Compile Data Set for Download or QSAR
Found 30 Enz. Inhib. hit(s) with Target = 'Carbonic anhydrase 1' and Ligand = 'BDBM10886'
TargetCarbonic anhydrase 1(Homo sapiens (Human))
Kochi Medical School

LigandPNGBDBM10886(2-N-benzene-1,3,4-thiadiazole-2,5-disulfonamide | ...)copy SMILEScopy InChI
Affinity DataKi:  15nMAssay Description:An Applied Photophysics stopped-flow instrument has been used for assaying the CA-catalyzed CO2 hydration activity. Phenol red has been used as indic...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2ZS2TQBPubMed
TargetCarbonic anhydrase 1(Homo sapiens (Human))
Kochi Medical School

LigandPNGBDBM10886(2-N-benzene-1,3,4-thiadiazole-2,5-disulfonamide | ...)copy SMILEScopy InChI
Affinity DataKi:  15nMAssay Description:Inhibition of full length human cytosolic carbonic anhydrase 1 preincubated for 15 mins by stop flow CO2 hydrase assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2H70K9RPubMed
TargetCarbonic anhydrase 1(Homo sapiens (Human))
Kochi Medical School

LigandPNGBDBM10886(2-N-benzene-1,3,4-thiadiazole-2,5-disulfonamide | ...)copy SMILEScopy InChI
Affinity DataKi:  15nMAssay Description:Inhibition of human recombinant carbonic anhydrase 1 preincubated for 15 mins by CO2 hydration stopped-flow assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2VQ3463PubMed
TargetCarbonic anhydrase 1(Homo sapiens (Human))
Kochi Medical School

LigandPNGBDBM10886(2-N-benzene-1,3,4-thiadiazole-2,5-disulfonamide | ...)copy SMILEScopy InChI
Affinity DataKi:  15nMAssay Description:Inhibition of human carbonic anhydrase-1 by stopped-flow CO2 hydration assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2WW7K7GPubMed
TargetCarbonic anhydrase 1(Homo sapiens (Human))
Kochi Medical School

LigandPNGBDBM10886(2-N-benzene-1,3,4-thiadiazole-2,5-disulfonamide | ...)copy SMILEScopy InChI
Affinity DataKi:  15nMAssay Description:Inhibition of human recombinant carbonic anhydrase 1 by stopped-flow CO2 hydration assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q20K2B62PubMed
TargetCarbonic anhydrase 1(Homo sapiens (Human))
Kochi Medical School

LigandPNGBDBM10886(2-N-benzene-1,3,4-thiadiazole-2,5-disulfonamide | ...)copy SMILEScopy InChI
Affinity DataKi:  15nMAssay Description:Inhibition of human recombinant Carbonic anhydrase 2 compound preincubated for 15 mins by stopped flow CO2 hydrase assay methodMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2959K68PubMed
TargetCarbonic anhydrase 1(Homo sapiens (Human))
Kochi Medical School

LigandPNGBDBM10886(2-N-benzene-1,3,4-thiadiazole-2,5-disulfonamide | ...)copy SMILEScopy InChI
Affinity DataKi:  15nMAssay Description:Inhibition of human recombinant carbonic anhydrase 1 by stopped flow CO2 hydrase assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q22R3T9XPubMed
TargetCarbonic anhydrase 1(Homo sapiens (Human))
Kochi Medical School

LigandPNGBDBM10886(2-N-benzene-1,3,4-thiadiazole-2,5-disulfonamide | ...)copy SMILEScopy InChI
Affinity DataKi:  15nMAssay Description:Inhibition of human carbonic anhydrase 1 pre-incubated for 15 mins by stopped-flow CO2 hydration assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2TX3H2MPubMed
TargetCarbonic anhydrase 1(Homo sapiens (Human))
Kochi Medical School

LigandPNGBDBM10886(2-N-benzene-1,3,4-thiadiazole-2,5-disulfonamide | ...)copy SMILEScopy InChI
Affinity DataKi:  15nMAssay Description:Inhibition of recombinant human carbonic anhydrase-1 by stopped flow CO2 hydrase assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2DB83QGPubMed
TargetCarbonic anhydrase 1(Homo sapiens (Human))
Kochi Medical School

