Found 57 Enz. Inhib. hit(s) with Target = 'ATP-dependent translocase ABCB1' and Ligand = 'BDBM50022815' TargetATP-dependent translocase ABCB1(Homo sapiens (Human))
University of North Carolina
Curated by ChEMBL
University of North Carolina
Curated by ChEMBL
Affinity DataKi: 20nMAssay Description:TP_TRANSPORTER: inhibition of Verapamil stimulated ATP hydrolysis in membranes from MDR1-expressing Sf9 cellsMore data for this Ligand-Target Pair
TargetATP-dependent translocase ABCB1(Homo sapiens (Human))
University of North Carolina
Curated by ChEMBL
University of North Carolina
Curated by ChEMBL
Affinity DataKi: 350nMAssay Description:TP_TRANSPORTER: transepithelial transport of digoxin (basal to apical) in Caco-2 cellsMore data for this Ligand-Target Pair
TargetATP-dependent translocase ABCB1(Homo sapiens (Human))
University of North Carolina
Curated by ChEMBL
University of North Carolina
Curated by ChEMBL
Affinity DataKi: 1.30E+3nMAssay Description:TP_TRANSPORTER: increase in Vinblastine intracellular accumulation in MDR1-expressing LLC-PK1 cellsMore data for this Ligand-Target Pair
TargetATP-dependent translocase ABCB1(Homo sapiens (Human))
University of North Carolina
Curated by ChEMBL
University of North Carolina
Curated by ChEMBL
Affinity DataKi: 1.80E+3nMAssay Description:TP_TRANSPORTER: inhibition of Calcein-AM efflux in CEM/VLB100 cellsMore data for this Ligand-Target Pair
TargetATP-dependent translocase ABCB1(Homo sapiens (Human))
University of North Carolina
Curated by ChEMBL
University of North Carolina
Curated by ChEMBL
Affinity DataKi: 2.18E+3nMAssay Description:TP_TRANSPORTER: inhibition of Digoxin transepithelial transport (basal to apical) in MDR1-expressing MDCK cellsMore data for this Ligand-Target Pair
TargetATP-dependent translocase ABCB1(Mus musculus)
St. Jude Children's Research Hospital
Curated by ChEMBL
St. Jude Children's Research Hospital
Curated by ChEMBL
Affinity DataKi: 3.50E+3nMAssay Description:TP_TRANSPORTER: increase in Calcein-AM intracellular accumulation in mdr1b-expressing LLC-PK1 cellsMore data for this Ligand-Target Pair
TargetATP-dependent translocase ABCB1(Mus musculus (Mouse))
St. Jude Children's Research Hospital
Curated by ChEMBL
St. Jude Children's Research Hospital
Curated by ChEMBL
Affinity DataKi: 3.65E+3nMAssay Description:TP_TRANSPORTER: increase in Calcein-AM intracellular accumulation in mdr1a-expressing LLC-PK1 cellsMore data for this Ligand-Target Pair
TargetATP-dependent translocase ABCB1(Homo sapiens (Human))
University of North Carolina
Curated by ChEMBL
University of North Carolina
Curated by ChEMBL
Affinity DataKi: 4.66E+3nMAssay Description:TP_TRANSPORTER: increase in Calcein-AM intracellular accumulation in MDR1-expressing LLC-PK1 cellsMore data for this Ligand-Target Pair
TargetATP-dependent translocase ABCB1(Homo sapiens (Human))
University of North Carolina
Curated by ChEMBL
University of North Carolina
Curated by ChEMBL
Affinity DataIC50: 102nMAssay Description:Inhibition of P-glycoprotein-mediated daunorubicin efflux from human CCRF-CEM/VCR1000 cells after 240 secs by FACS flow cytometric analysisMore data for this Ligand-Target Pair
TargetATP-dependent translocase ABCB1(Homo sapiens (Human))
University of North Carolina
Curated by ChEMBL
University of North Carolina
Curated by ChEMBL
Affinity DataIC50: 141nMAssay Description:Inhibition of paclitaxel stimulated- P-gp ATPase activity (unknown origin)More data for this Ligand-Target Pair
