Compile Data Set for Download or QSAR
Found 51 Enz. Inhib. hit(s) with all data for entry = 8522
TargetTyrosine-protein kinase SYK(Homo sapiens (Human))
Rigel Pharmaceuticals, Inc.

US Patent
LigandPNGBDBM255524(N4-[(2,2-Difluoro-4H-benzo[1,4]oxazin-3-one)-6-yl]...)copy SMILEScopy InChI
Affinity DataIC50: 0.450nMpH: 7.4 T: 2°CAssay Description:Several 2,4-pyrimidinediamine compounds were tested for the ability to inhibit Syk kinase catalyzed phosphorylation of a peptide substrate in a bioch...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2WW7GKQUS Patent
TargetTyrosine-protein kinase SYK(Homo sapiens (Human))
Rigel Pharmaceuticals, Inc.

US Patent
LigandPNGBDBM255515(US10828301, Compound R950368 | US9499493, R950368)copy SMILEScopy InChI
Affinity DataIC50: 10.7nMpH: 7.4 T: 2°CAssay Description:Several 2,4-pyrimidinediamine compounds were tested for the ability to inhibit Syk kinase catalyzed phosphorylation of a peptide substrate in a bioch...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2WW7GKQUS Patent
TargetTyrosine-protein kinase SYK(Homo sapiens (Human))
Rigel Pharmaceuticals, Inc.

US Patent
LigandPNGBDBM255514(US10828301, Compound R921304 | US9499493, R921304)copy SMILEScopy InChI
Affinity DataIC50: 12.8nMpH: 7.4 T: 2°CAssay Description:Several 2,4-pyrimidinediamine compounds were tested for the ability to inhibit Syk kinase catalyzed phosphorylation of a peptide substrate in a bioch...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2WW7GKQUS Patent
TargetTyrosine-protein kinase SYK(Homo sapiens (Human))
Rigel Pharmaceuticals, Inc.

US Patent
LigandPNGBDBM255518((+/-)-5-Fluoro-N2-[(N-methyl acetamido-2)-3-phenox...)copy SMILEScopy InChI
Affinity DataIC50: 24nMpH: 7.4 T: 2°CAssay Description:Several 2,4-pyrimidinediamine compounds were tested for the ability to inhibit Syk kinase catalyzed phosphorylation of a peptide substrate in a bioch...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2WW7GKQUS Patent
TargetTyrosine-protein kinase SYK(Homo sapiens (Human))
Rigel Pharmaceuticals, Inc.

US Patent
LigandPNGBDBM255508(US10828301, Compound R935302 | US9499493, R935302)copy SMILEScopy InChI
Affinity DataIC50: 26.5nMpH: 7.4 T: 2°CAssay Description:Several 2,4-pyrimidinediamine compounds were tested for the ability to inhibit Syk kinase catalyzed phosphorylation of a peptide substrate in a bioch...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2WW7GKQUS Patent
TargetTyrosine-protein kinase SYK(Homo sapiens (Human))
Rigel Pharmaceuticals, Inc.

US Patent
LigandPNGBDBM255513(US10828301, Compound R940338 | US9499493, R940338)copy SMILEScopy InChI
Affinity DataIC50: 28nMpH: 7.4 T: 2°CAssay Description:Several 2,4-pyrimidinediamine compounds were tested for the ability to inhibit Syk kinase catalyzed phosphorylation of a peptide substrate in a bioch...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2WW7GKQUS Patent
TargetTyrosine-protein kinase SYK(Homo sapiens (Human))
Rigel Pharmaceuticals, Inc.

US Patent
LigandPNGBDBM255525(N4-[(2,2-Dimethyl-4H-5-pyrido[1,4]oxazin-3-one)-6-...)copy SMILEScopy InChI
Affinity DataIC50: 34.5nMpH: 7.4 T: 2°CAssay Description:Several 2,4-pyrimidinediamine compounds were tested for the ability to inhibit Syk kinase catalyzed phosphorylation of a peptide substrate in a bioch...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2WW7GKQUS Patent
TargetTyrosine-protein kinase SYK(Homo sapiens (Human))
Rigel Pharmaceuticals, Inc.

