Compile Data Set for Download or QSAR
Found 20 Enz. Inhib. hit(s) with Target = 'Aurora kinase A' and Ligand = 'BDBM50277545'
TargetAurora kinase A(Homo sapiens (Human))
University of Tartu, Ravila 14A, 50411 Tartu (Estonia)

LigandPNGBDBM50277545(4-(9-chloro-7-(2-fluoro-6-methoxyphenyl)-5H-benzo[...)copy SMILEScopy InChI
Affinity DataKi:  0.136nM ΔG°:  -57.3kJ/mole IC50: 34.2nMT: 2°CAssay Description:Threefold dilution series of inhibitors in assay buffer were prepared in wells of a microtiter plate (final concentration stating from 2uM), and TAMR...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2028Q58PubMed
TargetAurora kinase A(Mus musculus (mouse))
Takeda Pharmaceuticals International Co. , 40 Landsdowne Street, Cambridge, Massachusetts 02139, United States.

Curated by ChEMBL
LigandPNGBDBM50277545(4-(9-chloro-7-(2-fluoro-6-methoxyphenyl)-5H-benzo[...)copy SMILEScopy InChI
Affinity DataKi:  0.300nMAssay Description:Competitive inhibition of recombinant mouse aurora kinase A expressed in insect Sf9 cells in presence of ATPMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2WS8W1VPubMed
TargetAurora kinase A(Homo sapiens (Human))
University of Tartu, Ravila 14A, 50411 Tartu (Estonia)

LigandPNGBDBM50277545(4-(9-chloro-7-(2-fluoro-6-methoxyphenyl)-5H-benzo[...)copy SMILEScopy InChI
Affinity DataIC50: 0.0400nMAssay Description:Inhibition of His-tagged human Aurora A kinase (122 to 40 residues) expressed in Escherichia coli BL21 (DE3) Rosetta cells using biotinylated STK2 su...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2JM2CM5PubMed
TargetAurora kinase A(Homo sapiens (Human))
University of Tartu, Ravila 14A, 50411 Tartu (Estonia)

LigandPNGBDBM50277545(4-(9-chloro-7-(2-fluoro-6-methoxyphenyl)-5H-benzo[...)copy SMILEScopy InChI
Affinity DataIC50: 0.600nMpH: 7.4 T: 2°CAssay Description:For in vitro method for measuring the inhibitory activity of the aforementioned compounds on the aurora A kinase activity was carried out referring t...More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q28K77Z2US Patent
TargetAurora kinase A(Homo sapiens (Human))
University of Tartu, Ravila 14A, 50411 Tartu (Estonia)

LigandPNGBDBM50277545(4-(9-chloro-7-(2-fluoro-6-methoxyphenyl)-5H-benzo[...)copy SMILEScopy InChI
Affinity DataIC50: 0.600nMpH: 7.4 T: 2°CAssay Description:For in vitro method for measuring the inhibitory activity of the aforementioned compounds on the aurora A kinase activity was carried out referring t...More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2ZG6V8BUS Patent
TargetAurora kinase A(Homo sapiens (Human))
University of Tartu, Ravila 14A, 50411 Tartu (Estonia)

LigandPNGBDBM50277545(4-(9-chloro-7-(2-fluoro-6-methoxyphenyl)-5H-benzo[...)copy SMILEScopy InChI
Affinity DataIC50: 0.690nMT: 2°CAssay Description:Threefold dilution series of inhibitors in assay buffer were prepared in wells of a microtiter plate (final concentration stating from 2uM). Subseque...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2028Q58PubMed
TargetAurora kinase A(Mus musculus (mouse))
Takeda Pharmaceuticals International Co. , 40 Landsdowne Street, Cambridge, Massachusetts 02139, United States.

Curated by ChEMBL
LigandPNGBDBM50277545(4-(9-chloro-7-(2-fluoro-6-methoxyphenyl)-5H-benzo[...)copy SMILEScopy InChI
Affinity DataIC50: 1nMAssay Description:Inhibition of recombinant mouse aurora kinase A expressed in insect Sf9 cells using biotin-GLRRASLG as substrate in presence of [gamma-33P]ATPMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2WS8W1VPubMed
TargetAurora kinase A(Homo sapiens (Human))
University of Tartu, Ravila 14A, 50411 Tartu (Estonia)

LigandPNGBDBM50277545(4-(9-chloro-7-(2-fluoro-6-methoxyphenyl)-5H-benzo[...)copy SMILEScopy InChI
Affinity DataIC50: 1nMAssay Description:Inhibition of aurora A (unknown origin)More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2T1559DPubMed
TargetAurora kinase A(Homo sapiens (Human))
University of Tartu, Ravila 14A, 50411 Tartu (Estonia)

LigandPNGBDBM50277545(4-(9-chloro-7-(2-fluoro-6-methoxyphenyl)-5H-benzo[...)copy SMILEScopy InChI
Affinity DataIC50: 1nMAssay Description:Inhibition of aurora A kinaseChecked by AuthorMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2B85920PubMed
TargetAurora kinase A(Homo sapiens (Human))
University of Tartu, Ravila 14A, 50411 Tartu (Estonia)