TargetATP-dependent translocase ABCB1(Homo sapiens (Human))
University of North Carolina
Curated by ChEMBL
University of North Carolina
Curated by ChEMBL
Affinity DataIC50: 440nMAssay Description:Inhibition of Pgp by daunorubicin accumulation assayMore data for this Ligand-Target Pair
TargetATP-dependent translocase ABCB1(Homo sapiens (Human))
University of North Carolina
Curated by ChEMBL
University of North Carolina
Curated by ChEMBL
Affinity DataIC50: 500nMAssay Description:Inhibition of P-glycoprotein using calcein-AM assay transfected in porcine PBCECMore data for this Ligand-Target Pair
TargetATP-dependent translocase ABCB1(Homo sapiens (Human))
University of North Carolina
Curated by ChEMBL
University of North Carolina
Curated by ChEMBL
Affinity DataIC50: 650nMAssay Description:Inhibition of human ABCB1-mediated rhodamine 123 efflux in mouse L5178 cells expressing human MDR1 after 20 mins by FACS analysisMore data for this Ligand-Target Pair
TargetATP-dependent translocase ABCB1(Homo sapiens (Human))
University of North Carolina
Curated by ChEMBL
University of North Carolina
Curated by ChEMBL
Affinity DataIC50: 670nMAssay Description:Inhibition of human MDR1 expressed in mouse L5178 cells assessed as increase in intracellular accumulation of rhodamine 123 by FACSCalibur flow cytom...More data for this Ligand-Target Pair
TargetATP-dependent translocase ABCB1(Homo sapiens (Human))
University of North Carolina
Curated by ChEMBL
University of North Carolina
Curated by ChEMBL
Affinity DataIC50: 676nMAssay Description:Inhibition of ABCB1 in human A2780/ADR cells preincubated for 30 mins followed by calcein AM addition and measured at 60 secs time interval by fluore...More data for this Ligand-Target Pair
TargetATP-dependent translocase ABCB1(Mus musculus)
St. Jude Children's Research Hospital
Curated by ChEMBL
St. Jude Children's Research Hospital
Curated by ChEMBL
Affinity DataIC50: 700nMAssay Description:Inhibition of P-glycoprotein, mouse L-mdr1b expressed in LLC-PK1 epithelial cells using calcein-AM polarisation assayMore data for this Ligand-Target Pair
TargetATP-dependent translocase ABCB1(Homo sapiens (Human))
University of North Carolina
Curated by ChEMBL
University of North Carolina
Curated by ChEMBL
Affinity DataIC50: 800nMAssay Description:TP_TRANSPORTER: inhibition of Calcein-AM efflux in MDR1-expressing LLC-PK1 cellsMore data for this Ligand-Target Pair
TargetATP-dependent translocase ABCB1(Homo sapiens (Human))
University of North Carolina
Curated by ChEMBL
University of North Carolina
Curated by ChEMBL
Affinity DataIC50: 800nMAssay Description:Inhibition of P-glycoprotein, human L-MDR1 expressed in LLC-PK1 epithelial cells using calcein-AM polarisation assayMore data for this Ligand-Target Pair
TargetATP-dependent translocase ABCB1(Homo sapiens (Human))
University of North Carolina
Curated by ChEMBL
University of North Carolina
Curated by ChEMBL
Affinity DataIC50: 919nMAssay Description:Inhibition of ABCB1 in human A2780adr cells pre-incubated for 30 mins followed by calcein AM addition and further incubated for 60 mins by calcein AM...More data for this Ligand-Target Pair
TargetATP-dependent translocase ABCB1(Homo sapiens (Human))
University of North Carolina
Curated by ChEMBL
University of North Carolina
Curated by ChEMBL
Affinity DataIC50: 920nMAssay Description:Inhibition of MDR1 in human doxorubicin-resistant A2780adr cells assessed as Calcein AM accumulation treated 30 mins before Calcein AM addition measu...More data for this Ligand-Target Pair
