 1(Homo sapiens (Human))
University of KwaZulu-Natal

Curated by ChEMBL
LigandPNGBDBM50087713((1-Ethyl-propyl)-[3-(4-methoxy-2-methyl-phenyl)-2,...)copy SMILEScopy InChI
Affinity DataKi:  1nMAssay Description:Displacement of [125I-Tyr0]-CRF from recombinant human CRF1 receptorMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2S184RNPubMed
TargetTranslocator protein(Rattus norvegicus (rat))
University of KwaZulu-Natal

Curated by ChEMBL
LigandPNGBDBM50232188(CHEMBL4070141)copy SMILEScopy InChI
Affinity DataKi:  1.40nMAssay Description:Displacement of [3H]Ro5-4864 from PBZR in rat kidney mitochondrial membranes measured after 90 mins by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2S184RNPubMed
TargetCorticotropin-releasing factor receptor 1(Homo sapiens (Human))
University of KwaZulu-Natal

Curated by ChEMBL
LigandPNGBDBM50232179(CHEMBL4105538)copy SMILEScopy InChI
Affinity DataKi:  1.5nMAssay Description:Displacement of [125I-Tyr0]-CRF from recombinant human CRF1 receptorMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2S184RNPubMed
TargetCorticotropin-releasing factor receptor 1(Homo sapiens (Human))
University of KwaZulu-Natal

Curated by ChEMBL
LigandPNGBDBM50232178(CHEMBL4081285)copy SMILEScopy InChI
Affinity DataKi:  1.70nMAssay Description:Displacement of [125I-Tyr0]-CRF from recombinant human CRF1 receptorMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2S184RNPubMed
TargetTranslocator protein(Rattus norvegicus (rat))
University of KwaZulu-Natal

Curated by ChEMBL
LigandPNGBDBM50232182(CHEMBL4097327)copy SMILEScopy InChI
Affinity DataKi:  1.70nMAssay Description:Displacement of [3H]Ro5-4864 from PBZR in rat kidney mitochondrial membranes measured after 90 mins by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2S184RNPubMed
TargetTranslocator protein(Rattus norvegicus (rat))
University of KwaZulu-Natal

Curated by ChEMBL
LigandPNGBDBM50232191(CHEMBL4089611)copy SMILEScopy InChI
Affinity DataKi:  2.40nMAssay Description:Displacement of [3H]PK11195 from PBZR in rat kidney mitochondrial membranes measured after 90 mins by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2S184RNPubMed
TargetTranslocator protein(Rattus norvegicus (rat))
University of KwaZulu-Natal

Curated by ChEMBL
LigandPNGBDBM50232188(CHEMBL4070141)copy SMILEScopy InChI
Affinity DataKi:  2.40nMAssay Description:Displacement of [3H]PK11195 from PBZR in rat kidney mitochondrial membranes measured after 90 mins by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2S184RNPubMed
TargetTranslocator protein(Rattus norvegicus (rat))
University of KwaZulu-Natal

Curated by ChEMBL
LigandPNGBDBM50232191(CHEMBL4089611)copy SMILEScopy InChI
Affinity DataKi:  2.5nMAssay Description:Displacement of [3H]Ro5-4864 from PBZR in rat kidney mitochondrial membranes measured after 90 mins by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2S184RNPubMed
TargetTranslocator protein(Rattus norvegicus (rat))
University of KwaZulu-Natal

Curated by ChEMBL
LigandPNGBDBM50232201(CHEMBL4099753)copy SMILEScopy InChI
Affinity DataKi:  2.70nMAssay Description:Displacement of [3H]Ro5-4864 from PBZR in rat kidney mitochondrial membranes measured after 90 mins by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2S184RNPubMed
TargetTranslocator protein(Rattus norvegicus (rat))
University of KwaZulu-Natal

Curated by ChEMBL
LigandPNGBDBM50232190(CHEMBL4061482)copy SMILEScopy InChI
Affinity DataKi:  3.10nMAssay Description:Displacement of [3H]Ro5-4864 from PBZR in rat kidney mitochondrial membranes measured after 90 mins by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2S184RNPubMed
TargetTranslocator protein(Rattus norvegicus (rat))
University of KwaZulu-Natal