LigandPNGBDBM50277545(4-(9-chloro-7-(2-fluoro-6-methoxyphenyl)-5H-benzo[...)copy SMILEScopy InChI
Affinity DataIC50: 1nMAssay Description:Inhibition of aurora A (unknown origin)More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q26111Q1PubMed
TargetAurora kinase A(Homo sapiens (Human))
University of Tartu, Ravila 14A, 50411 Tartu (Estonia)

LigandPNGBDBM50277545(4-(9-chloro-7-(2-fluoro-6-methoxyphenyl)-5H-benzo[...)copy SMILEScopy InChI
Affinity DataIC50: 1.20nMAssay Description:Inhibition of Aurora A kinase (unknown origin)More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2WD4385PubMed
TargetAurora kinase A(Homo sapiens (Human))
University of Tartu, Ravila 14A, 50411 Tartu (Estonia)

LigandPNGBDBM50277545(4-(9-chloro-7-(2-fluoro-6-methoxyphenyl)-5H-benzo[...)copy SMILEScopy InChI
Affinity DataIC50: 1.20nMMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2FF3XF8PubMed
TargetAurora kinase A(Homo sapiens (Human))
University of Tartu, Ravila 14A, 50411 Tartu (Estonia)

LigandPNGBDBM50277545(4-(9-chloro-7-(2-fluoro-6-methoxyphenyl)-5H-benzo[...)copy SMILEScopy InChI
Affinity DataIC50: 1.20nMAssay Description:Inhibition of recombinant Aurora A (unknown origin) by radioactive flashplate assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2PC35XXPubMed
TargetAurora kinase A(Homo sapiens (Human))
University of Tartu, Ravila 14A, 50411 Tartu (Estonia)

LigandPNGBDBM50277545(4-(9-chloro-7-(2-fluoro-6-methoxyphenyl)-5H-benzo[...)copy SMILEScopy InChI
Affinity DataIC50: 1.20nMAssay Description:Inhibition of Aurora A (unknown origin)More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2PN98WRPubMed
TargetAurora kinase A(Homo sapiens (Human))
University of Tartu, Ravila 14A, 50411 Tartu (Estonia)

LigandPNGBDBM50277545(4-(9-chloro-7-(2-fluoro-6-methoxyphenyl)-5H-benzo[...)copy SMILEScopy InChI
Affinity DataIC50: 1.20nMAssay Description:Inhibition of Aurora A (unknown origin)More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2MC93N5PubMed
TargetAurora kinase A(Homo sapiens (Human))
University of Tartu, Ravila 14A, 50411 Tartu (Estonia)

LigandPNGBDBM50277545(4-(9-chloro-7-(2-fluoro-6-methoxyphenyl)-5H-benzo[...)copy SMILEScopy InChI
Affinity DataIC50: 3.5nMT: 2°CAssay Description:Inhibition of Aurora A was assessed in duplicated radiometric assay containing 100uM [gamma-32P] ATP and quantified by p81 phosphocellulose assay.More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2DZ06N0PubMed
TargetAurora kinase A(Homo sapiens (Human))
University of Tartu, Ravila 14A, 50411 Tartu (Estonia)

LigandPNGBDBM50277545(4-(9-chloro-7-(2-fluoro-6-methoxyphenyl)-5H-benzo[...)copy SMILEScopy InChI
Affinity DataIC50: 6.70nMAssay Description:Inhibition of Aurora A kinase autophosphorylation at Thr288 in human HeLa Kyoto cells incubated for 20 hrsMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2JM2CM5PubMed
TargetAurora kinase A(Homo sapiens (Human))
University of Tartu, Ravila 14A, 50411 Tartu (Estonia)

LigandPNGBDBM50277545(4-(9-chloro-7-(2-fluoro-6-methoxyphenyl)-5H-benzo[...)copy SMILEScopy InChI
Affinity DataIC50: 7nMAssay Description:Inhibition of aurora kinase A autophosphorylation at T288 in human HCT116 cells by immunofluorescence analysisMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2WS8W1VPubMed
TargetAurora kinase A(Homo sapiens (Human))
University of Tartu, Ravila 14A, 50411 Tartu (Estonia)

LigandPNGBDBM50277545(4-(9-chloro-7-(2-fluoro-6-methoxyphenyl)-5H-benzo[...)copy SMILEScopy InChI
Affinity DataIC50: 13nMAssay Description:Inhibition of recombinant GST-tagged N-terminal truncated human Aurora A (123 to 401 residues) expressed in Sf9 insect cell using tetra-LRRASLG pepti...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2Q2444SPubMed
TargetAurora kinase A(Homo sapiens (Human))
University of Tartu, Ravila 14A, 50411 Tartu (Estonia)

LigandPNGBDBM50277545(4-(9-chloro-7-(2-fluoro-6-methoxyphenyl)-5H-benzo[...)copy SMILEScopy InChI
Affinity DataIC50: 100nMAssay Description:Inhibition of AURKA (unknown origin)More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2G44RQCPubMed