Compile Data Set for Download or QSAR
Found 4 Enz. Inhib. hit(s) with Target = 'Caspase-1' and Ligand = 'BDBM12197'
TargetCaspase-1(Homo sapiens (Human))
Pfizer

LigandPNGBDBM12197((3S)-3-[(2S)-2-[(2S)-2-[(2S)-2-acetamido-3-(4-hydr...)copy SMILEScopy InChI
Affinity DataKi:  11nM ΔG°:  -47.3kJ/molepH: 7.0 T: 2°CAssay Description:The substrate peptides terminating in AMC are processed by caspases with or without inhibitors, and the accumulation of AMC was assessed with a Cytof...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2BP011GPubMed
TargetCaspase-1(Homo sapiens (Human))
Pfizer

LigandPNGBDBM12197((3S)-3-[(2S)-2-[(2S)-2-[(2S)-2-acetamido-3-(4-hydr...)copy SMILEScopy InChI
Affinity DataKi:  11nMAssay Description:Inhibition of ICEMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2SQ90K1PubMed
TargetCaspase-1(Homo sapiens (Human))
Pfizer

LigandPNGBDBM12197((3S)-3-[(2S)-2-[(2S)-2-[(2S)-2-acetamido-3-(4-hydr...)copy SMILEScopy InChI
Affinity DataKi:  19nMAssay Description:The compound was tested for its inhibitory activity against IL-1 beta converting enzymeMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2BV7GJZ
TargetCaspase-1(Homo sapiens (Human))
Pfizer

LigandPNGBDBM12197((3S)-3-[(2S)-2-[(2S)-2-[(2S)-2-acetamido-3-(4-hydr...)copy SMILEScopy InChI
Affinity DataIC50: 78nMAssay Description:Inhibition of ICEMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2SQ90K1PubMed