Compile Data Set for Download or QSAR
Found 6 Enz. Inhib. hit(s) with Target = 'Bifunctional epoxide hydrolase 2' and Ligand = 'BDBM50100519'
TargetBifunctional epoxide hydrolase 2(Homo sapiens (Human))
Eicosis, LLC

US Patent
LigandPNGBDBM50100519(CHEMBL3327067 | US10377744, Compound No. 2391)copy SMILEScopy InChI
Affinity DataKi:  0.220nMAssay Description:FRET assays to determine Ki for the compounds of Table I were carried out as described previously (Lee et al. Analytical Biochemistry 434 (2013) 259-...More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2N3009KUS Patent
TargetBifunctional epoxide hydrolase 2(Homo sapiens (Human))
Eicosis, LLC

US Patent
LigandPNGBDBM50100519(CHEMBL3327067 | US10377744, Compound No. 2391)copy SMILEScopy InChI
Affinity DataKi:  0.220nMAssay Description:Inhibition of human recombinant soluble epoxide hydrolase by FRET-based ACPU displacement assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2FJ2JJQPubMed
TargetBifunctional epoxide hydrolase 2(Homo sapiens (Human))
Eicosis, LLC

US Patent
LigandPNGBDBM50100519(CHEMBL3327067 | US10377744, Compound No. 2391)copy SMILEScopy InChI
Affinity DataKi:  0.220nMAssay Description:Inhibition of recombinant human sEH expressed in baculovirus expression system assessed as reduction in ACPU binding incubated for 1 hr by FRET displ...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2SF30T4PubMed
TargetBifunctional epoxide hydrolase 2(Rattus norvegicus)
University of California Davis

Curated by ChEMBL
LigandPNGBDBM50100519(CHEMBL3327067 | US10377744, Compound No. 2391)copy SMILEScopy InChI
Affinity DataIC50: 1.30nMAssay Description:Inhibition of rat soluble epoxide hydrolase using [3H]-t-DPPO as a substrate by radiometric assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2FJ2JJQPubMed
TargetBifunctional epoxide hydrolase 2(Mus musculus (Mouse))
The Regents of the University of California

US Patent
LigandPNGBDBM50100519(CHEMBL3327067 | US10377744, Compound No. 2391)copy SMILEScopy InChI
Affinity DataIC50: 4nMAssay Description:fluoresence competitive assay.More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2TX3D7MUS Patent
TargetBifunctional epoxide hydrolase 2(Mus musculus (Mouse))
The Regents of the University of California

US Patent
LigandPNGBDBM50100519(CHEMBL3327067 | US10377744, Compound No. 2391)copy SMILEScopy InChI
Affinity DataIC50: 17.8nMAssay Description:Trans-diphenylpropene oxide is used in a radiometric competitive assay.More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2TX3D7MUS Patent