Compile Data Set for Download or QSAR
Found 48 Enz. Inhib. hit(s) with all data for entry = 6152
TargetReceptor-type tyrosine-protein kinase FLT3(Homo sapiens (Human))
Amgen Inc.

US Patent
LigandPNGBDBM112481(US8623885, 22)copy SMILEScopy InChI
Affinity DataIC50: 0.650nMpH: 7.6Assay Description:The FLT3 inhibitory activity of the CDK4/6-FLT3 inhibitors was determined with a HTRF kinase assay. The FLT3 enzyme (GST-FLT3 fusion) was purchased f...More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2DZ06Z1US Patent
TargetReceptor-type tyrosine-protein kinase FLT3(Homo sapiens (Human))
Amgen Inc.

US Patent
LigandPNGBDBM112460(US8623885, 1)copy SMILEScopy InChI
Affinity DataIC50: 1.30nMpH: 7.6Assay Description:The FLT3 inhibitory activity of the CDK4/6-FLT3 inhibitors was determined with a HTRF kinase assay. The FLT3 enzyme (GST-FLT3 fusion) was purchased f...More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2DZ06Z1US Patent
TargetReceptor-type tyrosine-protein kinase FLT3(Homo sapiens (Human))
Amgen Inc.

US Patent
LigandPNGBDBM112475(US8623885, 16)copy SMILEScopy InChI
Affinity DataIC50: 1.40nMpH: 7.6Assay Description:The FLT3 inhibitory activity of the CDK4/6-FLT3 inhibitors was determined with a HTRF kinase assay. The FLT3 enzyme (GST-FLT3 fusion) was purchased f...More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2DZ06Z1US Patent
TargetReceptor-type tyrosine-protein kinase FLT3(Homo sapiens (Human))
Amgen Inc.

US Patent
LigandPNGBDBM112464(US8623885, 5)copy SMILEScopy InChI
Affinity DataIC50: 1.5nMpH: 7.6Assay Description:The FLT3 inhibitory activity of the CDK4/6-FLT3 inhibitors was determined with a HTRF kinase assay. The FLT3 enzyme (GST-FLT3 fusion) was purchased f...More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2DZ06Z1US Patent
TargetReceptor-type tyrosine-protein kinase FLT3(Homo sapiens (Human))
Amgen Inc.

US Patent
LigandPNGBDBM112477(US8623885, 18a)copy SMILEScopy InChI
Affinity DataIC50: 1.60nMpH: 7.6Assay Description:The FLT3 inhibitory activity of the CDK4/6-FLT3 inhibitors was determined with a HTRF kinase assay. The FLT3 enzyme (GST-FLT3 fusion) was purchased f...More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2DZ06Z1US Patent
TargetReceptor-type tyrosine-protein kinase FLT3(Homo sapiens (Human))
Amgen Inc.

US Patent
LigandPNGBDBM112469(US8623885, 10)copy SMILEScopy InChI
Affinity DataIC50: 1.70nMpH: 7.6Assay Description:The FLT3 inhibitory activity of the CDK4/6-FLT3 inhibitors was determined with a HTRF kinase assay. The FLT3 enzyme (GST-FLT3 fusion) was purchased f...More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2DZ06Z1US Patent
TargetReceptor-type tyrosine-protein kinase FLT3(Homo sapiens (Human))
Amgen Inc.

US Patent
LigandPNGBDBM112472(US8623885, 13)copy SMILEScopy InChI
Affinity DataIC50: 1.80nMpH: 7.6Assay Description:The FLT3 inhibitory activity of the CDK4/6-FLT3 inhibitors was determined with a HTRF kinase assay. The FLT3 enzyme (GST-FLT3 fusion) was purchased f...More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2DZ06Z1US Patent
TargetReceptor-type tyrosine-protein kinase FLT3(Homo sapiens (Human))
Amgen Inc.

