Found 18 Enz. Inhib. hit(s) with Target = '11-beta-hydroxysteroid dehydrogenase 1' and Ligand = 'BDBM50233538' Target11-beta-hydroxysteroid dehydrogenase 1(Mus musculus (mouse))
Chinese Academy of Sciences
Curated by ChEMBL
Chinese Academy of Sciences
Curated by ChEMBL
Affinity DataIC50: 2nMAssay Description:Inhibition of mouse 11beta-HSD1 expressed in HEK293 cell microsomes assessed as inhibition of [3H]cortisone conversion to [3H]cortisol by scintillati...More data for this Ligand-Target Pair
Target11-beta-hydroxysteroid dehydrogenase 1(Mus musculus (mouse))
Chinese Academy of Sciences
Curated by ChEMBL
Chinese Academy of Sciences
Curated by ChEMBL
Affinity DataIC50: 5nMAssay Description:Inhibition of mouse 11beta-HSD1 expressed in HEK293 cells assessed as conversion of [3H]cortisone to [3H]cortisol by scintillation proximity assay in...More data for this Ligand-Target Pair
Target11-beta-hydroxysteroid dehydrogenase 1(Mus musculus (mouse))
Chinese Academy of Sciences
Curated by ChEMBL
Chinese Academy of Sciences
Curated by ChEMBL
Affinity DataIC50: 7.40nMAssay Description:Inhibition of full-length mouse 11beta-HSD1 expressed in HEK293 microsomal fraction using [3H]cortisone as substrate after 1 hr by scintillation prox...More data for this Ligand-Target Pair
Target11-beta-hydroxysteroid dehydrogenase 1(Homo sapiens (Human))
Shanghai Pharmaceutical Holding Co. Ltd
Curated by ChEMBL
Shanghai Pharmaceutical Holding Co. Ltd
Curated by ChEMBL
Affinity DataIC50: 8.60nMAssay Description:Inhibition of human 11beta HSD1 expressed in HEK293 cells assessed as assessed as inhibition of [1,2-(n)3H]cortisone to [3H]-cortisol after 60 mins b...More data for this Ligand-Target Pair
Target11-beta-hydroxysteroid dehydrogenase 1(Homo sapiens (Human))
Shanghai Pharmaceutical Holding Co. Ltd
Curated by ChEMBL
Shanghai Pharmaceutical Holding Co. Ltd
Curated by ChEMBL
Affinity DataIC50: 8.80nMAssay Description:Inhibition of human microsomal 11beta-HSD1 overexpressed in HEK293 cells using [3H]-cortisone as substrate assessed as formation of [3H]-cortisol usi...More data for this Ligand-Target Pair
Target11-beta-hydroxysteroid dehydrogenase 1(Mus musculus (mouse))
Chinese Academy of Sciences
Curated by ChEMBL
Chinese Academy of Sciences
Curated by ChEMBL
Affinity DataIC50: 9.40nMAssay Description:Inhibition of mouse microsomal 11beta-HSD1 overexpressed in HEK293 cells using [3H]-cortisone as substrate assessed as formation of [3H]-cortisol usi...More data for this Ligand-Target Pair
Target11-beta-hydroxysteroid dehydrogenase 1(Mus musculus (mouse))
Chinese Academy of Sciences
Curated by ChEMBL
Chinese Academy of Sciences
Curated by ChEMBL
Affinity DataIC50: 10.6nMAssay Description:Inhibition of mouse 11beta-HSD1More data for this Ligand-Target Pair
Target11-beta-hydroxysteroid dehydrogenase 1(Homo sapiens (Human))
Shanghai Pharmaceutical Holding Co. Ltd
Curated by ChEMBL
Shanghai Pharmaceutical Holding Co. Ltd
Curated by ChEMBL
Affinity DataIC50: 11nMAssay Description:Inhibition of full-length human 11beta-HSD1 expressed in HEK293 microsomal fraction using [3H]cortisone as substrate after 2 hr by scintillation prox...More data for this Ligand-Target Pair
Target11-beta-hydroxysteroid dehydrogenase 1(Homo sapiens (Human))
Shanghai Pharmaceutical Holding Co. Ltd
Curated by ChEMBL
Shanghai Pharmaceutical Holding Co. Ltd
Curated by ChEMBL