LigandPNGBDBM10886(2-N-benzene-1,3,4-thiadiazole-2,5-disulfonamide | ...)copy SMILEScopy InChI
Affinity DataKi:  15nMAssay Description:Inhibition of human Carbonic anhydrase1 using CO2 as substrate preincubated for 15 mins by stopped-flow CO2 hydration assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q26W9CXHPubMed
TargetCarbonic anhydrase 1(Homo sapiens (Human))
Kochi Medical School

LigandPNGBDBM10886(2-N-benzene-1,3,4-thiadiazole-2,5-disulfonamide | ...)copy SMILEScopy InChI
Affinity DataKi:  15nMAssay Description:Inhibition of human carbonic anhydrase 1 incubated for 15 mins by stopped-flow CO2 hydration assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2GM896MPubMed
TargetCarbonic anhydrase 1(Homo sapiens (Human))
Kochi Medical School

LigandPNGBDBM10886(2-N-benzene-1,3,4-thiadiazole-2,5-disulfonamide | ...)copy SMILEScopy InChI
Affinity DataKi:  15nMAssay Description:Inhibition of human recombinant CA1 by stopped-flow CO2 hydration assayChecked by AuthorMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q26D5T7KPubMed
TargetCarbonic anhydrase 1(Homo sapiens (Human))
Kochi Medical School

LigandPNGBDBM10886(2-N-benzene-1,3,4-thiadiazole-2,5-disulfonamide | ...)copy SMILEScopy InChI
Affinity DataKi:  15nMpH: 7.5Assay Description:Inhibition of human carbonic anhydrase 1 after 15 mins by CO2 hydrase assay at pH 7.5More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2QN672RPubMed
TargetCarbonic anhydrase 1(Homo sapiens (Human))
Kochi Medical School

LigandPNGBDBM10886(2-N-benzene-1,3,4-thiadiazole-2,5-disulfonamide | ...)copy SMILEScopy InChI
Affinity DataKi:  15nMpH: 7.5Assay Description:Inhibition of human carbonic anhydrase I by spectrophotometry at pH 7.5More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2C53M44PubMed
TargetCarbonic anhydrase 1(Homo sapiens (Human))
Kochi Medical School

LigandPNGBDBM10886(2-N-benzene-1,3,4-thiadiazole-2,5-disulfonamide | ...)copy SMILEScopy InChI
Affinity DataKi:  15nMpH: 7.5Assay Description:Inhibition of human recombinant carbonic anhydrase 1 at pH 7.5 by stopped flow CO2 hydration assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q24T6JRWPubMed
TargetCarbonic anhydrase 1(Homo sapiens (Human))
Kochi Medical School

LigandPNGBDBM10886(2-N-benzene-1,3,4-thiadiazole-2,5-disulfonamide | ...)copy SMILEScopy InChI
Affinity DataKi:  15nMAssay Description:Inhibition of human recombinant carbonic anhydrase 1 after 15 mins by stopped flow CO2 hydration assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2VH5P89PubMed
TargetCarbonic anhydrase 1(Homo sapiens (Human))
Kochi Medical School

LigandPNGBDBM10886(2-N-benzene-1,3,4-thiadiazole-2,5-disulfonamide | ...)copy SMILEScopy InChI
Affinity DataKi:  15nMAssay Description:Inhibitory activity against human carbonic anhydrase I (hCA I)More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2BR8SQ8PubMed
TargetCarbonic anhydrase 1(Homo sapiens (Human))
Kochi Medical School

LigandPNGBDBM10886(2-N-benzene-1,3,4-thiadiazole-2,5-disulfonamide | ...)copy SMILEScopy InChI
Affinity DataKi:  15nMAssay Description:Ki value against human carbonic anhydrase I (hCA I)More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q29887RZPubMed
TargetCarbonic anhydrase 1(Homo sapiens (Human))
Kochi Medical School

LigandPNGBDBM10886(2-N-benzene-1,3,4-thiadiazole-2,5-disulfonamide | ...)copy SMILEScopy InChI
Affinity DataKi:  15nMAssay Description:Binding affinity towards human cloned carbonic anhydrase IMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2154HT4PubMed
TargetCarbonic anhydrase 1(Homo sapiens (Human))
Kochi Medical School

LigandPNGBDBM10886(2-N-benzene-1,3,4-thiadiazole-2,5-disulfonamide | ...)copy SMILEScopy InChI
Affinity DataKi:  15nMAssay Description:Inhibition of human recombinant CA1More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2HM598PPubMed
TargetCarbonic anhydrase 1(Homo sapiens (Human))
Kochi Medical School

