Compile Data Set for Download or QSAR
Found 35 Enz. Inhib. hit(s) with all data for entry = 7618
TargetHistone deacetylase 6(Homo sapiens (Human))
Shandong University

LigandPNGBDBM25150((2E)-N-hydroxy-3-[3-(phenylsulfamoyl)phenyl]prop-2...)copy SMILEScopy InChI
Affinity DataIC50: 27nMAssay Description:To further ascertain HDAC isoform selectivity of 12m, we conducted enzymatic inhibitory assays against HDAC1 (class I), HDAC8 (class I), HDAC6 (class...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2SQ8Z69PubMed
TargetHistone deacetylase 1(Homo sapiens (Human))
Shandong University

LigandPNGBDBM25150((2E)-N-hydroxy-3-[3-(phenylsulfamoyl)phenyl]prop-2...)copy SMILEScopy InChI
Affinity DataIC50: 34nMAssay Description:To further ascertain HDAC isoform selectivity of 12m, we conducted enzymatic inhibitory assays against HDAC1 (class I), HDAC8 (class I), HDAC6 (class...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2SQ8Z69PubMed
TargetHistone deacetylase 1/11/4/6/8(Homo sapiens (Human))
Shandong University

LigandPNGBDBM206287((S)-N1-(3-(1H-indol-3-yl)-1-oxo-1-(p-tolylamino)pr...)copy SMILES
Affinity DataIC50: 74nMAssay Description:In brief, 10 μL of HeLa nuclear extract was mixed with various concentrations of target compounds (50 μL), SAHA, using 100% and none HDACs ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2SQ8Z69PubMed
TargetHistone deacetylase 1/11/4/6/8(Homo sapiens (Human))
Shandong University

LigandPNGBDBM206286((S)-N1-(3-(1H-indol-3-yl)-1-((4-iodophenyl)amino)-...)copy SMILES
Affinity DataIC50: 78nMAssay Description:In brief, 10 μL of HeLa nuclear extract was mixed with various concentrations of target compounds (50 μL), SAHA, using 100% and none HDACs ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2SQ8Z69PubMed
TargetHistone deacetylase 1/11/4/6/8(Homo sapiens (Human))
Shandong University

LigandPNGBDBM206285((S)-N1-(1-((4-bromophenyl)amino)-3-(1H-indol-3-yl)...)copy SMILES
Affinity DataIC50: 96nMAssay Description:In brief, 10 μL of HeLa nuclear extract was mixed with various concentrations of target compounds (50 μL), SAHA, using 100% and none HDACs ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2SQ8Z69PubMed
TargetHistone deacetylase 1/11/4/6/8(Homo sapiens (Human))
Shandong University

LigandPNGBDBM19149(CHEMBL98 | N-hydroxy-N'-phenyloctanediamide | SAHA...)copy SMILEScopy InChI
Affinity DataIC50: 131nMAssay Description:In brief, 10 μL of HeLa nuclear extract was mixed with various concentrations of target compounds (50 μL), SAHA, using 100% and none HDACs ...More data for this Ligand-Target Pair
TargetHistone deacetylase 1/11/4/6/8(Homo sapiens (Human))
Shandong University

LigandPNGBDBM206284((S)-N1-(1-((4-chlorophenyl)amino)-3-(1H-indol-3-yl...)copy SMILES
Affinity DataIC50: 150nMAssay Description:In brief, 10 μL of HeLa nuclear extract was mixed with various concentrations of target compounds (50 μL), SAHA, using 100% and none HDACs ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2SQ8Z69PubMed
TargetHistone deacetylase 6(Homo sapiens (Human))
Shandong University

LigandPNGBDBM206287((S)-N1-(3-(1H-indol-3-yl)-1-oxo-1-(p-tolylamino)pr...)copy SMILES
Affinity DataIC50: 168nMAssay Description:To further ascertain HDAC isoform selectivity of 12m, we conducted enzymatic inhibitory assays against HDAC1 (class I), HDAC8 (class I), HDAC6 (class...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2SQ8Z69PubMed
TargetHistone deacetylase 1/11/4/6/8(Homo sapiens (Human))
Shandong University

