Compile Data Set for Download or QSAR
Found 13 Enz. Inhib. hit(s) with Target = '11-beta-hydroxysteroid dehydrogenase 1' and Ligand = 'BDBM50353386'
Target11-beta-hydroxysteroid dehydrogenase 1(Homo sapiens (Human))
Vitae Pharmaceuticals, Inc.; Boehringer Ingelheim International GmbH

US Patent
LigandPNGBDBM50353386(CHEMBL1829763 | US8592410, 88 | US8592410, Compara...)copy SMILEScopy InChI
Affinity DataIC50: 0.75nMAssay Description:The inhibition of a microsomal preparation of 11β-HSD1 by compounds of the invention was measured essentially as previously described (K. Solly,...More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2CF9NRNUS Patent
Target11-beta-hydroxysteroid dehydrogenase 1(Homo sapiens (Human))
Vitae Pharmaceuticals, Inc.; Boehringer Ingelheim International GmbH

US Patent
LigandPNGBDBM50353386(CHEMBL1829763 | US8592410, 88 | US8592410, Compara...)copy SMILEScopy InChI
Affinity DataIC50: 0.75nMpH: 7.4Assay Description:The inhibition of a microsomal preparation of 11β-HSD1 by compounds of the invention was measured essentially as previously described (K. Solly,...More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q29K48WRUS Patent
Target11-beta-hydroxysteroid dehydrogenase 1(Homo sapiens (Human))
Vitae Pharmaceuticals, Inc.; Boehringer Ingelheim International GmbH

US Patent
LigandPNGBDBM50353386(CHEMBL1829763 | US8592410, 88 | US8592410, Compara...)copy SMILEScopy InChI
Affinity DataIC50: 0.75nMAssay Description:The inhibition of a microsomal preparation of 11β-HSD1 by compounds of the invention was measured essentially as previously described (K. Solly,...More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2416VPSUS Patent
Target11-beta-hydroxysteroid dehydrogenase 1(Homo sapiens (Human))
Vitae Pharmaceuticals, Inc.; Boehringer Ingelheim International GmbH

US Patent
LigandPNGBDBM50353386(CHEMBL1829763 | US8592410, 88 | US8592410, Compara...)copy SMILEScopy InChI
Affinity DataIC50: 0.800nMAssay Description:Inhibition of human 11 beta-HSD1 expressed in CHO cells assessed as conversion of [3H]cortisone to [3H]cortisol after 1 hr by scintillation proximity...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2P26ZH3PubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Homo sapiens (Human))
Vitae Pharmaceuticals, Inc.; Boehringer Ingelheim International GmbH

US Patent
LigandPNGBDBM50353386(CHEMBL1829763 | US8592410, 88 | US8592410, Compara...)copy SMILEScopy InChI
Affinity DataIC50: 0.800nMAssay Description:Inhibition of human 11beta-HSD1 expressed in CHO cell microsomes using [3H]cortisone as substrate preincubated with substrate for 10 mins followed by...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2KS6V0FPubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Homo sapiens (Human))
Vitae Pharmaceuticals, Inc.; Boehringer Ingelheim International GmbH

US Patent
LigandPNGBDBM50353386(CHEMBL1829763 | US8592410, 88 | US8592410, Compara...)copy SMILEScopy InChI
Affinity DataIC50: 0.800nMMore data for this Ligand-Target Pair
In DepthDetails
Target11-beta-hydroxysteroid dehydrogenase 1(Homo sapiens (Human))
Vitae Pharmaceuticals, Inc.; Boehringer Ingelheim International GmbH

US Patent
LigandPNGBDBM50353386(CHEMBL1829763 | US8592410, 88 | US8592410, Compara...)copy SMILEScopy InChI
Affinity DataIC50: 2.5nMAssay Description:Inhibition of 11beta-HSD1 in human omental adipocytes using [3H]cortisone as substrate preincubated for 1 hr followed by substrate addition measured ...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2KS6V0FPubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Homo sapiens (Human))
Vitae Pharmaceuticals, Inc.; Boehringer Ingelheim International GmbH

US Patent
LigandPNGBDBM50353386(CHEMBL1829763 | US8592410, 88 | US8592410, Compara...)copy SMILEScopy InChI
Affinity DataIC50: 2.5nMAssay Description:Inhibition of 11 beta-HSD1 in differentiated human adipocytes assessed as conversion of [3H]-cortisone to [3H]-cortisol after 10 mins by HPLCMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2P26ZH3PubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Homo sapiens (Human))
Vitae Pharmaceuticals, Inc.; Boehringer Ingelheim International GmbH

US Patent
LigandPNGBDBM50353386(CHEMBL1829763 | US8592410, 88 | US8592410, Compara...)copy SMILEScopy InChI
Affinity DataIC50: 17.7nMpH: 7.4Assay Description:The inhibition of a microsomal preparation of 11β-HSD1 by compounds of the invention was measured essentially as previously described (K. Solly,...More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q29K48WRUS Patent
Target11-beta-hydroxysteroid dehydrogenase 1(Homo sapiens (Human))
Vitae Pharmaceuticals, Inc.; Boehringer Ingelheim International GmbH

US Patent
LigandPNGBDBM50353386(CHEMBL1829763 | US8592410, 88 | US8592410, Compara...)copy SMILEScopy InChI
Affinity DataIC50: 17.7nMAssay Description:The inhibition assay using 11β-HSD1.More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2CF9NRNUS Patent
Target11-beta-hydroxysteroid dehydrogenase 1(Homo sapiens (Human))
Vitae Pharmaceuticals, Inc.; Boehringer Ingelheim International GmbH

US Patent
LigandPNGBDBM50353386(CHEMBL1829763 | US8592410, 88 | US8592410, Compara...)copy SMILEScopy InChI
Affinity DataIC50: 17.7nMAssay Description:Inhibition assay using 11β-HSD1 in the presence of 50% human plasma. More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2416VPSUS Patent
Target11-beta-hydroxysteroid dehydrogenase 1(Homo sapiens (Human))
Vitae Pharmaceuticals, Inc.; Boehringer Ingelheim International GmbH

US Patent
LigandPNGBDBM50353386(CHEMBL1829763 | US8592410, 88 | US8592410, Compara...)copy SMILEScopy InChI
Affinity DataIC50: 18nMAssay Description:Inhibition of human 11 beta-HSD1 expressed in CHO cells assessed as conversion of [3H]-cortisone to [3H]-cortisol after 1 hr by scintillation proximi...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2P26ZH3PubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Mus musculus (mouse))
Vitae Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50353386(CHEMBL1829763 | US8592410, 88 | US8592410, Compara...)copy SMILEScopy InChI
Affinity DataIC50: 670nMAssay Description:Inhibition of mouse 11 beta-HSD1More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2P26ZH3PubMed