TargetATP-dependent translocase ABCB1(Homo sapiens (Human))
University of North Carolina
Curated by ChEMBL
University of North Carolina
Curated by ChEMBL
Affinity DataIC50: 1.09E+3nMAssay Description:Inhibition of ABCB1 in human A2780/ADR cells assessed as reduction in calcein AM efflux pre-incubated for 30 mins before calcein AM addition and meas...More data for this Ligand-Target Pair
TargetATP-dependent translocase ABCB1(Homo sapiens (Human))
University of North Carolina
Curated by ChEMBL
University of North Carolina
Curated by ChEMBL
Affinity DataIC50: 1.17E+3nMAssay Description:Inhibition of ABCB1 in human A2780/ADR cells assessed as calcein-AM accumulation preincubated for 30 mins followed by calcein-AM addition measured ov...More data for this Ligand-Target Pair
TargetATP-dependent translocase ABCB1(Homo sapiens (Human))
University of North Carolina
Curated by ChEMBL
University of North Carolina
Curated by ChEMBL
Affinity DataIC50: 1.20E+3nMAssay Description:Inhibition of human ABCB1 expressed in A2780/ADR cells preincubated for 30 mins followed by calcein AM addition and measured every 60 secs for 60 min...More data for this Ligand-Target Pair
TargetATP-dependent translocase ABCB1(Homo sapiens (Human))
University of North Carolina
Curated by ChEMBL
University of North Carolina
Curated by ChEMBL
Affinity DataIC50: 1.20E+3nMAssay Description:Inhibition of ABCB1 (unknown origin) expressed in human A2780 ADR cells assessed as reduction in calcein AM efflux preincubated for 30 mins followed ...More data for this Ligand-Target Pair
TargetATP-dependent translocase ABCB1(Homo sapiens (Human))
University of North Carolina
Curated by ChEMBL
University of North Carolina
Curated by ChEMBL
Affinity DataIC50: 1.21E+3nMAssay Description:Inhibition of ABCB1 in human A2780/ADR cells assessed as reduction in calcien-AM efflux preincubated for 30 mins followed by calcien-AM addition meas...More data for this Ligand-Target Pair
TargetATP-dependent translocase ABCB1(Homo sapiens (Human))
University of North Carolina
Curated by ChEMBL
University of North Carolina
Curated by ChEMBL
Affinity DataIC50: 1.21E+3nMAssay Description:Inhibition of ABCB1 in human A2780adr cells assessed as reduction in calcein AM levels preincubated for 30 mins followed by calcein AM addition measu...More data for this Ligand-Target Pair
TargetATP-dependent translocase ABCB1(Homo sapiens (Human))
University of North Carolina
Curated by ChEMBL
University of North Carolina
Curated by ChEMBL
Affinity DataIC50: 1.21E+3nMAssay Description:Inhibition of ABCB1 in human A2780/ADR cells assessed as reduction in calcein-AM efflux preincubated for 30 mins followed by calcein-AM addition meas...More data for this Ligand-Target Pair
TargetATP-dependent translocase ABCB1(Homo sapiens (Human))
University of North Carolina
Curated by ChEMBL
University of North Carolina
Curated by ChEMBL
Affinity DataIC50: 1.21E+3nMAssay Description:Inhibition of ABCB1 in human A2780adr cells preincubated for 30 mins before calcein AM addition by calcein AM assayMore data for this Ligand-Target Pair
TargetATP-dependent translocase ABCB1(Homo sapiens (Human))
University of North Carolina
Curated by ChEMBL
University of North Carolina
Curated by ChEMBL
Affinity DataIC50: 1.21E+3nMAssay Description:Inhibition of ABCB1 in human A2780adr cells preincubated for 30 mins before calcein AM addition by calcein AM assayMore data for this Ligand-Target Pair