US Patent
LigandPNGBDBM112462(US8623885, 3)copy SMILEScopy InChI
Affinity DataIC50: 1.80nMpH: 7.6Assay Description:The FLT3 inhibitory activity of the CDK4/6-FLT3 inhibitors was determined with a HTRF kinase assay. The FLT3 enzyme (GST-FLT3 fusion) was purchased f...More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2DZ06Z1US Patent
TargetReceptor-type tyrosine-protein kinase FLT3(Homo sapiens (Human))
Amgen Inc.

US Patent
LigandPNGBDBM112463(US8623885, 4)copy SMILEScopy InChI
Affinity DataIC50: 2nMpH: 7.6Assay Description:The FLT3 inhibitory activity of the CDK4/6-FLT3 inhibitors was determined with a HTRF kinase assay. The FLT3 enzyme (GST-FLT3 fusion) was purchased f...More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2DZ06Z1US Patent
TargetCyclin-dependent kinase 4(Homo sapiens (Human))
Amgen Inc.

US Patent
LigandPNGBDBM112460(US8623885, 1)copy SMILEScopy InChI
Affinity DataIC50: 2.10nMpH: 7.4Assay Description:The CDK4 and CDK1 inhibitory activity of the CDK4/6-FLT3 inhibitors was determined with a filtration kinase assay. The compounds, kinase and substrat...More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2DZ06Z1US Patent
TargetReceptor-type tyrosine-protein kinase FLT3(Homo sapiens (Human))
Amgen Inc.

US Patent
LigandPNGBDBM112497(US8623885, 18b)copy SMILEScopy InChI
Affinity DataIC50: 2.30nMpH: 7.6Assay Description:The FLT3 inhibitory activity of the CDK4/6-FLT3 inhibitors was determined with a HTRF kinase assay. The FLT3 enzyme (GST-FLT3 fusion) was purchased f...More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2DZ06Z1US Patent
TargetCyclin-dependent kinase 4(Homo sapiens (Human))
Amgen Inc.

US Patent
LigandPNGBDBM112467(US8623885, 8)copy SMILEScopy InChI
Affinity DataIC50: 2.40nMpH: 7.4Assay Description:The CDK4 and CDK1 inhibitory activity of the CDK4/6-FLT3 inhibitors was determined with a filtration kinase assay. The compounds, kinase and substrat...More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2DZ06Z1US Patent
TargetCyclin-dependent kinase 4(Homo sapiens (Human))
Amgen Inc.

US Patent
LigandPNGBDBM112464(US8623885, 5)copy SMILEScopy InChI
Affinity DataIC50: 2.40nMpH: 7.4Assay Description:The CDK4 and CDK1 inhibitory activity of the CDK4/6-FLT3 inhibitors was determined with a filtration kinase assay. The compounds, kinase and substrat...More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2DZ06Z1US Patent
TargetCyclin-dependent kinase 4(Homo sapiens (Human))
Amgen Inc.

US Patent
LigandPNGBDBM112462(US8623885, 3)copy SMILEScopy InChI
Affinity DataIC50: 2.60nMpH: 7.4Assay Description:The CDK4 and CDK1 inhibitory activity of the CDK4/6-FLT3 inhibitors was determined with a filtration kinase assay. The compounds, kinase and substrat...More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2DZ06Z1US Patent
TargetReceptor-type tyrosine-protein kinase FLT3(Homo sapiens (Human))
Amgen Inc.

US Patent
LigandPNGBDBM112471(US8623885, 12)copy SMILEScopy InChI
Affinity DataIC50: 2.70nMpH: 7.6Assay Description:The FLT3 inhibitory activity of the CDK4/6-FLT3 inhibitors was determined with a HTRF kinase assay. The FLT3 enzyme (GST-FLT3 fusion) was purchased f...More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2DZ06Z1US Patent
TargetReceptor-type tyrosine-protein kinase FLT3(Homo sapiens (Human))
Amgen Inc.

