Compile Data Set for Download or QSAR
Found 17 Enz. Inhib. hit(s) with all data for entry = 770
TargetCyclin-dependent kinase 2/G1/S-specific cyclin-E1(Homo sapiens (Human))
Bristol-Myers Squibb Company

LigandPNGBDBM5668(2-amino-5-thio-substituted thiazole 45 | BMS-38703...)copy SMILEScopy InChI
Affinity DataIC50: 3nMpH: 8.0 T: 2°CAssay Description: The enzyme was assayed with substrate in the presence of 25 uM ATP/[gamma-33P] ATP and test compound. Dose response curves were generated to determ...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q26971SZPubMed
TargetCyclin-dependent kinase 2/G1/S-specific cyclin-E1(Homo sapiens (Human))
Bristol-Myers Squibb Company

LigandPNGBDBM5924(BMS-387032 analog 14 | N-(5-{[(5-tert-butyl-1,3-ox...)copy SMILEScopy InChI
Affinity DataIC50: 3nMpH: 8.0 T: 2°CAssay Description: The enzyme was assayed with substrate in the presence of 25 uM ATP/[gamma-33P] ATP and test compound. Dose response curves were generated to determ...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q26971SZPubMed
TargetCyclin-dependent kinase 2/G1/S-specific cyclin-E1(Homo sapiens (Human))
Bristol-Myers Squibb Company

LigandPNGBDBM5660(2-amino-5-thio-substituted thiazole 25 | 2-aminoth...)copy SMILEScopy InChI
Affinity DataIC50: 5nMpH: 8.0 T: 2°CAssay Description: The enzyme was assayed with substrate in the presence of 25 uM ATP/[gamma-33P] ATP and test compound. Dose response curves were generated to determ...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q26971SZPubMed
TargetCyclin-dependent kinase 2/G1/S-specific cyclin-E1(Homo sapiens (Human))
Bristol-Myers Squibb Company

LigandPNGBDBM5930(BMS-387032 analog 20 | N-(5-{[(5-tert-butyl-1,3-ox...)copy SMILEScopy InChI
Affinity DataIC50: 11nMpH: 8.0 T: 2°CAssay Description: The enzyme was assayed with substrate in the presence of 25 uM ATP/[gamma-33P] ATP and test compound. Dose response curves were generated to determ...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q26971SZPubMed
TargetCyclin-dependent kinase 2/G1/S-specific cyclin-E1(Homo sapiens (Human))
Bristol-Myers Squibb Company

LigandPNGBDBM5934(BMS-387032 analog 24 | N-(5-{[(5-tert-butyl-1,3-ox...)copy SMILEScopy InChI
Affinity DataIC50: 18nMpH: 8.0 T: 2°CAssay Description: The enzyme was assayed with substrate in the presence of 25 uM ATP/[gamma-33P] ATP and test compound. Dose response curves were generated to determ...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q26971SZPubMed
TargetCyclin-dependent kinase 2/G1/S-specific cyclin-E1(Homo sapiens (Human))
Bristol-Myers Squibb Company

LigandPNGBDBM5923(3-amino-N-(5-{[(5-tert-butyl-1,3-oxazol-2-yl)methy...)copy SMILEScopy InChI
Affinity DataIC50: 21nMpH: 8.0 T: 2°CAssay Description: The enzyme was assayed with substrate in the presence of 25 uM ATP/[gamma-33P] ATP and test compound. Dose response curves were generated to determ...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q26971SZPubMed
TargetCyclin-dependent kinase 2/G1/S-specific cyclin-E1(Homo sapiens (Human))
Bristol-Myers Squibb Company

LigandPNGBDBM5936(4-amino-N-(5-{[(5-tert-butyl-1,3-oxazol-2-yl)methy...)copy SMILEScopy InChI
Affinity DataIC50: 22nMpH: 8.0 T: 2°CAssay Description: The enzyme was assayed with substrate in the presence of 25 uM ATP/[gamma-33P] ATP and test compound. Dose response curves were generated to determ...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q26971SZPubMed
TargetCyclin-dependent kinase 2/G1/S-specific cyclin-E1(Homo sapiens (Human))
Bristol-Myers Squibb Company

LigandPNGBDBM5683(2-amino-5-thio-substituted thiazole 31 | BMS-38703...)copy SMILEScopy InChI
Affinity DataIC50: 26nMpH: 8.0 T: 2°CAssay Description: The enzyme was assayed with substrate in the presence of 25 uM ATP/[gamma-33P] ATP and test compound. Dose response curves were generated to determ...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q26971SZPubMed
TargetCyclin-dependent kinase 2/G1/S-specific cyclin-E1(Homo sapiens (Human))
Bristol-Myers Squibb Company

