Compile Data Set for Download or QSAR
Found 5 Enz. Inhib. hit(s) with Target = 'Beta-glucuronidase' and Ligand = 'BDBM163640'
TargetBeta-glucuronidase(Escherichia coli (Enterobacteria))
University of North Carolina at Chapel Hill

LigandPNGBDBM163640(5,11Dimethyl3(piperazin1yl)8thia4,6diazatricyclo[7...)copy SMILEScopy InChI
Affinity DataKi:  220nMAssay Description:Reactions were conducted similarly to the kinetic assays but the reaction consisted of 10 µL assay buffer, 5 µL inhibitor solution, 5 µL of 10 nM enz...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2Q52NCDPubMed
TargetBeta-glucuronidase(Homo sapiens (Human))
The University of North Carolina at Chapel Hill

US Patent
LigandPNGBDBM163640(5,11Dimethyl3(piperazin1yl)8thia4,6diazatricyclo[7...)copy SMILEScopy InChI
Affinity DataIC50: 213nMAssay Description:PheG Assay: Two ß-glucuronidase activity assays were employed to examine the potency of inhibitors both in vitro and in cell-based studies. An absorb...More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q270809VUS Patent
TargetBeta-glucuronidase(Homo sapiens (Human))
The University of North Carolina at Chapel Hill

US Patent
LigandPNGBDBM163640(5,11Dimethyl3(piperazin1yl)8thia4,6diazatricyclo[7...)copy SMILEScopy InChI
Affinity DataIC50: 231nMAssay Description:PNPG Assay: Two ß-glucuronidase activity assays were employed to examine the potency of inhibitors both in vitro and in cell-based studies. An absorb...More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q270809VUS Patent
TargetBeta-glucuronidase(Homo sapiens (Human))
The University of North Carolina at Chapel Hill

US Patent
LigandPNGBDBM163640(5,11Dimethyl3(piperazin1yl)8thia4,6diazatricyclo[7...)copy SMILEScopy InChI
Affinity DataEC50:  99.9nMAssay Description:PheG Assay: Two ß-glucuronidase activity assays were employed to examine the potency of inhibitors both in vitro and in cell-based studies. An absorb...More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q270809VUS Patent
TargetBeta-glucuronidase(Homo sapiens (Human))
The University of North Carolina at Chapel Hill

US Patent
LigandPNGBDBM163640(5,11Dimethyl3(piperazin1yl)8thia4,6diazatricyclo[7...)copy SMILEScopy InChI
Affinity DataEC50:  92.4nMAssay Description:PNPG Assay: Two ß-glucuronidase activity assays were employed to examine the potency of inhibitors both in vitro and in cell-based studies. An absorb...More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q270809VUS Patent