Curated by ChEMBL
LigandPNGBDBM50232201(CHEMBL4099753)copy SMILEScopy InChI
Affinity DataKi:  3.40nMAssay Description:Displacement of [3H]PK11195 from PBZR in rat kidney mitochondrial membranes measured after 90 mins by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2S184RNPubMed
TargetTranslocator protein(Rattus norvegicus (rat))
University of KwaZulu-Natal

Curated by ChEMBL
LigandPNGBDBM50232190(CHEMBL4061482)copy SMILEScopy InChI
Affinity DataKi:  4.70nMAssay Description:Displacement of [3H]PK11195 from PBZR in rat kidney mitochondrial membranes measured after 90 mins by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2S184RNPubMed
TargetCorticotropin-releasing factor receptor 1(Homo sapiens (Human))
University of KwaZulu-Natal

Curated by ChEMBL
LigandPNGBDBM50232183(CHEMBL4097805)copy SMILEScopy InChI
Affinity DataKi:  5nMAssay Description:Displacement of [125I]o-CRF from recombinant human CRF1 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2S184RNPubMed
TargetGamma-aminobutyric acid receptor subunit alpha-1(Rattus norvegicus (Rat))
University of KwaZulu-Natal

Curated by ChEMBL
LigandPNGBDBM50232200(CHEMBL4081736)copy SMILEScopy InChI
Affinity DataKi:  7nMAssay Description:Displacement of [3H]RO15-1788 from recombinant rat GABAalpha1 receptor expressed in HEK293 cells after 1 hrMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2S184RNPubMed
TargetGamma-aminobutyric acid receptor subunit alpha-5(RAT)
University of KwaZulu-Natal

Curated by ChEMBL
LigandPNGBDBM50000766(CHEMBL12 | DIAZEPAM | US9271961, Diazepam)copy SMILEScopy InChI
Affinity DataKi:  11nMAssay Description:Displacement of [3H]RO15-1788 from recombinant rat GABAalpha5 receptor expressed in HEK293 cells after 1 hrMore data for this Ligand-Target Pair
TargetGamma-aminobutyric acid receptor subunit alpha-1(Rattus norvegicus (Rat))
University of KwaZulu-Natal

Curated by ChEMBL
LigandPNGBDBM50000766(CHEMBL12 | DIAZEPAM | US9271961, Diazepam)copy SMILEScopy InChI
Affinity DataKi:  14nMAssay Description:Displacement of [3H]RO15-1788 from recombinant rat GABAalpha1 receptor expressed in HEK293 cells after 1 hrMore data for this Ligand-Target Pair
TargetGamma-aminobutyric acid receptor subunit alpha-3(Rattus norvegicus)
University of KwaZulu-Natal

Curated by ChEMBL
LigandPNGBDBM50000766(CHEMBL12 | DIAZEPAM | US9271961, Diazepam)copy SMILEScopy InChI
Affinity DataKi:  15nMAssay Description:Displacement of [3H]RO15-1788 from recombinant rat GABAalpha3 receptor expressed in HEK293 cells after 1 hrMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2S184RNPubMed
TargetGamma-aminobutyric acid receptor subunit alpha-2(Rattus norvegicus (Rat))
University of KwaZulu-Natal

Curated by ChEMBL
LigandPNGBDBM50000766(CHEMBL12 | DIAZEPAM | US9271961, Diazepam)copy SMILEScopy InChI
Affinity DataKi:  20nMAssay Description:Displacement of [3H]RO15-1788 from recombinant rat GABAalpha2 receptor expressed in HEK293 cells after 1 hrMore data for this Ligand-Target Pair
TargetGamma-aminobutyric acid receptor subunit alpha-1(Rattus norvegicus (Rat))
University of KwaZulu-Natal

