Compile Data Set for Download or QSAR
Found 8 Enz. Inhib. hit(s) with Target = 'Aldo-keto reductase family 1 member B1' and Ligand = 'BDBM50009777'
TargetAldo-keto reductase family 1 member B1(Rat)
National Eye Institute

Curated by ChEMBL
LigandPNGBDBM50009777((ponalrestat)[3-(4-Bromo-2-fluoro-benzyl)-4-oxo-3,...)copy SMILEScopy InChI
Affinity DataIC50: 16nMAssay Description:Inhibitory activity against purified rat lens aldose reductase (RLAR)More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2G73FCTPubMed
TargetAldo-keto reductase family 1 member B1(Rat)
National Eye Institute

Curated by ChEMBL
LigandPNGBDBM50009777((ponalrestat)[3-(4-Bromo-2-fluoro-benzyl)-4-oxo-3,...)copy SMILEScopy InChI
Affinity DataIC50: 20nMAssay Description:In vitro inhibition of Aldose reductase (AR) from rat lens (RL)More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2QJ7HXMPubMed
TargetAldo-keto reductase family 1 member B1(Human)
Pfizer Inc.

Curated by ChEMBL
LigandPNGBDBM50009777((ponalrestat)[3-(4-Bromo-2-fluoro-benzyl)-4-oxo-3,...)copy SMILEScopy InChI
Affinity DataIC50: 21nMAssay Description:Inhibition of aldose reductase (aldo-keto reductase, AKR1B1) isolated from human placenta.More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2513X6HPubMed
TargetAldo-keto reductase family 1 member B1(Pig)
Dainippon Pharmaceutical Company, Ltd.

Curated by ChEMBL
LigandPNGBDBM50009777((ponalrestat)[3-(4-Bromo-2-fluoro-benzyl)-4-oxo-3,...)copy SMILEScopy InChI
Affinity DataIC50: 21nMAssay Description:In vitro inhibitory activity against aldose reductase in porcine lens.More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q20V8BXHPubMed
TargetAldo-keto reductase family 1 member B1(Rat)
National Eye Institute

Curated by ChEMBL
LigandPNGBDBM50009777((ponalrestat)[3-(4-Bromo-2-fluoro-benzyl)-4-oxo-3,...)copy SMILEScopy InChI
Affinity DataIC50: 28nMAssay Description:Inhibitory activity measured against rat lens aldose reductase using 3-pyridinecarboxaldehyde as substrateChecked by AuthorMore data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2NK3FMZPubMed
TargetAldo-keto reductase family 1 member B1(Human)
Pfizer Inc.

Curated by ChEMBL
LigandPNGBDBM50009777((ponalrestat)[3-(4-Bromo-2-fluoro-benzyl)-4-oxo-3,...)copy SMILEScopy InChI
Affinity DataIC50: 56.5nMAssay Description:Inhibition of aldose reductaseMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2QR4WV6PubMed
TargetAldo-keto reductase family 1 member B1(Human)
Pfizer Inc.

Curated by ChEMBL
LigandPNGBDBM50009777((ponalrestat)[3-(4-Bromo-2-fluoro-benzyl)-4-oxo-3,...)copy SMILEScopy InChI
Affinity DataIC50: 66.5nMAssay Description:Inhibitory Activity against Human recombinant Aldose Reductase (wild type)More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2QZ2BPNPubMed
TargetAldo-keto reductase family 1 member B1(Rat)
National Eye Institute

Curated by ChEMBL
LigandPNGBDBM50009777((ponalrestat)[3-(4-Bromo-2-fluoro-benzyl)-4-oxo-3,...)copy SMILEScopy InChI
Affinity DataIC50: 2.40E+3nMAssay Description:In vitro inhibitory activity against L-Hexonate Dehydrogenase (L-HDH) from rat kidney (RK)More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2QJ7HXMPubMed