Affinity DataIC50: 11.8nMAssay Description:Inhibition of human 11beta-HSD1More data for this Ligand-Target Pair
Target11-beta-hydroxysteroid dehydrogenase 1(Homo sapiens (Human))
Shanghai Pharmaceutical Holding Co. Ltd
Curated by ChEMBL
Shanghai Pharmaceutical Holding Co. Ltd
Curated by ChEMBL
Affinity DataIC50: 13nMAssay Description:Inhibition of human 11beta-HSD1 expressed in HEK293 cells assessed as conversion of [3H]cortisone to [3H]cortisol by scintillation proximity assay in...More data for this Ligand-Target Pair
Target11-beta-hydroxysteroid dehydrogenase 1(Homo sapiens (Human))
Shanghai Pharmaceutical Holding Co. Ltd
Curated by ChEMBL
Shanghai Pharmaceutical Holding Co. Ltd
Curated by ChEMBL
Affinity DataIC50: 29nMAssay Description:Inhibition of human 11beta-HSD1 overexpressed in microsomal fraction of HEK293 cells assessed as formation of [3H]-cortisol from [3H]-cortisone by sc...More data for this Ligand-Target Pair
Target11-beta-hydroxysteroid dehydrogenase 1(Homo sapiens (Human))
Shanghai Pharmaceutical Holding Co. Ltd
Curated by ChEMBL
Shanghai Pharmaceutical Holding Co. Ltd
Curated by ChEMBL
Affinity DataIC50: 29nMAssay Description:Inhibition of human 11beta-HSD1 expressed in HEK293 cell microsomes assessed as inhibition of [3H]cortisone conversion to [3H]cortisol by scintillati...More data for this Ligand-Target Pair
Target11-beta-hydroxysteroid dehydrogenase 1(Mus musculus (mouse))
Chinese Academy of Sciences
Curated by ChEMBL
Chinese Academy of Sciences
Curated by ChEMBL
Affinity DataIC50: 40nMAssay Description:Inhibition of mouse 11beta-HSD1 overexpressed in microsomal fraction of HEK293 cells assessed as formation of [3H]-cortisol from [3H]-cortisone by sc...More data for this Ligand-Target Pair
Target11-beta-hydroxysteroid dehydrogenase 1(Rattus norvegicus (rat))
Vienna University of Technology
Curated by ChEMBL
Vienna University of Technology
Curated by ChEMBL
Affinity DataIC50: 90nMAssay Description:Inhibition of 11beta-HSD1 in rat liver assessed as cortisone levelMore data for this Ligand-Target Pair
Target11-beta-hydroxysteroid dehydrogenase 1(Rattus norvegicus (rat))
Vienna University of Technology
Curated by ChEMBL
Vienna University of Technology
Curated by ChEMBL
Affinity DataIC50: 90nMAssay Description:Inhibition of rat hepatic 11beta-HSD1More data for this Ligand-Target Pair
Target11-beta-hydroxysteroid dehydrogenase 1(Homo sapiens (Human))
Shanghai Pharmaceutical Holding Co. Ltd
Curated by ChEMBL
Shanghai Pharmaceutical Holding Co. Ltd
Curated by ChEMBL
Affinity DataIC50: 778nMAssay Description:Inhibition of human recombinant 11beta-HSD1 expressed in HEK293 cells assessed as conversion of [1,2-[3H]cortisone to cortisol after 10 mins by scint...More data for this Ligand-Target Pair
Target11-beta-hydroxysteroid dehydrogenase 1(Homo sapiens (Human))
Shanghai Pharmaceutical Holding Co. Ltd
Curated by ChEMBL
Shanghai Pharmaceutical Holding Co. Ltd
Curated by ChEMBL
Affinity DataIC50: 778nMAssay Description:Inhibition of human recombinant 11beta-HSD1 expressed in HEK293 cells assessed as conversion of [1,2-3H]-cortisone to cortisol by scintillation count...More data for this Ligand-Target Pair
Target11-beta-hydroxysteroid dehydrogenase 1(Homo sapiens (Human))
Shanghai Pharmaceutical Holding Co. Ltd
Curated by ChEMBL
Shanghai Pharmaceutical Holding Co. Ltd
Curated by ChEMBL
In DepthDetails