LigandPNGBDBM5932(1-Methyl-N-[5-[[[5-(1,1-dimethylethyl)-2-oxazolyl]...)copy SMILEScopy InChI
Affinity DataIC50: 43nMpH: 8.0 T: 2°CAssay Description: The enzyme was assayed with substrate in the presence of 25 uM ATP/[gamma-33P] ATP and test compound. Dose response curves were generated to determ...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q26971SZPubMed
TargetCyclin-dependent kinase 2/G1/S-specific cyclin-E1(Homo sapiens (Human))
Bristol-Myers Squibb Company

LigandPNGBDBM5931(BMS-387072 | CHEMBL296468 | N-(5-{[(5-tert-butyl-1...)copy SMILEScopy InChI
Affinity DataIC50: 48nMpH: 8.0 T: 2°CAssay Description: The enzyme was assayed with substrate in the presence of 25 uM ATP/[gamma-33P] ATP and test compound. Dose response curves were generated to determ...More data for this Ligand-Target Pair
TargetCyclin-dependent kinase 2/G1/S-specific cyclin-E1(Homo sapiens (Human))
Bristol-Myers Squibb Company

LigandPNGBDBM5926(BMS-387032 analog 16 | N-(5-{[(5-tert-butyl-1,3-ox...)copy SMILEScopy InChI
Affinity DataIC50: 50nMpH: 8.0 T: 2°CAssay Description: The enzyme was assayed with substrate in the presence of 25 uM ATP/[gamma-33P] ATP and test compound. Dose response curves were generated to determ...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q26971SZPubMed
TargetCyclin-dependent kinase 2/G1/S-specific cyclin-E1(Homo sapiens (Human))
Bristol-Myers Squibb Company

LigandPNGBDBM5928((+/-)-N-[5-[[[5-(1,1-Dimethylethyl)-2-oxazolyl]met...)copy SMILEScopy InChI
Affinity DataIC50: 50nMpH: 8.0 T: 2°CAssay Description: The enzyme was assayed with substrate in the presence of 25 uM ATP/[gamma-33P] ATP and test compound. Dose response curves were generated to determ...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q26971SZPubMed
TargetCyclin-dependent kinase 2/G1/S-specific cyclin-E1(Homo sapiens (Human))
Bristol-Myers Squibb Company

LigandPNGBDBM5933(BMS-387032 analog 23 | N-(5-{[(5-tert-butyl-1,3-ox...)copy SMILEScopy InChI
Affinity DataIC50: 74nMpH: 8.0 T: 2°CAssay Description: The enzyme was assayed with substrate in the presence of 25 uM ATP/[gamma-33P] ATP and test compound. Dose response curves were generated to determ...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q26971SZPubMed
TargetCyclin-dependent kinase 2/G1/S-specific cyclin-E1(Homo sapiens (Human))
Bristol-Myers Squibb Company

LigandPNGBDBM5929((+/-)-N-[5-[[[5-(1,1-Dimethylethyl)-2-oxazolyl]met...)copy SMILEScopy InChI
Affinity DataIC50: 83nMpH: 8.0 T: 2°CAssay Description: The enzyme was assayed with substrate in the presence of 25 uM ATP/[gamma-33P] ATP and test compound. Dose response curves were generated to determ...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q26971SZPubMed
TargetCyclin-dependent kinase 2/G1/S-specific cyclin-E1(Homo sapiens (Human))
Bristol-Myers Squibb Company

LigandPNGBDBM5937(4-amino-N-(5-{[(5-tert-butyl-1,3-oxazol-2-yl)methy...)copy SMILEScopy InChI
Affinity DataIC50: 150nMpH: 8.0 T: 2°CAssay Description: The enzyme was assayed with substrate in the presence of 25 uM ATP/[gamma-33P] ATP and test compound. Dose response curves were generated to determ...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q26971SZPubMed
TargetCyclin-dependent kinase 2/G1/S-specific cyclin-E1(Homo sapiens (Human))
Bristol-Myers Squibb Company

LigandPNGBDBM5935(BMS-387032 analog 25 | N-[5-[[[5-(1,1-Dimethylethy...)copy SMILEScopy InChI
Affinity DataIC50: 160nMpH: 8.0 T: 2°CAssay Description: The enzyme was assayed with substrate in the presence of 25 uM ATP/[gamma-33P] ATP and test compound. Dose response curves were generated to determ...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q26971SZPubMed
TargetCyclin-dependent kinase 2/G1/S-specific cyclin-E1(Homo sapiens (Human))
Bristol-Myers Squibb Company

LigandPNGBDBM5927(BMS-387032 analog 17 | N-(5-{[(5-tert-butyl-1,3-ox...)copy SMILEScopy InChI
Affinity DataIC50: 300nMpH: 8.0 T: 2°CAssay Description: The enzyme was assayed with substrate in the presence of 25 uM ATP/[gamma-33P] ATP and test compound. Dose response curves were generated to determ...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q26971SZPubMed