TargetATP-dependent translocase ABCB1(Homo sapiens (Human))
University of North Carolina
Curated by ChEMBL
University of North Carolina
Curated by ChEMBL
Affinity DataIC50: 1.30E+3nMAssay Description:TP_TRANSPORTER: inhibition of Digoxin transepithelial transport (basal to apical) (Digoxin: 5 uM) in Caco-2 cellsMore data for this Ligand-Target Pair
TargetATP-dependent translocase ABCB1(Homo sapiens (Human))
University of North Carolina
Curated by ChEMBL
University of North Carolina
Curated by ChEMBL
Affinity DataIC50: 1.40E+3nMAssay Description:TP_TRANSPORTER: inhibition of Daunorubicin efflux in NIH-3T3-G185 cellsMore data for this Ligand-Target Pair
TargetATP-dependent translocase ABCB1(Homo sapiens (Human))
University of North Carolina
Curated by ChEMBL
University of North Carolina
Curated by ChEMBL
Affinity DataIC50: 1.40E+3nMAssay Description:Inhibition of P-glycoprotein-mediated multidrug resistance in adriamycin-resistant human A2780/ADR cells by calcein AM assayMore data for this Ligand-Target Pair
TargetATP-dependent translocase ABCB1(Homo sapiens (Human))
University of North Carolina
Curated by ChEMBL
University of North Carolina
Curated by ChEMBL
Affinity DataIC50: 1.41E+3nMAssay Description:Inhibition of ABCB1 in human A2780/ADR cells incubated for 30 mins measured up to 3600 secs with time intervals of 60 secs by calcein accumulation as...More data for this Ligand-Target Pair
TargetATP-dependent translocase ABCB1(Homo sapiens (Human))
University of North Carolina
Curated by ChEMBL
University of North Carolina
Curated by ChEMBL
Affinity DataIC50: 1.41E+3nMAssay Description:Inhibition of human Pgp in A2780 cells after 30 mins by calcein AM assayMore data for this Ligand-Target Pair
TargetATP-dependent translocase ABCB1(Homo sapiens (Human))
University of North Carolina
Curated by ChEMBL
University of North Carolina
Curated by ChEMBL
Affinity DataIC50: 1.41E+3nMAssay Description:Inhibition of human Pgp in A2780 cells after 30 mins by Hoechst 33342 assayMore data for this Ligand-Target Pair
TargetATP-dependent translocase ABCB1(Homo sapiens (Human))
University of North Carolina
Curated by ChEMBL
University of North Carolina
Curated by ChEMBL
Affinity DataIC50: 1.41E+3nMAssay Description:Inhibition of P-glycoprotein expressed in A2780/ADR cells by calcein AM assayMore data for this Ligand-Target Pair
TargetATP-dependent translocase ABCB1(Homo sapiens (Human))
University of North Carolina
Curated by ChEMBL
University of North Carolina
Curated by ChEMBL
Affinity DataIC50: 1.41E+3nMAssay Description:Inhibition of P-glycoprotein by Hoechst assayMore data for this Ligand-Target Pair
TargetATP-dependent translocase ABCB1(Homo sapiens (Human))
University of North Carolina
Curated by ChEMBL
University of North Carolina
Curated by ChEMBL
Affinity DataIC50: 1.70E+3nMAssay Description:TP_TRANSPORTER: inhibition of Calcein-AM efflux in NIH-3T3-G185 cellsMore data for this Ligand-Target Pair
TargetATP-dependent translocase ABCB1(Homo sapiens (Human))
University of North Carolina
Curated by ChEMBL
University of North Carolina
Curated by ChEMBL
Affinity DataIC50: 1.70E+3nMAssay Description:TP_TRANSPORTER: inhibition of Rhodamine 123 efflux in NIH-3T3-G185 cellsMore data for this Ligand-Target Pair
TargetATP-dependent translocase ABCB1(Homo sapiens (Human))
University of North Carolina
Curated by ChEMBL
University of North Carolina
Curated by ChEMBL
Affinity DataIC50: 1.80E+3nMAssay Description:TP_TRANSPORTER: inhibition of LDS-751 efflux in NIH-3T3-G185 cellsMore data for this Ligand-Target Pair
