Compile Data Set for Download or QSAR
Found 8 Enz. Inhib. hit(s) with Target = 'Anoctamin-1' and Ligand = 'BDBM50239465'
TargetAnoctamin-1(Mus musculus)TBA
LigandPNGBDBM50239465(CHEMBL4080525 | US11274074, Control [Ani9])copy SMILEScopy InChI
Affinity DataIC50: 30nMAssay Description:Inhibition of GFP-fused mouse ANO1 channel expressed in HEK293A cells assessed as inhibition of ATP-induced channel current amplitude at membrane pot...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2N58R1TPubMed
TargetAnoctamin-1(Homo sapiens (Human))TBA
LigandPNGBDBM50239465(CHEMBL4080525 | US11274074, Control [Ani9])copy SMILEScopy InChI
Affinity DataIC50: 60nMAssay Description:Inhibition of human ANO1 channel expressed in HEK293 cells incubated for 10 mins by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2N58R1TPubMed
TargetAnoctamin-1(Homo sapiens (Human))TBA
LigandPNGBDBM50239465(CHEMBL4080525 | US11274074, Control [Ani9])copy SMILEScopy InChI
Affinity DataIC50: 77nMAssay Description:Inhibition of human TMEM16A expressed in FRT cells assessed as reduction of ATP-induced in chloride conductance preincubated for 20 mins followed by ...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2FT8P5GPubMed
TargetAnoctamin-1(Homo sapiens (Human))TBA
LigandPNGBDBM50239465(CHEMBL4080525 | US11274074, Control [Ani9])copy SMILEScopy InChI
Affinity DataIC50: 77nMAssay Description:Inhibition of ANO1 (unknown origin) expressed in FRT cells assessed as reduction in ATP-induced chloride current after 20 mins by electrophysiologica...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q24T6NMBPubMed
TargetAnoctamin-1(Homo sapiens (Human))TBA
LigandPNGBDBM50239465(CHEMBL4080525 | US11274074, Control [Ani9])copy SMILEScopy InChI
Affinity DataIC50: 77nMAssay Description:Inhibition of human ANO1 expressed in FRT cells assessed as inhibition of ATP-induced channel current treated 20 mins prior to ATP challenge and meas...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2N58R1TPubMed
TargetAnoctamin-1(Homo sapiens (Human))TBA
LigandPNGBDBM50239465(CHEMBL4080525 | US11274074, Control [Ani9])copy SMILEScopy InChI
Affinity DataIC50: 97nMAssay Description:The method for inhibiting the expression of ANO1 (TMEM16A) of the present disclosure includes a step of inhibiting the expression of ANO1 (TMEM16A) i...More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2GT5RDMUS Patent
TargetAnoctamin-1(Homo sapiens (Human))TBA
LigandPNGBDBM50239465(CHEMBL4080525 | US11274074, Control [Ani9])copy SMILEScopy InChI
Affinity DataIC50: 97nMAssay Description:Inhibition of YFP-fused ANO1 (unknown origin) expressed in FRT cells after 20 mins by fluorescence quenching methodMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q24T6NMBPubMed
TargetAnoctamin-1(Homo sapiens (Human))TBA
LigandPNGBDBM50239465(CHEMBL4080525 | US11274074, Control [Ani9])copy SMILEScopy InChI
Affinity DataIC50: 110nMAssay Description:Inhibition of human TMEM16A expressed in FRT cells assessed as reduction of ATP-induced in chloride conductance preincubated for 5 mins followed by A...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2FT8P5GPubMed