Compile Data Set for Download or QSAR
Found 5 Enz. Inhib. hit(s) with Target = 'Arginase-1' and Ligand = 'BDBM290365'
TargetArginase-1(Homo sapiens (Human))
Merck & Co., Inc.

Curated by ChEMBL
LigandPNGBDBM290365((1S,2S)-1-amino-2-(3-boronopropyl)cyclopentanecarb...)copy SMILEScopy InChI
Affinity DataIC50: 14nMAssay Description:Inhibition of human arginase1 in presence of DNTB by thio ornithine generation assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q26113VNPubMed
TargetArginase-1(Homo sapiens (Human))
Merck & Co., Inc.

Curated by ChEMBL
LigandPNGBDBM290365((1S,2S)-1-amino-2-(3-boronopropyl)cyclopentanecarb...)copy SMILEScopy InChI
Affinity DataIC50: 210nMAssay Description:Inhibition of human recombinant arginase 1 expressed in Escherichia coli BL21 (DE3) assessed as reduction in urea production using L-arginine as subs...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2X92FM9PubMed
TargetArginase-1(Homo sapiens (Human))
Merck & Co., Inc.

Curated by ChEMBL
LigandPNGBDBM290365((1S,2S)-1-amino-2-(3-boronopropyl)cyclopentanecarb...)copy SMILEScopy InChI
Affinity DataIC50: 625nMAssay Description:Inhibition of arginase I (ARG I) and arginase II (ARG II) by Formula I or Formula II compounds is followed spectrophotometrically at 530 nm. The comp...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q289193NUS Patent
TargetArginase-1(Homo sapiens (Human))
Merck & Co., Inc.

Curated by ChEMBL
LigandPNGBDBM290365((1S,2S)-1-amino-2-(3-boronopropyl)cyclopentanecarb...)copy SMILEScopy InChI
Affinity DataIC50: 625nMpH: 7.4 T: 2°CAssay Description:Inhibition of arginase I (ARG I) and arginase II (ARG II) by Formula I or Formula II compounds is followed spectrophotometrically at 530 nm. The comp...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2319XXKUS Patent
TargetArginase-1(Homo sapiens (Human))
Merck & Co., Inc.

Curated by ChEMBL
LigandPNGBDBM290365((1S,2S)-1-amino-2-(3-boronopropyl)cyclopentanecarb...)copy SMILEScopy InChI
Affinity DataIC50: 2.00E+3nMAssay Description:Inhibition of arginase I (ARG I) and arginase II (ARG II) by Formula I or Formula II compounds is followed spectrophotometrically at 530 nm. The comp...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2WD43K6US Patent