Compile Data Set for Download or QSAR
Found 29 Enz. Inhib. hit(s) with all data for entry = 7317
TargetThyrotropin receptor(Homo sapiens (Human))
Merck Sharp & Dohme B.V.

US Patent
LigandPNGBDBM60862(BDBM189328 | US9174940, 32)copy SMILEScopy InChI
Affinity DataIC50: 12nMAssay Description:Antagonist activity of three test compounds against human TSI at the human TSH receptor was tested in Chinese Hamster Ovary (CHO) cells (cultured 16 ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2F18XJCUS Patent
TargetThyrotropin receptor(Homo sapiens (Human))
Merck Sharp & Dohme B.V.

US Patent
LigandPNGBDBM189329((+)-(1-Acetyl-4-methyl-4-phenyl-1,2,3,4-tetrahydro...)copy SMILEScopy InChI
Affinity DataIC50: 47nMAssay Description:Antagonist activity of three test compounds against human TSI at the human TSH receptor was tested in Chinese Hamster Ovary (CHO) cells (cultured 16 ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2F18XJCUS Patent
TargetThyrotropin subunit beta(Bos taurus (Bovine))
Merck Sharp & Dohme B.V.

US Patent
LigandPNGBDBM60862(BDBM189328 | US9174940, 32)copy SMILEScopy InChI
Affinity DataIC50: 48nMAssay Description:Antagonist activity of three test compounds against human TSI at the human TSH receptor was tested in Chinese Hamster Ovary (CHO) cells (cultured 16 ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2F18XJCUS Patent
TargetThyrotropin receptor(Homo sapiens (Human))
Merck Sharp & Dohme B.V.

US Patent
LigandPNGBDBM189327(Hexanoic acid (Compound A) | US9174940, Compound A)copy SMILEScopy InChI
Affinity DataIC50: 88nMAssay Description:Antagonist activity of three test compounds against human TSI at the human TSH receptor was tested in Chinese Hamster Ovary (CHO) cells (cultured 16 ...More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2F18XJCUS Patent
TargetThyrotropin receptor(Homo sapiens (Human))
Merck Sharp & Dohme B.V.

US Patent
LigandPNGBDBM60849(US9174940, 12)copy SMILEScopy InChI
Affinity DataIC50: 100nMAssay Description:Antagonist activity of three test compounds against human TSI at the human TSH receptor was tested in Chinese Hamster Ovary (CHO) cells (cultured 16 ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2F18XJCUS Patent
TargetThyrotropin receptor(Homo sapiens (Human))
Merck Sharp & Dohme B.V.

US Patent
LigandPNGBDBM60850(US9174940, 13)copy SMILEScopy InChI
Affinity DataIC50: 100nMAssay Description:Antagonist activity of three test compounds against human TSI at the human TSH receptor was tested in Chinese Hamster Ovary (CHO) cells (cultured 16 ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2F18XJCUS Patent
TargetThyrotropin receptor(Homo sapiens (Human))
Merck Sharp & Dohme B.V.

US Patent
LigandPNGBDBM60851(US9174940, 18)copy SMILEScopy InChI
Affinity DataIC50: 100nMAssay Description:Antagonist activity of three test compounds against human TSI at the human TSH receptor was tested in Chinese Hamster Ovary (CHO) cells (cultured 16 ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2F18XJCUS Patent
TargetThyrotropin receptor(Homo sapiens (Human))
Merck Sharp & Dohme B.V.

US Patent
LigandPNGBDBM60848(US9174940, 11 | US9174940, 26)copy SMILEScopy InChI
Affinity DataIC50: 100nMAssay Description:Antagonist activity of three test compounds against human TSI at the human TSH receptor was tested in Chinese Hamster Ovary (CHO) cells (cultured 16 ...More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2F18XJCUS Patent
TargetThyrotropin receptor(Homo sapiens (Human))
Merck Sharp & Dohme B.V.

US Patent
LigandPNGBDBM60853(US9174940, 27)copy SMILEScopy InChI
Affinity DataIC50: 100nMAssay Description:Antagonist activity of three test compounds against human TSI at the human TSH receptor was tested in Chinese Hamster Ovary (CHO) cells (cultured 16 ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2F18XJCUS Patent
TargetThyrotropin receptor(Homo sapiens (Human))
Merck Sharp & Dohme B.V.