LigandPNGBDBM10886(2-N-benzene-1,3,4-thiadiazole-2,5-disulfonamide | ...)copy SMILEScopy InChI
Affinity DataKi:  15nMAssay Description:Ki value against human carbonic anhydrase IMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q25H7H1NPubMed
TargetCarbonic anhydrase 1(Homo sapiens (Human))
Kochi Medical School

LigandPNGBDBM10886(2-N-benzene-1,3,4-thiadiazole-2,5-disulfonamide | ...)copy SMILEScopy InChI
Affinity DataKi:  15nMAssay Description:Inhibition of human recombinant cytosolic isozyme CA I by stopped-flow CO2 hydrase methodMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q29G5NNHPubMed
TargetCarbonic anhydrase 1(Homo sapiens (Human))
Kochi Medical School

LigandPNGBDBM10886(2-N-benzene-1,3,4-thiadiazole-2,5-disulfonamide | ...)copy SMILEScopy InChI
Affinity DataKi:  15nMAssay Description:Inhibition of human recombinant carbonic anhydrase 1 by stopped flow CO2 hydration assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2CF9RFVPubMed
TargetCarbonic anhydrase 1(Homo sapiens (Human))
Kochi Medical School

LigandPNGBDBM10886(2-N-benzene-1,3,4-thiadiazole-2,5-disulfonamide | ...)copy SMILEScopy InChI
Affinity DataKi:  15nMAssay Description:Inhibition of human recombinant CA1 by stopped-flow CO2 assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2FJ2HQJPubMed
TargetCarbonic anhydrase 1(Homo sapiens (Human))
Kochi Medical School

LigandPNGBDBM10886(2-N-benzene-1,3,4-thiadiazole-2,5-disulfonamide | ...)copy SMILEScopy InChI
Affinity DataKi:  15nMAssay Description:Inhibition of human recombinant CA1 by stopped-flow CO2 hydrase assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2FB53WWPubMed
TargetCarbonic anhydrase 1(Homo sapiens (Human))
Kochi Medical School

LigandPNGBDBM10886(2-N-benzene-1,3,4-thiadiazole-2,5-disulfonamide | ...)copy SMILEScopy InChI
Affinity DataKi:  15nMAssay Description:Inhibition of recombinant human carbonic anhydrase 1 assessed as reduction in CO2 hydration preincubated for 15 mins followed by CO2 addition measure...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2PN97XSPubMed
TargetCarbonic anhydrase 1(Homo sapiens (Human))
Kochi Medical School

LigandPNGBDBM10886(2-N-benzene-1,3,4-thiadiazole-2,5-disulfonamide | ...)copy SMILEScopy InChI
Affinity DataKi:  15nMAssay Description:Inhibition of human carbonic anhydrase-1 assessed as reduction in CO2 hydration preincubated for 15 mins followed by CO2 addition measured for 10 to ...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q20Z75PZPubMed
TargetCarbonic anhydrase 1(Homo sapiens (Human))
Kochi Medical School

LigandPNGBDBM10886(2-N-benzene-1,3,4-thiadiazole-2,5-disulfonamide | ...)copy SMILEScopy InChI
Affinity DataKi:  15nMAssay Description:Inhibition of human CA1 incubated for 15 mins prior to testing by stopped flow CO2 hydrase assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2K93BJFPubMed
TargetCarbonic anhydrase 1(Homo sapiens (Human))
Kochi Medical School

LigandPNGBDBM10886(2-N-benzene-1,3,4-thiadiazole-2,5-disulfonamide | ...)copy SMILEScopy InChI
Affinity DataKi:  15nMAssay Description:Inhibition of full length human cytosolic carbonic anhydrase 1 preincubated for 15 mins by stop flow CO2 hydrase assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2H70K9RPubMed
TargetCarbonic anhydrase 1(Homo sapiens (Human))
Kochi Medical School

LigandPNGBDBM10886(2-N-benzene-1,3,4-thiadiazole-2,5-disulfonamide | ...)copy SMILEScopy InChI
Affinity DataKi:  15nM ΔG°:  -43.9kJ/molepH: 7.4 T: 2°CAssay Description:The initial rates of 4-nitrophenylacetate hydrolysis catalysed by different CA isozymes were monitored spectrophotometrically at 400nm with a Cary 3 ...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q20C4TBBPubMed