Compile Data Set for Download or QSAR
Found 10 Enz. Inhib. hit(s) with Target = '11-beta-hydroxysteroid dehydrogenase 1' and Ligand = 'BDBM50117901'
Target11-beta-hydroxysteroid dehydrogenase 1(Homo sapiens (Human))
Shanghai Pharmaceutical Holding Co. Ltd

Curated by ChEMBL
LigandPNGBDBM50117901(2-(2-(3-chloro-2-methylphenylsulfonamido)thiazol-4...)copy SMILEScopy InChI
Affinity DataIC50: 28.4nMAssay Description:Inhibition of human 11beta HSD1 expressed in HEK293 cells assessed as assessed as inhibition of [1,2-(n)3H]cortisone to [3H]-cortisol after 60 mins b...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q27H1K0CPubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Homo sapiens (Human))
Shanghai Pharmaceutical Holding Co. Ltd

Curated by ChEMBL
LigandPNGBDBM50117901(2-(2-(3-chloro-2-methylphenylsulfonamido)thiazol-4...)copy SMILEScopy InChI
Affinity DataIC50: 52nMAssay Description:Inhibition of human 11beta-HSD1More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q280546BPubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Homo sapiens (Human))
Shanghai Pharmaceutical Holding Co. Ltd

Curated by ChEMBL
LigandPNGBDBM50117901(2-(2-(3-chloro-2-methylphenylsulfonamido)thiazol-4...)copy SMILEScopy InChI
Affinity DataIC50: 52nMAssay Description:In vitro inhibitory activity against human 11 beta hydroxysteroid dehydrogenase type 1 using scintillation proximity assay (SPA)More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2S46SPWPubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Homo sapiens (Human))
Shanghai Pharmaceutical Holding Co. Ltd

Curated by ChEMBL
LigandPNGBDBM50117901(2-(2-(3-chloro-2-methylphenylsulfonamido)thiazol-4...)copy SMILEScopy InChI
Affinity DataIC50: 52nMAssay Description:Displacement of [3H]cortisone from human 11beta-HSD1 expressed in baculovirus-infected Sf9 cells after 1 hr by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2NV9JC3PubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Homo sapiens (Human))
Shanghai Pharmaceutical Holding Co. Ltd

Curated by ChEMBL
LigandPNGBDBM50117901(2-(2-(3-chloro-2-methylphenylsulfonamido)thiazol-4...)copy SMILEScopy InChI
Affinity DataIC50: 52nMAssay Description:Inhibition of human 11betaHSD1 by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2K938NZPubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Mus musculus (mouse))
AstraZeneca

Curated by ChEMBL
LigandPNGBDBM50117901(2-(2-(3-chloro-2-methylphenylsulfonamido)thiazol-4...)copy SMILEScopy InChI
Affinity DataIC50: 284nMAssay Description:Inhibition of mouse 11beta-HSD1More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q280546BPubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Mus musculus (mouse))
AstraZeneca

Curated by ChEMBL
LigandPNGBDBM50117901(2-(2-(3-chloro-2-methylphenylsulfonamido)thiazol-4...)copy SMILEScopy InChI
Affinity DataIC50: 284nMAssay Description:In vitro inhibitory activity against mouse 11 beta hydroxysteroid dehydrogenase type 1 using scintillation proximity assay (SPA).More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2S46SPWPubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Homo sapiens (Human))
Shanghai Pharmaceutical Holding Co. Ltd

Curated by ChEMBL
LigandPNGBDBM50117901(2-(2-(3-chloro-2-methylphenylsulfonamido)thiazol-4...)copy SMILEScopy InChI
Affinity DataIC50: 1.50E+3nMAssay Description:Inhibition of human 11beta-HSD1 expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q24M95CGPubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Homo sapiens (Human))
Shanghai Pharmaceutical Holding Co. Ltd

Curated by ChEMBL
LigandPNGBDBM50117901(2-(2-(3-chloro-2-methylphenylsulfonamido)thiazol-4...)copy SMILEScopy InChI
Affinity DataIC50: 1.50E+3nMAssay Description:Inhibitory concentration against human 11-beta-hydroxysteroid dehydrogenase 1More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2TB16DRPubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Homo sapiens (Human))
Shanghai Pharmaceutical Holding Co. Ltd

Curated by ChEMBL
LigandPNGBDBM50117901(2-(2-(3-chloro-2-methylphenylsulfonamido)thiazol-4...)copy SMILEScopy InChI
Affinity DataIC50: 1.00E+4nMAssay Description:Ability to convert [3H]cortisol to the tritium labeled cortisone in the presence of human 11 beta hydroxysteroid dehydrogenase type 2More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2S46SPWPubMed