Curated by ChEMBL
LigandPNGBDBM26266(Ambien | CHEMBL911 | Dalparan | N,N-dimethyl-2-[6-...)copy SMILEScopy InChI
Affinity DataKi:  27nMAssay Description:Displacement of [3H]RO15-1788 from recombinant rat GABAalpha1 receptor expressed in HEK293 cells after 1 hrMore data for this Ligand-Target Pair
TargetGamma-aminobutyric acid receptor subunit alpha-2(Rattus norvegicus (Rat))
University of KwaZulu-Natal

Curated by ChEMBL
LigandPNGBDBM26266(Ambien | CHEMBL911 | Dalparan | N,N-dimethyl-2-[6-...)copy SMILEScopy InChI
Affinity DataKi:  156nMAssay Description:Displacement of [3H]RO15-1788 from recombinant rat GABAalpha2 receptor expressed in HEK293 cells after 1 hrMore data for this Ligand-Target Pair
TargetGamma-aminobutyric acid receptor subunit alpha-3(Rattus norvegicus)
University of KwaZulu-Natal

Curated by ChEMBL
LigandPNGBDBM26266(Ambien | CHEMBL911 | Dalparan | N,N-dimethyl-2-[6-...)copy SMILEScopy InChI
Affinity DataKi:  383nMAssay Description:Displacement of [3H]RO15-1788 from recombinant rat GABAalpha3 receptor expressed in HEK293 cells after 1 hrMore data for this Ligand-Target Pair
TargetGamma-aminobutyric acid receptor subunit alpha-5(RAT)
University of KwaZulu-Natal

Curated by ChEMBL
LigandPNGBDBM50232200(CHEMBL4081736)copy SMILEScopy InChI
Affinity DataKi:  740nMAssay Description:Displacement of [3H]RO15-1788 from recombinant rat GABAalpha5 receptor expressed in HEK293 cells after 1 hrMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2S184RNPubMed
TargetGamma-aminobutyric acid receptor subunit alpha-2(Rattus norvegicus (Rat))
University of KwaZulu-Natal

Curated by ChEMBL
LigandPNGBDBM50232200(CHEMBL4081736)copy SMILEScopy InChI
Affinity DataKi:  927nMAssay Description:Displacement of [3H]RO15-1788 from recombinant rat GABAalpha2 receptor expressed in HEK293 cells after 1 hrMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2S184RNPubMed
TargetGamma-aminobutyric acid receptor subunit alpha-5(RAT)
University of KwaZulu-Natal

Curated by ChEMBL
LigandPNGBDBM26266(Ambien | CHEMBL911 | Dalparan | N,N-dimethyl-2-[6-...)copy SMILEScopy InChI
Affinity DataKi: >1.00E+4nMAssay Description:Displacement of [3H]RO15-1788 from recombinant rat GABAalpha5 receptor expressed in HEK293 cells after 1 hrMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2S184RNPubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
University of KwaZulu-Natal

Curated by ChEMBL
LigandPNGBDBM5413(1-(2-{4-[3-(thiophen-3-yl)pyrazolo[1,5-a]pyrimidin...)copy SMILEScopy InChI
Affinity DataIC50: 3nMAssay Description:Inhibition of recombinant human GST-fused KDR kinase expressed in insect Sf21 cells using poly-Glu/Tyr (4:1) peptide as substrateMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2S184RNPubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
University of KwaZulu-Natal

Curated by ChEMBL
LigandPNGBDBM5409(4-(2-{4-[3-(thiophen-3-yl)pyrazolo[1,5-a]pyrimidin...)copy SMILEScopy InChI
Affinity DataIC50: 4nMAssay Description:Inhibition of recombinant human GST-fused KDR kinase expressed in insect Sf21 cells using poly-Glu/Tyr (4:1) peptide as substrateMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2S184RNPubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
University of KwaZulu-Natal

Curated by ChEMBL
LigandPNGBDBM5410(4-(2-(4-(3-phenylpyrazolo[1,5- a]pyrimidin-6-yl)ph...)copy SMILEScopy InChI
Affinity DataIC50: 9nMAssay Description:Inhibition of recombinant human GST-fused KDR kinase expressed in insect Sf21 cells using poly-Glu/Tyr (4:1) peptide as substrateMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2S184RNPubMed
TargetProstaglandin G/H synthase 2(Homo sapiens (Human))
University of KwaZulu-Natal