US Patent
LigandPNGBDBM255501(US9499493, R908702)copy SMILEScopy InChI
Affinity DataIC50: 37.8nMpH: 7.4 T: 2°CAssay Description:Several 2,4-pyrimidinediamine compounds were tested for the ability to inhibit Syk kinase catalyzed phosphorylation of a peptide substrate in a bioch...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2WW7GKQUS Patent
TargetTyrosine-protein kinase SYK(Homo sapiens (Human))
Rigel Pharmaceuticals, Inc.

US Patent
LigandPNGBDBM255509(US10828301, Compound R935304 | US9499493, R935304)copy SMILEScopy InChI
Affinity DataIC50: 42nMpH: 7.4 T: 2°CAssay Description:Several 2,4-pyrimidinediamine compounds were tested for the ability to inhibit Syk kinase catalyzed phosphorylation of a peptide substrate in a bioch...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2WW7GKQUS Patent
TargetTyrosine-protein kinase SYK(Homo sapiens (Human))
Rigel Pharmaceuticals, Inc.

US Patent
LigandPNGBDBM255488(US10828301, Compound R935191 | US9499493, R935191)copy SMILEScopy InChI
Affinity DataIC50: 45nMpH: 7.4 T: 2°CAssay Description:Several 2,4-pyrimidinediamine compounds were tested for the ability to inhibit Syk kinase catalyzed phosphorylation of a peptide substrate in a bioch...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2WW7GKQUS Patent
TargetTyrosine-protein kinase SYK(Homo sapiens (Human))
Rigel Pharmaceuticals, Inc.

US Patent
LigandPNGBDBM255506(US9499493, R935237)copy SMILEScopy InChI
Affinity DataIC50: 45.5nMpH: 7.4 T: 2°CAssay Description:Several 2,4-pyrimidinediamine compounds were tested for the ability to inhibit Syk kinase catalyzed phosphorylation of a peptide substrate in a bioch...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2WW7GKQUS Patent
TargetTyrosine-protein kinase SYK(Homo sapiens (Human))
Rigel Pharmaceuticals, Inc.

US Patent
LigandPNGBDBM255487(US10828301, Compound R935190 | US9499493, R935190)copy SMILEScopy InChI
Affinity DataIC50: 46.5nMpH: 7.4 T: 2°CAssay Description:Several 2,4-pyrimidinediamine compounds were tested for the ability to inhibit Syk kinase catalyzed phosphorylation of a peptide substrate in a bioch...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2WW7GKQUS Patent
TargetTyrosine-protein kinase SYK(Homo sapiens (Human))
Rigel Pharmaceuticals, Inc.

US Patent
LigandPNGBDBM255507(US10828301, Compound R935293 | US9499493, R935293)copy SMILEScopy InChI
Affinity DataIC50: 46.5nMpH: 7.4 T: 2°CAssay Description:Several 2,4-pyrimidinediamine compounds were tested for the ability to inhibit Syk kinase catalyzed phosphorylation of a peptide substrate in a bioch...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2WW7GKQUS Patent
TargetTyrosine-protein kinase SYK(Homo sapiens (Human))
Rigel Pharmaceuticals, Inc.

US Patent
LigandPNGBDBM255505(US10828301, Compound R926839 | US9499493, R926839)copy SMILEScopy InChI
Affinity DataIC50: 55nMpH: 7.4 T: 2°CAssay Description:Several 2,4-pyrimidinediamine compounds were tested for the ability to inhibit Syk kinase catalyzed phosphorylation of a peptide substrate in a bioch...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2WW7GKQUS Patent
TargetTyrosine-protein kinase SYK(Homo sapiens (Human))
Rigel Pharmaceuticals, Inc.

