Compile Data Set for Download or QSAR
Found 5 Enz. Inhib. hit(s) with Target = '11-beta-hydroxysteroid dehydrogenase 1' and Ligand = 'BDBM50340386'
Target11-beta-hydroxysteroid dehydrogenase 1(Rattus norvegicus (rat))
Merck& Co.

Curated by ChEMBL
LigandPNGBDBM50340386(3-(4-(ethylsulfonylmethyl)bicyclo[2.2.2]octan-1-yl...)copy SMILEScopy InChI
Affinity DataKi:  13nMAssay Description:Inhibition of rat 11beta-HSD1More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q29S1SDMPubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Mus musculus (mouse))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50340386(3-(4-(ethylsulfonylmethyl)bicyclo[2.2.2]octan-1-yl...)copy SMILEScopy InChI
Affinity DataIC50: 4nMAssay Description:Inhibition of mouse 11beta-HSD1 expressed in CHO-K1 cells assessed as conversion of [3H]-cortisone to [3H]-cortisol by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2QJ7HMKPubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Rattus norvegicus (rat))
Merck& Co.

Curated by ChEMBL
LigandPNGBDBM50340386(3-(4-(ethylsulfonylmethyl)bicyclo[2.2.2]octan-1-yl...)copy SMILEScopy InChI
Affinity DataIC50: 9.10nMAssay Description:Inhibition of rat 11beta-HSD1More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q29S1SDMPubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50340386(3-(4-(ethylsulfonylmethyl)bicyclo[2.2.2]octan-1-yl...)copy SMILEScopy InChI
Affinity DataIC50: 25nMAssay Description:Inhibition of human 11beta-HSD1 expressed in CHO-K1 cells assessed as conversion of [3H]-cortisone to [3H]-cortisol by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2QJ7HMKPubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50340386(3-(4-(ethylsulfonylmethyl)bicyclo[2.2.2]octan-1-yl...)copy SMILEScopy InChI
Affinity DataIC50: 4.00E+3nMAssay Description:Inhibition of human microsomal 11beta-HSD1 assessed as inhibition of conversion of radiolabeled cortisone to radiolabeled cortisol by cell-based assa...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q29S1SDMPubMed