Curated by ChEMBL
LigandPNGBDBM50102311(3-(4-Fluoro-phenyl)-2-(4-methanesulfonyl-phenyl)-6...)copy SMILEScopy InChI
Affinity DataIC50: 12nMAssay Description:Inhibition of human 143.98.2 cell derived COX2 assessed as reduction in PGE2 level using arachidonic acid as substrate pretreated for 15 mins followe...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2S184RNPubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
University of KwaZulu-Natal

Curated by ChEMBL
LigandPNGBDBM5413(1-(2-{4-[3-(thiophen-3-yl)pyrazolo[1,5-a]pyrimidin...)copy SMILEScopy InChI
Affinity DataIC50: 18nMAssay Description:Inhibition of recombinant human GST-fused KDR kinase expressed in insect Sf21 cells using poly-Glu/Tyr (4:1) peptide as substrate by ECMAMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2S184RNPubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
University of KwaZulu-Natal

Curated by ChEMBL
LigandPNGBDBM50232192(CHEMBL4082186)copy SMILEScopy InChI
Affinity DataIC50: 19nMAssay Description:Inhibition of recombinant human GST-fused KDR kinase expressed in insect Sf21 cells using poly-Glu/Tyr (4:1) peptide as substrateMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2S184RNPubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
University of KwaZulu-Natal

Curated by ChEMBL
LigandPNGBDBM5409(4-(2-{4-[3-(thiophen-3-yl)pyrazolo[1,5-a]pyrimidin...)copy SMILEScopy InChI
Affinity DataIC50: 22nMAssay Description:Inhibition of recombinant human GST-fused KDR kinase expressed in insect Sf21 cells using poly-Glu/Tyr (4:1) peptide as substrate by ECMAMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2S184RNPubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
University of KwaZulu-Natal

Curated by ChEMBL
LigandPNGBDBM50232184(CHEMBL4081227)copy SMILEScopy InChI
Affinity DataIC50: 24nMAssay Description:Inhibition of recombinant human GST-fused KDR kinase expressed in insect Sf21 cells using poly-Glu/Tyr (4:1) peptide as substrateMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2S184RNPubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
University of KwaZulu-Natal

Curated by ChEMBL
LigandPNGBDBM5410(4-(2-(4-(3-phenylpyrazolo[1,5- a]pyrimidin-6-yl)ph...)copy SMILEScopy InChI
Affinity DataIC50: 32nMAssay Description:Inhibition of recombinant human GST-fused KDR kinase expressed in insect Sf21 cells using poly-Glu/Tyr (4:1) peptide as substrate by ECMAMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2S184RNPubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
University of KwaZulu-Natal

Curated by ChEMBL
LigandPNGBDBM5430(4-[3-(4-methoxyphenyl)pyrazolo[1,5-a]pyrimidin-6-y...)copy SMILEScopy InChI
Affinity DataIC50: 37nMAssay Description:Inhibition of recombinant human GST-fused KDR kinase expressed in insect Sf21 cells using poly-Glu/Tyr (4:1) peptide as substrateMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2S184RNPubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
University of KwaZulu-Natal

Curated by ChEMBL
LigandPNGBDBM5417(4-[6-(pyridin-4-yl)pyrazolo[1,5-a]pyrimidin-3-yl]p...)copy SMILEScopy InChI
Affinity DataIC50: 224nMAssay Description:Inhibition of recombinant human GST-fused KDR kinase expressed in insect Sf21 cells using poly-Glu/Tyr (4:1) peptide as substrateMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2S184RNPubMed
TargetProstaglandin G/H synthase 1(Homo sapiens (Human))
University of KwaZulu-Natal

Curated by ChEMBL
LigandPNGBDBM50102311(3-(4-Fluoro-phenyl)-2-(4-methanesulfonyl-phenyl)-6...)copy SMILEScopy InChI
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human U-937 cell derived COX1 assessed as reduction in PGE2 level using arachidonic acid as substrate pretreated for 15 mins followed b...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2S184RNPubMed