BindingDB PrimarySearch

Found 2 Enz. Inhib. hit(s) with Target = '3-hydroxy-3-methylglutaryl-coenzyme A reductase' and Ligand = 'BDBM18374'

3-hydroxy-3-methylglutaryl-coenzyme A reductase(Homo sapiens (Human))
Pfizer Global Research & Development

Curated by ChEMBL

BDBM18374(CHEMBL394937 | Pyrrole-based compound, 30 | sodium...)copy SMILEScopy InChI

IC50: 1.80nMAssay Description:Inhibition of HMG-CoA reductaseMore data for this Ligand-Target Pair

PDB
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar

CHEMBL KEGG PC cid PC sid Patents Similars

Details Article
BindingDB Entry DOI: 10.7270/Q2SJ1K9QPubMed

3-hydroxy-3-methylglutaryl-coenzyme A reductase(Rattus norvegicus (rat))
Pfizer

BDBM18374(CHEMBL394937 | Pyrrole-based compound, 30 | sodium...)copy SMILEScopy InChI

IC50: 12nMpH: 7.2 T: 2°CAssay Description:Assay for HMG-CoA reductase was based on the conversion of isotopically labeled HMG-CoA to mevalonic acid using rat liver microsomes as enzyme source...More data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD GoogleScholar

CHEMBL KEGG PC cid PC sid Patents Similars

Details Article
BindingDB Entry DOI: 10.7270/Q23J3B7GPubMed