US Patent
LigandPNGBDBM112476(US8623885, 17)copy SMILEScopy InChI
Affinity DataIC50: 2.90nMpH: 7.6Assay Description:The FLT3 inhibitory activity of the CDK4/6-FLT3 inhibitors was determined with a HTRF kinase assay. The FLT3 enzyme (GST-FLT3 fusion) was purchased f...More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2DZ06Z1US Patent
TargetCyclin-dependent kinase 4(Homo sapiens (Human))
Amgen Inc.

US Patent
LigandPNGBDBM112496(US8623885, 37)copy SMILEScopy InChI
Affinity DataIC50: 3nMpH: 7.4Assay Description:The CDK4 and CDK1 inhibitory activity of the CDK4/6-FLT3 inhibitors was determined with a filtration kinase assay. The compounds, kinase and substrat...More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2DZ06Z1US Patent
TargetReceptor-type tyrosine-protein kinase FLT3(Homo sapiens (Human))
Amgen Inc.

US Patent
LigandPNGBDBM112474(US8623885, 15)copy SMILEScopy InChI
Affinity DataIC50: 3.10nMpH: 7.6Assay Description:The FLT3 inhibitory activity of the CDK4/6-FLT3 inhibitors was determined with a HTRF kinase assay. The FLT3 enzyme (GST-FLT3 fusion) was purchased f...More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2DZ06Z1US Patent
TargetReceptor-type tyrosine-protein kinase FLT3(Homo sapiens (Human))
Amgen Inc.

US Patent
LigandPNGBDBM112473(US8623885, 14)copy SMILEScopy InChI
Affinity DataIC50: 3.20nMpH: 7.6Assay Description:The FLT3 inhibitory activity of the CDK4/6-FLT3 inhibitors was determined with a HTRF kinase assay. The FLT3 enzyme (GST-FLT3 fusion) was purchased f...More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2DZ06Z1US Patent
TargetReceptor-type tyrosine-protein kinase FLT3(Homo sapiens (Human))
Amgen Inc.

US Patent
LigandPNGBDBM112461(US8623885, 2)copy SMILEScopy InChI
Affinity DataIC50: 3.20nMpH: 7.6Assay Description:The FLT3 inhibitory activity of the CDK4/6-FLT3 inhibitors was determined with a HTRF kinase assay. The FLT3 enzyme (GST-FLT3 fusion) was purchased f...More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2DZ06Z1US Patent
TargetReceptor-type tyrosine-protein kinase FLT3(Homo sapiens (Human))
Amgen Inc.

US Patent
LigandPNGBDBM112465(US8623885, 6)copy SMILEScopy InChI
Affinity DataIC50: 3.30nMpH: 7.6Assay Description:The FLT3 inhibitory activity of the CDK4/6-FLT3 inhibitors was determined with a HTRF kinase assay. The FLT3 enzyme (GST-FLT3 fusion) was purchased f...More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2DZ06Z1US Patent
TargetReceptor-type tyrosine-protein kinase FLT3(Homo sapiens (Human))
Amgen Inc.

US Patent
LigandPNGBDBM112468(US8623885, 9)copy SMILEScopy InChI
Affinity DataIC50: 3.40nMpH: 7.6Assay Description:The FLT3 inhibitory activity of the CDK4/6-FLT3 inhibitors was determined with a HTRF kinase assay. The FLT3 enzyme (GST-FLT3 fusion) was purchased f...More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2DZ06Z1US Patent
TargetCyclin-dependent kinase 4(Homo sapiens (Human))
Amgen Inc.

US Patent
LigandPNGBDBM112473(US8623885, 14)copy SMILEScopy InChI
Affinity DataIC50: 4.40nMpH: 7.4Assay Description:The CDK4 and CDK1 inhibitory activity of the CDK4/6-FLT3 inhibitors was determined with a filtration kinase assay. The compounds, kinase and substrat...More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2DZ06Z1US Patent
TargetCyclin-dependent kinase 4(Homo sapiens (Human))
Amgen Inc.