US Patent
LigandPNGBDBM255510(US10828301, Compound R935307 | US9499493, R935307)copy SMILEScopy InChI
Affinity DataIC50: 57nMpH: 7.4 T: 2°CAssay Description:Several 2,4-pyrimidinediamine compounds were tested for the ability to inhibit Syk kinase catalyzed phosphorylation of a peptide substrate in a bioch...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2WW7GKQUS Patent
TargetTyrosine-protein kinase SYK(Homo sapiens (Human))
Rigel Pharmaceuticals, Inc.

US Patent
LigandPNGBDBM255485(US10828301, Compound R926816 | US9499493, R926816)copy SMILEScopy InChI
Affinity DataIC50: 61.5nMpH: 7.4 T: 2°CAssay Description:Several 2,4-pyrimidinediamine compounds were tested for the ability to inhibit Syk kinase catalyzed phosphorylation of a peptide substrate in a bioch...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2WW7GKQUS Patent
TargetTyrosine-protein kinase SYK(Homo sapiens (Human))
Rigel Pharmaceuticals, Inc.

US Patent
LigandPNGBDBM255523(N4-[(2,2-Dimethyl-4H-benzo[1,4]oxazin-3-one)-6-yl]...)copy SMILEScopy InChI
Affinity DataIC50: 62nMpH: 7.4 T: 2°CAssay Description:Several 2,4-pyrimidinediamine compounds were tested for the ability to inhibit Syk kinase catalyzed phosphorylation of a peptide substrate in a bioch...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2WW7GKQUS Patent
TargetTyrosine-protein kinase SYK(Homo sapiens (Human))
Rigel Pharmaceuticals, Inc.

US Patent
LigandPNGBDBM255526(N4-(3-Methylcarbonyloximephenyl)-5-fluoro-N2-[3-(N...)copy SMILEScopy InChI
Affinity DataIC50: 66.5nMpH: 7.4 T: 2°CAssay Description:Several 2,4-pyrimidinediamine compounds were tested for the ability to inhibit Syk kinase catalyzed phosphorylation of a peptide substrate in a bioch...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2WW7GKQUS Patent
TargetTyrosine-protein kinase SYK(Homo sapiens (Human))
Rigel Pharmaceuticals, Inc.

US Patent
LigandPNGBDBM255477(US10828301, Compound R926505 | US9499493, R926505)copy SMILEScopy InChI
Affinity DataIC50: 70.3nMpH: 7.4 T: 2°CAssay Description:Several 2,4-pyrimidinediamine compounds were tested for the ability to inhibit Syk kinase catalyzed phosphorylation of a peptide substrate in a bioch...More data for this Ligand-Target Pair
Ligand InfoKEGGPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2WW7GKQUS Patent
TargetTyrosine-protein kinase SYK(Homo sapiens (Human))
Rigel Pharmaceuticals, Inc.

US Patent
LigandPNGBDBM255489(US9499493, R935193)copy SMILEScopy InChI
Affinity DataIC50: 75nMpH: 7.4 T: 2°CAssay Description:Several 2,4-pyrimidinediamine compounds were tested for the ability to inhibit Syk kinase catalyzed phosphorylation of a peptide substrate in a bioch...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2WW7GKQUS Patent
TargetTyrosine-protein kinase SYK(Homo sapiens (Human))
Rigel Pharmaceuticals, Inc.

US Patent
LigandPNGBDBM255481(US10828301, Compound R926745 | US9499493, R926745)copy SMILEScopy InChI
Affinity DataIC50: 92.5nMpH: 7.4 T: 2°CAssay Description:Several 2,4-pyrimidinediamine compounds were tested for the ability to inhibit Syk kinase catalyzed phosphorylation of a peptide substrate in a bioch...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2WW7GKQUS Patent
TargetTyrosine-protein kinase SYK(Homo sapiens (Human))
Rigel Pharmaceuticals, Inc.