TargetATP-dependent translocase ABCB1(Homo sapiens (Human))
University of North Carolina
Curated by ChEMBL
University of North Carolina
Curated by ChEMBL
Affinity DataIC50: 2.10E+3nMAssay Description:TP_TRANSPORTER: inhibition of Tetramethylrosamine efflux in NIH-3T3-G185 cellsMore data for this Ligand-Target Pair
TargetATP-dependent translocase ABCB1(Homo sapiens (Human))
University of North Carolina
Curated by ChEMBL
University of North Carolina
Curated by ChEMBL
Affinity DataIC50: 2.40E+3nMAssay Description:TP_TRANSPORTER: inhibition of Fluo-3-AM efflux in NIH-3T3-G185 cellsMore data for this Ligand-Target Pair
TargetATP-dependent translocase ABCB1(Homo sapiens (Human))
University of North Carolina
Curated by ChEMBL
University of North Carolina
Curated by ChEMBL
Affinity DataIC50: 3.40E+3nMAssay Description:Inhibitory activity against Human MDR1 P-Glycoprotein ABC Transporter using leukemia CEM cellsMore data for this Ligand-Target Pair
TargetATP-dependent translocase ABCB1(Homo sapiens (Human))
University of North Carolina
Curated by ChEMBL
University of North Carolina
Curated by ChEMBL
Affinity DataIC50: 3.41E+3nMAssay Description:TP_TRANSPORTER: inhibition of Calcein-AM efflux (Calcein-AM: 0.25 uM) in CEM/VLB100 cellsMore data for this Ligand-Target Pair
TargetATP-dependent translocase ABCB1(Homo sapiens (Human))
University of North Carolina
Curated by ChEMBL
University of North Carolina
Curated by ChEMBL
Affinity DataIC50: 3.66E+3nMAssay Description:TP_TRANSPORTER: inhibition of Doxorubicin transepithelial transport (basal to apical) (Digoxin: 0.8 uM) in MDR1-expressing LLC-PK1 cellsMore data for this Ligand-Target Pair
TargetATP-dependent translocase ABCB1(Homo sapiens (Human))
University of North Carolina
Curated by ChEMBL
University of North Carolina
Curated by ChEMBL
Affinity DataIC50: 4.30E+3nMAssay Description:TP_TRANSPORTER: inhibition of JC-1 efflux in NIH-3T3-G185 cellsMore data for this Ligand-Target Pair
TargetATP-dependent translocase ABCB1(Mus musculus (Mouse))
St. Jude Children's Research Hospital
Curated by ChEMBL
St. Jude Children's Research Hospital
Curated by ChEMBL
Affinity DataIC50: 4.80E+3nMAssay Description:Inhibition of P-glycoprotein, mouse L-mdr1a expressed in LLC-PK1 epithelial cells using calcein-AM polarisation assayMore data for this Ligand-Target Pair
TargetATP-dependent translocase ABCB1(Homo sapiens (Human))
University of North Carolina
Curated by ChEMBL
University of North Carolina
Curated by ChEMBL
Affinity DataIC50: 9.34E+3nMAssay Description:Inhibition of human MDR1-dependent accumulation of calcein-AM expressed in MDCK2 cellsMore data for this Ligand-Target Pair
TargetATP-dependent translocase ABCB1(Homo sapiens (Human))
University of North Carolina
Curated by ChEMBL
University of North Carolina
Curated by ChEMBL
Affinity DataIC50: 5.91E+4nMAssay Description:Inhibition of P-glycoprotein in human MCF7/ADR cells assessed as reversal fold by measuring reduction in doxorubicin IC50 at 5 uM incubated for 48 hr...More data for this Ligand-Target Pair
TargetATP-dependent translocase ABCB1(Homo sapiens (Human))
University of North Carolina
Curated by ChEMBL
University of North Carolina
Curated by ChEMBL
Affinity DataEC50: 32nMAssay Description:Inhibition of P-gp (unknown origin) expressed in human LCC6MDR cells assessed as reversal of paclitaxel resistance after 5 days by MTS/PMS assayMore data for this Ligand-Target Pair
