Compile Data Set for Download or QSAR
Found 19 Enz. Inhib. hit(s) with Target = 'Aromatase' and Ligand = 'BDBM50240798'
TargetAromatase(Homo sapiens (Human))TBA
LigandPNGBDBM50240798((8R,9S,10R,13S,14S)-4-Hydroxy-10,13-dimethyl-1,6,7...)copy SMILEScopy InChI
Affinity DataKi:  0.160nMMore data for this Ligand-Target Pair
In DepthDetails
TargetAromatase(Homo sapiens (Human))TBA
LigandPNGBDBM50240798((8R,9S,10R,13S,14S)-4-Hydroxy-10,13-dimethyl-1,6,7...)copy SMILEScopy InChI
Affinity DataKi:  27nMAssay Description:Inhibition constant for human placental cytochrome P450 19A1More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2VD7022PubMed
TargetAromatase(Homo sapiens (Human))TBA
LigandPNGBDBM50240798((8R,9S,10R,13S,14S)-4-Hydroxy-10,13-dimethyl-1,6,7...)copy SMILEScopy InChI
Affinity DataKi:  43nMAssay Description:Irreversible inhibition of human aromatase extracted from placental microsomesMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2W66NMZPubMed
TargetAromatase(Homo sapiens (Human))TBA
LigandPNGBDBM50240798((8R,9S,10R,13S,14S)-4-Hydroxy-10,13-dimethyl-1,6,7...)copy SMILEScopy InChI
Affinity DataKi:  50nMAssay Description:Binding affinity was measured on Cytochrome P450 19A1More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2VM4CW9PubMed
TargetAromatase(Homo sapiens (Human))TBA
LigandPNGBDBM50240798((8R,9S,10R,13S,14S)-4-Hydroxy-10,13-dimethyl-1,6,7...)copy SMILEScopy InChI
Affinity DataKi:  54nMAssay Description:Evaluated for its competitive inhibitory activity against Cytochrome P450 19A1 with the use of human placental microsomal preparationMore data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2VM4DFWPubMed
TargetAromatase(Homo sapiens (Human))TBA
LigandPNGBDBM50240798((8R,9S,10R,13S,14S)-4-Hydroxy-10,13-dimethyl-1,6,7...)copy SMILEScopy InChI
Affinity DataKi:  542nMAssay Description:Binding affinity(KI) for formation of reversible enzyme-ligand complex with human placental aromatase (PL2)More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2736RHXPubMed
TargetAromatase(Homo sapiens (Human))TBA
LigandPNGBDBM50240798((8R,9S,10R,13S,14S)-4-Hydroxy-10,13-dimethyl-1,6,7...)copy SMILEScopy InChI
Affinity DataIC50: 30nMAssay Description:Inhibition of particulate fractions of human breast cancer derived aromataseMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2TM7D2SPubMed
TargetAromatase(Homo sapiens (Human))TBA
LigandPNGBDBM50240798((8R,9S,10R,13S,14S)-4-Hydroxy-10,13-dimethyl-1,6,7...)copy SMILEScopy InChI
Affinity DataIC50: 30nMMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2NP28CDPubMed
TargetAromatase(Homo sapiens (Human))TBA
LigandPNGBDBM50240798((8R,9S,10R,13S,14S)-4-Hydroxy-10,13-dimethyl-1,6,7...)copy SMILEScopy InChI
Affinity DataIC50: 42nMAssay Description:Inhibition of human placental aromataseChecked by AuthorMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2G44QH8PubMed
TargetAromatase(Homo sapiens (Human))TBA
LigandPNGBDBM50240798((8R,9S,10R,13S,14S)-4-Hydroxy-10,13-dimethyl-1,6,7...)copy SMILEScopy InChI
Affinity DataIC50: 42nMAssay Description:Inhibitory concentration against aromatase protein from human placental microsomes using [1-beta-3H]-androstenedione; Competitive inhibitionMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q25M66GDPubMed