US Patent
LigandPNGBDBM255511(US10828301, Compound R935309 | US9499493, R935309)copy SMILEScopy InChI
Affinity DataIC50: 98nMpH: 7.4 T: 2°CAssay Description:Several 2,4-pyrimidinediamine compounds were tested for the ability to inhibit Syk kinase catalyzed phosphorylation of a peptide substrate in a bioch...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2WW7GKQUS Patent
TargetTyrosine-protein kinase SYK(Homo sapiens (Human))
Rigel Pharmaceuticals, Inc.

US Patent
LigandPNGBDBM255519(5-Fluoro-N4-(3-hydroxy-4-methylphenyl)-N2-[3-[(N-m...)copy SMILEScopy InChI
Affinity DataIC50: 108nMpH: 7.4 T: 2°CAssay Description:Several 2,4-pyrimidinediamine compounds were tested for the ability to inhibit Syk kinase catalyzed phosphorylation of a peptide substrate in a bioch...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2WW7GKQUS Patent
TargetTyrosine-protein kinase SYK(Homo sapiens (Human))
Rigel Pharmaceuticals, Inc.

US Patent
LigandPNGBDBM255482(US10828301, Compound R926782 | US9499493, R926782)copy SMILEScopy InChI
Affinity DataIC50: 117nMpH: 7.4 T: 2°CAssay Description:Several 2,4-pyrimidinediamine compounds were tested for the ability to inhibit Syk kinase catalyzed phosphorylation of a peptide substrate in a bioch...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2WW7GKQUS Patent
TargetTyrosine-protein kinase SYK(Homo sapiens (Human))
Rigel Pharmaceuticals, Inc.

US Patent
LigandPNGBDBM255502(US10828301, Compound R909268 | US9499493, R909268)copy SMILEScopy InChI
Affinity DataIC50: 125nMpH: 7.4 T: 2°CAssay Description:Several 2,4-pyrimidinediamine compounds were tested for the ability to inhibit Syk kinase catalyzed phosphorylation of a peptide substrate in a bioch...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2WW7GKQUS Patent
TargetTyrosine-protein kinase SYK(Homo sapiens (Human))
Rigel Pharmaceuticals, Inc.

US Patent
LigandPNGBDBM255495(US10828301, Compound R940276 | US9499493, R940276)copy SMILEScopy InChI
Affinity DataIC50: 127nMpH: 7.4 T: 2°CAssay Description:Several 2,4-pyrimidinediamine compounds were tested for the ability to inhibit Syk kinase catalyzed phosphorylation of a peptide substrate in a bioch...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2WW7GKQUS Patent
TargetTyrosine-protein kinase SYK(Homo sapiens (Human))
Rigel Pharmaceuticals, Inc.

US Patent
LigandPNGBDBM255478(US10828301, Compound R926508 | US9499493, R926508)copy SMILEScopy InChI
Affinity DataIC50: 132nMpH: 7.4 T: 2°CAssay Description:Several 2,4-pyrimidinediamine compounds were tested for the ability to inhibit Syk kinase catalyzed phosphorylation of a peptide substrate in a bioch...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2WW7GKQUS Patent
TargetTyrosine-protein kinase SYK(Homo sapiens (Human))
Rigel Pharmaceuticals, Inc.

US Patent
LigandPNGBDBM255503(US9499493, R920410)copy SMILEScopy InChI
Affinity DataIC50: 157nMpH: 7.4 T: 2°CAssay Description:Several 2,4-pyrimidinediamine compounds were tested for the ability to inhibit Syk kinase catalyzed phosphorylation of a peptide substrate in a bioch...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2WW7GKQUS Patent
TargetTyrosine-protein kinase SYK(Homo sapiens (Human))
Rigel Pharmaceuticals, Inc.