LigandPNGBDBM206281((S)-N1-(1-((3-bromophenyl)amino)-3-(1H-indol-3-yl)...)copy SMILES
Affinity DataIC50: 189nMAssay Description:In brief, 10 μL of HeLa nuclear extract was mixed with various concentrations of target compounds (50 μL), SAHA, using 100% and none HDACs ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2SQ8Z69PubMed
TargetHistone deacetylase 1/11/4/6/8(Homo sapiens (Human))
Shandong University

LigandPNGBDBM206283((S)-N1-(1-((4-fluorophenyl)amino)-3-(1H-indol-3-yl...)copy SMILES
Affinity DataIC50: 202nMAssay Description:In brief, 10 μL of HeLa nuclear extract was mixed with various concentrations of target compounds (50 μL), SAHA, using 100% and none HDACs ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2SQ8Z69PubMed
TargetHistone deacetylase 1(Homo sapiens (Human))
Shandong University

LigandPNGBDBM206287((S)-N1-(3-(1H-indol-3-yl)-1-oxo-1-(p-tolylamino)pr...)copy SMILES
Affinity DataIC50: 219nMAssay Description:To further ascertain HDAC isoform selectivity of 12m, we conducted enzymatic inhibitory assays against HDAC1 (class I), HDAC8 (class I), HDAC6 (class...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2SQ8Z69PubMed
TargetHistone deacetylase 1/11/4/6/8(Homo sapiens (Human))
Shandong University

LigandPNGBDBM206278((S)-N1-(3-(1H-indol-3-yl)-1-((naphthalen-1-ylmethy...)copy SMILES
Affinity DataIC50: 225nMAssay Description:In brief, 10 μL of HeLa nuclear extract was mixed with various concentrations of target compounds (50 μL), SAHA, using 100% and none HDACs ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2SQ8Z69PubMed
TargetHistone deacetylase 1/11/4/6/8(Homo sapiens (Human))
Shandong University

LigandPNGBDBM206267((S)-N1-(3-(1H-indol-3-yl)-1-oxo-1-(propylamino)pro...)copy SMILES
Affinity DataIC50: 227nMAssay Description:In brief, 10 μL of HeLa nuclear extract was mixed with various concentrations of target compounds (50 μL), SAHA, using 100% and none HDACs ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2SQ8Z69PubMed
TargetHistone deacetylase 1/11/4/6/8(Homo sapiens (Human))
Shandong University

LigandPNGBDBM206279((S)-N1-(1-((3-fluorophenyl)amino)-3-(1H-indol-3-yl...)copy SMILES
Affinity DataIC50: 234nMAssay Description:In brief, 10 μL of HeLa nuclear extract was mixed with various concentrations of target compounds (50 μL), SAHA, using 100% and none HDACs ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2SQ8Z69PubMed
TargetHistone deacetylase 1/11/4/6/8(Homo sapiens (Human))
Shandong University

LigandPNGBDBM206277((S)-N1-(3-(1H-indol-3-yl)-1-oxo-1-(phenethylamino)...)copy SMILES
Affinity DataIC50: 301nMAssay Description:In brief, 10 μL of HeLa nuclear extract was mixed with various concentrations of target compounds (50 μL), SAHA, using 100% and none HDACs ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2SQ8Z69PubMed
TargetHistone deacetylase 1/11/4/6/8(Homo sapiens (Human))
Shandong University

LigandPNGBDBM206289((S)-N1-(1-((4-ethoxyphenyl)amino)-3-(1H-indol-3-yl...)copy SMILES
Affinity DataIC50: 335nMAssay Description:In brief, 10 μL of HeLa nuclear extract was mixed with various concentrations of target compounds (50 μL), SAHA, using 100% and none HDACs ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2SQ8Z69PubMed
TargetHistone deacetylase 1/11/4/6/8(Homo sapiens (Human))
Shandong University

LigandPNGBDBM206276((S)-N1-(1-(benzylamino)-3-(1H-indol-3-yl)-1-oxopro...)copy SMILES
Affinity DataIC50: 346nMAssay Description:In brief, 10 μL of HeLa nuclear extract was mixed with various concentrations of target compounds (50 μL), SAHA, using 100% and none HDACs ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2SQ8Z69PubMed
TargetHistone deacetylase 8(Homo sapiens (Human))
Shandong University

