BindingDB PrimarySearch

Found 14 Enz. Inhib. hit(s) with Target = 'Amine oxidase [flavin-containing] B' and Ligand = 'BDBM50240772'

Amine oxidase [flavin-containing] B(Homo sapiens (Human))
Dart NeuroScience, LLC

Curated by ChEMBL

BDBM50240772((1R,2S)-(-)-2-phenylcyclopropylamine | (1R,2S)-2-p...)copy SMILEScopy InChI

Ki: 26nMAssay Description:Inhibition of human recombinant soluble MAO-B expressed in Pichia pastoris incubated for 30 mins prior to substrate addition measured after 60 mins b...More data for this Ligand-Target Pair

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BindingDB Entry DOI: 10.7270/Q2J38V8KPubMed

Amine oxidase [flavin-containing] B(Homo sapiens (Human))
Dart NeuroScience, LLC

Curated by ChEMBL

BDBM50240772((1R,2S)-(-)-2-phenylcyclopropylamine | (1R,2S)-2-p...)copy SMILEScopy InChI

Ki: 1.60E+4nMAssay Description:Inhibition of human MAO-B expressed in baculovirus infected BTI insect cells using tyramine as substrate by 4-AAP/3,5-DCHBS and amplex red dye based ...More data for this Ligand-Target Pair

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BindingDB Entry DOI: 10.7270/Q28K7DTBPubMed

Amine oxidase [flavin-containing] B(Homo sapiens (Human))
Dart NeuroScience, LLC

Curated by ChEMBL

BDBM50240772((1R,2S)-(-)-2-phenylcyclopropylamine | (1R,2S)-2-p...)copy SMILEScopy InChI

IC50: 9.40nMAssay Description:Inhibition of recombinant human MAOB expressed in baculovirus infected BTI insect cells using beetle luciferin as substrate after 1 hr by MAO-Glo ass...More data for this Ligand-Target Pair

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BindingDB Entry DOI: 10.7270/Q27W6GG3PubMed

Amine oxidase [flavin-containing] B(Homo sapiens (Human))
Dart NeuroScience, LLC

Curated by ChEMBL

BDBM50240772((1R,2S)-(-)-2-phenylcyclopropylamine | (1R,2S)-2-p...)copy SMILEScopy InChI

IC50: 35nMAssay Description:Compound was evaluated for inhibition of Microbial tyramine oxidase; competitiveMore data for this Ligand-Target Pair

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BindingDB Entry DOI: 10.7270/Q21G0N12PubMed

Amine oxidase [flavin-containing] B(Homo sapiens (Human))
Dart NeuroScience, LLC

Curated by ChEMBL

BDBM50240772((1R,2S)-(-)-2-phenylcyclopropylamine | (1R,2S)-2-p...)copy SMILEScopy InChI

IC50: 560nMAssay Description:Inhibition of MAOB (unknown origin) by Promega MAO-Glo assayMore data for this Ligand-Target Pair

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BindingDB Entry DOI: 10.7270/Q2WH2TB1PubMed

Amine oxidase [flavin-containing] B(Homo sapiens (Human))
Dart NeuroScience, LLC

Curated by ChEMBL

BDBM50240772((1R,2S)-(-)-2-phenylcyclopropylamine | (1R,2S)-2-p...)copy SMILEScopy InChI

IC50: 600nMpH: 7.5Assay Description:Human recombinant monoamine oxidase proteins MAO-A and MAO-B were purchased from Sigma Aldrich. MAOs catalyze the oxidative deamination of 1, 2 and 3...More data for this Ligand-Target Pair

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BindingDB Entry DOI: 10.7270/Q29P30CCUS Patent

Amine oxidase [flavin-containing] B(Homo sapiens (Human))
Dart NeuroScience, LLC

Curated by ChEMBL

BDBM50240772((1R,2S)-(-)-2-phenylcyclopropylamine | (1R,2S)-2-p...)copy SMILEScopy InChI

IC50: 800nMAssay Description:Inhibition of recombinant human MAOB incubated for 15 mins measured after 30 mins by luminescence-Glo assayMore data for this Ligand-Target Pair

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BindingDB Entry DOI: 10.7270/Q26112KNPubMed

Amine oxidase [flavin-containing] B(Homo sapiens (Human))
Dart NeuroScience, LLC

Curated by ChEMBL

BDBM50240772((1R,2S)-(-)-2-phenylcyclopropylamine | (1R,2S)-2-p...)copy SMILEScopy InChI

IC50: 890nMAssay Description:Inhibition of human recombinant MAOB expressed in Pichia pastoris incubated for 15 mins prior to substrate addition measured after 30 mins by lumines...More data for this Ligand-Target Pair

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BindingDB Entry DOI: 10.7270/Q2JQ12QFPubMed