US Patent
LigandPNGBDBM255490(US10828301, Compound R935194 | US9499493, R935194)copy SMILEScopy InChI
Affinity DataIC50: 169nMpH: 7.4 T: 2°CAssay Description:Several 2,4-pyrimidinediamine compounds were tested for the ability to inhibit Syk kinase catalyzed phosphorylation of a peptide substrate in a bioch...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2WW7GKQUS Patent
TargetTyrosine-protein kinase SYK(Homo sapiens (Human))
Rigel Pharmaceuticals, Inc.

US Patent
LigandPNGBDBM255521(N4-(3-Chloro-4-methoxyphenyl)-5-fluoro-N2-[3-[(N-m...)copy SMILEScopy InChI
Affinity DataIC50: 170nMpH: 7.4 T: 2°CAssay Description:Several 2,4-pyrimidinediamine compounds were tested for the ability to inhibit Syk kinase catalyzed phosphorylation of a peptide substrate in a bioch...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2WW7GKQUS Patent
TargetTyrosine-protein kinase SYK(Homo sapiens (Human))
Rigel Pharmaceuticals, Inc.

US Patent
LigandPNGBDBM255497(US10828301, Compound R940290 | US9499493, R940290)copy SMILEScopy InChI
Affinity DataIC50: 187nMpH: 7.4 T: 2°CAssay Description:Several 2,4-pyrimidinediamine compounds were tested for the ability to inhibit Syk kinase catalyzed phosphorylation of a peptide substrate in a bioch...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2WW7GKQUS Patent
TargetTyrosine-protein kinase SYK(Homo sapiens (Human))
Rigel Pharmaceuticals, Inc.

US Patent
LigandPNGBDBM255512(US10828301, Compound R935310 | US9499493, R935310)copy SMILEScopy InChI
Affinity DataIC50: 200nMpH: 7.4 T: 2°CAssay Description:Several 2,4-pyrimidinediamine compounds were tested for the ability to inhibit Syk kinase catalyzed phosphorylation of a peptide substrate in a bioch...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2WW7GKQUS Patent
TargetTyrosine-protein kinase SYK(Homo sapiens (Human))
Rigel Pharmaceuticals, Inc.

US Patent
LigandPNGBDBM255483(US10828301, Compound R926791 | US9499493, R926791)copy SMILEScopy InChI
Affinity DataIC50: 207nMpH: 7.4 T: 2°CAssay Description:Several 2,4-pyrimidinediamine compounds were tested for the ability to inhibit Syk kinase catalyzed phosphorylation of a peptide substrate in a bioch...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2WW7GKQUS Patent
TargetTyrosine-protein kinase SYK(Homo sapiens (Human))
Rigel Pharmaceuticals, Inc.

US Patent
LigandPNGBDBM255496(US10828301, Compound R940277 | US9499493, R940277)copy SMILEScopy InChI
Affinity DataIC50: 214nMpH: 7.4 T: 2°CAssay Description:Several 2,4-pyrimidinediamine compounds were tested for the ability to inhibit Syk kinase catalyzed phosphorylation of a peptide substrate in a bioch...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2WW7GKQUS Patent
TargetTyrosine-protein kinase SYK(Homo sapiens (Human))
Rigel Pharmaceuticals, Inc.

US Patent
LigandPNGBDBM255486(US9499493, R935138)copy SMILEScopy InChI
Affinity DataIC50: 229nMpH: 7.4 T: 2°CAssay Description:Several 2,4-pyrimidinediamine compounds were tested for the ability to inhibit Syk kinase catalyzed phosphorylation of a peptide substrate in a bioch...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2WW7GKQUS Patent
TargetTyrosine-protein kinase SYK(Homo sapiens (Human))
Rigel Pharmaceuticals, Inc.

