Compile Data Set for Download or QSAR
Found 18 Enz. Inhib. hit(s) with Target = '72 kDa type IV collagenase' and Ligand = 'BDBM50062351'
Target72 kDa type IV collagenase(Homo sapiens (Human))
Glycomed, Inc.

Curated by ChEMBL
LigandPNGBDBM50062351((R)-N*4*-Hydroxy-N*1*-[(S)-2-(1H-indol-3-yl)-1-met...)copy SMILEScopy InChI
Affinity DataKi:  0.390nMAssay Description:Binding affinity towards 72 kDa gelatinase (Matrix metalloproteinase-2)More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2Q52NRBPubMed
Target72 kDa type IV collagenase(Homo sapiens (Human))
Glycomed, Inc.

Curated by ChEMBL
LigandPNGBDBM50062351((R)-N*4*-Hydroxy-N*1*-[(S)-2-(1H-indol-3-yl)-1-met...)copy SMILEScopy InChI
Affinity DataKi:  0.390nMMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2GB281XPubMed
Target72 kDa type IV collagenase(Homo sapiens (Human))
Glycomed, Inc.

Curated by ChEMBL
LigandPNGBDBM50062351((R)-N*4*-Hydroxy-N*1*-[(S)-2-(1H-indol-3-yl)-1-met...)copy SMILEScopy InChI
Affinity DataKi:  0.570nMAssay Description:Inhibition of Matrix metalloproteinase-2More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2610ZK1PubMed
Target72 kDa type IV collagenase(Homo sapiens (Human))
Glycomed, Inc.

Curated by ChEMBL
LigandPNGBDBM50062351((R)-N*4*-Hydroxy-N*1*-[(S)-2-(1H-indol-3-yl)-1-met...)copy SMILEScopy InChI
Affinity DataIC50: 0.104nMAssay Description:Inhibition of human matrix metalloproteinase-2More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2PN952RPubMed
Target72 kDa type IV collagenase(Homo sapiens (Human))
Glycomed, Inc.

Curated by ChEMBL
LigandPNGBDBM50062351((R)-N*4*-Hydroxy-N*1*-[(S)-2-(1H-indol-3-yl)-1-met...)copy SMILEScopy InChI
Affinity DataIC50: 0.190nMMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2KD231GPubMed
Target72 kDa type IV collagenase(Homo sapiens (Human))
Glycomed, Inc.

Curated by ChEMBL
LigandPNGBDBM50062351((R)-N*4*-Hydroxy-N*1*-[(S)-2-(1H-indol-3-yl)-1-met...)copy SMILEScopy InChI
Affinity DataIC50: 0.390nMMore data for this Ligand-Target Pair
In DepthDetails
Target72 kDa type IV collagenase(Homo sapiens (Human))
Glycomed, Inc.

Curated by ChEMBL
LigandPNGBDBM50062351((R)-N*4*-Hydroxy-N*1*-[(S)-2-(1H-indol-3-yl)-1-met...)copy SMILEScopy InChI
Affinity DataIC50: 0.400nMAssay Description:Inhibition of Matrix metalloproteinase-2More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2WH2PCTPubMed
Target72 kDa type IV collagenase(Homo sapiens (Human))
Glycomed, Inc.

Curated by ChEMBL
LigandPNGBDBM50062351((R)-N*4*-Hydroxy-N*1*-[(S)-2-(1H-indol-3-yl)-1-met...)copy SMILEScopy InChI
Affinity DataIC50: 0.400nMAssay Description:Inhibition of human recombinant pro-MMP2 by spectrofluorimeterMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2R49QM0PubMed
Target72 kDa type IV collagenase(Homo sapiens (Human))
Glycomed, Inc.

Curated by ChEMBL
LigandPNGBDBM50062351((R)-N*4*-Hydroxy-N*1*-[(S)-2-(1H-indol-3-yl)-1-met...)copy SMILEScopy InChI
Affinity DataIC50: 0.422nMAssay Description:Inhibition of human MMP-2 by fluorometric assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2Q81HPFPubMed
Target72 kDa type IV collagenase(Homo sapiens (Human))
Glycomed, Inc.