LigandPNGBDBM25150((2E)-N-hydroxy-3-[3-(phenylsulfamoyl)phenyl]prop-2...)copy SMILEScopy InChI
Affinity DataIC50: 353nMAssay Description:To further ascertain HDAC isoform selectivity of 12m, we conducted enzymatic inhibitory assays against HDAC1 (class I), HDAC8 (class I), HDAC6 (class...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2SQ8Z69PubMed
TargetHistone deacetylase 1/11/4/6/8(Homo sapiens (Human))
Shandong University

LigandPNGBDBM206280((S)-N1-(1-((3-chlorophenyl)amino)-3-(1H-indol-3-yl...)copy SMILES
Affinity DataIC50: 360nMAssay Description:In brief, 10 μL of HeLa nuclear extract was mixed with various concentrations of target compounds (50 μL), SAHA, using 100% and none HDACs ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2SQ8Z69PubMed
TargetHistone deacetylase 1/11/4/6/8(Homo sapiens (Human))
Shandong University

LigandPNGBDBM206275((S)-N1-(3-(1H-indol-3-yl)-1-oxo-1-(phenylamino)pro...)copy SMILES
Affinity DataIC50: 361nMAssay Description:In brief, 10 μL of HeLa nuclear extract was mixed with various concentrations of target compounds (50 μL), SAHA, using 100% and none HDACs ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2SQ8Z69PubMed
TargetHistone deacetylase 1/11/4/6/8(Homo sapiens (Human))
Shandong University

LigandPNGBDBM206288((S)-N1-(3-(1H-indol-3-yl)-1-((4-methoxyphenyl)amin...)copy SMILES
Affinity DataIC50: 413nMAssay Description:In brief, 10 μL of HeLa nuclear extract was mixed with various concentrations of target compounds (50 μL), SAHA, using 100% and none HDACs ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2SQ8Z69PubMed
TargetHistone deacetylase 1/11/4/6/8(Homo sapiens (Human))
Shandong University

LigandPNGBDBM206274((S)-N1-(1-(cyclohexylamino)-3-(1H-indol-3-yl)-1-ox...)copy SMILES
Affinity DataIC50: 416nMAssay Description:In brief, 10 μL of HeLa nuclear extract was mixed with various concentrations of target compounds (50 μL), SAHA, using 100% and none HDACs ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2SQ8Z69PubMed
TargetHistone deacetylase 1/11/4/6/8(Homo sapiens (Human))
Shandong University

LigandPNGBDBM206282((S)-N1-(3-(1H-indol-3-yl)-1-((3-methoxyphenyl)amin...)copy SMILES
Affinity DataIC50: 435nMAssay Description:In brief, 10 μL of HeLa nuclear extract was mixed with various concentrations of target compounds (50 μL), SAHA, using 100% and none HDACs ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2SQ8Z69PubMed
TargetHistone deacetylase 1/11/4/6/8(Homo sapiens (Human))
Shandong University

LigandPNGBDBM206272((S)-N1-(1-(tert-butylamino)-3-(1H-indol-3-yl)-1-ox...)copy SMILES
Affinity DataIC50: 504nMAssay Description:In brief, 10 μL of HeLa nuclear extract was mixed with various concentrations of target compounds (50 μL), SAHA, using 100% and none HDACs ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2SQ8Z69PubMed
TargetHistone deacetylase 1/11/4/6/8(Homo sapiens (Human))
Shandong University

LigandPNGBDBM206271((S)-N1-(3-(1H-indol-3-yl)-1-(isobutylamino)-1-oxop...)copy SMILES
Affinity DataIC50: 527nMAssay Description:In brief, 10 μL of HeLa nuclear extract was mixed with various concentrations of target compounds (50 μL), SAHA, using 100% and none HDACs ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2SQ8Z69PubMed
TargetHistone deacetylase 1/11/4/6/8(Homo sapiens (Human))
Shandong University

LigandPNGBDBM206273((S)-N1-(1-(cyclopropylamino)-3-(1H-indol-3-yl)-1-o...)copy SMILES
Affinity DataIC50: 683nMAssay Description:In brief, 10 μL of HeLa nuclear extract was mixed with various concentrations of target compounds (50 μL), SAHA, using 100% and none HDACs ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2SQ8Z69PubMed
TargetHistone deacetylase 1/11/4/6/8(Homo sapiens (Human))
Shandong University