US Patent
LigandPNGBDBM112461(US8623885, 2)copy SMILEScopy InChI
Affinity DataIC50: 4.5nMpH: 7.4Assay Description:The CDK4 and CDK1 inhibitory activity of the CDK4/6-FLT3 inhibitors was determined with a filtration kinase assay. The compounds, kinase and substrat...More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2DZ06Z1US Patent
TargetCyclin-dependent kinase 4(Homo sapiens (Human))
Amgen Inc.

US Patent
LigandPNGBDBM112463(US8623885, 4)copy SMILEScopy InChI
Affinity DataIC50: 4.60nMpH: 7.4Assay Description:The CDK4 and CDK1 inhibitory activity of the CDK4/6-FLT3 inhibitors was determined with a filtration kinase assay. The compounds, kinase and substrat...More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2DZ06Z1US Patent
TargetCyclin-dependent kinase 4(Homo sapiens (Human))
Amgen Inc.

US Patent
LigandPNGBDBM112483(US8623885, 24)copy SMILEScopy InChI
Affinity DataIC50: 4.70nMpH: 7.4Assay Description:The CDK4 and CDK1 inhibitory activity of the CDK4/6-FLT3 inhibitors was determined with a filtration kinase assay. The compounds, kinase and substrat...More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2DZ06Z1US Patent
TargetCyclin-dependent kinase 4(Homo sapiens (Human))
Amgen Inc.

US Patent
LigandPNGBDBM112489(US8623885, 30)copy SMILEScopy InChI
Affinity DataIC50: 6.30nMpH: 7.4Assay Description:The CDK4 and CDK1 inhibitory activity of the CDK4/6-FLT3 inhibitors was determined with a filtration kinase assay. The compounds, kinase and substrat...More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2DZ06Z1US Patent
TargetCyclin-dependent kinase 4(Homo sapiens (Human))
Amgen Inc.

US Patent
LigandPNGBDBM112482(US8623885, 23)copy SMILEScopy InChI
Affinity DataIC50: 8.60nMpH: 7.4Assay Description:The CDK4 and CDK1 inhibitory activity of the CDK4/6-FLT3 inhibitors was determined with a filtration kinase assay. The compounds, kinase and substrat...More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2DZ06Z1US Patent
TargetCyclin-dependent kinase 4(Homo sapiens (Human))
Amgen Inc.

US Patent
LigandPNGBDBM112469(US8623885, 10)copy SMILEScopy InChI
Affinity DataIC50: 10.5nMpH: 7.4Assay Description:The CDK4 and CDK1 inhibitory activity of the CDK4/6-FLT3 inhibitors was determined with a filtration kinase assay. The compounds, kinase and substrat...More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2DZ06Z1US Patent
TargetCyclin-dependent kinase 4(Homo sapiens (Human))
Amgen Inc.

US Patent
LigandPNGBDBM112475(US8623885, 16)copy SMILEScopy InChI
Affinity DataIC50: 16.5nMpH: 7.4Assay Description:The CDK4 and CDK1 inhibitory activity of the CDK4/6-FLT3 inhibitors was determined with a filtration kinase assay. The compounds, kinase and substrat...More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2DZ06Z1US Patent
TargetCyclin-dependent kinase 4(Homo sapiens (Human))
Amgen Inc.

US Patent
LigandPNGBDBM112471(US8623885, 12)copy SMILEScopy InChI
Affinity DataIC50: 18.4nMpH: 7.4Assay Description:The CDK4 and CDK1 inhibitory activity of the CDK4/6-FLT3 inhibitors was determined with a filtration kinase assay. The compounds, kinase and substrat...More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2DZ06Z1US Patent
TargetCyclin-dependent kinase 4(Homo sapiens (Human))
Amgen Inc.