US Patent
LigandPNGBDBM255522(5-Fluoro-N4-[(1H)-indol-5-yl]-N2-[3-[(N-methylamin...)copy SMILEScopy InChI
Affinity DataIC50: 255nMpH: 7.4 T: 2°CAssay Description:Several 2,4-pyrimidinediamine compounds were tested for the ability to inhibit Syk kinase catalyzed phosphorylation of a peptide substrate in a bioch...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2WW7GKQUS Patent
TargetTyrosine-protein kinase SYK(Homo sapiens (Human))
Rigel Pharmaceuticals, Inc.

US Patent
LigandPNGBDBM255516(N2-[3-(1-Bis(N-methylaminocarbonyl)ethoxy)phenyl]-...)copy SMILEScopy InChI
Affinity DataIC50: 266nMpH: 7.4 T: 2°CAssay Description:Several 2,4-pyrimidinediamine compounds were tested for the ability to inhibit Syk kinase catalyzed phosphorylation of a peptide substrate in a bioch...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2WW7GKQUS Patent
TargetTyrosine-protein kinase SYK(Homo sapiens (Human))
Rigel Pharmaceuticals, Inc.

US Patent
LigandPNGBDBM255517(N2,N4-Bis(3-aminophenyl)-5-fluoro-2,4-pyrimidinedi...)copy SMILEScopy InChI
Affinity DataIC50: 268nMpH: 7.4 T: 2°CAssay Description:Several 2,4-pyrimidinediamine compounds were tested for the ability to inhibit Syk kinase catalyzed phosphorylation of a peptide substrate in a bioch...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2WW7GKQUS Patent
TargetTyrosine-protein kinase SYK(Homo sapiens (Human))
Rigel Pharmaceuticals, Inc.

US Patent
LigandPNGBDBM255504(US10828301, Compound R926834 | US9499493, R926834)copy SMILEScopy InChI
Affinity DataIC50: 292nMpH: 7.4 T: 2°CAssay Description:Several 2,4-pyrimidinediamine compounds were tested for the ability to inhibit Syk kinase catalyzed phosphorylation of a peptide substrate in a bioch...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2WW7GKQUS Patent
TargetTyrosine-protein kinase SYK(Homo sapiens (Human))
Rigel Pharmaceuticals, Inc.

US Patent
LigandPNGBDBM255500(US9499493, R945144)copy SMILEScopy InChI
Affinity DataIC50: 383nMpH: 7.4 T: 2°CAssay Description:Several 2,4-pyrimidinediamine compounds were tested for the ability to inhibit Syk kinase catalyzed phosphorylation of a peptide substrate in a bioch...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2WW7GKQUS Patent
TargetTyrosine-protein kinase SYK(Homo sapiens (Human))
Rigel Pharmaceuticals, Inc.

US Patent
LigandPNGBDBM255484(US10828301, Compound R926813 | US9499493, R926813)copy SMILEScopy InChI
Affinity DataIC50: 405nMpH: 7.4 T: 2°CAssay Description:Several 2,4-pyrimidinediamine compounds were tested for the ability to inhibit Syk kinase catalyzed phosphorylation of a peptide substrate in a bioch...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2WW7GKQUS Patent
TargetTyrosine-protein kinase SYK(Homo sapiens (Human))
Rigel Pharmaceuticals, Inc.

US Patent
LigandPNGBDBM50068779(CHEMBL3402397 | US10828301, Compound R945071 | US9...)copy SMILEScopy InChI
Affinity DataIC50: 430nMpH: 7.4 T: 2°CAssay Description:Several 2,4-pyrimidinediamine compounds were tested for the ability to inhibit Syk kinase catalyzed phosphorylation of a peptide substrate in a bioch...More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2WW7GKQUS Patent
TargetTyrosine-protein kinase SYK(Homo sapiens (Human))
Rigel Pharmaceuticals, Inc.