US Patent
LigandPNGBDBM60855(US9174940, 28)copy SMILEScopy InChI
Affinity DataIC50: 100nMAssay Description:Antagonist activity of three test compounds against human TSI at the human TSH receptor was tested in Chinese Hamster Ovary (CHO) cells (cultured 16 ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2F18XJCUS Patent
TargetThyrotropin receptor(Homo sapiens (Human))
Merck Sharp & Dohme B.V.

US Patent
LigandPNGBDBM60856(US9174940, 29)copy SMILEScopy InChI
Affinity DataIC50: 100nMAssay Description:Antagonist activity of three test compounds against human TSI at the human TSH receptor was tested in Chinese Hamster Ovary (CHO) cells (cultured 16 ...More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2F18XJCUS Patent
TargetThyrotropin receptor(Homo sapiens (Human))
Merck Sharp & Dohme B.V.

US Patent
LigandPNGBDBM60857(US9174940, 30)copy SMILEScopy InChI
Affinity DataIC50: 100nMAssay Description:Antagonist activity of three test compounds against human TSI at the human TSH receptor was tested in Chinese Hamster Ovary (CHO) cells (cultured 16 ...More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2F18XJCUS Patent
TargetThyrotropin receptor(Homo sapiens (Human))
Merck Sharp & Dohme B.V.

US Patent
LigandPNGBDBM60860(US9174940, 31)copy SMILEScopy InChI
Affinity DataIC50: 100nMAssay Description:Antagonist activity of three test compounds against human TSI at the human TSH receptor was tested in Chinese Hamster Ovary (CHO) cells (cultured 16 ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2F18XJCUS Patent
TargetThyrotropin receptor(Homo sapiens (Human))
Merck Sharp & Dohme B.V.

US Patent
LigandPNGBDBM60862(BDBM189328 | US9174940, 32)copy SMILEScopy InChI
Affinity DataIC50: 100nMAssay Description:Antagonist activity of three test compounds against human TSI at the human TSH receptor was tested in Chinese Hamster Ovary (CHO) cells (cultured 16 ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2F18XJCUS Patent
TargetThyrotropin receptor(Homo sapiens (Human))
Merck Sharp & Dohme B.V.

US Patent
LigandPNGBDBM60863(US9174940, 33)copy SMILEScopy InChI
Affinity DataIC50: 100nMAssay Description:Antagonist activity of three test compounds against human TSI at the human TSH receptor was tested in Chinese Hamster Ovary (CHO) cells (cultured 16 ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2F18XJCUS Patent
TargetThyrotropin receptor(Homo sapiens (Human))
Merck Sharp & Dohme B.V.

US Patent
LigandPNGBDBM60864(US9174940, 34)copy SMILEScopy InChI
Affinity DataIC50: 100nMAssay Description:Antagonist activity of three test compounds against human TSI at the human TSH receptor was tested in Chinese Hamster Ovary (CHO) cells (cultured 16 ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2F18XJCUS Patent
TargetThyrotropin receptor(Homo sapiens (Human))
Merck Sharp & Dohme B.V.

US Patent
LigandPNGBDBM60865(US9174940, 35)copy SMILEScopy InChI
Affinity DataIC50: 100nMAssay Description:Antagonist activity of three test compounds against human TSI at the human TSH receptor was tested in Chinese Hamster Ovary (CHO) cells (cultured 16 ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2F18XJCUS Patent
TargetThyrotropin receptor(Homo sapiens (Human))
Merck Sharp & Dohme B.V.

US Patent
LigandPNGBDBM60866(US9174940, 36)copy SMILEScopy InChI
Affinity DataIC50: 100nMAssay Description:Antagonist activity of three test compounds against human TSI at the human TSH receptor was tested in Chinese Hamster Ovary (CHO) cells (cultured 16 ...More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2F18XJCUS Patent
TargetThyrotropin receptor(Homo sapiens (Human))
Merck Sharp & Dohme B.V.

US Patent
LigandPNGBDBM60867(US9174940, 37)copy SMILEScopy InChI
Affinity DataIC50: 100nMAssay Description:Antagonist activity of three test compounds against human TSI at the human TSH receptor was tested in Chinese Hamster Ovary (CHO) cells (cultured 16 ...More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2F18XJCUS Patent
TargetThyrotropin receptor(Homo sapiens (Human))
Merck Sharp & Dohme B.V.