Amine oxidase [flavin-containing] B(Homo sapiens (Human))
Dart NeuroScience, LLC

Curated by ChEMBL

BDBM50240772((1R,2S)-(-)-2-phenylcyclopropylamine | (1R,2S)-2-p...)copy SMILEScopy InChI

IC50: 2.40E+3nMAssay Description:Inhibition of recombinant human MAO-B expressed in baculovirus infected BTI insect cells using (4S)-4,5-dihydro-2-(6-hydroxybenzothiazolyl)-4-thiazol...More data for this Ligand-Target Pair

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BindingDB Entry DOI: 10.7270/Q28W3GX3PubMed

Amine oxidase [flavin-containing] B(Homo sapiens (Human))
Dart NeuroScience, LLC

Curated by ChEMBL

BDBM50240772((1R,2S)-(-)-2-phenylcyclopropylamine | (1R,2S)-2-p...)copy SMILEScopy InChI

IC50: 2.50E+3nMAssay Description:Inhibition of human recombinant MAO-B expressed in Pichia pastoris using benzylamine as substrate after 5 minsMore data for this Ligand-Target Pair

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BindingDB Entry DOI: 10.7270/Q2028VHDPubMed

Amine oxidase [flavin-containing] B(Homo sapiens (Human))
Dart NeuroScience, LLC

Curated by ChEMBL

BDBM50240772((1R,2S)-(-)-2-phenylcyclopropylamine | (1R,2S)-2-p...)copy SMILEScopy InChI

IC50: 2.80E+3nMAssay Description:Inhibition of MAO-B (unknown origin) by luminescence assayMore data for this Ligand-Target Pair

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BindingDB Entry DOI: 10.7270/Q2N0195VPubMed

Amine oxidase [flavin-containing] B(Homo sapiens (Human))
Dart NeuroScience, LLC

Curated by ChEMBL

BDBM50240772((1R,2S)-(-)-2-phenylcyclopropylamine | (1R,2S)-2-p...)copy SMILEScopy InChI

IC50: 6.21E+3nMAssay Description:Inhibition of MAOB (unknown origin)More data for this Ligand-Target Pair

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BindingDB Entry DOI: 10.7270/Q2CC12CZPubMed

Amine oxidase [flavin-containing] B(Homo sapiens (Human))
Dart NeuroScience, LLC

Curated by ChEMBL

BDBM50240772((1R,2S)-(-)-2-phenylcyclopropylamine | (1R,2S)-2-p...)copy SMILEScopy InChI

IC50: 6.54E+3nMAssay Description:Inhibition of human MAOB using (4S)-4, 5-dihydro-2-(6-hydroxybenzothiazolyl)-4-thiazolecarboxylic acid substrate incubated for 60 mins by MAO-Glo ass...More data for this Ligand-Target Pair

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BindingDB Entry DOI: 10.7270/Q21N83Q5PubMed

Amine oxidase [flavin-containing] B(Homo sapiens (Human))
Dart NeuroScience, LLC

Curated by ChEMBL

BDBM50240772((1R,2S)-(-)-2-phenylcyclopropylamine | (1R,2S)-2-p...)copy SMILEScopy InChI

IC50: 7.00E+3nMAssay Description:Screening method: Monoamine oxidase MAOA and MAOB activity screeningInstrument: microplate reader Envision� (PerkinElmer, USA).MATERIALS: Human recom...More data for this Ligand-Target Pair

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BindingDB Entry DOI: 10.7270/Q2FX7DJRUS Patent