LigandPNGBDBM206290((S)-N1-(3-(1H-indol-3-yl)-1-oxo-1-((4-(trifluorome...)copy SMILES
Affinity DataIC50: 1.29E+3nMAssay Description:In brief, 10 μL of HeLa nuclear extract was mixed with various concentrations of target compounds (50 μL), SAHA, using 100% and none HDACs ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2SQ8Z69PubMed
TargetHistone deacetylase 1/11/4/6/8(Homo sapiens (Human))
Shandong University

LigandPNGBDBM206268((S)-N1-(3-(1H-indol-3-yl)-1-oxo-1-(propylamino)pro...)copy SMILES
Affinity DataIC50: 1.65E+3nMAssay Description:In brief, 10 μL of HeLa nuclear extract was mixed with various concentrations of target compounds (50 μL), SAHA, using 100% and none HDACs ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2SQ8Z69PubMed
TargetHistone deacetylase 1/11/4/6/8(Homo sapiens (Human))
Shandong University

LigandPNGBDBM206269((S)-N1-(1-(butylamino)-3-(1H-indol-3-yl)-1-oxoprop...)copy SMILES
Affinity DataIC50: 1.74E+3nMAssay Description:In brief, 10 μL of HeLa nuclear extract was mixed with various concentrations of target compounds (50 μL), SAHA, using 100% and none HDACs ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2SQ8Z69PubMed
TargetHistone deacetylase 11(Homo sapiens (Human))
Shandong University

LigandPNGBDBM206287((S)-N1-(3-(1H-indol-3-yl)-1-oxo-1-(p-tolylamino)pr...)copy SMILES
Affinity DataIC50: 3.50E+3nMAssay Description:To further ascertain HDAC isoform selectivity of 12m, we conducted enzymatic inhibitory assays against HDAC1 (class I), HDAC8 (class I), HDAC6 (class...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2SQ8Z69PubMed
TargetHistone deacetylase 8(Homo sapiens (Human))
Shandong University

LigandPNGBDBM206287((S)-N1-(3-(1H-indol-3-yl)-1-oxo-1-(p-tolylamino)pr...)copy SMILES
Affinity DataIC50: 5.50E+3nMAssay Description:To further ascertain HDAC isoform selectivity of 12m, we conducted enzymatic inhibitory assays against HDAC1 (class I), HDAC8 (class I), HDAC6 (class...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2SQ8Z69PubMed
TargetHistone deacetylase 4(Homo sapiens (Human))
Shandong University

LigandPNGBDBM25150((2E)-N-hydroxy-3-[3-(phenylsulfamoyl)phenyl]prop-2...)copy SMILEScopy InChI
Affinity DataIC50: 9.90E+3nMAssay Description:To further ascertain HDAC isoform selectivity of 12m, we conducted enzymatic inhibitory assays against HDAC1 (class I), HDAC8 (class I), HDAC6 (class...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2SQ8Z69PubMed
TargetHistone deacetylase 11(Homo sapiens (Human))
Shandong University

LigandPNGBDBM25150((2E)-N-hydroxy-3-[3-(phenylsulfamoyl)phenyl]prop-2...)copy SMILEScopy InChI
Affinity DataIC50: 2.50E+4nMAssay Description:To further ascertain HDAC isoform selectivity of 12m, we conducted enzymatic inhibitory assays against HDAC1 (class I), HDAC8 (class I), HDAC6 (class...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2SQ8Z69PubMed
TargetHistone deacetylase 1/11/4/6/8(Homo sapiens (Human))
Shandong University

LigandPNGBDBM206270((S)-N1-(1-(dodecylamino)-3-(1H-indol-3-yl)-1-oxopr...)copy SMILES
Affinity DataIC50: 2.50E+4nMAssay Description:In brief, 10 μL of HeLa nuclear extract was mixed with various concentrations of target compounds (50 μL), SAHA, using 100% and none HDACs ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2SQ8Z69PubMed
TargetHistone deacetylase 4(Homo sapiens (Human))
Shandong University

LigandPNGBDBM206287((S)-N1-(3-(1H-indol-3-yl)-1-oxo-1-(p-tolylamino)pr...)copy SMILES
Affinity DataIC50: 1.00E+5nMAssay Description:To further ascertain HDAC isoform selectivity of 12m, we conducted enzymatic inhibitory assays against HDAC1 (class I), HDAC8 (class I), HDAC6 (class...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2SQ8Z69PubMed