US Patent
LigandPNGBDBM60869(US9174940, 38)copy SMILEScopy InChI
Affinity DataIC50: 100nMAssay Description:Antagonist activity of three test compounds against human TSI at the human TSH receptor was tested in Chinese Hamster Ovary (CHO) cells (cultured 16 ...More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2F18XJCUS Patent
TargetThyrotropin receptor(Homo sapiens (Human))
Merck Sharp & Dohme B.V.

US Patent
LigandPNGBDBM60870(US9174940, 39)copy SMILEScopy InChI
Affinity DataIC50: 100nMAssay Description:Antagonist activity of three test compounds against human TSI at the human TSH receptor was tested in Chinese Hamster Ovary (CHO) cells (cultured 16 ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2F18XJCUS Patent
TargetThyrotropin receptor(Homo sapiens (Human))
Merck Sharp & Dohme B.V.

US Patent
LigandPNGBDBM60872(US9174940, 40)copy SMILEScopy InChI
Affinity DataIC50: 100nMAssay Description:Antagonist activity of three test compounds against human TSI at the human TSH receptor was tested in Chinese Hamster Ovary (CHO) cells (cultured 16 ...More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2F18XJCUS Patent
TargetThyrotropin receptor(Homo sapiens (Human))
Merck Sharp & Dohme B.V.

US Patent
LigandPNGBDBM60848(US9174940, 11 | US9174940, 26)copy SMILEScopy InChI
Affinity DataIC50: 100nMAssay Description:Antagonist activity of three test compounds against human TSI at the human TSH receptor was tested in Chinese Hamster Ovary (CHO) cells (cultured 16 ...More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2F18XJCUS Patent
TargetThyrotropin receptor(Homo sapiens (Human))
Merck Sharp & Dohme B.V.

US Patent
LigandPNGBDBM60847(US9174940, 7)copy SMILEScopy InChI
Affinity DataIC50: 100nMAssay Description:Antagonist activity of three test compounds against human TSI at the human TSH receptor was tested in Chinese Hamster Ovary (CHO) cells (cultured 16 ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2F18XJCUS Patent
TargetThyrotropin receptor(Homo sapiens (Human))
Merck Sharp & Dohme B.V.

US Patent
LigandPNGBDBM60845(US9174940, 6)copy SMILEScopy InChI
Affinity DataIC50: 100nMAssay Description:Antagonist activity of three test compounds against human TSI at the human TSH receptor was tested in Chinese Hamster Ovary (CHO) cells (cultured 16 ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2F18XJCUS Patent
TargetThyrotropin receptor(Homo sapiens (Human))
Merck Sharp & Dohme B.V.

US Patent
LigandPNGBDBM60843(US9174940, 1)copy SMILEScopy InChI
Affinity DataIC50: 100nMAssay Description:Antagonist activity of three test compounds against human TSI at the human TSH receptor was tested in Chinese Hamster Ovary (CHO) cells (cultured 16 ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2F18XJCUS Patent
TargetThyrotropin receptor(Homo sapiens (Human))
Merck Sharp & Dohme B.V.

US Patent
LigandPNGBDBM60844(US9174940, 4)copy SMILEScopy InChI
Affinity DataIC50: 100nMAssay Description:Antagonist activity of three test compounds against human TSI at the human TSH receptor was tested in Chinese Hamster Ovary (CHO) cells (cultured 16 ...More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2F18XJCUS Patent
TargetThyrotropin subunit beta(Bos taurus (Bovine))
Merck Sharp & Dohme B.V.

US Patent
LigandPNGBDBM189329((+)-(1-Acetyl-4-methyl-4-phenyl-1,2,3,4-tetrahydro...)copy SMILEScopy InChI
Affinity DataIC50: 192nMAssay Description:Antagonist activity of three test compounds against human TSI at the human TSH receptor was tested in Chinese Hamster Ovary (CHO) cells (cultured 16 ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2F18XJCUS Patent
TargetThyrotropin subunit beta(Bos taurus (Bovine))
Merck Sharp & Dohme B.V.

US Patent
LigandPNGBDBM189327(Hexanoic acid (Compound A) | US9174940, Compound A)copy SMILEScopy InChI
Affinity DataIC50: 368nMAssay Description:Antagonist activity of three test compounds against human TSI at the human TSH receptor was tested in Chinese Hamster Ovary (CHO) cells (cultured 16 ...More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2F18XJCUS Patent