Targets 1 ▿
- Amine oxidase [flavin-containing] B 14
Publications 13 ▿
- Bioorg Med Chem Lett 29: 844-847 (2019) 1
- Eur J Med Chem 94: 163-74 (2015) 1
- J Med Chem 47: 1796-806 (2004) 1
- US Patent US10836743 (2020) 1
- Bioorg Med Chem Lett 29: 544-548 (2019) 1
- J Med Chem 57: 42-55 (2014) 1
- Bioorg Med Chem Lett 28: 167-169 (2018) 1
- J Med Chem 60: 1673-1692 (2017) 1
- Bioorg Med Chem 26: 775-785 (2018) 1
- Eur J Med Chem 148: 210-220 (2018) 1
- Bioorg Med Chem 23: 770-8 (2015) 1
- J Med Chem 58: 1705-16 (2015) 1
- US Patent US8993808 (2015) 1
Institutions 13 ▿
- [European Institute of Oncology, Medical University of South Carolina, National Institute of Diabetes and Digestive and Kidney Diseases, Sapienza University of Roma, SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES, Dart NeuroScience, LLC, Liaoning Shihua University, Sapienza University of Rome, Taizhou People's Hospital, Waseda University, Oryzon Genomics, S.A., Kyoto Prefectural University of Medicine, Zhengzhou University] 1
- [European Institute of Oncology, Medical University of South Carolina, National Institute of Diabetes and Digestive and Kidney Diseases, Sapienza University of Roma, SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES, Dart NeuroScience, LLC, Liaoning Shihua University, Sapienza University of Rome, Taizhou People's Hospital, Waseda University, Oryzon Genomics, S.A., Kyoto Prefectural University of Medicine, Zhengzhou University] 1
- [European Institute of Oncology, Medical University of South Carolina, National Institute of Diabetes and Digestive and Kidney Diseases, Sapienza University of Roma, SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES, Dart NeuroScience, LLC, Liaoning Shihua University, Sapienza University of Rome, Taizhou People's Hospital, Waseda University, Oryzon Genomics, S.A., Kyoto Prefectural University of Medicine, Zhengzhou University] 1
- [European Institute of Oncology, Medical University of South Carolina, National Institute of Diabetes and Digestive and Kidney Diseases, Sapienza University of Roma, SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES, Dart NeuroScience, LLC, Liaoning Shihua University, Sapienza University of Rome, Taizhou People's Hospital, Waseda University, Oryzon Genomics, S.A., Kyoto Prefectural University of Medicine, Zhengzhou University] 1
- [European Institute of Oncology, Medical University of South Carolina, National Institute of Diabetes and Digestive and Kidney Diseases, Sapienza University of Roma, SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES, Dart NeuroScience, LLC, Liaoning Shihua University, Sapienza University of Rome, Taizhou People's Hospital, Waseda University, Oryzon Genomics, S.A., Kyoto Prefectural University of Medicine, Zhengzhou University] 1
- [European Institute of Oncology, Medical University of South Carolina, National Institute of Diabetes and Digestive and Kidney Diseases, Sapienza University of Roma, SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES, Dart NeuroScience, LLC, Liaoning Shihua University, Sapienza University of Rome, Taizhou People's Hospital, Waseda University, Oryzon Genomics, S.A., Kyoto Prefectural University of Medicine, Zhengzhou University] 1
- [European Institute of Oncology, Medical University of South Carolina, National Institute of Diabetes and Digestive and Kidney Diseases, Sapienza University of Roma, SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES, Dart NeuroScience, LLC, Liaoning Shihua University, Sapienza University of Rome, Taizhou People's Hospital, Waseda University, Oryzon Genomics, S.A., Kyoto Prefectural University of Medicine, Zhengzhou University] 1
- [European Institute of Oncology, Medical University of South Carolina, National Institute of Diabetes and Digestive and Kidney Diseases, Sapienza University of Roma, SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES, Dart NeuroScience, LLC, Liaoning Shihua University, Sapienza University of Rome, Taizhou People's Hospital, Waseda University, Oryzon Genomics, S.A., Kyoto Prefectural University of Medicine, Zhengzhou University] 1
- [European Institute of Oncology, Medical University of South Carolina, National Institute of Diabetes and Digestive and Kidney Diseases, Sapienza University of Roma, SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES, Dart NeuroScience, LLC, Liaoning Shihua University, Sapienza University of Rome, Taizhou People's Hospital, Waseda University, Oryzon Genomics, S.A., Kyoto Prefectural University of Medicine, Zhengzhou University] 1
- [European Institute of Oncology, Medical University of South Carolina, National Institute of Diabetes and Digestive and Kidney Diseases, Sapienza University of Roma, SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES, Dart NeuroScience, LLC, Liaoning Shihua University, Sapienza University of Rome, Taizhou People's Hospital, Waseda University, Oryzon Genomics, S.A., Kyoto Prefectural University of Medicine, Zhengzhou University] 1
- [European Institute of Oncology, Medical University of South Carolina, National Institute of Diabetes and Digestive and Kidney Diseases, Sapienza University of Roma, SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES, Dart NeuroScience, LLC, Liaoning Shihua University, Sapienza University of Rome, Taizhou People's Hospital, Waseda University, Oryzon Genomics, S.A., Kyoto Prefectural University of Medicine, Zhengzhou University] 1
- [European Institute of Oncology, Medical University of South Carolina, National Institute of Diabetes and Digestive and Kidney Diseases, Sapienza University of Roma, SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES, Dart NeuroScience, LLC, Liaoning Shihua University, Sapienza University of Rome, Taizhou People's Hospital, Waseda University, Oryzon Genomics, S.A., Kyoto Prefectural University of Medicine, Zhengzhou University] 1
- [European Institute of Oncology, Medical University of South Carolina, National Institute of Diabetes and Digestive and Kidney Diseases, Sapienza University of Roma, SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES, Dart NeuroScience, LLC, Liaoning Shihua University, Sapienza University of Rome, Taizhou People's Hospital, Waseda University, Oryzon Genomics, S.A., Kyoto Prefectural University of Medicine, Zhengzhou University] 1
Affinity: 9.4 to 1.6E+4 nM▿
- Ki 2
- IC50 12
- Affinity ≤ nM
Xtal structures: 0
Docked structures: 0
Catalog Cmpds: 1