US Patent
LigandPNGBDBM255520(5-Fluoro-N4-(3-hydroxyphenyl)-N2-[4-methyl-3-[(N-m...)copy SMILEScopy InChI
Affinity DataIC50: 510nMpH: 7.4 T: 2°CAssay Description:Several 2,4-pyrimidinediamine compounds were tested for the ability to inhibit Syk kinase catalyzed phosphorylation of a peptide substrate in a bioch...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2WW7GKQUS Patent
TargetTyrosine-protein kinase SYK(Homo sapiens (Human))
Rigel Pharmaceuticals, Inc.

US Patent
LigandPNGBDBM255480(US10828301, Compound R926715 | US9499493, R926715)copy SMILEScopy InChI
Affinity DataIC50: 534nMpH: 7.4 T: 2°CAssay Description:Several 2,4-pyrimidinediamine compounds were tested for the ability to inhibit Syk kinase catalyzed phosphorylation of a peptide substrate in a bioch...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2WW7GKQUS Patent
TargetTyrosine-protein kinase SYK(Homo sapiens (Human))
Rigel Pharmaceuticals, Inc.

US Patent
LigandPNGBDBM255498(US10828301, Compound R945140 | US9499493, R945140)copy SMILEScopy InChI
Affinity DataIC50: 611nMpH: 7.4 T: 2°CAssay Description:Several 2,4-pyrimidinediamine compounds were tested for the ability to inhibit Syk kinase catalyzed phosphorylation of a peptide substrate in a bioch...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2WW7GKQUS Patent
TargetTyrosine-protein kinase SYK(Homo sapiens (Human))
Rigel Pharmaceuticals, Inc.

US Patent
LigandPNGBDBM255493(US10828301, Compound R940269 | US9499493, R940269)copy SMILEScopy InChI
Affinity DataIC50: 685nMpH: 7.4 T: 2°CAssay Description:Several 2,4-pyrimidinediamine compounds were tested for the ability to inhibit Syk kinase catalyzed phosphorylation of a peptide substrate in a bioch...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2WW7GKQUS Patent
TargetTyrosine-protein kinase SYK(Homo sapiens (Human))
Rigel Pharmaceuticals, Inc.

US Patent
LigandPNGBDBM255494(US9499493, R940275)copy SMILEScopy InChI
Affinity DataIC50: 734nMpH: 7.4 T: 2°CAssay Description:Several 2,4-pyrimidinediamine compounds were tested for the ability to inhibit Syk kinase catalyzed phosphorylation of a peptide substrate in a bioch...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2WW7GKQUS Patent
TargetTyrosine-protein kinase SYK(Homo sapiens (Human))
Rigel Pharmaceuticals, Inc.

US Patent
LigandPNGBDBM255491(US10828301, Compound R940256 | US9499493, R940255 ...)copy SMILEScopy InChI
Affinity DataIC50: 771nMpH: 7.4 T: 2°CAssay Description:Several 2,4-pyrimidinediamine compounds were tested for the ability to inhibit Syk kinase catalyzed phosphorylation of a peptide substrate in a bioch...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2WW7GKQUS Patent
TargetTyrosine-protein kinase SYK(Homo sapiens (Human))
Rigel Pharmaceuticals, Inc.

US Patent
LigandPNGBDBM255479(US10828301, Compound R926594 | US9499493, R926594)copy SMILEScopy InChI
Affinity DataIC50: 771nMpH: 7.4 T: 2°CAssay Description:Several 2,4-pyrimidinediamine compounds were tested for the ability to inhibit Syk kinase catalyzed phosphorylation of a peptide substrate in a bioch...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2WW7GKQUS Patent
TargetTyrosine-protein kinase SYK(Homo sapiens (Human))
Rigel Pharmaceuticals, Inc.

US Patent
LigandPNGBDBM255499(US10828301, Compound R945142 | US9499493, R945142)copy SMILEScopy InChI
Affinity DataIC50: 2.01E+3nMpH: 7.4 T: 2°CAssay Description:Several 2,4-pyrimidinediamine compounds were tested for the ability to inhibit Syk kinase catalyzed phosphorylation of a peptide substrate in a bioch...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2WW7GKQUS Patent
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