US Patent
LigandPNGBDBM112477(US8623885, 18a)copy SMILEScopy InChI
Affinity DataIC50: 18.8nMpH: 7.4Assay Description:The CDK4 and CDK1 inhibitory activity of the CDK4/6-FLT3 inhibitors was determined with a filtration kinase assay. The compounds, kinase and substrat...More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2DZ06Z1US Patent
TargetCyclin-dependent kinase 4(Homo sapiens (Human))
Amgen Inc.

US Patent
LigandPNGBDBM112476(US8623885, 17)copy SMILEScopy InChI
Affinity DataIC50: 19.2nMpH: 7.4Assay Description:The CDK4 and CDK1 inhibitory activity of the CDK4/6-FLT3 inhibitors was determined with a filtration kinase assay. The compounds, kinase and substrat...More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2DZ06Z1US Patent
TargetCyclin-dependent kinase 4(Homo sapiens (Human))
Amgen Inc.

US Patent
LigandPNGBDBM112474(US8623885, 15)copy SMILEScopy InChI
Affinity DataIC50: 20.3nMpH: 7.4Assay Description:The CDK4 and CDK1 inhibitory activity of the CDK4/6-FLT3 inhibitors was determined with a filtration kinase assay. The compounds, kinase and substrat...More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2DZ06Z1US Patent
TargetReceptor-type tyrosine-protein kinase FLT3(Homo sapiens (Human))
Amgen Inc.

US Patent
LigandPNGBDBM112466(US8623885, 7)copy SMILEScopy InChI
Affinity DataIC50: 21.4nMpH: 7.6Assay Description:The FLT3 inhibitory activity of the CDK4/6-FLT3 inhibitors was determined with a HTRF kinase assay. The FLT3 enzyme (GST-FLT3 fusion) was purchased f...More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2DZ06Z1US Patent
TargetCyclin-dependent kinase 4(Homo sapiens (Human))
Amgen Inc.

US Patent
LigandPNGBDBM112472(US8623885, 13)copy SMILEScopy InChI
Affinity DataIC50: 31.3nMpH: 7.4Assay Description:The CDK4 and CDK1 inhibitory activity of the CDK4/6-FLT3 inhibitors was determined with a filtration kinase assay. The compounds, kinase and substrat...More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2DZ06Z1US Patent
TargetReceptor-type tyrosine-protein kinase FLT3(Homo sapiens (Human))
Amgen Inc.

US Patent
LigandPNGBDBM112478(US8623885, 19)copy SMILEScopy InChI
Affinity DataIC50: 33nMpH: 7.6Assay Description:The FLT3 inhibitory activity of the CDK4/6-FLT3 inhibitors was determined with a HTRF kinase assay. The FLT3 enzyme (GST-FLT3 fusion) was purchased f...More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2DZ06Z1US Patent
TargetCyclin-dependent kinase 4(Homo sapiens (Human))
Amgen Inc.

US Patent
LigandPNGBDBM112481(US8623885, 22)copy SMILEScopy InChI
Affinity DataIC50: 36nMpH: 7.4Assay Description:The CDK4 and CDK1 inhibitory activity of the CDK4/6-FLT3 inhibitors was determined with a filtration kinase assay. The compounds, kinase and substrat...More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2DZ06Z1US Patent
TargetReceptor-type tyrosine-protein kinase FLT3(Homo sapiens (Human))
Amgen Inc.

US Patent
LigandPNGBDBM112467(US8623885, 8)copy SMILEScopy InChI
Affinity DataIC50: 36.1nMpH: 7.6Assay Description:The FLT3 inhibitory activity of the CDK4/6-FLT3 inhibitors was determined with a HTRF kinase assay. The FLT3 enzyme (GST-FLT3 fusion) was purchased f...More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2DZ06Z1US Patent
TargetCyclin-dependent kinase 4(Homo sapiens (Human))
Amgen Inc.

US Patent
LigandPNGBDBM112466(US8623885, 7)copy SMILEScopy InChI
Affinity DataIC50: 52.4nMpH: 7.4Assay Description:The CDK4 and CDK1 inhibitory activity of the CDK4/6-FLT3 inhibitors was determined with a filtration kinase assay. The compounds, kinase and substrat...More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2DZ06Z1US Patent
TargetCyclin-dependent kinase 4(Homo sapiens (Human))
Amgen Inc.

