Compile Data Set for Download or QSAR
Found 16 Enz. Inhib. hit(s) with Target = 'Bromodomain-containing protein 4' and Ligand = 'BDBM439497'
TargetBromodomain-containing protein 4(Homo sapiens (Human))
AbbVie Inc.

Curated by ChEMBL
LigandPNGBDBM439497(US10633379, Example 35 | US10633379, Example 82)copy SMILEScopy InChI
Affinity DataKi:  1.60nMAssay Description:Inhibition of human N-terminal His6 tagged BRD4 BD2 (352 to 457) residues expressed in Escherichia coli BL21(DE3) cells after 1 hr by TR-FRET assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2057K8MPubMed
TargetBromodomain-containing protein 4(Homo sapiens (Human))
AbbVie Inc.

Curated by ChEMBL
LigandPNGBDBM439497(US10633379, Example 35 | US10633379, Example 82)copy SMILEScopy InChI
Affinity DataKi:  1.60nMAssay Description:pA2 for NK2 receptor of rabbit pulmonary arteryMore data for this Ligand-Target Pair
In DepthDetails
TargetBromodomain-containing protein 4(Homo sapiens (Human))
AbbVie Inc.

Curated by ChEMBL
LigandPNGBDBM439497(US10633379, Example 35 | US10633379, Example 82)copy SMILEScopy InChI
Affinity DataKi:  520nMAssay Description:Inhibition of human N-terminal His6 tagged BRD4 BD1 (57 to 168) residues expressed in Escherichia coli BL21(DE3) cells after 1 hr by TR-FRET assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2057K8MPubMed
TargetBromodomain-containing protein 4(Homo sapiens (Human))
AbbVie Inc.

Curated by ChEMBL
LigandPNGBDBM439497(US10633379, Example 35 | US10633379, Example 82)copy SMILEScopy InChI
Affinity DataKi:  520nMAssay Description:pA2 for NK2 receptor of rabbit pulmonary arteryMore data for this Ligand-Target Pair
In DepthDetails
TargetBromodomain-containing protein 4(Homo sapiens (Human))
AbbVie Inc.

Curated by ChEMBL
LigandPNGBDBM439497(US10633379, Example 35 | US10633379, Example 82)copy SMILEScopy InChI
Affinity DataIC50: 0.650nMMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2QJ7NBNPubMed
TargetBromodomain-containing protein 4(Homo sapiens (Human))
AbbVie Inc.

Curated by ChEMBL
LigandPNGBDBM439497(US10633379, Example 35 | US10633379, Example 82)copy SMILEScopy InChI
Affinity DataIC50: 1.80nMMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q24M98MVPubMed
TargetBromodomain-containing protein 4(Homo sapiens (Human))
AbbVie Inc.

Curated by ChEMBL
LigandPNGBDBM439497(US10633379, Example 35 | US10633379, Example 82)copy SMILEScopy InChI
Affinity DataIC50: 3.30nMAssay Description:Inhibition of His-tagged BRD4 bromodomain 2 (unknown origin) using [Lys (5,8,12,16) Ac] H4(1-21) as substrate by fluorescence based assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q26M3BJ4PubMed
TargetBromodomain-containing protein 4(Homo sapiens (Human))
AbbVie Inc.

Curated by ChEMBL
LigandPNGBDBM439497(US10633379, Example 35 | US10633379, Example 82)copy SMILEScopy InChI
Affinity DataIC50: 28nMAssay Description:Inhibition of NanoLuc-tagged BRD4 BD2 (unknown origin) expressed in human HeLa cells after 2 hrs by NanoBRET assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2057K8MPubMed
TargetBromodomain-containing protein 4(Homo sapiens (Human))
AbbVie Inc.

Curated by ChEMBL
LigandPNGBDBM439497(US10633379, Example 35 | US10633379, Example 82)copy SMILEScopy InChI
Affinity DataIC50: 238nMMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2QJ7NBNPubMed
TargetBromodomain-containing protein 4(Homo sapiens (Human))
AbbVie Inc.

Curated by ChEMBL
LigandPNGBDBM439497(US10633379, Example 35 | US10633379, Example 82)copy SMILEScopy InChI
Affinity DataIC50: 300nMMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q24M98MVPubMed
TargetBromodomain-containing protein 4(Homo sapiens (Human))
AbbVie Inc.

Curated by ChEMBL
LigandPNGBDBM439497(US10633379, Example 35 | US10633379, Example 82)copy SMILEScopy InChI
Affinity DataIC50: 328nMAssay Description:Inhibition of His-tagged BRD4 bromodomain 1 (unknown origin) using [Lys (5,8,12,16) Ac] H4(1-21) as substrate by fluorescence based assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q26M3BJ4PubMed
TargetBromodomain-containing protein 4(Homo sapiens (Human))
AbbVie Inc.

Curated by ChEMBL
LigandPNGBDBM439497(US10633379, Example 35 | US10633379, Example 82)copy SMILEScopy InChI
Affinity DataIC50: 2.07E+4nMAssay Description:Inhibition of NanoLuc-tagged BRD4 BD1 (unknown origin) expressed in human HeLa cells after 2 hrs by NanoBRET assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2057K8MPubMed
TargetBromodomain-containing protein 4(Homo sapiens (Human))
AbbVie Inc.

Curated by ChEMBL
LigandPNGBDBM439497(US10633379, Example 35 | US10633379, Example 82)copy SMILEScopy InChI
Affinity DataKd:  2.10nMAssay Description:Binding affinity to human partial length BRD4 BD2 expressed in bacterial expression system assessed as dissociation constant by BROMOscan assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2PR80VNPubMed
TargetBromodomain-containing protein 4(Homo sapiens (Human))
AbbVie Inc.

Curated by ChEMBL
LigandPNGBDBM439497(US10633379, Example 35 | US10633379, Example 82)copy SMILEScopy InChI
Affinity DataKd:  3.30E+3nMAssay Description:Binding affinity to BRD4 BD1 (unknown origin) assessed as dissociation constant by Discover X assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2PR80VNPubMed
TargetBromodomain-containing protein 4(Homo sapiens (Human))
AbbVie Inc.

Curated by ChEMBL
LigandPNGBDBM439497(US10633379, Example 35 | US10633379, Example 82)copy SMILEScopy InChI
Affinity DataKd:  520nMAssay Description:Inhibition of BRD4-BD1 (unknown origin) assessed as dissociation constant by TR-FRET methodMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q20Z7752PubMed
TargetBromodomain-containing protein 4(Homo sapiens (Human))
AbbVie Inc.

Curated by ChEMBL
LigandPNGBDBM439497(US10633379, Example 35 | US10633379, Example 82)copy SMILEScopy InChI
Affinity DataKd:  1.60nMAssay Description:Inhibition of BRD4-BD2 (unknown origin) assessed as dissociation constant by TR-FRET methodMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q20Z7752PubMed