Compile Data Set for Download or QSAR
Found 8 Enz. Inhib. hit(s) with all data for entry = 7530
TargetIsoform 1 of Metabotropic glutamate receptor 5 (5a)(Homo sapiens (Human))
Hoffman-La Roche Inc.

US Patent
LigandPNGBDBM199988(US9227959, 2)copy SMILEScopy InChI
Affinity DataKi:  19nMpH: 7.4Assay Description:For binding experiments, cDNA encoding human mGlu 5a receptor was transiently transfected into EBNA cells using a procedure described by Schlaeger ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q25D8QNJUS Patent
TargetIsoform 1 of Metabotropic glutamate receptor 5 (5a)(Homo sapiens (Human))
Hoffman-La Roche Inc.

US Patent
LigandPNGBDBM199989(US9227959, 3)copy SMILEScopy InChI
Affinity DataKi:  23nMpH: 7.4Assay Description:For binding experiments, cDNA encoding human mGlu 5a receptor was transiently transfected into EBNA cells using a procedure described by Schlaeger ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q25D8QNJUS Patent
TargetIsoform 1 of Metabotropic glutamate receptor 5 (5a)(Homo sapiens (Human))
Hoffman-La Roche Inc.

US Patent
LigandPNGBDBM199990(US9227959, 4)copy SMILEScopy InChI
Affinity DataKi:  67nMpH: 7.4Assay Description:For binding experiments, cDNA encoding human mGlu 5a receptor was transiently transfected into EBNA cells using a procedure described by Schlaeger ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q25D8QNJUS Patent
TargetIsoform 1 of Metabotropic glutamate receptor 5 (5a)(Homo sapiens (Human))
Hoffman-La Roche Inc.

US Patent
LigandPNGBDBM199987(US9227959, 1)copy SMILEScopy InChI
Affinity DataKi:  72nMpH: 7.4Assay Description:For binding experiments, cDNA encoding human mGlu 5a receptor was transiently transfected into EBNA cells using a procedure described by Schlaeger ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q25D8QNJUS Patent
TargetIsoform 1 of Metabotropic glutamate receptor 5 (5a)(Homo sapiens (Human))
Hoffman-La Roche Inc.

US Patent
LigandPNGBDBM199985(US9227959, Reference Compound 1, Ex. 35)copy SMILEScopy InChI
Affinity DataKi:  201nMpH: 7.4Assay Description:For binding experiments, cDNA encoding human mGlu 5a receptor was transiently transfected into EBNA cells using a procedure described by Schlaeger ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q25D8QNJUS Patent
TargetIsoform 1 of Metabotropic glutamate receptor 5 (5a)(Homo sapiens (Human))
Hoffman-La Roche Inc.

US Patent
LigandPNGBDBM199986(US9227959, Reference Compound 2, Ex. 46)copy SMILEScopy InChI
Affinity DataKi:  315nMpH: 7.4Assay Description:For binding experiments, cDNA encoding human mGlu 5a receptor was transiently transfected into EBNA cells using a procedure described by Schlaeger ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q25D8QNJUS Patent
TargetIsoform 1 of Metabotropic glutamate receptor 5 (5a)(Homo sapiens (Human))
Hoffman-La Roche Inc.

US Patent
LigandPNGBDBM199986(US9227959, Reference Compound 2, Ex. 46)copy SMILEScopy InChI
Affinity DataEC50:  50nMT: 2°CAssay Description:A monoclonal HEK-293 cell line stably transfected with a cDNA encoding for the human mGlu5a receptor was generated; for the work with mGlu5 Positive ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q25D8QNJUS Patent
TargetIsoform 1 of Metabotropic glutamate receptor 5 (5a)(Homo sapiens (Human))
Hoffman-La Roche Inc.

US Patent
LigandPNGBDBM199985(US9227959, Reference Compound 1, Ex. 35)copy SMILEScopy InChI
Affinity DataEC50:  46nMT: 2°CAssay Description:A monoclonal HEK-293 cell line stably transfected with a cDNA encoding for the human mGlu5a receptor was generated; for the work with mGlu5 Positive ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q25D8QNJUS Patent