Compile Data Set for Download or QSAR
Found 4 Enz. Inhib. hit(s) with Target = 'Beta-secretase 1' and Ligand = 'BDBM150688'
TargetBeta-secretase 1(Mus musculus (Mouse))TBA
LigandPNGBDBM150688(US8987254, 3 | US9999624, 3)copy SMILEScopy InChI
Affinity DataIC50: 0.481nMAssay Description:Inhibition of BACE1 in mouse primary cortical neuron assessed as reduction in Amyloid-beta level incubated for 24 hrs by sandwich ELISA assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q29W0KBWPubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Eli Lilly and Company

US Patent
LigandPNGBDBM150688(US8987254, 3 | US9999624, 3)copy SMILEScopy InChI
Affinity DataIC50: 0.554nMpH: 4.6 T: 2°CAssay Description:Serial dilutions of test compounds are prepared as described above. Compounds are further diluted 20x in KH2PO4 buffer. Ten uL of each dilution is ad...More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2FX786MUS Patent
TargetBeta-secretase 1(Homo sapiens (Human))
Eli Lilly and Company

US Patent
LigandPNGBDBM150688(US8987254, 3 | US9999624, 3)copy SMILEScopy InChI
Affinity DataIC50: 0.603nMAssay Description:Inhibition of recombinant human BACE1 using (MCA)-S-E-V-N-L-D-A-E-F-R-K(dinitrophenol)-R-R-R-R-NH2 as substrate incubated for 8 hrs by FRET assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q29W0KBWPubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Eli Lilly and Company

US Patent
LigandPNGBDBM150688(US8987254, 3 | US9999624, 3)copy SMILEScopy InChI
Affinity DataIC50: 0.603nMAssay Description:Serial dilutions of test compounds are prepared as described above. Compounds are further diluted 20× in KH2PO4 buffer. Ten μL of each dilution ...More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q27H1MZBUS Patent