Compile Data Set for Download or QSAR
Found 15 Enz. Inhib. hit(s) with Target = 'C-C chemokine receptor type 5' and Ligand = 'BDBM50088301'
TargetC-C chemokine receptor type 5(Homo sapiens (Human))TBA
LigandPNGBDBM50088301((E)-N,N-dimethyl-N-(4-(2-p-tolyl-6,7-dihydro-5H-be...)copy SMILEScopy InChI
Affinity DataKi:  1.10nMMore data for this Ligand-Target Pair
In DepthDetails
TargetC-C chemokine receptor type 5(Homo sapiens (Human))TBA
LigandPNGBDBM50088301((E)-N,N-dimethyl-N-(4-(2-p-tolyl-6,7-dihydro-5H-be...)copy SMILEScopy InChI
Affinity DataKi:  1.40nMAssay Description:Inhibitory activity of the compound against specific binding of [125I]-MIP-1 alpha to human CCR5 receptorMore data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2668CFZPubMed
TargetC-C chemokine receptor type 5(Homo sapiens (Human))TBA
LigandPNGBDBM50088301((E)-N,N-dimethyl-N-(4-(2-p-tolyl-6,7-dihydro-5H-be...)copy SMILEScopy InChI
Affinity DataIC50: 1.20nMAssay Description:Inhibition of chemotactic protein to CCR5More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2CN74NDPubMed
TargetC-C chemokine receptor type 5(Homo sapiens (Human))TBA
LigandPNGBDBM50088301((E)-N,N-dimethyl-N-(4-(2-p-tolyl-6,7-dihydro-5H-be...)copy SMILEScopy InChI
Affinity DataIC50: 1.40nMAssay Description:Inhibition of CCR5 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2GH9HVZPubMed
TargetC-C chemokine receptor type 5(Homo sapiens (Human))TBA
LigandPNGBDBM50088301((E)-N,N-dimethyl-N-(4-(2-p-tolyl-6,7-dihydro-5H-be...)copy SMILEScopy InChI
Affinity DataIC50: 1.40nMAssay Description:Inhibition of membrane fusion between HIV1 JR-FL Env-expressing COS7 cells and MOLT4/CCR5More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q23N2303PubMed
TargetC-C chemokine receptor type 5(Homo sapiens (Human))TBA
LigandPNGBDBM50088301((E)-N,N-dimethyl-N-(4-(2-p-tolyl-6,7-dihydro-5H-be...)copy SMILEScopy InChI
Affinity DataIC50: 1.40nMAssay Description:Binding affinity to CCR5More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2862HKRPubMed
TargetC-C chemokine receptor type 5(Homo sapiens (Human))TBA
LigandPNGBDBM50088301((E)-N,N-dimethyl-N-(4-(2-p-tolyl-6,7-dihydro-5H-be...)copy SMILEScopy InChI
Affinity DataIC50: 1.40nMAssay Description:Displacement of [125I]RANTES from human CCR5 expressed in CHO cells after 40 mins by scintillation counting analysisMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2Z60RH6PubMed
TargetC-C chemokine receptor type 5(Homo sapiens (Human))TBA
LigandPNGBDBM50088301((E)-N,N-dimethyl-N-(4-(2-p-tolyl-6,7-dihydro-5H-be...)copy SMILEScopy InChI
Affinity DataIC50: 1.40nMAssay Description:Displacement of [125I]RANTES from CCR5 expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q23N2303PubMed
TargetC-C chemokine receptor type 5(Homo sapiens (Human))TBA
LigandPNGBDBM50088301((E)-N,N-dimethyl-N-(4-(2-p-tolyl-6,7-dihydro-5H-be...)copy SMILEScopy InChI
Affinity DataIC50: 1.40nMAssay Description:Compound was evaluated for the antagonist activity against C-C chemokine receptor type 5More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2H70F2ZPubMed
TargetC-C chemokine receptor type 5(Homo sapiens (Human))TBA
LigandPNGBDBM50088301((E)-N,N-dimethyl-N-(4-(2-p-tolyl-6,7-dihydro-5H-be...)copy SMILEScopy InChI
Affinity DataIC50: 1.40nMMore data for this Ligand-Target Pair
In DepthDetails
TargetC-C chemokine receptor type 5(Homo sapiens (Human))TBA
LigandPNGBDBM50088301((E)-N,N-dimethyl-N-(4-(2-p-tolyl-6,7-dihydro-5H-be...)copy SMILEScopy InChI
Affinity DataIC50: 1.40nMAssay Description:Inhibitory effect on Chemokine binding to C-C chemokine receptor type 5 using [125I]-RANTESMore data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q26D5S75PubMed
TargetC-C chemokine receptor type 5(Homo sapiens (Human))TBA
LigandPNGBDBM50088301((E)-N,N-dimethyl-N-(4-(2-p-tolyl-6,7-dihydro-5H-be...)copy SMILEScopy InChI
Affinity DataIC50: 1.80nMAssay Description:Inhibitory effect on Chemokine binding to C-C chemokine receptor type 5 using [125I]-RANTESMore data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q26D5S75PubMed
TargetC-C chemokine receptor type 5(Homo sapiens (Human))TBA
LigandPNGBDBM50088301((E)-N,N-dimethyl-N-(4-(2-p-tolyl-6,7-dihydro-5H-be...)copy SMILEScopy InChI
Affinity DataIC50: 2nMAssay Description:Displacement of [3H]TAK-779 from CCR5 (unknown origin) after 120 mins by scintillation counting methodMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2Z60RH6PubMed
TargetC-C chemokine receptor type 5(Homo sapiens (Human))TBA
LigandPNGBDBM50088301((E)-N,N-dimethyl-N-(4-(2-p-tolyl-6,7-dihydro-5H-be...)copy SMILEScopy InChI
Affinity DataIC50: 6nMAssay Description:Antagonist activity at human TEV cleavage site-linked CCR5 expressed in human U2OS cells harboring beta-lactamase reporter gene assessed as inhibitio...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2QR51DDPubMed
TargetC-C chemokine receptor type 5(Homo sapiens (Human))TBA
LigandPNGBDBM50088301((E)-N,N-dimethyl-N-(4-(2-p-tolyl-6,7-dihydro-5H-be...)copy SMILEScopy InChI
Affinity DataEC50:  7nMAssay Description:Positive allosteric modulation of human CCR5 expressed in HEK293T cells co-expressing CAMYEL assessed as increase in CCL4-induced inhibition of forsk...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2Z60RH6PubMed