TargetAromatase(Homo sapiens (Human))TBA
LigandPNGBDBM50240798((8R,9S,10R,13S,14S)-4-Hydroxy-10,13-dimethyl-1,6,7...)copy SMILEScopy InChI
Affinity DataIC50: 42nMAssay Description:Inhibition of aromatase in human placental microsomes using [1beta-3H]androstenedione as substrate after 15 mins by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q22V2H52PubMed
TargetAromatase(Homo sapiens (Human))TBA
LigandPNGBDBM50240798((8R,9S,10R,13S,14S)-4-Hydroxy-10,13-dimethyl-1,6,7...)copy SMILEScopy InChI
Affinity DataIC50: 48.6nMAssay Description:Inhibition of human placental aromatase using [3H]-1beta-androstenedione as substrate after 16 hrs by [3H]-water methodMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2BZ675SPubMed
TargetAromatase(Homo sapiens (Human))TBA
LigandPNGBDBM50240798((8R,9S,10R,13S,14S)-4-Hydroxy-10,13-dimethyl-1,6,7...)copy SMILEScopy InChI
Affinity DataIC50: 92nMAssay Description:Inhibition of human placental aromatase assessed as conversion of [1beta-3H]androstenedione to [1beta-3H]estrone after 20 mins by liquid scintillatio...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q27D2V58PubMed
TargetAromatase(Homo sapiens (Human))TBA
LigandPNGBDBM50240798((8R,9S,10R,13S,14S)-4-Hydroxy-10,13-dimethyl-1,6,7...)copy SMILEScopy InChI
Affinity DataIC50: 370nMAssay Description:Inhibition of cytochrome P450 19A1 aromatase from human placental microsomesMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2X06722
TargetAromatase(Homo sapiens (Human))TBA
LigandPNGBDBM50240798((8R,9S,10R,13S,14S)-4-Hydroxy-10,13-dimethyl-1,6,7...)copy SMILEScopy InChI
Affinity DataIC50: 370nMAssay Description:Inhibition of cytochrome P450 19A1More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2VD7022PubMed
TargetAromatase(Homo sapiens (Human))TBA
LigandPNGBDBM50240798((8R,9S,10R,13S,14S)-4-Hydroxy-10,13-dimethyl-1,6,7...)copy SMILEScopy InChI
Affinity DataIC50: 410nMAssay Description:Inhibition of 1 uM [1-beta-3H]-androstenedione binding to human placental microsome Cytochrome P450 19A1More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2MG7Q45PubMed
TargetAromatase(Homo sapiens (Human))TBA
LigandPNGBDBM50240798((8R,9S,10R,13S,14S)-4-Hydroxy-10,13-dimethyl-1,6,7...)copy SMILEScopy InChI
Affinity DataIC50: 470nMAssay Description:Inhibition of human aromatase using androstenedione as substrate assessed as estrone formation at 10 uM after 30 mins by LC-MS/MS analysisMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2CR5VWHPubMed
TargetAromatase(Homo sapiens (Human))TBA
LigandPNGBDBM50240798((8R,9S,10R,13S,14S)-4-Hydroxy-10,13-dimethyl-1,6,7...)copy SMILEScopy InChI
Affinity DataIC50: 800nMAssay Description:Inhibition of aromatase in human placental microsomes assessed as tritiated water release after 15 mins using [1beta, 3H]androstenedione as substrate...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2ZW1KPNPubMed
TargetAromatase(Homo sapiens (Human))TBA
LigandPNGBDBM50240798((8R,9S,10R,13S,14S)-4-Hydroxy-10,13-dimethyl-1,6,7...)copy SMILEScopy InChI
Affinity DataIC50: 5.86E+4nMAssay Description:Inhibition of aromatase (unknown origin) using dibenzylfluorescein as substrate after 30 mins by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2N87C7MPubMed