Compile Data Set for Download or QSAR
Found 3 Enz. Inhib. hit(s) with Target = 'Bile acid receptor' and Ligand = 'BDBM50323544'
TargetBile acid receptor(Homo sapiens (Human))
Phenex Pharmaceuticals AG

Curated by ChEMBL
LigandPNGBDBM50323544(4-(1-(6-((5-cyclopropyl-3-(2,6-dichlorophenyl)isox...)copy SMILEScopy InChI
Affinity DataEC50:  189nMAssay Description:Agonist activity at human GST-fused FXR LBD expressed in HEK293 cells coexpressing GAL4-DNA bindig domain and pFRluc by mammalian one-hybrid assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q21V5F52PubMed
TargetBile acid receptor(Homo sapiens (Human))
Phenex Pharmaceuticals AG

Curated by ChEMBL
LigandPNGBDBM50323544(4-(1-(6-((5-cyclopropyl-3-(2,6-dichlorophenyl)isox...)copy SMILEScopy InChI
Affinity DataEC50:  611nMAssay Description:Agonist activity at human full length FXR transfected in HEK293 cells coexpressing pTRexDest/pGL2promotor assessed as luciferase activity by direct r...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q21V5F52PubMed
TargetBile acid receptor(Homo sapiens (Human))
Phenex Pharmaceuticals AG

Curated by ChEMBL
LigandPNGBDBM50323544(4-(1-(6-((5-cyclopropyl-3-(2,6-dichlorophenyl)isox...)copy SMILEScopy InChI
Affinity DataEC50:  352nMAssay Description:Agonist activity at human GST-fused FXR LBD assessed as cofactor peptide interaction with receptor ligand binding domain by FRET assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q21V5F52PubMed