US Patent
LigandPNGBDBM112468(US8623885, 9)copy SMILEScopy InChI
Affinity DataIC50: 72.8nMpH: 7.4Assay Description:The CDK4 and CDK1 inhibitory activity of the CDK4/6-FLT3 inhibitors was determined with a filtration kinase assay. The compounds, kinase and substrat...More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2DZ06Z1US Patent
TargetReceptor-type tyrosine-protein kinase FLT3(Homo sapiens (Human))
Amgen Inc.

US Patent
LigandPNGBDBM112470(US8623885, 11)copy SMILEScopy InChI
Affinity DataIC50: 73.7nMpH: 7.6Assay Description:The FLT3 inhibitory activity of the CDK4/6-FLT3 inhibitors was determined with a HTRF kinase assay. The FLT3 enzyme (GST-FLT3 fusion) was purchased f...More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2DZ06Z1US Patent
TargetCyclin-dependent kinase 4(Homo sapiens (Human))
Amgen Inc.

US Patent
LigandPNGBDBM112465(US8623885, 6)copy SMILEScopy InChI
Affinity DataIC50: 120nMpH: 7.4Assay Description:The CDK4 and CDK1 inhibitory activity of the CDK4/6-FLT3 inhibitors was determined with a filtration kinase assay. The compounds, kinase and substrat...More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2DZ06Z1US Patent
TargetReceptor-type tyrosine-protein kinase FLT3(Homo sapiens (Human))
Amgen Inc.

US Patent
LigandPNGBDBM112479(US8623885, 20)copy SMILEScopy InChI
Affinity DataIC50: 144nMpH: 7.6Assay Description:The FLT3 inhibitory activity of the CDK4/6-FLT3 inhibitors was determined with a HTRF kinase assay. The FLT3 enzyme (GST-FLT3 fusion) was purchased f...More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2DZ06Z1US Patent
TargetCyclin-dependent kinase 4(Homo sapiens (Human))
Amgen Inc.

US Patent
LigandPNGBDBM112470(US8623885, 11)copy SMILEScopy InChI
Affinity DataIC50: 257nMpH: 7.4Assay Description:The CDK4 and CDK1 inhibitory activity of the CDK4/6-FLT3 inhibitors was determined with a filtration kinase assay. The compounds, kinase and substrat...More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2DZ06Z1US Patent
TargetCyclin-dependent kinase 4(Homo sapiens (Human))
Amgen Inc.

US Patent
LigandPNGBDBM112497(US8623885, 18b)copy SMILEScopy InChI
Affinity DataIC50: 463nMpH: 7.4Assay Description:The CDK4 and CDK1 inhibitory activity of the CDK4/6-FLT3 inhibitors was determined with a filtration kinase assay. The compounds, kinase and substrat...More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2DZ06Z1US Patent
TargetCyclin-dependent kinase 4(Homo sapiens (Human))
Amgen Inc.

US Patent
LigandPNGBDBM112479(US8623885, 20)copy SMILEScopy InChI
Affinity DataIC50: 847nMpH: 7.4Assay Description:The CDK4 and CDK1 inhibitory activity of the CDK4/6-FLT3 inhibitors was determined with a filtration kinase assay. The compounds, kinase and substrat...More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2DZ06Z1US Patent
TargetCyclin-dependent kinase 4(Homo sapiens (Human))
Amgen Inc.

US Patent
LigandPNGBDBM112478(US8623885, 19)copy SMILEScopy InChI
Affinity DataIC50: 1.79E+3nMpH: 7.4Assay Description:The CDK4 and CDK1 inhibitory activity of the CDK4/6-FLT3 inhibitors was determined with a filtration kinase assay. The compounds, kinase and substrat...More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2DZ06Z1US Patent