Curated by ChEMBL
LigandPNGBDBM50062351((R)-N*4*-Hydroxy-N*1*-[(S)-2-(1H-indol-3-yl)-1-met...)copy SMILEScopy InChI
Affinity DataIC50: 0.940nMAssay Description:Inhibition of human recombinant MMP2 using Mca-Pro-Leu-Gly-Leu-Dpa-Ala-Arg-NH2 as substrate preincubated for 60 mins followed by substrate addition b...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2MW2K1DPubMed
Target72 kDa type IV collagenase(Homo sapiens (Human))
Glycomed, Inc.

Curated by ChEMBL
LigandPNGBDBM50062351((R)-N*4*-Hydroxy-N*1*-[(S)-2-(1H-indol-3-yl)-1-met...)copy SMILEScopy InChI
Affinity DataIC50: 1nMpH: 7.5 T: 2°CAssay Description:Stock solution of substrate (Mca-Lys-Pro-Leu-Gly-Leu-Dpa-Ala-Arg-NH2) was prepared in DMSO at a concentration of 6 mM. Assays were performed in an as...More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2W094VZUS Patent
Target72 kDa type IV collagenase(Homo sapiens (Human))
Glycomed, Inc.

Curated by ChEMBL
LigandPNGBDBM50062351((R)-N*4*-Hydroxy-N*1*-[(S)-2-(1H-indol-3-yl)-1-met...)copy SMILEScopy InChI
Affinity DataIC50: 1.10nMAssay Description:Inhibition of MMP2More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2Q23ZXNPubMed
Target72 kDa type IV collagenase(Homo sapiens (Human))
Glycomed, Inc.

Curated by ChEMBL
LigandPNGBDBM50062351((R)-N*4*-Hydroxy-N*1*-[(S)-2-(1H-indol-3-yl)-1-met...)copy SMILEScopy InChI
Affinity DataIC50: 1.10nMAssay Description:Activity against Matrix metalloproteinase-2 (MMP-2).More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2SQ8ZHBPubMed
Target72 kDa type IV collagenase(Homo sapiens (Human))
Glycomed, Inc.

Curated by ChEMBL
LigandPNGBDBM50062351((R)-N*4*-Hydroxy-N*1*-[(S)-2-(1H-indol-3-yl)-1-met...)copy SMILEScopy InChI
Affinity DataIC50: 1.10nMMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2GB281XPubMed
Target72 kDa type IV collagenase(Homo sapiens (Human))
Glycomed, Inc.

Curated by ChEMBL
LigandPNGBDBM50062351((R)-N*4*-Hydroxy-N*1*-[(S)-2-(1H-indol-3-yl)-1-met...)copy SMILEScopy InChI
Affinity DataIC50: 7nMAssay Description:Inhibitory activity against MMP2More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2WQ03C3PubMed
Target72 kDa type IV collagenase(Homo sapiens (Human))
Glycomed, Inc.

Curated by ChEMBL
LigandPNGBDBM50062351((R)-N*4*-Hydroxy-N*1*-[(S)-2-(1H-indol-3-yl)-1-met...)copy SMILEScopy InChI
Affinity DataIC50: 7nMAssay Description:Inhibition of matrix metalloproteinase-2 (MMP-2)More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q22J6B79PubMed
Target72 kDa type IV collagenase(Homo sapiens (Human))
Glycomed, Inc.

Curated by ChEMBL
LigandPNGBDBM50062351((R)-N*4*-Hydroxy-N*1*-[(S)-2-(1H-indol-3-yl)-1-met...)copy SMILEScopy InChI
Affinity DataIC50: 10nMAssay Description:Inhibition of human recombinant MMP2 using Mca-Lys-Pro- Leu-Gly-Leu-Dap(Dnp)-Ala-Arg-NH2 as substrate incubated for 2 hrs prior to substrate addition...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q20C4X4WPubMed
Target72 kDa type IV collagenase(Homo sapiens (Human))
Glycomed, Inc.

Curated by ChEMBL
LigandPNGBDBM50062351((R)-N*4*-Hydroxy-N*1*-[(S)-2-(1H-indol-3-yl)-1-met...)copy SMILEScopy InChI
Affinity DataIC50: 10nMAssay Description:Inhibition of MMP2More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2Z89C58PubMed