Compile Data Set for Download or QSAR
Found 5 Enz. Inhib. hit(s) with Target = '11-beta-hydroxysteroid dehydrogenase 1' and Ligand = 'BDBM50334682'
Target11-beta-hydroxysteroid dehydrogenase 1(Homo sapiens (Human))
Amgen Inc

Curated by ChEMBL
LigandPNGBDBM50334682(((1R)-4-(N-cyclopropyl-4-((S)-1,1,1-trifluoro-2-hy...)copy SMILEScopy InChI
Affinity DataIC50: 3.5nMAssay Description:Inhibition of human full length 11beta-HSD1 assessed as inhibition of conversion of [3H]cortisone to [3H]cortisol by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2K937SBPubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Homo sapiens (Human))
Amgen Inc

Curated by ChEMBL
LigandPNGBDBM50334682(((1R)-4-(N-cyclopropyl-4-((S)-1,1,1-trifluoro-2-hy...)copy SMILEScopy InChI
Affinity DataIC50: 19nMAssay Description:Inhibition of human recombinant full length 11beta-HSD1 expressed in HEK293 cells assessed as inhibition of conversion of [3H]cortisone to [3H]cortis...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2K937SBPubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Homo sapiens (Human))
Amgen Inc

Curated by ChEMBL
LigandPNGBDBM50334682(((1R)-4-(N-cyclopropyl-4-((S)-1,1,1-trifluoro-2-hy...)copy SMILEScopy InChI
Affinity DataIC50: 25nMAssay Description:Inhibition of human recombinant full length 11beta-HSD1 expressed in human adipocytes assessed as inhibition of conversion of [3H]cortisone to [3H]co...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2K937SBPubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Homo sapiens (Human))
Amgen Inc

Curated by ChEMBL
LigandPNGBDBM50334682(((1R)-4-(N-cyclopropyl-4-((S)-1,1,1-trifluoro-2-hy...)copy SMILEScopy InChI
Affinity DataIC50: 74nMAssay Description:Inhibition of human recombinant full length 11beta-HSD1 expressed in HEK293 cells assessed as inhibition of conversion of [3H]cortisone to [3H]cortis...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2K937SBPubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Rattus norvegicus (rat))
Amgen Inc

Curated by ChEMBL
LigandPNGBDBM50334682(((1R)-4-(N-cyclopropyl-4-((S)-1,1,1-trifluoro-2-hy...)copy SMILEScopy InChI
Affinity DataIC50: 220nMAssay Description:Inhibition of rat 11beta-HSD1 assessed as inhibition of conversion of [3H]cortisone to [3H]cortisol by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2K937SBPubMed