Compile Data Set for Download or QSAR
Found 13 Enz. Inhib. hit(s) with Target = 'Adenosine kinase' and Ligand = 'BDBM50375654'
TargetAdenosine kinase(Rattus norvegicus (rat))
University of Bonn

Curated by ChEMBL
LigandPNGBDBM50375654(CHEMBL99203 | US11633415, Compound 5-iodotubercidi...)copy SMILEScopy InChI
Affinity DataKi:  9.30nMAssay Description:Inhibition of Sprague-Dawley rat brain cytosolic Adk using [2-3H]adenosine incubated for 15 mins by scintillation spectrometryMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2TB1BDDPubMed
TargetAdenosine kinase(Homo sapiens (Human))
University of Bonn

Curated by ChEMBL
LigandPNGBDBM50375654(CHEMBL99203 | US11633415, Compound 5-iodotubercidi...)copy SMILEScopy InChI
Affinity DataKi:  16nMAssay Description:Reversible inhibition of recombinant human Adk-short expressed in Escherichia coli BL21[DE3] assessed as [3H]AMP formation preincubated for 15 mins f...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2TB1BDDPubMed
TargetAdenosine kinase(Rattus norvegicus (rat))
University of Bonn

Curated by ChEMBL
LigandPNGBDBM50375654(CHEMBL99203 | US11633415, Compound 5-iodotubercidi...)copy SMILEScopy InChI
Affinity DataKi:  17nMAssay Description:Inhibition of rat brain ADK expressed in Escherichia coliMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2TB1BDDPubMed
TargetAdenosine kinase(Homo sapiens (Human))
University of Bonn

Curated by ChEMBL
LigandPNGBDBM50375654(CHEMBL99203 | US11633415, Compound 5-iodotubercidi...)copy SMILEScopy InChI
Affinity DataKi:  26nMAssay Description:Inhibition of recombinant human Adk using [U-14C]adenosine by liquid scintillation counting methodMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2TB1BDDPubMed
TargetAdenosine kinase(Homo sapiens (Human))
University of Bonn

Curated by ChEMBL
LigandPNGBDBM50375654(CHEMBL99203 | US11633415, Compound 5-iodotubercidi...)copy SMILEScopy InChI
Affinity DataKi:  30nMAssay Description:Inhibition of human placental adenosine kinaseMore data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2NG4R8JPubMed
TargetAdenosine kinase(Homo sapiens (Human))
University of Bonn

Curated by ChEMBL
LigandPNGBDBM50375654(CHEMBL99203 | US11633415, Compound 5-iodotubercidi...)copy SMILEScopy InChI
Affinity DataKi:  30nMAssay Description:Inhibition of adhenosine kinaseChecked by AuthorMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2DB82RHPubMed
TargetAdenosine kinase(Homo sapiens (Human))
University of Bonn

Curated by ChEMBL
LigandPNGBDBM50375654(CHEMBL99203 | US11633415, Compound 5-iodotubercidi...)copy SMILEScopy InChI
Affinity DataKi:  30nMAssay Description:Inhibition of purified human adenosine kinase using varying levels of [3H]Ado as substrate in presence of adenosine deaminase inhibitor deoxycoformyc...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2028VZ7PubMed
TargetAdenosine kinase(Mycobacterium tuberculosis (strain ATCC 25618 / H3...)
Texas A&M University

Curated by ChEMBL
LigandPNGBDBM50375654(CHEMBL99203 | US11633415, Compound 5-iodotubercidi...)copy SMILEScopy InChI
Affinity DataKi:  210nMAssay Description:Inhibition of Mycobacterium tuberculosis H37Ra ATCC 25177 adenosine kinase using varying levels of [3H]Ado as substrate in presence of adenosine deam...More data for this Ligand-Target Pair
TargetAdenosine kinase(Homo sapiens (Human))
University of Bonn

Curated by ChEMBL
LigandPNGBDBM50375654(CHEMBL99203 | US11633415, Compound 5-iodotubercidi...)copy SMILEScopy InChI
Affinity DataIC50: 25.7nMAssay Description:Concentration required for 50% inhibition of the adenosine kinase (AK) activity.More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2CZ38BMPubMed
TargetAdenosine kinase(Homo sapiens (Human))
University of Bonn

Curated by ChEMBL
LigandPNGBDBM50375654(CHEMBL99203 | US11633415, Compound 5-iodotubercidi...)copy SMILEScopy InChI
Affinity DataIC50: 26nMAssay Description:Inhibition of human adenosine kinase assessed as reduction in conversion of adenosine to AMPMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2TF01TQPubMed
TargetAdenosine kinase(Homo sapiens (Human))
University of Bonn

Curated by ChEMBL
LigandPNGBDBM50375654(CHEMBL99203 | US11633415, Compound 5-iodotubercidi...)copy SMILEScopy InChI
Affinity DataIC50: 820nMAssay Description:Inhibition of human adenosine kinase assessed as effect on reduced nicotinamide-adenine dinculeotide appearance using inosine as substrate in presenc...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2TF01TQPubMed
TargetAdenosine kinase(Mycobacterium tuberculosis (strain ATCC 25618 / H3...)
Texas A&M University

Curated by ChEMBL
LigandPNGBDBM50375654(CHEMBL99203 | US11633415, Compound 5-iodotubercidi...)copy SMILEScopy InChI
Affinity DataIC50: 1.20E+3nMAssay Description:Inhibition of wild-type N-terminal TEV cleavage site-fused/His-tagged Mycobacterium tuberculosis H37Rv adenosine kinase expressed in Escherichia coli...More data for this Ligand-Target Pair
TargetAdenosine kinase(Homo sapiens (Human))
University of Bonn

Curated by ChEMBL
LigandPNGBDBM50375654(CHEMBL99203 | US11633415, Compound 5-iodotubercidi...)copy SMILEScopy InChI
Affinity DataIC50: 2.60E+7nMAssay Description:Inhibition of adenosine kinase (unknown origin)More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2XG9V11